High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy
• Multifocal motor neuropathy is associated with the HLA class II HLA-DRB1*15:01-DQB1*06:02 and HLA-DRB1*12:01-DQB1*03:01 haplotypes. • Patients with MMN carrying either of these haplotypes do not have a distinct disease course. • The associations could serve as a genetic tag for other disease assoc...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bos, Jeroen W. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors - Zidane, Mustapha ELSEVIER, 2021, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:101 ; year:2021 ; pages:79-84 ; extent:6 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.neurobiolaging.2021.01.014 |
|---|
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| 520 | |a • Multifocal motor neuropathy is associated with the HLA class II HLA-DRB1*15:01-DQB1*06:02 and HLA-DRB1*12:01-DQB1*03:01 haplotypes. • Patients with MMN carrying either of these haplotypes do not have a distinct disease course. • The associations could serve as a genetic tag for other disease associated regions on chromosome 6, including the MHC class III region. • Though a direct link though antigen presentation seems unlikely, these associations imply the role of T cells in the specific inflammation underlying MMN. | ||
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10.1016/j.neurobiolaging.2021.01.014 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001410.pica (DE-627)ELV053976118 (ELSEVIER)S0197-4580(21)00021-X DE-627 ger DE-627 rakwb eng 550 520 VZ 38.70 bkl 39.53 bkl Bos, Jeroen W. verfasserin aut High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy 2021 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Multifocal motor neuropathy is associated with the HLA class II HLA-DRB1*15:01-DQB1*06:02 and HLA-DRB1*12:01-DQB1*03:01 haplotypes. • Patients with MMN carrying either of these haplotypes do not have a distinct disease course. • The associations could serve as a genetic tag for other disease associated regions on chromosome 6, including the MHC class III region. • Though a direct link though antigen presentation seems unlikely, these associations imply the role of T cells in the specific inflammation underlying MMN. Otten, Henny G. oth Herraets, Ingrid J.T. oth Goedee, H. Stephan oth Cats, E.A. oth de Hoop, Talitha oth Verduijn, Willem oth van der Pol, W. Ludo oth van den Berg, Leonard H. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:101 year:2021 pages:79-84 extent:6 https://doi.org/10.1016/j.neurobiolaging.2021.01.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 101 2021 79-84 6 |
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10.1016/j.neurobiolaging.2021.01.014 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001410.pica (DE-627)ELV053976118 (ELSEVIER)S0197-4580(21)00021-X DE-627 ger DE-627 rakwb eng 550 520 VZ 38.70 bkl 39.53 bkl Bos, Jeroen W. verfasserin aut High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy 2021 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Multifocal motor neuropathy is associated with the HLA class II HLA-DRB1*15:01-DQB1*06:02 and HLA-DRB1*12:01-DQB1*03:01 haplotypes. • Patients with MMN carrying either of these haplotypes do not have a distinct disease course. • The associations could serve as a genetic tag for other disease associated regions on chromosome 6, including the MHC class III region. • Though a direct link though antigen presentation seems unlikely, these associations imply the role of T cells in the specific inflammation underlying MMN. Otten, Henny G. oth Herraets, Ingrid J.T. oth Goedee, H. Stephan oth Cats, E.A. oth de Hoop, Talitha oth Verduijn, Willem oth van der Pol, W. Ludo oth van den Berg, Leonard H. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:101 year:2021 pages:79-84 extent:6 https://doi.org/10.1016/j.neurobiolaging.2021.01.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 101 2021 79-84 6 |
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10.1016/j.neurobiolaging.2021.01.014 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001410.pica (DE-627)ELV053976118 (ELSEVIER)S0197-4580(21)00021-X DE-627 ger DE-627 rakwb eng 550 520 VZ 38.70 bkl 39.53 bkl Bos, Jeroen W. verfasserin aut High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy 2021 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Multifocal motor neuropathy is associated with the HLA class II HLA-DRB1*15:01-DQB1*06:02 and HLA-DRB1*12:01-DQB1*03:01 haplotypes. • Patients with MMN carrying either of these haplotypes do not have a distinct disease course. • The associations could serve as a genetic tag for other disease associated regions on chromosome 6, including the MHC class III region. • Though a direct link though antigen presentation seems unlikely, these associations imply the role of T cells in the specific inflammation underlying MMN. Otten, Henny G. oth Herraets, Ingrid J.T. oth Goedee, H. Stephan oth Cats, E.A. oth de Hoop, Talitha oth Verduijn, Willem oth van der Pol, W. Ludo oth van den Berg, Leonard H. oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:101 year:2021 pages:79-84 extent:6 https://doi.org/10.1016/j.neurobiolaging.2021.01.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 101 2021 79-84 6 |
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Bos, Jeroen W. |
| doi_str_mv |
10.1016/j.neurobiolaging.2021.01.014 |
| dewey-full |
550 520 |
| title_sort |
high-resolution mapping identifies hla class ii associations with multifocal motor neuropathy |
| title_auth |
High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy |
| abstract |
• Multifocal motor neuropathy is associated with the HLA class II HLA-DRB1*15:01-DQB1*06:02 and HLA-DRB1*12:01-DQB1*03:01 haplotypes. • Patients with MMN carrying either of these haplotypes do not have a distinct disease course. • The associations could serve as a genetic tag for other disease associated regions on chromosome 6, including the MHC class III region. • Though a direct link though antigen presentation seems unlikely, these associations imply the role of T cells in the specific inflammation underlying MMN. |
| abstractGer |
• Multifocal motor neuropathy is associated with the HLA class II HLA-DRB1*15:01-DQB1*06:02 and HLA-DRB1*12:01-DQB1*03:01 haplotypes. • Patients with MMN carrying either of these haplotypes do not have a distinct disease course. • The associations could serve as a genetic tag for other disease associated regions on chromosome 6, including the MHC class III region. • Though a direct link though antigen presentation seems unlikely, these associations imply the role of T cells in the specific inflammation underlying MMN. |
| abstract_unstemmed |
• Multifocal motor neuropathy is associated with the HLA class II HLA-DRB1*15:01-DQB1*06:02 and HLA-DRB1*12:01-DQB1*03:01 haplotypes. • Patients with MMN carrying either of these haplotypes do not have a distinct disease course. • The associations could serve as a genetic tag for other disease associated regions on chromosome 6, including the MHC class III region. • Though a direct link though antigen presentation seems unlikely, these associations imply the role of T cells in the specific inflammation underlying MMN. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST |
| title_short |
High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy |
| url |
https://doi.org/10.1016/j.neurobiolaging.2021.01.014 |
| remote_bool |
true |
| author2 |
Otten, Henny G. Herraets, Ingrid J.T. Goedee, H. Stephan Cats, E.A. de Hoop, Talitha Verduijn, Willem van der Pol, W. Ludo van den Berg, Leonard H. |
| author2Str |
Otten, Henny G. Herraets, Ingrid J.T. Goedee, H. Stephan Cats, E.A. de Hoop, Talitha Verduijn, Willem van der Pol, W. Ludo van den Berg, Leonard H. |
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| doi_str |
10.1016/j.neurobiolaging.2021.01.014 |
| up_date |
2024-07-06T20:25:44.187Z |
| _version_ |
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