Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model
Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and des...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gao, Jing [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Summer bloom of - Moreira-González, Angel R. ELSEVIER, 2020, environmental control, risk assessment, impact and management, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:414 ; year:2021 ; day:15 ; month:07 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.jhazmat.2021.125492 |
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| 245 | 1 | 0 | |a Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model |
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| 520 | |a Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. | ||
| 520 | |a Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. | ||
| 650 | 7 | |a Enantioselectivity |2 Elsevier | |
| 650 | 7 | |a Metabolites |2 Elsevier | |
| 650 | 7 | |a Toxicity |2 Elsevier | |
| 650 | 7 | |a Phenylpyrazole insecticide |2 Elsevier | |
| 650 | 7 | |a Accumulation |2 Elsevier | |
| 700 | 1 | |a Wang, Fang |4 oth | |
| 700 | 1 | |a Cui, Jingna |4 oth | |
| 700 | 1 | |a Zhang, Qiang |4 oth | |
| 700 | 1 | |a Wang, Peng |4 oth | |
| 700 | 1 | |a Liu, Donghui |4 oth | |
| 700 | 1 | |a Zhou, Zhiqiang |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Science Direct |a Moreira-González, Angel R. ELSEVIER |t Summer bloom of |d 2020 |d environmental control, risk assessment, impact and management |g New York, NY [u.a.] |w (DE-627)ELV005292484 |
| 773 | 1 | 8 | |g volume:414 |g year:2021 |g day:15 |g month:07 |g pages:0 |
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10.1016/j.jhazmat.2021.125492 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001600.pica (DE-627)ELV054049253 (ELSEVIER)S0304-3894(21)00455-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Gao, Jing verfasserin aut Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Enantioselectivity Elsevier Metabolites Elsevier Toxicity Elsevier Phenylpyrazole insecticide Elsevier Accumulation Elsevier Wang, Fang oth Cui, Jingna oth Zhang, Qiang oth Wang, Peng oth Liu, Donghui oth Zhou, Zhiqiang oth Enthalten in Science Direct Moreira-González, Angel R. ELSEVIER Summer bloom of 2020 environmental control, risk assessment, impact and management New York, NY [u.a.] (DE-627)ELV005292484 volume:414 year:2021 day:15 month:07 pages:0 https://doi.org/10.1016/j.jhazmat.2021.125492 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 414 2021 15 0715 0 |
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10.1016/j.jhazmat.2021.125492 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001600.pica (DE-627)ELV054049253 (ELSEVIER)S0304-3894(21)00455-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Gao, Jing verfasserin aut Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Enantioselectivity Elsevier Metabolites Elsevier Toxicity Elsevier Phenylpyrazole insecticide Elsevier Accumulation Elsevier Wang, Fang oth Cui, Jingna oth Zhang, Qiang oth Wang, Peng oth Liu, Donghui oth Zhou, Zhiqiang oth Enthalten in Science Direct Moreira-González, Angel R. ELSEVIER Summer bloom of 2020 environmental control, risk assessment, impact and management New York, NY [u.a.] (DE-627)ELV005292484 volume:414 year:2021 day:15 month:07 pages:0 https://doi.org/10.1016/j.jhazmat.2021.125492 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 414 2021 15 0715 0 |
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10.1016/j.jhazmat.2021.125492 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001600.pica (DE-627)ELV054049253 (ELSEVIER)S0304-3894(21)00455-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Gao, Jing verfasserin aut Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Enantioselectivity Elsevier Metabolites Elsevier Toxicity Elsevier Phenylpyrazole insecticide Elsevier Accumulation Elsevier Wang, Fang oth Cui, Jingna oth Zhang, Qiang oth Wang, Peng oth Liu, Donghui oth Zhou, Zhiqiang oth Enthalten in Science Direct Moreira-González, Angel R. ELSEVIER Summer bloom of 2020 environmental control, risk assessment, impact and management New York, NY [u.a.] (DE-627)ELV005292484 volume:414 year:2021 day:15 month:07 pages:0 https://doi.org/10.1016/j.jhazmat.2021.125492 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 414 2021 15 0715 0 |
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10.1016/j.jhazmat.2021.125492 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001600.pica (DE-627)ELV054049253 (ELSEVIER)S0304-3894(21)00455-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Gao, Jing verfasserin aut Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Enantioselectivity Elsevier Metabolites Elsevier Toxicity Elsevier Phenylpyrazole insecticide Elsevier Accumulation Elsevier Wang, Fang oth Cui, Jingna oth Zhang, Qiang oth Wang, Peng oth Liu, Donghui oth Zhou, Zhiqiang oth Enthalten in Science Direct Moreira-González, Angel R. ELSEVIER Summer bloom of 2020 environmental control, risk assessment, impact and management New York, NY [u.a.] (DE-627)ELV005292484 volume:414 year:2021 day:15 month:07 pages:0 https://doi.org/10.1016/j.jhazmat.2021.125492 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 414 2021 15 0715 0 |
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10.1016/j.jhazmat.2021.125492 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001600.pica (DE-627)ELV054049253 (ELSEVIER)S0304-3894(21)00455-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Gao, Jing verfasserin aut Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. Enantioselectivity Elsevier Metabolites Elsevier Toxicity Elsevier Phenylpyrazole insecticide Elsevier Accumulation Elsevier Wang, Fang oth Cui, Jingna oth Zhang, Qiang oth Wang, Peng oth Liu, Donghui oth Zhou, Zhiqiang oth Enthalten in Science Direct Moreira-González, Angel R. ELSEVIER Summer bloom of 2020 environmental control, risk assessment, impact and management New York, NY [u.a.] (DE-627)ELV005292484 volume:414 year:2021 day:15 month:07 pages:0 https://doi.org/10.1016/j.jhazmat.2021.125492 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 414 2021 15 0715 0 |
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Assessment of toxicity and environmental behavior of chiral ethiprole and its metabolites using zebrafish model |
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Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. |
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Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. |
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Ethiprole is effective against a wide range of insects and has been used throughout the world. In this work, the toxicity, bioaccumulation and elimination of ethiprole and its main metabolites (ethiprole sulfone (M1), ethiprole sulfide (M2), ethiprole amide (M3), ethiprole sulfone amide (M4) and desethylsulfinyl ethiprole (M5)) in zebrafish Danio rerio were investigated at enantiomeric level. Rac-ethiprole showed high toxicity (96 h LC50 = 708 μg L−1) and M2 was six times more toxic than ethiprole (111 μg L−1). Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. This study indicated assessment of metabolites and enantioselectivity should be taken into consideration in evaluating environmental risks of ethiprole. |
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Enantioselective toxicity was observed, with the S-ethiprole (924 μg L−1) being more toxic than R-ethiprole (2195 μg·L−1). Rac-ethiprole and M2 could induce oxidative stress in the liver of adult zebrafish and developmental toxicity in zebrafish embryos. Zebrafish were exposed to 100 μg L−1 rac-/R-/S-ethiprole and the bioaccumulation was monitored during a 21 d period followed by a 7 d metabolism. The bioconcentration factor (BCF) of rac-ethiprole was 17, and the half-lives of rac-ethiprole and metabolites varied between 0.44 and 2.99 d. R-ethiprole was preferentially accumulated and metabolized in zebrafish. Besides, the metabolic pathways of R- and S-ethiprole were found to be different. 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ELSEVIER</subfield><subfield code="t">Summer bloom of</subfield><subfield code="d">2020</subfield><subfield code="d">environmental control, risk assessment, impact and management</subfield><subfield code="g">New York, NY [u.a.]</subfield><subfield code="w">(DE-627)ELV005292484</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:414</subfield><subfield code="g">year:2021</subfield><subfield code="g">day:15</subfield><subfield code="g">month:07</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.jhazmat.2021.125492</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">43.12</subfield><subfield code="j">Umweltchemie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">43.13</subfield><subfield code="j">Umwelttoxikologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.13</subfield><subfield code="j">Medizinische Ökologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">414</subfield><subfield code="j">2021</subfield><subfield code="b">15</subfield><subfield code="c">0715</subfield><subfield code="h">0</subfield></datafield></record></collection>
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