Identification of a prognostic signature based on immune-related genes in bladder cancer
Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lv, Zhengtong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Umfang: |
16 |
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| Übergeordnetes Werk: |
Enthalten in: Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt - Redwan, Mostafa ELSEVIER, 2017transfer abstract, an international journal for analysis of the human and other genomes, San Diego, Calif |
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| Übergeordnetes Werk: |
volume:113 ; year:2021 ; number:3 ; pages:1203-1218 ; extent:16 |
| Links: |
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| DOI / URN: |
10.1016/j.ygeno.2021.03.012 |
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| 520 | |a Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. | ||
| 520 | |a Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. | ||
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10.1016/j.ygeno.2021.03.012 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001949.pica (DE-627)ELV05439032X (ELSEVIER)S0888-7543(21)00104-X DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Lv, Zhengtong verfasserin aut Identification of a prognostic signature based on immune-related genes in bladder cancer 2021transfer abstract 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Pang, Cheng oth Wang, Jinfu oth Xia, Haoran oth Liu, Jingchao oth Yan, Qiuxia oth Liu, Shengjie oth Liu, Ming oth Wang, Jianye oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:3 pages:1203-1218 extent:16 https://doi.org/10.1016/j.ygeno.2021.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 3 1203-1218 16 |
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10.1016/j.ygeno.2021.03.012 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001949.pica (DE-627)ELV05439032X (ELSEVIER)S0888-7543(21)00104-X DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Lv, Zhengtong verfasserin aut Identification of a prognostic signature based on immune-related genes in bladder cancer 2021transfer abstract 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Pang, Cheng oth Wang, Jinfu oth Xia, Haoran oth Liu, Jingchao oth Yan, Qiuxia oth Liu, Shengjie oth Liu, Ming oth Wang, Jianye oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:3 pages:1203-1218 extent:16 https://doi.org/10.1016/j.ygeno.2021.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 3 1203-1218 16 |
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10.1016/j.ygeno.2021.03.012 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001949.pica (DE-627)ELV05439032X (ELSEVIER)S0888-7543(21)00104-X DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Lv, Zhengtong verfasserin aut Identification of a prognostic signature based on immune-related genes in bladder cancer 2021transfer abstract 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Pang, Cheng oth Wang, Jinfu oth Xia, Haoran oth Liu, Jingchao oth Yan, Qiuxia oth Liu, Shengjie oth Liu, Ming oth Wang, Jianye oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:3 pages:1203-1218 extent:16 https://doi.org/10.1016/j.ygeno.2021.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 3 1203-1218 16 |
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10.1016/j.ygeno.2021.03.012 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001949.pica (DE-627)ELV05439032X (ELSEVIER)S0888-7543(21)00104-X DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Lv, Zhengtong verfasserin aut Identification of a prognostic signature based on immune-related genes in bladder cancer 2021transfer abstract 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Pang, Cheng oth Wang, Jinfu oth Xia, Haoran oth Liu, Jingchao oth Yan, Qiuxia oth Liu, Shengjie oth Liu, Ming oth Wang, Jianye oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:3 pages:1203-1218 extent:16 https://doi.org/10.1016/j.ygeno.2021.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 3 1203-1218 16 |
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10.1016/j.ygeno.2021.03.012 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001949.pica (DE-627)ELV05439032X (ELSEVIER)S0888-7543(21)00104-X DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Lv, Zhengtong verfasserin aut Identification of a prognostic signature based on immune-related genes in bladder cancer 2021transfer abstract 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. Pang, Cheng oth Wang, Jinfu oth Xia, Haoran oth Liu, Jingchao oth Yan, Qiuxia oth Liu, Shengjie oth Liu, Ming oth Wang, Jianye oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:3 pages:1203-1218 extent:16 https://doi.org/10.1016/j.ygeno.2021.03.012 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 3 1203-1218 16 |
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Enthalten in Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt San Diego, Calif volume:113 year:2021 number:3 pages:1203-1218 extent:16 |
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Enthalten in Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt San Diego, Calif volume:113 year:2021 number:3 pages:1203-1218 extent:16 |
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Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt |
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identification of a prognostic signature based on immune-related genes in bladder cancer |
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Identification of a prognostic signature based on immune-related genes in bladder cancer |
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Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. |
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Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. |
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Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients. |
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Identification of a prognostic signature based on immune-related genes in bladder cancer |
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