Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality
Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8%...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alghamdi, Jahad [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt - Redwan, Mostafa ELSEVIER, 2017transfer abstract, an international journal for analysis of the human and other genomes, San Diego, Calif |
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| Übergeordnetes Werk: |
volume:113 ; year:2021 ; number:4 ; pages:1733-1741 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.ygeno.2021.04.002 |
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| 520 | |a Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. | ||
| 520 | |a Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. | ||
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10.1016/j.ygeno.2021.04.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001789.pica (DE-627)ELV054526078 (ELSEVIER)S0888-7543(21)00128-2 DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Alghamdi, Jahad verfasserin aut Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Alaamery, Manal oth Barhoumi, Tlili oth Rashid, Mamoon oth Alajmi, Hala oth Aljasser, Nasser oth Alhendi, Yaseen oth Alkhalaf, Hind oth Alqahtani, Hanadi oth Algablan, Omer oth Alshaya, Abdulraham I. oth Tashkandi, Nabiha oth Massadeh, Salam oth Almuzzaini, Bader oth Ehaideb, Salleh N. oth Bosaeed, Mohammad oth Ayoub, Kamal oth Yezli, Saber oth Khan, Anas oth Alaskar, Ahmed oth Bouchama, Abderrezak oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:4 pages:1733-1741 extent:9 https://doi.org/10.1016/j.ygeno.2021.04.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 4 1733-1741 9 |
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10.1016/j.ygeno.2021.04.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001789.pica (DE-627)ELV054526078 (ELSEVIER)S0888-7543(21)00128-2 DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Alghamdi, Jahad verfasserin aut Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Alaamery, Manal oth Barhoumi, Tlili oth Rashid, Mamoon oth Alajmi, Hala oth Aljasser, Nasser oth Alhendi, Yaseen oth Alkhalaf, Hind oth Alqahtani, Hanadi oth Algablan, Omer oth Alshaya, Abdulraham I. oth Tashkandi, Nabiha oth Massadeh, Salam oth Almuzzaini, Bader oth Ehaideb, Salleh N. oth Bosaeed, Mohammad oth Ayoub, Kamal oth Yezli, Saber oth Khan, Anas oth Alaskar, Ahmed oth Bouchama, Abderrezak oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:4 pages:1733-1741 extent:9 https://doi.org/10.1016/j.ygeno.2021.04.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 4 1733-1741 9 |
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10.1016/j.ygeno.2021.04.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001789.pica (DE-627)ELV054526078 (ELSEVIER)S0888-7543(21)00128-2 DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Alghamdi, Jahad verfasserin aut Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Alaamery, Manal oth Barhoumi, Tlili oth Rashid, Mamoon oth Alajmi, Hala oth Aljasser, Nasser oth Alhendi, Yaseen oth Alkhalaf, Hind oth Alqahtani, Hanadi oth Algablan, Omer oth Alshaya, Abdulraham I. oth Tashkandi, Nabiha oth Massadeh, Salam oth Almuzzaini, Bader oth Ehaideb, Salleh N. oth Bosaeed, Mohammad oth Ayoub, Kamal oth Yezli, Saber oth Khan, Anas oth Alaskar, Ahmed oth Bouchama, Abderrezak oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:4 pages:1733-1741 extent:9 https://doi.org/10.1016/j.ygeno.2021.04.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 4 1733-1741 9 |
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10.1016/j.ygeno.2021.04.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001789.pica (DE-627)ELV054526078 (ELSEVIER)S0888-7543(21)00128-2 DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Alghamdi, Jahad verfasserin aut Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Alaamery, Manal oth Barhoumi, Tlili oth Rashid, Mamoon oth Alajmi, Hala oth Aljasser, Nasser oth Alhendi, Yaseen oth Alkhalaf, Hind oth Alqahtani, Hanadi oth Algablan, Omer oth Alshaya, Abdulraham I. oth Tashkandi, Nabiha oth Massadeh, Salam oth Almuzzaini, Bader oth Ehaideb, Salleh N. oth Bosaeed, Mohammad oth Ayoub, Kamal oth Yezli, Saber oth Khan, Anas oth Alaskar, Ahmed oth Bouchama, Abderrezak oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:4 pages:1733-1741 extent:9 https://doi.org/10.1016/j.ygeno.2021.04.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 4 1733-1741 9 |
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10.1016/j.ygeno.2021.04.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001789.pica (DE-627)ELV054526078 (ELSEVIER)S0888-7543(21)00128-2 DE-627 ger DE-627 rakwb eng 550 VZ 620 VZ 55.50 bkl 55.60 bkl 55.60 bkl Alghamdi, Jahad verfasserin aut Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Alaamery, Manal oth Barhoumi, Tlili oth Rashid, Mamoon oth Alajmi, Hala oth Aljasser, Nasser oth Alhendi, Yaseen oth Alkhalaf, Hind oth Alqahtani, Hanadi oth Algablan, Omer oth Alshaya, Abdulraham I. oth Tashkandi, Nabiha oth Massadeh, Salam oth Almuzzaini, Bader oth Ehaideb, Salleh N. oth Bosaeed, Mohammad oth Ayoub, Kamal oth Yezli, Saber oth Khan, Anas oth Alaskar, Ahmed oth Bouchama, Abderrezak oth Enthalten in Academic Press Redwan, Mostafa ELSEVIER Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt 2017transfer abstract an international journal for analysis of the human and other genomes San Diego, Calif (DE-627)ELV020260245 volume:113 year:2021 number:4 pages:1733-1741 extent:9 https://doi.org/10.1016/j.ygeno.2021.04.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-AST 55.50 Luftfahrzeugtechnik VZ 55.60 Raumfahrttechnik VZ 55.60 Raumfahrttechnik VZ AR 113 2021 4 1733-1741 9 |
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Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality |
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Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. |
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Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. |
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Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. |
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Early identification of these individuals at higher risk of death may inform precision public health response.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population . We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01–2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16–4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNγ were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alaamery, Manal</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barhoumi, Tlili</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rashid, Mamoon</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alajmi, Hala</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Aljasser, Nasser</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alhendi, Yaseen</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alkhalaf, Hind</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alqahtani, Hanadi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Algablan, Omer</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alshaya, Abdulraham I.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tashkandi, Nabiha</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Massadeh, Salam</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Almuzzaini, Bader</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ehaideb, Salleh N.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bosaeed, Mohammad</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ayoub, Kamal</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yezli, Saber</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Khan, Anas</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alaskar, Ahmed</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bouchama, Abderrezak</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Academic Press</subfield><subfield code="a">Redwan, Mostafa ELSEVIER</subfield><subfield code="t">Flood hazard assessment and heavy metal distributions around Um Gheig mine area, Eastern Desert, Egypt</subfield><subfield code="d">2017transfer abstract</subfield><subfield code="d">an international journal for analysis of the human and other genomes</subfield><subfield code="g">San Diego, Calif</subfield><subfield code="w">(DE-627)ELV020260245</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:113</subfield><subfield code="g">year:2021</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:1733-1741</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ygeno.2021.04.002</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-AST</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">55.50</subfield><subfield code="j">Luftfahrzeugtechnik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">55.60</subfield><subfield code="j">Raumfahrttechnik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">55.60</subfield><subfield code="j">Raumfahrttechnik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">113</subfield><subfield code="j">2021</subfield><subfield code="e">4</subfield><subfield code="h">1733-1741</subfield><subfield code="g">9</subfield></datafield></record></collection>
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