Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process
Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with e...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jiang, Tiantian [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
|---|
| Umfang: |
13 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Role of sulfur in combating arsenic stress through upregulation of important proteins, and - Amna, Syeda ELSEVIER, 2020, an international journal on the science and technology of wet and dry particulate systems, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:392 ; year:2021 ; pages:690-702 ; extent:13 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.powtec.2021.07.059 |
|---|
| Katalog-ID: |
ELV054824575 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV054824575 | ||
| 003 | DE-627 | ||
| 005 | 20230626040810.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210910s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.powtec.2021.07.059 |2 doi | |
| 028 | 5 | 2 | |a /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001474.pica |
| 035 | |a (DE-627)ELV054824575 | ||
| 035 | |a (ELSEVIER)S0032-5910(21)00649-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 630 |a 640 |a 580 |q VZ |
| 084 | |a BIODIV |q DE-30 |2 fid | ||
| 084 | |a 42.00 |2 bkl | ||
| 100 | 1 | |a Jiang, Tiantian |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process |
| 264 | 1 | |c 2021transfer abstract | |
| 300 | |a 13 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. | ||
| 520 | |a Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. | ||
| 700 | 1 | |a Yan, Shen |4 oth | |
| 700 | 1 | |a Zhang, Shengyu |4 oth | |
| 700 | 1 | |a Yin, Quanyi |4 oth | |
| 700 | 1 | |a Chen, Xiao Dong |4 oth | |
| 700 | 1 | |a Wu, Winston Duo |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Amna, Syeda ELSEVIER |t Role of sulfur in combating arsenic stress through upregulation of important proteins, and |d 2020 |d an international journal on the science and technology of wet and dry particulate systems |g Amsterdam [u.a.] |w (DE-627)ELV005093252 |
| 773 | 1 | 8 | |g volume:392 |g year:2021 |g pages:690-702 |g extent:13 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.powtec.2021.07.059 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a FID-BIODIV | ||
| 936 | b | k | |a 42.00 |j Biologie: Allgemeines |q VZ |
| 951 | |a AR | ||
| 952 | |d 392 |j 2021 |h 690-702 |g 13 | ||
| author_variant |
t j tj |
|---|---|
| matchkey_str |
jiangtiantianyanshenzhangshengyuyinquany:2021----:nfrlcoeirshrsihihrsalntfbiaebmcoliisryrigehooy |
| hierarchy_sort_str |
2021transfer abstract |
| bklnumber |
42.00 |
| publishDate |
2021 |
| allfields |
10.1016/j.powtec.2021.07.059 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001474.pica (DE-627)ELV054824575 (ELSEVIER)S0032-5910(21)00649-5 DE-627 ger DE-627 rakwb eng 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Jiang, Tiantian verfasserin aut Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Yan, Shen oth Zhang, Shengyu oth Yin, Quanyi oth Chen, Xiao Dong oth Wu, Winston Duo oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:392 year:2021 pages:690-702 extent:13 https://doi.org/10.1016/j.powtec.2021.07.059 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 392 2021 690-702 13 |
| spelling |
10.1016/j.powtec.2021.07.059 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001474.pica (DE-627)ELV054824575 (ELSEVIER)S0032-5910(21)00649-5 DE-627 ger DE-627 rakwb eng 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Jiang, Tiantian verfasserin aut Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Yan, Shen oth Zhang, Shengyu oth Yin, Quanyi oth Chen, Xiao Dong oth Wu, Winston Duo oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:392 year:2021 pages:690-702 extent:13 https://doi.org/10.1016/j.powtec.2021.07.059 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 392 2021 690-702 13 |
| allfields_unstemmed |
10.1016/j.powtec.2021.07.059 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001474.pica (DE-627)ELV054824575 (ELSEVIER)S0032-5910(21)00649-5 DE-627 ger DE-627 rakwb eng 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Jiang, Tiantian verfasserin aut Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Yan, Shen oth Zhang, Shengyu oth Yin, Quanyi oth Chen, Xiao Dong oth Wu, Winston Duo oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:392 year:2021 pages:690-702 extent:13 https://doi.org/10.1016/j.powtec.2021.07.059 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 392 2021 690-702 13 |
| allfieldsGer |
10.1016/j.powtec.2021.07.059 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001474.pica (DE-627)ELV054824575 (ELSEVIER)S0032-5910(21)00649-5 DE-627 ger DE-627 rakwb eng 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Jiang, Tiantian verfasserin aut Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Yan, Shen oth Zhang, Shengyu oth Yin, Quanyi oth Chen, Xiao Dong oth Wu, Winston Duo oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:392 year:2021 pages:690-702 extent:13 https://doi.org/10.1016/j.powtec.2021.07.059 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 392 2021 690-702 13 |
| allfieldsSound |
10.1016/j.powtec.2021.07.059 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001474.pica (DE-627)ELV054824575 (ELSEVIER)S0032-5910(21)00649-5 DE-627 ger DE-627 rakwb eng 630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Jiang, Tiantian verfasserin aut Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. Yan, Shen oth Zhang, Shengyu oth Yin, Quanyi oth Chen, Xiao Dong oth Wu, Winston Duo oth Enthalten in Elsevier Science Amna, Syeda ELSEVIER Role of sulfur in combating arsenic stress through upregulation of important proteins, and 2020 an international journal on the science and technology of wet and dry particulate systems Amsterdam [u.a.] (DE-627)ELV005093252 volume:392 year:2021 pages:690-702 extent:13 https://doi.org/10.1016/j.powtec.2021.07.059 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV 42.00 Biologie: Allgemeines VZ AR 392 2021 690-702 13 |
| language |
English |
| source |
Enthalten in Role of sulfur in combating arsenic stress through upregulation of important proteins, and Amsterdam [u.a.] volume:392 year:2021 pages:690-702 extent:13 |
| sourceStr |
Enthalten in Role of sulfur in combating arsenic stress through upregulation of important proteins, and Amsterdam [u.a.] volume:392 year:2021 pages:690-702 extent:13 |
| format_phy_str_mv |
Article |
| bklname |
Biologie: Allgemeines |
| institution |
findex.gbv.de |
| dewey-raw |
630 |
| isfreeaccess_bool |
false |
| container_title |
Role of sulfur in combating arsenic stress through upregulation of important proteins, and |
| authorswithroles_txt_mv |
Jiang, Tiantian @@aut@@ Yan, Shen @@oth@@ Zhang, Shengyu @@oth@@ Yin, Quanyi @@oth@@ Chen, Xiao Dong @@oth@@ Wu, Winston Duo @@oth@@ |
| publishDateDaySort_date |
2021-01-01T00:00:00Z |
| hierarchy_top_id |
ELV005093252 |
| dewey-sort |
3630 |
| id |
ELV054824575 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV054824575</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626040810.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">210910s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.powtec.2021.07.059</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">/cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001474.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV054824575</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0032-5910(21)00649-5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="a">640</subfield><subfield code="a">580</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Jiang, Tiantian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">13</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yan, Shen</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Shengyu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yin, Quanyi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Xiao Dong</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wu, Winston Duo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Amna, Syeda ELSEVIER</subfield><subfield code="t">Role of sulfur in combating arsenic stress through upregulation of important proteins, and</subfield><subfield code="d">2020</subfield><subfield code="d">an international journal on the science and technology of wet and dry particulate systems</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV005093252</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:392</subfield><subfield code="g">year:2021</subfield><subfield code="g">pages:690-702</subfield><subfield code="g">extent:13</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.powtec.2021.07.059</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.00</subfield><subfield code="j">Biologie: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">392</subfield><subfield code="j">2021</subfield><subfield code="h">690-702</subfield><subfield code="g">13</subfield></datafield></record></collection>
|
| author |
Jiang, Tiantian |
| spellingShingle |
Jiang, Tiantian ddc 630 fid BIODIV bkl 42.00 Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process |
| authorStr |
Jiang, Tiantian |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV005093252 |
| format |
electronic Article |
| dewey-ones |
630 - Agriculture & related technologies 640 - Home & family management 580 - Plants (Botany) |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
630 640 580 VZ BIODIV DE-30 fid 42.00 bkl Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process |
| topic |
ddc 630 fid BIODIV bkl 42.00 |
| topic_unstemmed |
ddc 630 fid BIODIV bkl 42.00 |
| topic_browse |
ddc 630 fid BIODIV bkl 42.00 |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
s y sy s z sz q y qy x d c xd xdc w d w wd wdw |
| hierarchy_parent_title |
Role of sulfur in combating arsenic stress through upregulation of important proteins, and |
| hierarchy_parent_id |
ELV005093252 |
| dewey-tens |
630 - Agriculture 640 - Home & family management 580 - Plants (Botany) |
| hierarchy_top_title |
Role of sulfur in combating arsenic stress through upregulation of important proteins, and |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV005093252 |
| title |
Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process |
| ctrlnum |
(DE-627)ELV054824575 (ELSEVIER)S0032-5910(21)00649-5 |
| title_full |
Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process |
| author_sort |
Jiang, Tiantian |
| journal |
Role of sulfur in combating arsenic stress through upregulation of important proteins, and |
| journalStr |
Role of sulfur in combating arsenic stress through upregulation of important proteins, and |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology 500 - Science |
| recordtype |
marc |
| publishDateSort |
2021 |
| contenttype_str_mv |
zzz |
| container_start_page |
690 |
| author_browse |
Jiang, Tiantian |
| container_volume |
392 |
| physical |
13 |
| class |
630 640 580 VZ BIODIV DE-30 fid 42.00 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Jiang, Tiantian |
| doi_str_mv |
10.1016/j.powtec.2021.07.059 |
| dewey-full |
630 640 580 |
| title_sort |
uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process |
| title_auth |
Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process |
| abstract |
Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. |
| abstractGer |
Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. |
| abstract_unstemmed |
Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV |
| title_short |
Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process |
| url |
https://doi.org/10.1016/j.powtec.2021.07.059 |
| remote_bool |
true |
| author2 |
Yan, Shen Zhang, Shengyu Yin, Quanyi Chen, Xiao Dong Wu, Winston Duo |
| author2Str |
Yan, Shen Zhang, Shengyu Yin, Quanyi Chen, Xiao Dong Wu, Winston Duo |
| ppnlink |
ELV005093252 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth |
| doi_str |
10.1016/j.powtec.2021.07.059 |
| up_date |
2024-07-06T22:48:23.341Z |
| _version_ |
1803871692618989568 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV054824575</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626040810.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">210910s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.powtec.2021.07.059</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">/cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001474.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV054824575</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0032-5910(21)00649-5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="a">640</subfield><subfield code="a">580</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Jiang, Tiantian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying technology combined with post-treatment process</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">13</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with ethanol/water post-treatment process. The effects of feed solution composition and ethanol/water volume ratio on particle size, morphology, density, crystal property and hygroscopicity were investigated. The obtained spherical lactose/PEG 200 microparticles were partially crystallized (30-50%), exhibiting dominant crystal forms of anhydrous Lα and Lβ. After removing PEG 200 by ethanol/water, the resulting microparticles remained uniform and spherical with enhanced crystallinity (92.90 ± 1.40%), high Lα·H2O content (68.57%) and ultra-low hygroscopicity (0.29%). Possible mechanism of “micro-zone competitive dissolution-reprecipitation” was proposed to reveal the influence of PEG 200 and ethanol/water volume ratio on promoting crystallinity and maintaining spherical morphology of lactose microparticles. This work provides a promising and up-scalable way to manufacture spherical crystalline microparticles.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yan, Shen</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Shengyu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yin, Quanyi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Xiao Dong</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wu, Winston Duo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Amna, Syeda ELSEVIER</subfield><subfield code="t">Role of sulfur in combating arsenic stress through upregulation of important proteins, and</subfield><subfield code="d">2020</subfield><subfield code="d">an international journal on the science and technology of wet and dry particulate systems</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV005093252</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:392</subfield><subfield code="g">year:2021</subfield><subfield code="g">pages:690-702</subfield><subfield code="g">extent:13</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.powtec.2021.07.059</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.00</subfield><subfield code="j">Biologie: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">392</subfield><subfield code="j">2021</subfield><subfield code="h">690-702</subfield><subfield code="g">13</subfield></datafield></record></collection>
|
| score |
7.399935 |