Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease
Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
McKnight, Colin D. [verfasserIn] Trujillo, Paula [verfasserIn] Lopez, Alexander M. [verfasserIn] Petersen, Kalen [verfasserIn] Considine, Ciaran [verfasserIn] Lin, Ya-Chen [verfasserIn] Yan, Yan [verfasserIn] Kang, Hakmook [verfasserIn] Donahue, Manus J. [verfasserIn] Claassen, Daniel O. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Parkinsonism & related disorders - Amsterdam [u.a.] : Elsevier Science, 1995, 89, Seite 98-104 |
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| Übergeordnetes Werk: |
volume:89 ; pages:98-104 |
| DOI / URN: |
10.1016/j.parkreldis.2021.06.004 |
|---|
| Katalog-ID: |
ELV055111866 |
|---|
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| 100 | 1 | |a McKnight, Colin D. |e verfasserin |0 (orcid)0000-0002-4386-8999 |4 aut | |
| 245 | 1 | 0 | |a Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease |
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| 520 | |a Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. | ||
| 650 | 4 | |a Glymphatic | |
| 650 | 4 | |a Diffusion | |
| 650 | 4 | |a Parkinson disease | |
| 650 | 4 | |a Essential tremor | |
| 650 | 4 | |a Dementia | |
| 650 | 4 | |a DTI-ALPS | |
| 700 | 1 | |a Trujillo, Paula |e verfasserin |0 (orcid)0000-0001-9753-7071 |4 aut | |
| 700 | 1 | |a Lopez, Alexander M. |e verfasserin |4 aut | |
| 700 | 1 | |a Petersen, Kalen |e verfasserin |0 (orcid)0000-0002-4864-9648 |4 aut | |
| 700 | 1 | |a Considine, Ciaran |e verfasserin |0 (orcid)0000-0002-8171-2821 |4 aut | |
| 700 | 1 | |a Lin, Ya-Chen |e verfasserin |0 (orcid)0000-0003-3660-4570 |4 aut | |
| 700 | 1 | |a Yan, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Hakmook |e verfasserin |4 aut | |
| 700 | 1 | |a Donahue, Manus J. |e verfasserin |4 aut | |
| 700 | 1 | |a Claassen, Daniel O. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Parkinsonism & related disorders |d Amsterdam [u.a.] : Elsevier Science, 1995 |g 89, Seite 98-104 |h Online-Ressource |w (DE-627)32448898X |w (DE-600)2027635-7 |w (DE-576)272349704 |x 1873-5126 |7 nnns |
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10.1016/j.parkreldis.2021.06.004 doi (DE-627)ELV055111866 (ELSEVIER)S1353-8020(21)00215-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl McKnight, Colin D. verfasserin (orcid)0000-0002-4386-8999 aut Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. Glymphatic Diffusion Parkinson disease Essential tremor Dementia DTI-ALPS Trujillo, Paula verfasserin (orcid)0000-0001-9753-7071 aut Lopez, Alexander M. verfasserin aut Petersen, Kalen verfasserin (orcid)0000-0002-4864-9648 aut Considine, Ciaran verfasserin (orcid)0000-0002-8171-2821 aut Lin, Ya-Chen verfasserin (orcid)0000-0003-3660-4570 aut Yan, Yan verfasserin aut Kang, Hakmook verfasserin aut Donahue, Manus J. verfasserin aut Claassen, Daniel O. verfasserin aut Enthalten in Parkinsonism & related disorders Amsterdam [u.a.] : Elsevier Science, 1995 89, Seite 98-104 Online-Ressource (DE-627)32448898X (DE-600)2027635-7 (DE-576)272349704 1873-5126 nnns volume:89 pages:98-104 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ AR 89 98-104 |
| spelling |
10.1016/j.parkreldis.2021.06.004 doi (DE-627)ELV055111866 (ELSEVIER)S1353-8020(21)00215-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl McKnight, Colin D. verfasserin (orcid)0000-0002-4386-8999 aut Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. Glymphatic Diffusion Parkinson disease Essential tremor Dementia DTI-ALPS Trujillo, Paula verfasserin (orcid)0000-0001-9753-7071 aut Lopez, Alexander M. verfasserin aut Petersen, Kalen verfasserin (orcid)0000-0002-4864-9648 aut Considine, Ciaran verfasserin (orcid)0000-0002-8171-2821 aut Lin, Ya-Chen verfasserin (orcid)0000-0003-3660-4570 aut Yan, Yan verfasserin aut Kang, Hakmook verfasserin aut Donahue, Manus J. verfasserin aut Claassen, Daniel O. verfasserin aut Enthalten in Parkinsonism & related disorders Amsterdam [u.a.] : Elsevier Science, 1995 89, Seite 98-104 Online-Ressource (DE-627)32448898X (DE-600)2027635-7 (DE-576)272349704 1873-5126 nnns volume:89 pages:98-104 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ AR 89 98-104 |
| allfields_unstemmed |
10.1016/j.parkreldis.2021.06.004 doi (DE-627)ELV055111866 (ELSEVIER)S1353-8020(21)00215-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl McKnight, Colin D. verfasserin (orcid)0000-0002-4386-8999 aut Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. Glymphatic Diffusion Parkinson disease Essential tremor Dementia DTI-ALPS Trujillo, Paula verfasserin (orcid)0000-0001-9753-7071 aut Lopez, Alexander M. verfasserin aut Petersen, Kalen verfasserin (orcid)0000-0002-4864-9648 aut Considine, Ciaran verfasserin (orcid)0000-0002-8171-2821 aut Lin, Ya-Chen verfasserin (orcid)0000-0003-3660-4570 aut Yan, Yan verfasserin aut Kang, Hakmook verfasserin aut Donahue, Manus J. verfasserin aut Claassen, Daniel O. verfasserin aut Enthalten in Parkinsonism & related disorders Amsterdam [u.a.] : Elsevier Science, 1995 89, Seite 98-104 Online-Ressource (DE-627)32448898X (DE-600)2027635-7 (DE-576)272349704 1873-5126 nnns volume:89 pages:98-104 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ AR 89 98-104 |
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10.1016/j.parkreldis.2021.06.004 doi (DE-627)ELV055111866 (ELSEVIER)S1353-8020(21)00215-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl McKnight, Colin D. verfasserin (orcid)0000-0002-4386-8999 aut Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. Glymphatic Diffusion Parkinson disease Essential tremor Dementia DTI-ALPS Trujillo, Paula verfasserin (orcid)0000-0001-9753-7071 aut Lopez, Alexander M. verfasserin aut Petersen, Kalen verfasserin (orcid)0000-0002-4864-9648 aut Considine, Ciaran verfasserin (orcid)0000-0002-8171-2821 aut Lin, Ya-Chen verfasserin (orcid)0000-0003-3660-4570 aut Yan, Yan verfasserin aut Kang, Hakmook verfasserin aut Donahue, Manus J. verfasserin aut Claassen, Daniel O. verfasserin aut Enthalten in Parkinsonism & related disorders Amsterdam [u.a.] : Elsevier Science, 1995 89, Seite 98-104 Online-Ressource (DE-627)32448898X (DE-600)2027635-7 (DE-576)272349704 1873-5126 nnns volume:89 pages:98-104 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ AR 89 98-104 |
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10.1016/j.parkreldis.2021.06.004 doi (DE-627)ELV055111866 (ELSEVIER)S1353-8020(21)00215-7 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl McKnight, Colin D. verfasserin (orcid)0000-0002-4386-8999 aut Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. Glymphatic Diffusion Parkinson disease Essential tremor Dementia DTI-ALPS Trujillo, Paula verfasserin (orcid)0000-0001-9753-7071 aut Lopez, Alexander M. verfasserin aut Petersen, Kalen verfasserin (orcid)0000-0002-4864-9648 aut Considine, Ciaran verfasserin (orcid)0000-0002-8171-2821 aut Lin, Ya-Chen verfasserin (orcid)0000-0003-3660-4570 aut Yan, Yan verfasserin aut Kang, Hakmook verfasserin aut Donahue, Manus J. verfasserin aut Claassen, Daniel O. verfasserin aut Enthalten in Parkinsonism & related disorders Amsterdam [u.a.] : Elsevier Science, 1995 89, Seite 98-104 Online-Ressource (DE-627)32448898X (DE-600)2027635-7 (DE-576)272349704 1873-5126 nnns volume:89 pages:98-104 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.90 Neurologie VZ AR 89 98-104 |
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Enthalten in Parkinsonism & related disorders 89, Seite 98-104 volume:89 pages:98-104 |
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Enthalten in Parkinsonism & related disorders 89, Seite 98-104 volume:89 pages:98-104 |
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Glymphatic Diffusion Parkinson disease Essential tremor Dementia DTI-ALPS |
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McKnight, Colin D. @@aut@@ Trujillo, Paula @@aut@@ Lopez, Alexander M. @@aut@@ Petersen, Kalen @@aut@@ Considine, Ciaran @@aut@@ Lin, Ya-Chen @@aut@@ Yan, Yan @@aut@@ Kang, Hakmook @@aut@@ Donahue, Manus J. @@aut@@ Claassen, Daniel O. @@aut@@ |
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2021-01-01T00:00:00Z |
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McKnight, Colin D. |
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McKnight, Colin D. ddc 610 bkl 44.90 misc Glymphatic misc Diffusion misc Parkinson disease misc Essential tremor misc Dementia misc DTI-ALPS Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease |
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610 VZ 44.90 bkl Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease Glymphatic Diffusion Parkinson disease Essential tremor Dementia DTI-ALPS |
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ddc 610 bkl 44.90 misc Glymphatic misc Diffusion misc Parkinson disease misc Essential tremor misc Dementia misc DTI-ALPS |
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Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease |
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McKnight, Colin D. |
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McKnight, Colin D. Trujillo, Paula Lopez, Alexander M. Petersen, Kalen Considine, Ciaran Lin, Ya-Chen Yan, Yan Kang, Hakmook Donahue, Manus J. Claassen, Daniel O. |
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10.1016/j.parkreldis.2021.06.004 |
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diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in parkinson disease |
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Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease |
| abstract |
Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. |
| abstractGer |
Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. |
| abstract_unstemmed |
Background: Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.Objectives: To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.Methods: 181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm2; directions = 33) measures of diffusion (mm2/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and the ratio of these measures (ALPS-index), were calculated. Regions were identified by a board-certified neuroradiologist from T 1-weighted and T 2-weighted MRI. Evaluations of motor impairment and mild cognitive impairment (MCI) were interpreted by a board-certified neurologist and neuropsychologist, respectively. Multiple regression with false discovery rate correction was applied to understand how diffusion metrics related to (i) disease category (PD vs. ET), (ii) cognition (MCI status), and (iii) white matter disease severity from the Fazekas score.Results: The ALPS-index was reduced in PD compared to ET participants (p = 0.037). No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. The ALPS-index was inversely associated with age (p = 0.007).Conclusion: Diffusion aberrations near perivascular spaces are evident in patients with alpha-synuclein related neurodegenerative disorders, and are related to age and white matter disease severity. |
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Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease |
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No association between the ALPS-index and MCI status, but an inverse association between the ALPS-index and Fazekas score (p = 0.002), was observed. 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