Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit
This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to d...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Junyang [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Editorial Comment - Unwala, Darius J. ELSEVIER, 2013, a journal on accelerators, instrumentation and techniques applied to research in nuclear and atomic physics, materials science and related fields in physics, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:508 ; year:2021 ; day:1 ; month:12 ; pages:1-9 ; extent:9 |
| Links: |
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| DOI / URN: |
10.1016/j.nimb.2021.09.014 |
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ELV055664105 |
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| 245 | 1 | 0 | |a Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit |
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| 520 | |a This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. | ||
| 520 | |a This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. | ||
| 650 | 7 | |a BNCT |2 Elsevier | |
| 650 | 7 | |a Collimator |2 Elsevier | |
| 650 | 7 | |a UTCP |2 Elsevier | |
| 650 | 7 | |a Beam Shaping Assembly (BSA) |2 Elsevier | |
| 700 | 1 | |a Hu, Zhiliang |4 oth | |
| 700 | 1 | |a Tong, Jianfei |4 oth | |
| 700 | 1 | |a Zhou, Bin |4 oth | |
| 700 | 1 | |a Zhang, Ruiqiang |4 oth | |
| 700 | 1 | |a Zhao, Chongguang |4 oth | |
| 700 | 1 | |a Xu, Jun |4 oth | |
| 700 | 1 | |a nian Fu, Shi |4 oth | |
| 700 | 1 | |a Liang, Tianjiao |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Unwala, Darius J. ELSEVIER |t Editorial Comment |d 2013 |d a journal on accelerators, instrumentation and techniques applied to research in nuclear and atomic physics, materials science and related fields in physics |g Amsterdam [u.a.] |w (DE-627)ELV011304669 |
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10.1016/j.nimb.2021.09.014 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001560.pica (DE-627)ELV055664105 (ELSEVIER)S0168-583X(21)00301-3 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Chen, Junyang verfasserin aut Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. BNCT Elsevier Collimator Elsevier UTCP Elsevier Beam Shaping Assembly (BSA) Elsevier Hu, Zhiliang oth Tong, Jianfei oth Zhou, Bin oth Zhang, Ruiqiang oth Zhao, Chongguang oth Xu, Jun oth nian Fu, Shi oth Liang, Tianjiao oth Enthalten in Elsevier Unwala, Darius J. ELSEVIER Editorial Comment 2013 a journal on accelerators, instrumentation and techniques applied to research in nuclear and atomic physics, materials science and related fields in physics Amsterdam [u.a.] (DE-627)ELV011304669 volume:508 year:2021 day:1 month:12 pages:1-9 extent:9 https://doi.org/10.1016/j.nimb.2021.09.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_21 GBV_ILN_22 GBV_ILN_24 GBV_ILN_40 GBV_ILN_62 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 44.85 Kardiologie Angiologie VZ AR 508 2021 1 1201 1-9 9 |
| spelling |
10.1016/j.nimb.2021.09.014 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001560.pica (DE-627)ELV055664105 (ELSEVIER)S0168-583X(21)00301-3 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Chen, Junyang verfasserin aut Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. BNCT Elsevier Collimator Elsevier UTCP Elsevier Beam Shaping Assembly (BSA) Elsevier Hu, Zhiliang oth Tong, Jianfei oth Zhou, Bin oth Zhang, Ruiqiang oth Zhao, Chongguang oth Xu, Jun oth nian Fu, Shi oth Liang, Tianjiao oth Enthalten in Elsevier Unwala, Darius J. ELSEVIER Editorial Comment 2013 a journal on accelerators, instrumentation and techniques applied to research in nuclear and atomic physics, materials science and related fields in physics Amsterdam [u.a.] (DE-627)ELV011304669 volume:508 year:2021 day:1 month:12 pages:1-9 extent:9 https://doi.org/10.1016/j.nimb.2021.09.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_21 GBV_ILN_22 GBV_ILN_24 GBV_ILN_40 GBV_ILN_62 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 44.85 Kardiologie Angiologie VZ AR 508 2021 1 1201 1-9 9 |
| allfields_unstemmed |
10.1016/j.nimb.2021.09.014 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001560.pica (DE-627)ELV055664105 (ELSEVIER)S0168-583X(21)00301-3 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Chen, Junyang verfasserin aut Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. BNCT Elsevier Collimator Elsevier UTCP Elsevier Beam Shaping Assembly (BSA) Elsevier Hu, Zhiliang oth Tong, Jianfei oth Zhou, Bin oth Zhang, Ruiqiang oth Zhao, Chongguang oth Xu, Jun oth nian Fu, Shi oth Liang, Tianjiao oth Enthalten in Elsevier Unwala, Darius J. ELSEVIER Editorial Comment 2013 a journal on accelerators, instrumentation and techniques applied to research in nuclear and atomic physics, materials science and related fields in physics Amsterdam [u.a.] (DE-627)ELV011304669 volume:508 year:2021 day:1 month:12 pages:1-9 extent:9 https://doi.org/10.1016/j.nimb.2021.09.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_21 GBV_ILN_22 GBV_ILN_24 GBV_ILN_40 GBV_ILN_62 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 44.85 Kardiologie Angiologie VZ AR 508 2021 1 1201 1-9 9 |
| allfieldsGer |
10.1016/j.nimb.2021.09.014 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001560.pica (DE-627)ELV055664105 (ELSEVIER)S0168-583X(21)00301-3 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Chen, Junyang verfasserin aut Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. BNCT Elsevier Collimator Elsevier UTCP Elsevier Beam Shaping Assembly (BSA) Elsevier Hu, Zhiliang oth Tong, Jianfei oth Zhou, Bin oth Zhang, Ruiqiang oth Zhao, Chongguang oth Xu, Jun oth nian Fu, Shi oth Liang, Tianjiao oth Enthalten in Elsevier Unwala, Darius J. ELSEVIER Editorial Comment 2013 a journal on accelerators, instrumentation and techniques applied to research in nuclear and atomic physics, materials science and related fields in physics Amsterdam [u.a.] (DE-627)ELV011304669 volume:508 year:2021 day:1 month:12 pages:1-9 extent:9 https://doi.org/10.1016/j.nimb.2021.09.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_21 GBV_ILN_22 GBV_ILN_24 GBV_ILN_40 GBV_ILN_62 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 44.85 Kardiologie Angiologie VZ AR 508 2021 1 1201 1-9 9 |
| allfieldsSound |
10.1016/j.nimb.2021.09.014 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001560.pica (DE-627)ELV055664105 (ELSEVIER)S0168-583X(21)00301-3 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Chen, Junyang verfasserin aut Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit 2021transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. BNCT Elsevier Collimator Elsevier UTCP Elsevier Beam Shaping Assembly (BSA) Elsevier Hu, Zhiliang oth Tong, Jianfei oth Zhou, Bin oth Zhang, Ruiqiang oth Zhao, Chongguang oth Xu, Jun oth nian Fu, Shi oth Liang, Tianjiao oth Enthalten in Elsevier Unwala, Darius J. ELSEVIER Editorial Comment 2013 a journal on accelerators, instrumentation and techniques applied to research in nuclear and atomic physics, materials science and related fields in physics Amsterdam [u.a.] (DE-627)ELV011304669 volume:508 year:2021 day:1 month:12 pages:1-9 extent:9 https://doi.org/10.1016/j.nimb.2021.09.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_21 GBV_ILN_22 GBV_ILN_24 GBV_ILN_40 GBV_ILN_62 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 44.85 Kardiologie Angiologie VZ AR 508 2021 1 1201 1-9 9 |
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Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit |
| abstract |
This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. |
| abstractGer |
This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. |
| abstract_unstemmed |
This work addresses the neutronic design of a Beam Shaping Assembly (BSA) that is appropriate for a Accelerator-based Boron Neutron Capture Therapy (AB-BNCT). Instead of designing a moderator utilizing the IAEA-1223 recommendation and in-phantom figure of merit, in this work we study neutronics to decrease the out-of-beam dosimetry by employing radiobiological figures of merit to assess the beam quality. In particular, in the radiobiological probability model, we include two normal tissue cases, and accordingly optimize the thickness and cone angle of the collimator. Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. From our findings, we conclude that upon considering radiobiological figures of merit, collimators with a tunable design shape are more appealing due to adapting to different treatment situations. |
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Study of BNCT neutronics optimization for out-of-beam dosimetry based on radiobiological figures of merit |
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Hence, in this study, for a large opening diameter, i.e., 10 cm, we use a small cone angle, which can decrease the out-of-beam dosimetry effectively. Accordingly, for a small opening diameter, i.e., 2 cm in this study, we employ a large cone angle to guarantee that the neutron flux is large enough. Our simulation results demonstrate that the neutronics optimization of the collimator is a tradeoff between the out-of-beam dosimetry and the neutron flux. 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