Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study
Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pavisic, Ivanna M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Articles That May Change Your Practice: Pelvic Binders Revisited - MacDonald, Russell D. ELSEVIER, 2023, an international journal in behavioural and cognitive neuroscience, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:162 ; year:2021 ; day:12 ; month:11 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.neuropsychologia.2021.108028 |
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ELV055706037 |
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| 520 | |a Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. | ||
| 520 | |a Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. | ||
| 650 | 7 | |a Visual short-term memory |2 Elsevier | |
| 650 | 7 | |a Preclinical Alzheimer's disease |2 Elsevier | |
| 650 | 7 | |a Familial Alzheimer's disease |2 Elsevier | |
| 650 | 7 | |a Estimated symptom onset |2 Elsevier | |
| 650 | 7 | |a Alzheimer's disease |2 Elsevier | |
| 700 | 1 | |a Nicholas, Jennifer M. |4 oth | |
| 700 | 1 | |a Pertzov, Yoni |4 oth | |
| 700 | 1 | |a O'Connor, Antoinette |4 oth | |
| 700 | 1 | |a Liang, Yuying |4 oth | |
| 700 | 1 | |a Collins, Jessica D. |4 oth | |
| 700 | 1 | |a Lu, Kirsty |4 oth | |
| 700 | 1 | |a Weston, Philip S.J. |4 oth | |
| 700 | 1 | |a Ryan, Natalie S. |4 oth | |
| 700 | 1 | |a Husain, Masud |4 oth | |
| 700 | 1 | |a Fox, Nick C. |4 oth | |
| 700 | 1 | |a Crutch, Sebastian J. |4 oth | |
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10.1016/j.neuropsychologia.2021.108028 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001563.pica (DE-627)ELV055706037 (ELSEVIER)S0028-3932(21)00281-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.71 bkl Pavisic, Ivanna M. verfasserin aut Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory Elsevier Preclinical Alzheimer's disease Elsevier Familial Alzheimer's disease Elsevier Estimated symptom onset Elsevier Alzheimer's disease Elsevier Nicholas, Jennifer M. oth Pertzov, Yoni oth O'Connor, Antoinette oth Liang, Yuying oth Collins, Jessica D. oth Lu, Kirsty oth Weston, Philip S.J. oth Ryan, Natalie S. oth Husain, Masud oth Fox, Nick C. oth Crutch, Sebastian J. oth Enthalten in Elsevier Science MacDonald, Russell D. ELSEVIER Articles That May Change Your Practice: Pelvic Binders Revisited 2023 an international journal in behavioural and cognitive neuroscience Amsterdam [u.a.] (DE-627)ELV009449108 volume:162 year:2021 day:12 month:11 pages:0 https://doi.org/10.1016/j.neuropsychologia.2021.108028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.71 Verkehrsmedizin VZ AR 162 2021 12 1112 0 |
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10.1016/j.neuropsychologia.2021.108028 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001563.pica (DE-627)ELV055706037 (ELSEVIER)S0028-3932(21)00281-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.71 bkl Pavisic, Ivanna M. verfasserin aut Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory Elsevier Preclinical Alzheimer's disease Elsevier Familial Alzheimer's disease Elsevier Estimated symptom onset Elsevier Alzheimer's disease Elsevier Nicholas, Jennifer M. oth Pertzov, Yoni oth O'Connor, Antoinette oth Liang, Yuying oth Collins, Jessica D. oth Lu, Kirsty oth Weston, Philip S.J. oth Ryan, Natalie S. oth Husain, Masud oth Fox, Nick C. oth Crutch, Sebastian J. oth Enthalten in Elsevier Science MacDonald, Russell D. ELSEVIER Articles That May Change Your Practice: Pelvic Binders Revisited 2023 an international journal in behavioural and cognitive neuroscience Amsterdam [u.a.] (DE-627)ELV009449108 volume:162 year:2021 day:12 month:11 pages:0 https://doi.org/10.1016/j.neuropsychologia.2021.108028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.71 Verkehrsmedizin VZ AR 162 2021 12 1112 0 |
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10.1016/j.neuropsychologia.2021.108028 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001563.pica (DE-627)ELV055706037 (ELSEVIER)S0028-3932(21)00281-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.71 bkl Pavisic, Ivanna M. verfasserin aut Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory Elsevier Preclinical Alzheimer's disease Elsevier Familial Alzheimer's disease Elsevier Estimated symptom onset Elsevier Alzheimer's disease Elsevier Nicholas, Jennifer M. oth Pertzov, Yoni oth O'Connor, Antoinette oth Liang, Yuying oth Collins, Jessica D. oth Lu, Kirsty oth Weston, Philip S.J. oth Ryan, Natalie S. oth Husain, Masud oth Fox, Nick C. oth Crutch, Sebastian J. oth Enthalten in Elsevier Science MacDonald, Russell D. ELSEVIER Articles That May Change Your Practice: Pelvic Binders Revisited 2023 an international journal in behavioural and cognitive neuroscience Amsterdam [u.a.] (DE-627)ELV009449108 volume:162 year:2021 day:12 month:11 pages:0 https://doi.org/10.1016/j.neuropsychologia.2021.108028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.71 Verkehrsmedizin VZ AR 162 2021 12 1112 0 |
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10.1016/j.neuropsychologia.2021.108028 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001563.pica (DE-627)ELV055706037 (ELSEVIER)S0028-3932(21)00281-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.71 bkl Pavisic, Ivanna M. verfasserin aut Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory Elsevier Preclinical Alzheimer's disease Elsevier Familial Alzheimer's disease Elsevier Estimated symptom onset Elsevier Alzheimer's disease Elsevier Nicholas, Jennifer M. oth Pertzov, Yoni oth O'Connor, Antoinette oth Liang, Yuying oth Collins, Jessica D. oth Lu, Kirsty oth Weston, Philip S.J. oth Ryan, Natalie S. oth Husain, Masud oth Fox, Nick C. oth Crutch, Sebastian J. oth Enthalten in Elsevier Science MacDonald, Russell D. ELSEVIER Articles That May Change Your Practice: Pelvic Binders Revisited 2023 an international journal in behavioural and cognitive neuroscience Amsterdam [u.a.] (DE-627)ELV009449108 volume:162 year:2021 day:12 month:11 pages:0 https://doi.org/10.1016/j.neuropsychologia.2021.108028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.71 Verkehrsmedizin VZ AR 162 2021 12 1112 0 |
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10.1016/j.neuropsychologia.2021.108028 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001563.pica (DE-627)ELV055706037 (ELSEVIER)S0028-3932(21)00281-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.71 bkl Pavisic, Ivanna M. verfasserin aut Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. Visual short-term memory Elsevier Preclinical Alzheimer's disease Elsevier Familial Alzheimer's disease Elsevier Estimated symptom onset Elsevier Alzheimer's disease Elsevier Nicholas, Jennifer M. oth Pertzov, Yoni oth O'Connor, Antoinette oth Liang, Yuying oth Collins, Jessica D. oth Lu, Kirsty oth Weston, Philip S.J. oth Ryan, Natalie S. oth Husain, Masud oth Fox, Nick C. oth Crutch, Sebastian J. oth Enthalten in Elsevier Science MacDonald, Russell D. ELSEVIER Articles That May Change Your Practice: Pelvic Binders Revisited 2023 an international journal in behavioural and cognitive neuroscience Amsterdam [u.a.] (DE-627)ELV009449108 volume:162 year:2021 day:12 month:11 pages:0 https://doi.org/10.1016/j.neuropsychologia.2021.108028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.71 Verkehrsmedizin VZ AR 162 2021 12 1112 0 |
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Visual short-term memory impairments in presymptomatic familial Alzheimer's disease: A longitudinal observational study |
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Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. |
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Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. |
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Visual short-term memory (VSTM) deficits including VSTM binding have been associated with Alzheimer's disease (AD) from preclinical to dementia stages, cross-sectionally. Yet, longitudinal investigations are lacking. The objective of this study was to evaluate VSTM function longitudinally and in relation to expected symptom onset in a cohort of familial Alzheimer's disease. Ninety-nine individuals (23 presymptomatic; 9 symptomatic and 67 controls) were included in an extension cross-sectional study and a sub-sample of 48 (23 presymptomatic carriers, 6 symptomatic and 19 controls), attending two to five visits with a median interval of 1.3 years, included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Compared to controls, presymptomatic carriers within 8.5 years of estimated symptom onset showed a faster rate of decline in localisation performance in long-delay conditions (4s) and in traditional neuropsychology measures of verbal episodic memory. This study represents the first longitudinal VSTM investigation and shows that changes in memory resolution may be sensitive to tracking cognitive decline in preclinical AD at least as early as changes in the more traditional verbal episodic memory tasks. |
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