Systems for in vivo hypermutation: a quest for scale and depth in directed evolution
Traditional approaches to the directed evolution of genes of interest (GOIs) place constraints on the scale of experimentation and depth of evolutionary search reasonably achieved. Engineered genetic systems that dramatically elevate the mutation of target GOIs in vivo relieve these constraints by e...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rix, Gordon [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Schlagwörter: |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Medical technology assessment of polysomnography, type 2: full PSG at home – night to night variability in Apnea Hypopnea Index (AHI) and Periodic Limb Movement Index (PLMI) - Arends-Derks, W. ELSEVIER, 2013, London |
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| Übergeordnetes Werk: |
volume:64 ; year:2021 ; pages:20-26 ; extent:7 |
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| DOI / URN: |
10.1016/j.cbpa.2021.02.008 |
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| 520 | |a Traditional approaches to the directed evolution of genes of interest (GOIs) place constraints on the scale of experimentation and depth of evolutionary search reasonably achieved. Engineered genetic systems that dramatically elevate the mutation of target GOIs in vivo relieve these constraints by enabling continuous evolution, affording new strategies in the exploration of sequence space and fitness landscapes for GOIs. We describe various in vivo hypermutation systems for continuous evolution, discuss how different architectures for in vivo hypermutation facilitate evolutionary search scale and depth in their application to problems in protein evolution and engineering, and outline future opportunities for the field. | ||
| 520 | |a Traditional approaches to the directed evolution of genes of interest (GOIs) place constraints on the scale of experimentation and depth of evolutionary search reasonably achieved. Engineered genetic systems that dramatically elevate the mutation of target GOIs in vivo relieve these constraints by enabling continuous evolution, affording new strategies in the exploration of sequence space and fitness landscapes for GOIs. We describe various in vivo hypermutation systems for continuous evolution, discuss how different architectures for in vivo hypermutation facilitate evolutionary search scale and depth in their application to problems in protein evolution and engineering, and outline future opportunities for the field. | ||
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Systems for in vivo hypermutation: a quest for scale and depth in directed evolution |
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Rix, Gordon |
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Medical technology assessment of polysomnography, type 2: full PSG at home – night to night variability in Apnea Hypopnea Index (AHI) and Periodic Limb Movement Index (PLMI) |
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Medical technology assessment of polysomnography, type 2: full PSG at home – night to night variability in Apnea Hypopnea Index (AHI) and Periodic Limb Movement Index (PLMI) |
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Rix, Gordon |
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Rix, Gordon |
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10.1016/j.cbpa.2021.02.008 |
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610 530 510 000 |
| title_sort |
systems for in vivo hypermutation: a quest for scale and depth in directed evolution |
| title_auth |
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution |
| abstract |
Traditional approaches to the directed evolution of genes of interest (GOIs) place constraints on the scale of experimentation and depth of evolutionary search reasonably achieved. Engineered genetic systems that dramatically elevate the mutation of target GOIs in vivo relieve these constraints by enabling continuous evolution, affording new strategies in the exploration of sequence space and fitness landscapes for GOIs. We describe various in vivo hypermutation systems for continuous evolution, discuss how different architectures for in vivo hypermutation facilitate evolutionary search scale and depth in their application to problems in protein evolution and engineering, and outline future opportunities for the field. |
| abstractGer |
Traditional approaches to the directed evolution of genes of interest (GOIs) place constraints on the scale of experimentation and depth of evolutionary search reasonably achieved. Engineered genetic systems that dramatically elevate the mutation of target GOIs in vivo relieve these constraints by enabling continuous evolution, affording new strategies in the exploration of sequence space and fitness landscapes for GOIs. We describe various in vivo hypermutation systems for continuous evolution, discuss how different architectures for in vivo hypermutation facilitate evolutionary search scale and depth in their application to problems in protein evolution and engineering, and outline future opportunities for the field. |
| abstract_unstemmed |
Traditional approaches to the directed evolution of genes of interest (GOIs) place constraints on the scale of experimentation and depth of evolutionary search reasonably achieved. Engineered genetic systems that dramatically elevate the mutation of target GOIs in vivo relieve these constraints by enabling continuous evolution, affording new strategies in the exploration of sequence space and fitness landscapes for GOIs. We describe various in vivo hypermutation systems for continuous evolution, discuss how different architectures for in vivo hypermutation facilitate evolutionary search scale and depth in their application to problems in protein evolution and engineering, and outline future opportunities for the field. |
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| title_short |
Systems for in vivo hypermutation: a quest for scale and depth in directed evolution |
| url |
https://doi.org/10.1016/j.cbpa.2021.02.008 |
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Liu, Chang C. |
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Liu, Chang C. |
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