Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices

A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching e...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Talaat, Wael [verfasserIn] Kaddah, Mohamed M.Y. [verfasserIn] Keshk, Reda Mohammed [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	Quenching Trifluridine Tipiracil dosage form Biological fluids Furopyridine

Übergeordnetes Werk:	Enthalten in: Talanta - Amsterdam [u.a.] : Elsevier Science, 1958, 238
Übergeordnetes Werk:	volume:238

DOI / URN:	10.1016/j.talanta.2021.123009

Katalog-ID:	ELV056061455

Internformat


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245	1	0	\|a Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices
264		1	\|c 2021
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied.
650		4	\|a Quenching
650		4	\|a Trifluridine
650		4	\|a Tipiracil dosage form
650		4	\|a Biological fluids
650		4	\|a Furopyridine
700	1		\|a Kaddah, Mohamed M.Y. \|e verfasserin \|0 (orcid)0000-0003-0575-2458 \|4 aut
700	1		\|a Keshk, Reda Mohammed \|e verfasserin \|4 aut
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912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
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912			\|a GBV_ILN_110
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912			\|a GBV_ILN_370
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912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
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912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
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912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
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publishDate	2021
allfields	10.1016/j.talanta.2021.123009 doi (DE-627)ELV056061455 (ELSEVIER)S0039-9140(21)00931-0 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Talaat, Wael verfasserin (orcid)0000-0003-0013-1222 aut Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied. Quenching Trifluridine Tipiracil dosage form Biological fluids Furopyridine Kaddah, Mohamed M.Y. verfasserin (orcid)0000-0003-0575-2458 aut Keshk, Reda Mohammed verfasserin aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 238 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:238 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 238
spelling	10.1016/j.talanta.2021.123009 doi (DE-627)ELV056061455 (ELSEVIER)S0039-9140(21)00931-0 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Talaat, Wael verfasserin (orcid)0000-0003-0013-1222 aut Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied. Quenching Trifluridine Tipiracil dosage form Biological fluids Furopyridine Kaddah, Mohamed M.Y. verfasserin (orcid)0000-0003-0575-2458 aut Keshk, Reda Mohammed verfasserin aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 238 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:238 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 238
allfields_unstemmed	10.1016/j.talanta.2021.123009 doi (DE-627)ELV056061455 (ELSEVIER)S0039-9140(21)00931-0 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Talaat, Wael verfasserin (orcid)0000-0003-0013-1222 aut Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied. Quenching Trifluridine Tipiracil dosage form Biological fluids Furopyridine Kaddah, Mohamed M.Y. verfasserin (orcid)0000-0003-0575-2458 aut Keshk, Reda Mohammed verfasserin aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 238 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:238 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 238
allfieldsGer	10.1016/j.talanta.2021.123009 doi (DE-627)ELV056061455 (ELSEVIER)S0039-9140(21)00931-0 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Talaat, Wael verfasserin (orcid)0000-0003-0013-1222 aut Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied. Quenching Trifluridine Tipiracil dosage form Biological fluids Furopyridine Kaddah, Mohamed M.Y. verfasserin (orcid)0000-0003-0575-2458 aut Keshk, Reda Mohammed verfasserin aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 238 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:238 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 238
allfieldsSound	10.1016/j.talanta.2021.123009 doi (DE-627)ELV056061455 (ELSEVIER)S0039-9140(21)00931-0 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Talaat, Wael verfasserin (orcid)0000-0003-0013-1222 aut Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices 2021 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied. Quenching Trifluridine Tipiracil dosage form Biological fluids Furopyridine Kaddah, Mohamed M.Y. verfasserin (orcid)0000-0003-0575-2458 aut Keshk, Reda Mohammed verfasserin aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 238 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:238 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 238
language	English
source	Enthalten in Talanta 238 volume:238
sourceStr	Enthalten in Talanta 238 volume:238
format_phy_str_mv	Article
bklname	Chemie: Allgemeines
institution	findex.gbv.de
topic_facet	Quenching Trifluridine Tipiracil dosage form Biological fluids Furopyridine
dewey-raw	540
isfreeaccess_bool	false
container_title	Talanta
authorswithroles_txt_mv	Talaat, Wael @@aut@@ Kaddah, Mohamed M.Y. @@aut@@ Keshk, Reda Mohammed @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	306712571
dewey-sort	3540
id	ELV056061455
language_de	englisch
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author	Talaat, Wael
spellingShingle	Talaat, Wael ddc 540 bkl 35.00 misc Quenching misc Trifluridine misc Tipiracil dosage form misc Biological fluids misc Furopyridine Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices
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topic_title	540 VZ 35.00 bkl Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices Quenching Trifluridine Tipiracil dosage form Biological fluids Furopyridine
topic	ddc 540 bkl 35.00 misc Quenching misc Trifluridine misc Tipiracil dosage form misc Biological fluids misc Furopyridine
topic_unstemmed	ddc 540 bkl 35.00 misc Quenching misc Trifluridine misc Tipiracil dosage form misc Biological fluids misc Furopyridine
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title	Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices
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title_full	Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices
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author_browse	Talaat, Wael Kaddah, Mohamed M.Y. Keshk, Reda Mohammed
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title_sort	selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices
title_auth	Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices
abstract	A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied.
abstractGer	A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied.
abstract_unstemmed	A new fluorescent sensor is introduced to analyze nucleoside analogue, trifluridine and tipiracil in tablets and biological fluids. The synthesized fluorophore exhibits good fluorescence at 446 nm after excitation at 257 nm. The interaction between the studied drugs and the reagent was a quenching effect. Different experimental parameters and the mechanism of quenching were discussed. The present method was utilized to analyze trifluridine and tipiracil raw materials and tablets over the concentration range of 20–1000 ng/mL and spiked biological fluids over the range of 30–1000 ng/mL. The method is selective, specific, and possesses good accuracy and high precision. The method is highly sensitive, with detection limits of 5.8 and 6.0 ng/mL for trifluridine and tipiracil, respectively, and quantitation limits of 17.7 and 18.1 ng/mL for trifluridine and tipiracil, respectively. In vivo analysis of trifluridine was achieved selectively and the mean pharmacokinetic parameters were studied.
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title_short	Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices
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author2	Kaddah, Mohamed M.Y. Keshk, Reda Mohammed
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doi_str	10.1016/j.talanta.2021.123009
up_date	2024-07-06T19:19:27.092Z
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Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices

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