Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures
• Astroglial calcineurin KO (ACN-KO) mice, at 1 mo, show alterations of protein expression at posttranscriptional level. • Bioinformatic analysis links ACN-KO proteomics to Alzheimer's disease and epilepsy. • In Barnes maze ACN-KO mice use serial search strategy. • From 5 month of age ACN-KO mi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tapella, Laura [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: The phenolic compounds from Dracocephalum moldavica L. - Yang, Li-Na ELSEVIER, 2014, Edinburgh [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:100 ; year:2021 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.ceca.2021.102480 |
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10.1016/j.ceca.2021.102480 |
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570 150 |
| title_sort |
deletion of calcineurin from astrocytes reproduces proteome signature of alzheimer's disease and epilepsy and predisposes to seizures |
| title_auth |
Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures |
| abstract |
• Astroglial calcineurin KO (ACN-KO) mice, at 1 mo, show alterations of protein expression at posttranscriptional level. • Bioinformatic analysis links ACN-KO proteomics to Alzheimer's disease and epilepsy. • In Barnes maze ACN-KO mice use serial search strategy. • From 5 month of age ACN-KO mice show increased risk to develop epileptic seizures. |
| abstractGer |
• Astroglial calcineurin KO (ACN-KO) mice, at 1 mo, show alterations of protein expression at posttranscriptional level. • Bioinformatic analysis links ACN-KO proteomics to Alzheimer's disease and epilepsy. • In Barnes maze ACN-KO mice use serial search strategy. • From 5 month of age ACN-KO mice show increased risk to develop epileptic seizures. |
| abstract_unstemmed |
• Astroglial calcineurin KO (ACN-KO) mice, at 1 mo, show alterations of protein expression at posttranscriptional level. • Bioinformatic analysis links ACN-KO proteomics to Alzheimer's disease and epilepsy. • In Barnes maze ACN-KO mice use serial search strategy. • From 5 month of age ACN-KO mice show increased risk to develop epileptic seizures. |
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GBV_USEFLAG_U GBV_ELV SYSFLAG_U |
| title_short |
Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures |
| url |
https://doi.org/10.1016/j.ceca.2021.102480 |
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| author2 |
Dematteis, Giulia Ruffinatti, Federico Alessandro Ponzoni, Luisa Fiordaliso, Fabio Corbelli, Alessandro Albanese, Enrico Pistolato, Beatrice Pagano, Jessica Barberis, Elettra Marengo, Emilio Balducci, Claudia Forloni, Gianluigi Verpelli, Chiara Sala, Carlo Distasi, Carla Sala, Mariaelvina Manfredi, Marcello Genazzani, Armando A. Lim, Dmitry |
| author2Str |
Dematteis, Giulia Ruffinatti, Federico Alessandro Ponzoni, Luisa Fiordaliso, Fabio Corbelli, Alessandro Albanese, Enrico Pistolato, Beatrice Pagano, Jessica Barberis, Elettra Marengo, Emilio Balducci, Claudia Forloni, Gianluigi Verpelli, Chiara Sala, Carlo Distasi, Carla Sala, Mariaelvina Manfredi, Marcello Genazzani, Armando A. Lim, Dmitry |
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| doi_str |
10.1016/j.ceca.2021.102480 |
| up_date |
2024-07-06T19:27:17.233Z |
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