Blocking IAg7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice
Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gupta, Shivai [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2022 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling - Abd-Elhady, M.S. ELSEVIER, 2016, including pharmacology letters, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:288 ; year:2022 ; day:1 ; month:01 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.lfs.2021.120182 |
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10.1016/j.lfs.2021.120182 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001616.pica (DE-627)ELV056262752 (ELSEVIER)S0024-3205(21)01169-3 DE-627 ger DE-627 rakwb eng 690 VZ 530 620 VZ 52.56 bkl Gupta, Shivai verfasserin aut Blocking IAg7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice 2022 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg7 antigen presentation in the NOD mouse would alleviate SjS by preventing the recognition of autoantigens by pathogenic T cells. Li, Danmeng oth Ostrov, David A. oth Nguyen, Cuong Q. oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:288 year:2022 day:1 month:01 pages:0 https://doi.org/10.1016/j.lfs.2021.120182 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 288 2022 1 0101 0 |
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10.1016/j.lfs.2021.120182 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001616.pica (DE-627)ELV056262752 (ELSEVIER)S0024-3205(21)01169-3 DE-627 ger DE-627 rakwb eng 690 VZ 530 620 VZ 52.56 bkl Gupta, Shivai verfasserin aut Blocking IAg7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice 2022 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg7 antigen presentation in the NOD mouse would alleviate SjS by preventing the recognition of autoantigens by pathogenic T cells. Li, Danmeng oth Ostrov, David A. oth Nguyen, Cuong Q. oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:288 year:2022 day:1 month:01 pages:0 https://doi.org/10.1016/j.lfs.2021.120182 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 288 2022 1 0101 0 |
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Blocking IAg7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice |
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Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg7 antigen presentation in the NOD mouse would alleviate SjS by preventing the recognition of autoantigens by pathogenic T cells. |
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Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg7 antigen presentation in the NOD mouse would alleviate SjS by preventing the recognition of autoantigens by pathogenic T cells. |
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Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg7 antigen presentation in the NOD mouse would alleviate SjS by preventing the recognition of autoantigens by pathogenic T cells. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV056262752</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230624230749.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220105s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.lfs.2021.120182</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">/cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001616.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV056262752</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0024-3205(21)01169-3</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">690</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">530</subfield><subfield code="a">620</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">52.56</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Gupta, Shivai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Blocking IAg7 class II major histocompatibility complex by drug-like small molecules alleviated Sjögren's syndrome in NOD mice</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. 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