High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy
Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. H...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gleichgerrcht, Ezequiel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Field study of a soft X-ray aerosol neutralizer combined with electrostatic classifiers for nanoparticle size distribution measurements - Nicosia, Alessia ELSEVIER, 2017, a journal of brain function, Orlando, Fla |
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| Übergeordnetes Werk: |
volume:248 ; year:2022 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.neuroimage.2021.118866 |
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| 520 | |a Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. | ||
| 520 | |a Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. | ||
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| 700 | 1 | |a Biswas, Shubhabrata |4 oth | |
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| 700 | 1 | |a Wilmskoetter, Janina |4 oth | |
| 700 | 1 | |a Jensen, Jens H. |4 oth | |
| 700 | 1 | |a Bonilha, Leonardo |4 oth | |
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10.1016/j.neuroimage.2021.118866 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001829.pica (DE-627)ELV056596944 (ELSEVIER)S1053-8119(21)01137-X DE-627 ger DE-627 rakwb eng Gleichgerrcht, Ezequiel verfasserin aut High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. DKI Elsevier DTI Elsevier FBI Elsevier Keller, Simon S. oth Bryant, Lorna oth Moss, Hunter oth Kellermann, Tanja S. oth Biswas, Shubhabrata oth Marson, Anthony G. oth Wilmskoetter, Janina oth Jensen, Jens H. oth Bonilha, Leonardo oth Enthalten in Academic Press Nicosia, Alessia ELSEVIER Field study of a soft X-ray aerosol neutralizer combined with electrostatic classifiers for nanoparticle size distribution measurements 2017 a journal of brain function Orlando, Fla (DE-627)ELV001942808 volume:248 year:2022 pages:0 https://doi.org/10.1016/j.neuroimage.2021.118866 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 248 2022 0 |
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10.1016/j.neuroimage.2021.118866 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001829.pica (DE-627)ELV056596944 (ELSEVIER)S1053-8119(21)01137-X DE-627 ger DE-627 rakwb eng Gleichgerrcht, Ezequiel verfasserin aut High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. DKI Elsevier DTI Elsevier FBI Elsevier Keller, Simon S. oth Bryant, Lorna oth Moss, Hunter oth Kellermann, Tanja S. oth Biswas, Shubhabrata oth Marson, Anthony G. oth Wilmskoetter, Janina oth Jensen, Jens H. oth Bonilha, Leonardo oth Enthalten in Academic Press Nicosia, Alessia ELSEVIER Field study of a soft X-ray aerosol neutralizer combined with electrostatic classifiers for nanoparticle size distribution measurements 2017 a journal of brain function Orlando, Fla (DE-627)ELV001942808 volume:248 year:2022 pages:0 https://doi.org/10.1016/j.neuroimage.2021.118866 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 248 2022 0 |
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10.1016/j.neuroimage.2021.118866 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001829.pica (DE-627)ELV056596944 (ELSEVIER)S1053-8119(21)01137-X DE-627 ger DE-627 rakwb eng Gleichgerrcht, Ezequiel verfasserin aut High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. DKI Elsevier DTI Elsevier FBI Elsevier Keller, Simon S. oth Bryant, Lorna oth Moss, Hunter oth Kellermann, Tanja S. oth Biswas, Shubhabrata oth Marson, Anthony G. oth Wilmskoetter, Janina oth Jensen, Jens H. oth Bonilha, Leonardo oth Enthalten in Academic Press Nicosia, Alessia ELSEVIER Field study of a soft X-ray aerosol neutralizer combined with electrostatic classifiers for nanoparticle size distribution measurements 2017 a journal of brain function Orlando, Fla (DE-627)ELV001942808 volume:248 year:2022 pages:0 https://doi.org/10.1016/j.neuroimage.2021.118866 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 248 2022 0 |
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10.1016/j.neuroimage.2021.118866 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001829.pica (DE-627)ELV056596944 (ELSEVIER)S1053-8119(21)01137-X DE-627 ger DE-627 rakwb eng Gleichgerrcht, Ezequiel verfasserin aut High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. DKI Elsevier DTI Elsevier FBI Elsevier Keller, Simon S. oth Bryant, Lorna oth Moss, Hunter oth Kellermann, Tanja S. oth Biswas, Shubhabrata oth Marson, Anthony G. oth Wilmskoetter, Janina oth Jensen, Jens H. oth Bonilha, Leonardo oth Enthalten in Academic Press Nicosia, Alessia ELSEVIER Field study of a soft X-ray aerosol neutralizer combined with electrostatic classifiers for nanoparticle size distribution measurements 2017 a journal of brain function Orlando, Fla (DE-627)ELV001942808 volume:248 year:2022 pages:0 https://doi.org/10.1016/j.neuroimage.2021.118866 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 248 2022 0 |
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10.1016/j.neuroimage.2021.118866 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001829.pica (DE-627)ELV056596944 (ELSEVIER)S1053-8119(21)01137-X DE-627 ger DE-627 rakwb eng Gleichgerrcht, Ezequiel verfasserin aut High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. DKI Elsevier DTI Elsevier FBI Elsevier Keller, Simon S. oth Bryant, Lorna oth Moss, Hunter oth Kellermann, Tanja S. oth Biswas, Shubhabrata oth Marson, Anthony G. oth Wilmskoetter, Janina oth Jensen, Jens H. oth Bonilha, Leonardo oth Enthalten in Academic Press Nicosia, Alessia ELSEVIER Field study of a soft X-ray aerosol neutralizer combined with electrostatic classifiers for nanoparticle size distribution measurements 2017 a journal of brain function Orlando, Fla (DE-627)ELV001942808 volume:248 year:2022 pages:0 https://doi.org/10.1016/j.neuroimage.2021.118866 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 248 2022 0 |
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However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. 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high b-value diffusion tractography: abnormal axonal network organization associated with medication-refractory epilepsy |
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High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy |
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Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. |
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Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. |
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Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter tissue. High b-value diffusion imaging overcomes this limitation by better isolating axonal pathways. In this study, we introduce tractography derived from fiber ball imaging (FBI), a high b-value approach which excludes non-axonal signals, to identify atypical neuronal networks in patients with epilepsy. Specifically, we compared network properties obtained from multiple diffusion tractography approaches (diffusion tensor imaging, diffusion kurtosis imaging, FBI) in order to assess the pathophysiological relevance of network rearrangement in medication-responsive vs. medication-refractory adults with focal epilepsy. We show that drug-resistant epilepsy is associated with increased global network segregation detected by FBI-based tractography. We propose exploring FBI as a clinically feasible alternative to quantify topological changes that could be used to track disease progression and inform on clinical outcomes. |
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