Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review
Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Revi...
Ausführliche Beschreibung
Autor*in: |
Silveira, Felipe Martins [verfasserIn] Mello, André Luiz Rodrigues [verfasserIn] da Silva Fonseca, Laura [verfasserIn] dos Santos Ferreira, Luíse [verfasserIn] Kirschnick, Laura Borges [verfasserIn] Martins, Manoela Domingues [verfasserIn] Schuch, Lauren Frenzel [verfasserIn] de Arruda, José Alcides Almeida [verfasserIn] Soares, Ciro Dantas [verfasserIn] de Oliveira Sales, Alexandre [verfasserIn] Bologna-Molina, Ronell [verfasserIn] Santos-Silva, Alan Roger [verfasserIn] Vasconcelos, Ana Carolina Uchoa [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Archives of oral biology - Amsterdam [u.a.] : Elsevier Science, 1959, 136 |
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Übergeordnetes Werk: |
volume:136 |
DOI / URN: |
10.1016/j.archoralbio.2022.105374 |
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Katalog-ID: |
ELV057070768 |
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245 | 1 | 0 | |a Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review |
264 | 1 | |c 2022 | |
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520 | |a Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. | ||
650 | 4 | |a COVID-19 | |
650 | 4 | |a Oral pathology | |
650 | 4 | |a Molecular pathology | |
650 | 4 | |a Pandemics | |
650 | 4 | |a SARS-CoV-2 | |
700 | 1 | |a Mello, André Luiz Rodrigues |e verfasserin |4 aut | |
700 | 1 | |a da Silva Fonseca, Laura |e verfasserin |4 aut | |
700 | 1 | |a dos Santos Ferreira, Luíse |e verfasserin |4 aut | |
700 | 1 | |a Kirschnick, Laura Borges |e verfasserin |4 aut | |
700 | 1 | |a Martins, Manoela Domingues |e verfasserin |4 aut | |
700 | 1 | |a Schuch, Lauren Frenzel |e verfasserin |4 aut | |
700 | 1 | |a de Arruda, José Alcides Almeida |e verfasserin |4 aut | |
700 | 1 | |a Soares, Ciro Dantas |e verfasserin |4 aut | |
700 | 1 | |a de Oliveira Sales, Alexandre |e verfasserin |4 aut | |
700 | 1 | |a Bologna-Molina, Ronell |e verfasserin |4 aut | |
700 | 1 | |a Santos-Silva, Alan Roger |e verfasserin |4 aut | |
700 | 1 | |a Vasconcelos, Ana Carolina Uchoa |e verfasserin |4 aut | |
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2022 |
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44.96 42.00 |
publishDate |
2022 |
allfields |
10.1016/j.archoralbio.2022.105374 doi (DE-627)ELV057070768 (ELSEVIER)S0003-9969(22)00030-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 42.00 bkl Silveira, Felipe Martins verfasserin aut Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. COVID-19 Oral pathology Molecular pathology Pandemics SARS-CoV-2 Mello, André Luiz Rodrigues verfasserin aut da Silva Fonseca, Laura verfasserin aut dos Santos Ferreira, Luíse verfasserin aut Kirschnick, Laura Borges verfasserin aut Martins, Manoela Domingues verfasserin aut Schuch, Lauren Frenzel verfasserin aut de Arruda, José Alcides Almeida verfasserin aut Soares, Ciro Dantas verfasserin aut de Oliveira Sales, Alexandre verfasserin aut Bologna-Molina, Ronell verfasserin aut Santos-Silva, Alan Roger verfasserin aut Vasconcelos, Ana Carolina Uchoa verfasserin aut Enthalten in Archives of oral biology Amsterdam [u.a.] : Elsevier Science, 1959 136 Online-Ressource (DE-627)30631553X (DE-600)1496079-5 (DE-576)094080399 1879-1506 nnns volume:136 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 42.00 Biologie: Allgemeines VZ AR 136 |
spelling |
10.1016/j.archoralbio.2022.105374 doi (DE-627)ELV057070768 (ELSEVIER)S0003-9969(22)00030-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 42.00 bkl Silveira, Felipe Martins verfasserin aut Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. COVID-19 Oral pathology Molecular pathology Pandemics SARS-CoV-2 Mello, André Luiz Rodrigues verfasserin aut da Silva Fonseca, Laura verfasserin aut dos Santos Ferreira, Luíse verfasserin aut Kirschnick, Laura Borges verfasserin aut Martins, Manoela Domingues verfasserin aut Schuch, Lauren Frenzel verfasserin aut de Arruda, José Alcides Almeida verfasserin aut Soares, Ciro Dantas verfasserin aut de Oliveira Sales, Alexandre verfasserin aut Bologna-Molina, Ronell verfasserin aut Santos-Silva, Alan Roger verfasserin aut Vasconcelos, Ana Carolina Uchoa verfasserin aut Enthalten in Archives of oral biology Amsterdam [u.a.] : Elsevier Science, 1959 136 Online-Ressource (DE-627)30631553X (DE-600)1496079-5 (DE-576)094080399 1879-1506 nnns volume:136 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 42.00 Biologie: Allgemeines VZ AR 136 |
allfields_unstemmed |
10.1016/j.archoralbio.2022.105374 doi (DE-627)ELV057070768 (ELSEVIER)S0003-9969(22)00030-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 42.00 bkl Silveira, Felipe Martins verfasserin aut Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. COVID-19 Oral pathology Molecular pathology Pandemics SARS-CoV-2 Mello, André Luiz Rodrigues verfasserin aut da Silva Fonseca, Laura verfasserin aut dos Santos Ferreira, Luíse verfasserin aut Kirschnick, Laura Borges verfasserin aut Martins, Manoela Domingues verfasserin aut Schuch, Lauren Frenzel verfasserin aut de Arruda, José Alcides Almeida verfasserin aut Soares, Ciro Dantas verfasserin aut de Oliveira Sales, Alexandre verfasserin aut Bologna-Molina, Ronell verfasserin aut Santos-Silva, Alan Roger verfasserin aut Vasconcelos, Ana Carolina Uchoa verfasserin aut Enthalten in Archives of oral biology Amsterdam [u.a.] : Elsevier Science, 1959 136 Online-Ressource (DE-627)30631553X (DE-600)1496079-5 (DE-576)094080399 1879-1506 nnns volume:136 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 42.00 Biologie: Allgemeines VZ AR 136 |
allfieldsGer |
10.1016/j.archoralbio.2022.105374 doi (DE-627)ELV057070768 (ELSEVIER)S0003-9969(22)00030-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 42.00 bkl Silveira, Felipe Martins verfasserin aut Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. COVID-19 Oral pathology Molecular pathology Pandemics SARS-CoV-2 Mello, André Luiz Rodrigues verfasserin aut da Silva Fonseca, Laura verfasserin aut dos Santos Ferreira, Luíse verfasserin aut Kirschnick, Laura Borges verfasserin aut Martins, Manoela Domingues verfasserin aut Schuch, Lauren Frenzel verfasserin aut de Arruda, José Alcides Almeida verfasserin aut Soares, Ciro Dantas verfasserin aut de Oliveira Sales, Alexandre verfasserin aut Bologna-Molina, Ronell verfasserin aut Santos-Silva, Alan Roger verfasserin aut Vasconcelos, Ana Carolina Uchoa verfasserin aut Enthalten in Archives of oral biology Amsterdam [u.a.] : Elsevier Science, 1959 136 Online-Ressource (DE-627)30631553X (DE-600)1496079-5 (DE-576)094080399 1879-1506 nnns volume:136 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 42.00 Biologie: Allgemeines VZ AR 136 |
allfieldsSound |
10.1016/j.archoralbio.2022.105374 doi (DE-627)ELV057070768 (ELSEVIER)S0003-9969(22)00030-9 DE-627 ger DE-627 rda eng 610 VZ 44.96 bkl 42.00 bkl Silveira, Felipe Martins verfasserin aut Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. COVID-19 Oral pathology Molecular pathology Pandemics SARS-CoV-2 Mello, André Luiz Rodrigues verfasserin aut da Silva Fonseca, Laura verfasserin aut dos Santos Ferreira, Luíse verfasserin aut Kirschnick, Laura Borges verfasserin aut Martins, Manoela Domingues verfasserin aut Schuch, Lauren Frenzel verfasserin aut de Arruda, José Alcides Almeida verfasserin aut Soares, Ciro Dantas verfasserin aut de Oliveira Sales, Alexandre verfasserin aut Bologna-Molina, Ronell verfasserin aut Santos-Silva, Alan Roger verfasserin aut Vasconcelos, Ana Carolina Uchoa verfasserin aut Enthalten in Archives of oral biology Amsterdam [u.a.] : Elsevier Science, 1959 136 Online-Ressource (DE-627)30631553X (DE-600)1496079-5 (DE-576)094080399 1879-1506 nnns volume:136 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 44.96 Zahnmedizin VZ 42.00 Biologie: Allgemeines VZ AR 136 |
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Enthalten in Archives of oral biology 136 volume:136 |
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COVID-19 Oral pathology Molecular pathology Pandemics SARS-CoV-2 |
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Silveira, Felipe Martins @@aut@@ Mello, André Luiz Rodrigues @@aut@@ da Silva Fonseca, Laura @@aut@@ dos Santos Ferreira, Luíse @@aut@@ Kirschnick, Laura Borges @@aut@@ Martins, Manoela Domingues @@aut@@ Schuch, Lauren Frenzel @@aut@@ de Arruda, José Alcides Almeida @@aut@@ Soares, Ciro Dantas @@aut@@ de Oliveira Sales, Alexandre @@aut@@ Bologna-Molina, Ronell @@aut@@ Santos-Silva, Alan Roger @@aut@@ Vasconcelos, Ana Carolina Uchoa @@aut@@ |
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2022-01-01T00:00:00Z |
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Silveira, Felipe Martins |
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Silveira, Felipe Martins ddc 610 bkl 44.96 bkl 42.00 misc COVID-19 misc Oral pathology misc Molecular pathology misc Pandemics misc SARS-CoV-2 Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review |
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610 VZ 44.96 bkl 42.00 bkl Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review COVID-19 Oral pathology Molecular pathology Pandemics SARS-CoV-2 |
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ddc 610 bkl 44.96 bkl 42.00 misc COVID-19 misc Oral pathology misc Molecular pathology misc Pandemics misc SARS-CoV-2 |
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Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review |
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Silveira, Felipe Martins Mello, André Luiz Rodrigues da Silva Fonseca, Laura dos Santos Ferreira, Luíse Kirschnick, Laura Borges Martins, Manoela Domingues Schuch, Lauren Frenzel de Arruda, José Alcides Almeida Soares, Ciro Dantas de Oliveira Sales, Alexandre Bologna-Molina, Ronell Santos-Silva, Alan Roger Vasconcelos, Ana Carolina Uchoa |
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10.1016/j.archoralbio.2022.105374 |
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morphological and tissue-based molecular characterization of oral lesions in patients with covid-19: a living systematic review |
title_auth |
Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review |
abstract |
Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. |
abstractGer |
Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. |
abstract_unstemmed |
Objective: This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined. |
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title_short |
Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review |
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Mello, André Luiz Rodrigues da Silva Fonseca, Laura dos Santos Ferreira, Luíse Kirschnick, Laura Borges Martins, Manoela Domingues Schuch, Lauren Frenzel de Arruda, José Alcides Almeida Soares, Ciro Dantas de Oliveira Sales, Alexandre Bologna-Molina, Ronell Santos-Silva, Alan Roger Vasconcelos, Ana Carolina Uchoa |
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score |
7.401908 |