Inhibition of renalase drives tumour rejection by promoting T cell activation
Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibit...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Guo, Xiaojia [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Umfang: |
16 |
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| Übergeordnetes Werk: |
Enthalten in: The effect of early cognitive therapy in improving cognitive functions using neuropsychology and diffusion tensor imaging measurements following mild traumatic brain injury: A pilot study - Hamzah, N. ELSEVIER, 2018, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:165 ; year:2022 ; pages:81-96 ; extent:16 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.ejca.2022.01.002 |
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ELV057163154 |
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| 520 | |a Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). | ||
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Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). |
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Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). |
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Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). |
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| title_short |
Inhibition of renalase drives tumour rejection by promoting T cell activation |
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https://doi.org/10.1016/j.ejca.2022.01.002 |
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| author2 |
Jessel, Shlomit Qu, Rihao Kluger, Yuval Chen, Tian-Min Hollander, Lindsay Safirstein, Robert Nelson, Bryce Cha, Charles Bosenberg, Marcus Jilaveanu, Lucia B. Rimm, David Rothlin, Carla V. Kluger, Harriet M. Desir, Gary V. |
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Jessel, Shlomit Qu, Rihao Kluger, Yuval Chen, Tian-Min Hollander, Lindsay Safirstein, Robert Nelson, Bryce Cha, Charles Bosenberg, Marcus Jilaveanu, Lucia B. Rimm, David Rothlin, Carla V. Kluger, Harriet M. Desir, Gary V. |
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| doi_str |
10.1016/j.ejca.2022.01.002 |
| up_date |
2024-07-06T22:27:45.358Z |
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