Inhibition of renalase drives tumour rejection by promoting T cell activation
Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibit...
Ausführliche Beschreibung
Autor*in: |
Guo, Xiaojia [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Umfang: |
16 |
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Übergeordnetes Werk: |
Enthalten in: The effect of early cognitive therapy in improving cognitive functions using neuropsychology and diffusion tensor imaging measurements following mild traumatic brain injury: A pilot study - Hamzah, N. ELSEVIER, 2018, Amsterdam [u.a.] |
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Übergeordnetes Werk: |
volume:165 ; year:2022 ; pages:81-96 ; extent:16 |
Links: |
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DOI / URN: |
10.1016/j.ejca.2022.01.002 |
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Katalog-ID: |
ELV057163154 |
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10.1016/j.ejca.2022.01.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001709.pica (DE-627)ELV057163154 (ELSEVIER)S0959-8049(22)00006-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.52 bkl Guo, Xiaojia verfasserin aut Inhibition of renalase drives tumour rejection by promoting T cell activation 2022 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). Anti-PD-1 Elsevier Tumour immune microenvironment Elsevier Renalase Elsevier Jessel, Shlomit oth Qu, Rihao oth Kluger, Yuval oth Chen, Tian-Min oth Hollander, Lindsay oth Safirstein, Robert oth Nelson, Bryce oth Cha, Charles oth Bosenberg, Marcus oth Jilaveanu, Lucia B. oth Rimm, David oth Rothlin, Carla V. oth Kluger, Harriet M. oth Desir, Gary V. oth Enthalten in Elsevier Hamzah, N. ELSEVIER The effect of early cognitive therapy in improving cognitive functions using neuropsychology and diffusion tensor imaging measurements following mild traumatic brain injury: A pilot study 2018 Amsterdam [u.a.] (DE-627)ELV000241849 volume:165 year:2022 pages:81-96 extent:16 https://doi.org/10.1016/j.ejca.2022.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.52 Therapie Medizin VZ AR 165 2022 81-96 16 |
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10.1016/j.ejca.2022.01.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001709.pica (DE-627)ELV057163154 (ELSEVIER)S0959-8049(22)00006-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.52 bkl Guo, Xiaojia verfasserin aut Inhibition of renalase drives tumour rejection by promoting T cell activation 2022 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). Anti-PD-1 Elsevier Tumour immune microenvironment Elsevier Renalase Elsevier Jessel, Shlomit oth Qu, Rihao oth Kluger, Yuval oth Chen, Tian-Min oth Hollander, Lindsay oth Safirstein, Robert oth Nelson, Bryce oth Cha, Charles oth Bosenberg, Marcus oth Jilaveanu, Lucia B. oth Rimm, David oth Rothlin, Carla V. oth Kluger, Harriet M. oth Desir, Gary V. oth Enthalten in Elsevier Hamzah, N. ELSEVIER The effect of early cognitive therapy in improving cognitive functions using neuropsychology and diffusion tensor imaging measurements following mild traumatic brain injury: A pilot study 2018 Amsterdam [u.a.] (DE-627)ELV000241849 volume:165 year:2022 pages:81-96 extent:16 https://doi.org/10.1016/j.ejca.2022.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.52 Therapie Medizin VZ AR 165 2022 81-96 16 |
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10.1016/j.ejca.2022.01.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001709.pica (DE-627)ELV057163154 (ELSEVIER)S0959-8049(22)00006-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.52 bkl Guo, Xiaojia verfasserin aut Inhibition of renalase drives tumour rejection by promoting T cell activation 2022 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). Anti-PD-1 Elsevier Tumour immune microenvironment Elsevier Renalase Elsevier Jessel, Shlomit oth Qu, Rihao oth Kluger, Yuval oth Chen, Tian-Min oth Hollander, Lindsay oth Safirstein, Robert oth Nelson, Bryce oth Cha, Charles oth Bosenberg, Marcus oth Jilaveanu, Lucia B. oth Rimm, David oth Rothlin, Carla V. oth Kluger, Harriet M. oth Desir, Gary V. oth Enthalten in Elsevier Hamzah, N. ELSEVIER The effect of early cognitive therapy in improving cognitive functions using neuropsychology and diffusion tensor imaging measurements following mild traumatic brain injury: A pilot study 2018 Amsterdam [u.a.] (DE-627)ELV000241849 volume:165 year:2022 pages:81-96 extent:16 https://doi.org/10.1016/j.ejca.2022.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.52 Therapie Medizin VZ AR 165 2022 81-96 16 |
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10.1016/j.ejca.2022.01.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001709.pica (DE-627)ELV057163154 (ELSEVIER)S0959-8049(22)00006-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.52 bkl Guo, Xiaojia verfasserin aut Inhibition of renalase drives tumour rejection by promoting T cell activation 2022 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). Anti-PD-1 Elsevier Tumour immune microenvironment Elsevier Renalase Elsevier Jessel, Shlomit oth Qu, Rihao oth Kluger, Yuval oth Chen, Tian-Min oth Hollander, Lindsay oth Safirstein, Robert oth Nelson, Bryce oth Cha, Charles oth Bosenberg, Marcus oth Jilaveanu, Lucia B. oth Rimm, David oth Rothlin, Carla V. oth Kluger, Harriet M. oth Desir, Gary V. oth Enthalten in Elsevier Hamzah, N. ELSEVIER The effect of early cognitive therapy in improving cognitive functions using neuropsychology and diffusion tensor imaging measurements following mild traumatic brain injury: A pilot study 2018 Amsterdam [u.a.] (DE-627)ELV000241849 volume:165 year:2022 pages:81-96 extent:16 https://doi.org/10.1016/j.ejca.2022.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.52 Therapie Medizin VZ AR 165 2022 81-96 16 |
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10.1016/j.ejca.2022.01.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001709.pica (DE-627)ELV057163154 (ELSEVIER)S0959-8049(22)00006-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.52 bkl Guo, Xiaojia verfasserin aut Inhibition of renalase drives tumour rejection by promoting T cell activation 2022 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). Anti-PD-1 Elsevier Tumour immune microenvironment Elsevier Renalase Elsevier Jessel, Shlomit oth Qu, Rihao oth Kluger, Yuval oth Chen, Tian-Min oth Hollander, Lindsay oth Safirstein, Robert oth Nelson, Bryce oth Cha, Charles oth Bosenberg, Marcus oth Jilaveanu, Lucia B. oth Rimm, David oth Rothlin, Carla V. oth Kluger, Harriet M. oth Desir, Gary V. oth Enthalten in Elsevier Hamzah, N. ELSEVIER The effect of early cognitive therapy in improving cognitive functions using neuropsychology and diffusion tensor imaging measurements following mild traumatic brain injury: A pilot study 2018 Amsterdam [u.a.] (DE-627)ELV000241849 volume:165 year:2022 pages:81-96 extent:16 https://doi.org/10.1016/j.ejca.2022.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.52 Therapie Medizin VZ AR 165 2022 81-96 16 |
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Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). |
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Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). |
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Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME). |
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Inhibition of renalase drives tumour rejection by promoting T cell activation |
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Jessel, Shlomit Qu, Rihao Kluger, Yuval Chen, Tian-Min Hollander, Lindsay Safirstein, Robert Nelson, Bryce Cha, Charles Bosenberg, Marcus Jilaveanu, Lucia B. Rimm, David Rothlin, Carla V. Kluger, Harriet M. Desir, Gary V. |
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Jessel, Shlomit Qu, Rihao Kluger, Yuval Chen, Tian-Min Hollander, Lindsay Safirstein, Robert Nelson, Bryce Cha, Charles Bosenberg, Marcus Jilaveanu, Lucia B. Rimm, David Rothlin, Carla V. Kluger, Harriet M. Desir, Gary V. |
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