Response to elexacaftor/tezacaftor/ivacaftor in intestinal organoids derived from people with cystic fibrosis
• First report evaluating the effect of ELX/TEZ/IVA on intestinal organoids. • ELX/TEZ/IVA effect is significantly superior to TEZ/IVA in vitro. • CFTR variants beyond the Phe508del mutation might affect treatment response.
Gespeichert in:
| Autor*in: |
Furstova, Eva [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
|---|
| Umfang: |
3 |
|---|
| Übergeordnetes Werk: |
Enthalten in: In vitro evaluation of synergistic effect of primary and tertiary amino groups in chitosan used as a non-viral gene carrier system - Gök, Mehmet Koray ELSEVIER, 2019, the official journal of the European Cystic Fibrosis Society, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:21 ; year:2022 ; number:2 ; pages:243-245 ; extent:3 |
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| DOI / URN: |
10.1016/j.jcf.2021.07.006 |
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Response to elexacaftor/tezacaftor/ivacaftor in intestinal organoids derived from people with cystic fibrosis |
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• First report evaluating the effect of ELX/TEZ/IVA on intestinal organoids. • ELX/TEZ/IVA effect is significantly superior to TEZ/IVA in vitro. • CFTR variants beyond the Phe508del mutation might affect treatment response. |
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