Transcriptome analysis revealed a two-step transformation of vascular smooth muscle cells to macrophage-like cells
It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to addr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhang, Zhong [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: No title available - 346(2022), Seite 26-35 |
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| Übergeordnetes Werk: |
volume:346 ; year:2022 ; pages:26-35 ; extent:10 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.atherosclerosis.2022.02.021 |
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| 520 | |a It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to address the question of how VSMCs are selected to perform distinct functions under a similar environmental stress, and how much cellular reprogramming happens during VSMC-to-macrophage-like transformation. | ||
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10.1016/j.atherosclerosis.2022.02.021 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001716.pica (DE-627)ELV05722644X (ELSEVIER)S0021-9150(22)00101-0 DE-627 ger DE-627 rakwb eng Zhang, Zhong verfasserin aut Transcriptome analysis revealed a two-step transformation of vascular smooth muscle cells to macrophage-like cells 2022 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to address the question of how VSMCs are selected to perform distinct functions under a similar environmental stress, and how much cellular reprogramming happens during VSMC-to-macrophage-like transformation. NOTCH signaling Elsevier Metabolic reprograming Elsevier Atherosclerosis Elsevier Macrophage-like cells Elsevier VSMC Elsevier Genetic reprogramming Elsevier Huang, Jiaxin oth Wang, Yan oth Shen, Wei oth Enthalten in No title available 346(2022), Seite 26-35 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:346 year:2022 pages:26-35 extent:10 https://doi.org/10.1016/j.atherosclerosis.2022.02.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 346 2022 26-35 10 |
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10.1016/j.atherosclerosis.2022.02.021 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001716.pica (DE-627)ELV05722644X (ELSEVIER)S0021-9150(22)00101-0 DE-627 ger DE-627 rakwb eng Zhang, Zhong verfasserin aut Transcriptome analysis revealed a two-step transformation of vascular smooth muscle cells to macrophage-like cells 2022 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to address the question of how VSMCs are selected to perform distinct functions under a similar environmental stress, and how much cellular reprogramming happens during VSMC-to-macrophage-like transformation. NOTCH signaling Elsevier Metabolic reprograming Elsevier Atherosclerosis Elsevier Macrophage-like cells Elsevier VSMC Elsevier Genetic reprogramming Elsevier Huang, Jiaxin oth Wang, Yan oth Shen, Wei oth Enthalten in No title available 346(2022), Seite 26-35 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:346 year:2022 pages:26-35 extent:10 https://doi.org/10.1016/j.atherosclerosis.2022.02.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 346 2022 26-35 10 |
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10.1016/j.atherosclerosis.2022.02.021 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001716.pica (DE-627)ELV05722644X (ELSEVIER)S0021-9150(22)00101-0 DE-627 ger DE-627 rakwb eng Zhang, Zhong verfasserin aut Transcriptome analysis revealed a two-step transformation of vascular smooth muscle cells to macrophage-like cells 2022 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to address the question of how VSMCs are selected to perform distinct functions under a similar environmental stress, and how much cellular reprogramming happens during VSMC-to-macrophage-like transformation. NOTCH signaling Elsevier Metabolic reprograming Elsevier Atherosclerosis Elsevier Macrophage-like cells Elsevier VSMC Elsevier Genetic reprogramming Elsevier Huang, Jiaxin oth Wang, Yan oth Shen, Wei oth Enthalten in No title available 346(2022), Seite 26-35 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:346 year:2022 pages:26-35 extent:10 https://doi.org/10.1016/j.atherosclerosis.2022.02.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 346 2022 26-35 10 |
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10.1016/j.atherosclerosis.2022.02.021 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001716.pica (DE-627)ELV05722644X (ELSEVIER)S0021-9150(22)00101-0 DE-627 ger DE-627 rakwb eng Zhang, Zhong verfasserin aut Transcriptome analysis revealed a two-step transformation of vascular smooth muscle cells to macrophage-like cells 2022 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to address the question of how VSMCs are selected to perform distinct functions under a similar environmental stress, and how much cellular reprogramming happens during VSMC-to-macrophage-like transformation. NOTCH signaling Elsevier Metabolic reprograming Elsevier Atherosclerosis Elsevier Macrophage-like cells Elsevier VSMC Elsevier Genetic reprogramming Elsevier Huang, Jiaxin oth Wang, Yan oth Shen, Wei oth Enthalten in No title available 346(2022), Seite 26-35 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:346 year:2022 pages:26-35 extent:10 https://doi.org/10.1016/j.atherosclerosis.2022.02.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 346 2022 26-35 10 |
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It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to address the question of how VSMCs are selected to perform distinct functions under a similar environmental stress, and how much cellular reprogramming happens during VSMC-to-macrophage-like transformation. |
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It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to address the question of how VSMCs are selected to perform distinct functions under a similar environmental stress, and how much cellular reprogramming happens during VSMC-to-macrophage-like transformation. |
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It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. Here, we aim to address the question of how VSMCs are selected to perform distinct functions under a similar environmental stress, and how much cellular reprogramming happens during VSMC-to-macrophage-like transformation. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV05722644X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625001240.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">220808s2022 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.atherosclerosis.2022.02.021</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">/cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001716.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV05722644X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0021-9150(22)00101-0</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Zhang, Zhong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Transcriptome analysis revealed a two-step transformation of vascular smooth muscle cells to macrophage-like cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">It is known that vascular smooth muscle cells (VSMCs) represent a major part of the atherosclerotic plaque. In addition to forming fibrous cap cells that stabilize the atherosclerotic plaque, VSMCs trans-differentiate into macrophage-like cells that exacerbate the necrotic core. 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