Beta-band bursting activity in computational model of heterogeneous external globus pallidus circuits
Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a chal...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Xiaomin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification - Tan, Yuyu ELSEVIER, 2014transfer abstract, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:110 ; year:2022 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.cnsns.2022.106388 |
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ELV057324069 |
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| 520 | |a Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. | ||
| 520 | |a Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. | ||
| 650 | 7 | |a Striatum–GPe circuit |2 Elsevier | |
| 650 | 7 | |a Heterogeneous GPe |2 Elsevier | |
| 650 | 7 | |a Bursting |2 Elsevier | |
| 650 | 7 | |a Parkinson’s disease |2 Elsevier | |
| 650 | 7 | |a Beta-band oscillations |2 Elsevier | |
| 700 | 1 | |a Yu, Ying |4 oth | |
| 700 | 1 | |a Han, Fang |4 oth | |
| 700 | 1 | |a Wang, Qingyun |4 oth | |
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10.1016/j.cnsns.2022.106388 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001727.pica (DE-627)ELV057324069 (ELSEVIER)S1007-5704(22)00080-6 DE-627 ger DE-627 rakwb eng 570 VZ 610 VZ 630 640 VZ 49.00 bkl Wang, Xiaomin verfasserin aut Beta-band bursting activity in computational model of heterogeneous external globus pallidus circuits 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Striatum–GPe circuit Elsevier Heterogeneous GPe Elsevier Bursting Elsevier Parkinson’s disease Elsevier Beta-band oscillations Elsevier Yu, Ying oth Han, Fang oth Wang, Qingyun oth Enthalten in Elsevier Tan, Yuyu ELSEVIER Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification 2014transfer abstract Amsterdam [u.a.] (DE-627)ELV012515639 volume:110 year:2022 pages:0 https://doi.org/10.1016/j.cnsns.2022.106388 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 49.00 Hauswirtschaft: Allgemeines VZ AR 110 2022 0 |
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10.1016/j.cnsns.2022.106388 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001727.pica (DE-627)ELV057324069 (ELSEVIER)S1007-5704(22)00080-6 DE-627 ger DE-627 rakwb eng 570 VZ 610 VZ 630 640 VZ 49.00 bkl Wang, Xiaomin verfasserin aut Beta-band bursting activity in computational model of heterogeneous external globus pallidus circuits 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Striatum–GPe circuit Elsevier Heterogeneous GPe Elsevier Bursting Elsevier Parkinson’s disease Elsevier Beta-band oscillations Elsevier Yu, Ying oth Han, Fang oth Wang, Qingyun oth Enthalten in Elsevier Tan, Yuyu ELSEVIER Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification 2014transfer abstract Amsterdam [u.a.] (DE-627)ELV012515639 volume:110 year:2022 pages:0 https://doi.org/10.1016/j.cnsns.2022.106388 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 49.00 Hauswirtschaft: Allgemeines VZ AR 110 2022 0 |
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10.1016/j.cnsns.2022.106388 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001727.pica (DE-627)ELV057324069 (ELSEVIER)S1007-5704(22)00080-6 DE-627 ger DE-627 rakwb eng 570 VZ 610 VZ 630 640 VZ 49.00 bkl Wang, Xiaomin verfasserin aut Beta-band bursting activity in computational model of heterogeneous external globus pallidus circuits 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Striatum–GPe circuit Elsevier Heterogeneous GPe Elsevier Bursting Elsevier Parkinson’s disease Elsevier Beta-band oscillations Elsevier Yu, Ying oth Han, Fang oth Wang, Qingyun oth Enthalten in Elsevier Tan, Yuyu ELSEVIER Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification 2014transfer abstract Amsterdam [u.a.] (DE-627)ELV012515639 volume:110 year:2022 pages:0 https://doi.org/10.1016/j.cnsns.2022.106388 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 49.00 Hauswirtschaft: Allgemeines VZ AR 110 2022 0 |
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10.1016/j.cnsns.2022.106388 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001727.pica (DE-627)ELV057324069 (ELSEVIER)S1007-5704(22)00080-6 DE-627 ger DE-627 rakwb eng 570 VZ 610 VZ 630 640 VZ 49.00 bkl Wang, Xiaomin verfasserin aut Beta-band bursting activity in computational model of heterogeneous external globus pallidus circuits 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Striatum–GPe circuit Elsevier Heterogeneous GPe Elsevier Bursting Elsevier Parkinson’s disease Elsevier Beta-band oscillations Elsevier Yu, Ying oth Han, Fang oth Wang, Qingyun oth Enthalten in Elsevier Tan, Yuyu ELSEVIER Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification 2014transfer abstract Amsterdam [u.a.] (DE-627)ELV012515639 volume:110 year:2022 pages:0 https://doi.org/10.1016/j.cnsns.2022.106388 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 49.00 Hauswirtschaft: Allgemeines VZ AR 110 2022 0 |
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10.1016/j.cnsns.2022.106388 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001727.pica (DE-627)ELV057324069 (ELSEVIER)S1007-5704(22)00080-6 DE-627 ger DE-627 rakwb eng 570 VZ 610 VZ 630 640 VZ 49.00 bkl Wang, Xiaomin verfasserin aut Beta-band bursting activity in computational model of heterogeneous external globus pallidus circuits 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. Striatum–GPe circuit Elsevier Heterogeneous GPe Elsevier Bursting Elsevier Parkinson’s disease Elsevier Beta-band oscillations Elsevier Yu, Ying oth Han, Fang oth Wang, Qingyun oth Enthalten in Elsevier Tan, Yuyu ELSEVIER Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification 2014transfer abstract Amsterdam [u.a.] (DE-627)ELV012515639 volume:110 year:2022 pages:0 https://doi.org/10.1016/j.cnsns.2022.106388 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 49.00 Hauswirtschaft: Allgemeines VZ AR 110 2022 0 |
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Enthalten in Proximity-dependent protein detection based on enzyme-assisted fluorescence signal amplification Amsterdam [u.a.] volume:110 year:2022 pages:0 |
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Beta-band bursting activity in computational model of heterogeneous external globus pallidus circuits |
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Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. |
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Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. |
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Exaggerated beta oscillations (13–35 Hz) in basal ganglia (BG) are the hallmark of dynamical properties in Parkinson’s disease (PD). Physiological experiments have shown that different subtypes of external globus pallidus (GPe) exhibit different changes in pathological conditions, which poses a challenge to the classic basal ganglia network modeling of PD, as the mechanism behind some novel phenomenon is almost impossible to reveal by classical models. We propose an extended striatum–GPe model including two subtypes of GPe, the calcium-binding protein parvalbumin GPe (PV GPe) and Lim homeobox 6 GPe (Lhx6 GPe). Based on this model, we illustrate the effect of inhibitory connections in GPe on neural bursting activities. The increase in self-inhibition of homogeneous GPe neurons can expand the spectral power of the beta-band, while mutual inhibition between heterogeneous GPe can regulate the burst of beta-band. Meanwhile, through the discussion about coupling parameters of GPe, we obtain a set of physiological parameters simulated healthy state. Furthermore, we find that both reducing M-current in striatal medium spine neuron (MSN) and degrading PV GPe to Lhx6 GPe could lead to bursting behaviors in PV GPe, and removing the connection from Lhx6 GPe to PV GPe can reduce the power of the beta-band. The role of heterogeneous GPe in Parkinsonian beta-band bursting is also revealed by simulating the specific optogenetic stimulation on GPe. These results demonstrate the facilitation and control function of heterogeneous GPe to abnormal oscillations and provide a novel insight into designing therapeutic interventions. |
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