Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial

We aimed to assess the efficacy and safety of two neutralising monoclonal antibody therapies (sotrovimab [Vir Biotechnology and GlaxoSmithKline] and BRII-196 plus BRII-198 [Brii Biosciences]) for adults admitted to hospital for COVID-19 (hereafter referred to as hospitalised) with COVID-19.

Gespeichert in:
Autor*in:

Self, Wesley H. [verfasserIn]

Sandkovsky, Uriel

Reilly, Cavan S.

Vock, David M.

Gottlieb, Robert L.

Mack, Michael

Golden, Kevin

Dishner, Emma

Vekstein, Andrew

Ko, Emily R.

Der, Tatyana

Franzone, John

Almasri, Eyad

Fayed, Mohamed

Filbin, Michael R.

Hibbert, Kathryn A.

Rice, Todd W.

Casey, Jonathan D.

Hayanga, J. Awori

Badhwar, Vinay

Leshnower, Bradley G.

Sharifpour, Milad

Knowlton, Kirk U.

Peltan, Ithan D.

Bakowska, Elizieta

Kowalska, Justyna

Bowdish, Michael E.

Sturek, Jeffrey M.

Rogers, Angela J.

Files, D. Clark

Mosier, Jarrod M.

Gong, Michelle N.

Douin, David J.

Hite, R. Duncan

Trautner, Barbara W.

Jain, Mamta K.

Gardner, Edward M.

Khan, Akram

Jensen, Jens-Ulrik

Matthay, Michael A.

Ginde, Adit A.

Brown, Samuel M.

Higgs, Elizabeth S.

Pett, Sarah

Weintrob, Amy C.

Chang, Christina C.

Murrary, Daniel D.

Günthard, Huldrych F.

Moquete, Ellen

Grandits, Greg

Engen, Nicole

Grund, Birgit

Sharma, Shweta

Cao, Huyen

Gupta, Rajesh

Osei, Suzette

Margolis, David

Zhu, Qing

Polizzotto, Mark N.

Babiker, Abdel G.

Davey, Victoria J.

Kan, Virginia

Thompson, B. Taylor

Gelijns, Annetine C.

Neaton, James D.

Lane, H. Clifford

Jundgren, Jens D.

Tierney, John

Barrett, Kevin

Herpin, Betsey R.

Smolskis, Mary C.

Voge, Susan E.

McNay, Laura A.

Cahill, Kelly

Crew, Page

Kirchoff, Matthew

Sardana, Ratna

Raim, Sharon Segal

Chiu, Joseph

Hensley, Lisa

Lorenzo, Josua

Mock, Rebecca

Shaw-Saliba, Katy

Zuckerman, Judith

Adam, Stacey J.

Currier, Judy

Read, Sarah

Hughes, Eric

Amos, Laura

Carlsen, Amy

Carter, Anita

Davis, Bionca

Denning, Eileen

DuChene, Alain

Harrison, Merrie

Kaiser, Payton

Koopmeiners, Joseph

Meger, Sue

Murray, Thomas

Quan, Kien

Quan, Siu Fun

Thompson, Greg

Walski, Jamie

Wentworth, Deborah

Moskowitz, Alan J.

Bagiella, Emilia

O'Sullivan, Karen

Marks, Mary E.

Accardi, Evan

Kinzel, Emily

Bedoya, Gabriela

Gupta, Lopa

Overbey, Jessica R.

Padillia, Maria L.

Santos, Milerva

Gillinov, Marc A.

Miller, Marissa A.

Taddei-Peters, Wendy C.

Fenton, Kathleen

Berhe, Mezgebe

Haley, Clinton

Bettacchi, Christopher

Duhaime, Erin

Ryan, Madison

Burris, Sarah

Jones, Felecia

Villa, Samantha

Want, Samantha

Robert, Raven

Coleman, Tanquinisha

Clariday, Laura

Baker, Rebecca

Hurutado-Rodriguez, Marian

Iram, Nazia

Fresnedo, Michelle

Davis, Allyson

Leonard, Kiara

Ramierez, Noelia

Thammavong, Jon

Duque, Krizia

Turner, Emma

Fisher, Tammy

Robinson, Dianna

Ransom, Desirae

Lusk, Erica

Killian, Aaron

Palacious, Adriana

Solis, Edilia

Jerrow, Janet

Watts, Matthew

Whitacre, Heather

Cothran, Elizabeth

Smith, Peter K.

Barkauskas, Christina E.

Dreyer, Grace R.

Witte, Marie

Mosaly, Nilima

Mourad, Ahmad

Holland, Thomas L.

Lane, Kathleen

Bouffler, Andrew

McGowan, Lauren M.

Motta, Marry

Tipton, Gregory

Stallings, Ben

Stout, Gennifer

McLendon-Arvik, Beth

Hollister, Beth A.

Giangiacomo, Dana M.

Sharma, Sunil

Pappers, Brian

McCarthy, Paul

Krupica, Troy

Sarwari, Arif

Reece, Rebecca

Fornaresio, Lisa

Glaze, Chad

Evans, Raquel

Preamble, Katarina

Sutton, Lisa Giblin

Buterbaugh, Sabrina

Bartolo, Elizabeth Berry

Williams, Roger

Bunner, Robin

Bender, William

Miller, Jeffrey

Baio, Kim T.

McBride, Mary K.

Fielding, Michele

Mathewson, Sonya

Porte, Kristina

Maton, Missy

Ponder, Chari

Haley, Elizabeth

Spainhour, Christine

Rogers, Susan

Tyler, Derrick

Wald-Dickler, Noah

Hutcheon, Douglass

Towfighi, Amytis

Lee, May M.

Lewis, Meghan R.

Spellberg, Brad

Sher, Linda

Sharma, Aniket

Olds, Anna P.

Justino, Chris

Lozano, Edward

Romero, Chris

Leong, Janet

Rodina, Valentina

Possemato, Tammie

Escobar, Jose

Chiu, Charlene

Weissman, Kevin

Barros, Andrew

Enfield, Kyle B.

Kadl, Alexandra

Green, China J.

Simon, Rachel M.

Fox, Ashley

Thornton, Kara

Parrino, Patrick E.

Spindel, Stephen

Bansal, Aditya

Baumgarten, Katherine

Hand, Jonathan

Vonderhaar, Derek

Nossaman, Bobby

Laudun, Sylvia

Ames, DeAnna

Broussard, Shane

Hernandez, Nilmo

Isaac, Geralyn

Dinh, Huan

Zheng, Yiling

Tran, Sonny

McDaniel, Hunter

Crovetto, Nicolle

Miller, Leslie

Schelle, Beth

McLean, Sherry

Rothbaum, Howard R.

Alvarez, Michael S.

Kalan, Shivam P.

Germann, Heather H.

Hendershot, Jennifer

Maroney, Karen

Herring, Karen

Cook, Sharri

Paul, Pam

Madathil, Ronson J.

Rabin, Joseph

Levine, Andrea

Saharia, Kapil

Tabatabai, Ali

Lau, Christine

Gammie, James S.

Peguero, Maya-Loren

McKernan, Kimberley

Audette, Matthew

Fleischmann, Emily

Akbari, Freshta

Lee, Maia

Lee, Myounghee

Chi, Andrew

Salehi, Hanna

Pariser, Alan

Nguyen, Phuong Tran

Moore, Jessica

Gee, Adrienne

Vincent, Shelika

Zuckerman, Richard A.

Iribarne, Alexander

Metzler, Sara

Shipman, Samantha

Caccia, Taylor

Johnson, Haley

Newton, Crystallee

Parr, Doug

Rodriguez, Vicente

Bokhart, Gordon

Eichman, Sharon M.

North, Crystal

Oldmixon, Cathryn

Ringwood, Nancy

Fitzgerald, Laura

Morin, Haley D.

Muzikansky, Ariela

Morse, Richard

Brower, Roy G.

Reineck, Lora A.

Aggarwal, Neil R.

Bienstock, Karen

Hou, Peter

Steingrub, Jay

Tidswell, Mark A.

Kozikowski, Lori-Ann

Kardos, Cynthia

DeSouza, Leslie

Thornton-Thompson, Sherell

Talmor, Daniel

Shapiro, Nathan

Banner-Goodspeed, Valerie

Boyle, Katherine L.

Hayes, Sharon

Jones, Alan E.

Galbraith, James

Nandi, Utsav

Peacock, Rebekah K.

Parry, Blair Alden

Margolin, Justin D.

Brait, Kelsey

Beakes, Caroline

Kangelaris, Kirsten N.

Yee, Kimberly J.

Ashktorab, Kimia

Jauregui, Alejandra E.

Zhuo, Hanjing

Hendey, Gregory

Hubel, Kinsley A.

Hughes, Alyssa R.

Garcia, Rebekah L.

Wilson, Jennifer G.

Vojnik, Rosemary

Roque, Jonasel

Perez, Cynthia

Lim, George W.

Chang, Steven Y.

Beutler, Rebecca

Agarwal, Trisha

Vargas, Julia

Moss, Marc

Baduashvili, Amiran

Chauhan, Lakshmi

Finck, Lani L.

Howell, Michelle

Hyzy, Robert C.

Park, Pauline K.

Nelson, Kristine

McSparron, Jake I.

Co, Ivan N.

Wang, Bonnie R.

Jia, Shijing

Sullins, Barbara

Hanna, Sinan

Olbrich, Norman

Richardson, Lynne D.

Nair, Rahul

Offor, Obiageli

Lopez, Brenda

Amosu, Omowunmi

Tzehaie, Hiwet

Terndrup, Thomas E.

Wiedemann, Herbert P.

Duggal, Abhijit

Thiruchelvam, Nirosshan

Ashok, Kiran

King, Alexander H.

Mehkri, Omar

Hudock, Kristin

Kiran, Simra

More, Harshada

Roads, Tammy

Martinkovic, Jamie

Kennedy, Sarah

Robinson, Bryce H.

Hough, Catherine L.

Krol, Olivia F.

Kinjal, Mistry

Mills, Emmanuel

McDougal, Madeline

Deshmukh, Rupali

Chen, Peter

Torbati, Sam S.

Matusov, Yuri

Choe, June

Hindoyan, Niree A.

Jackman, Susan E.

Bayoumi, Emad

Wynter, Timothy

Caudill, Antonina

Pascual, Ethan

Clapham, Gregg J.

Herrera, Lisa

Ojukwu, Cristabelle

Mehdikhani, Shaunt

O'Mahony, D. Shane

Nyatsatsang, Sonam T.

Wilson, David M.

Wallick, Julie A.

Miller, Chadwick

Gibbs, Keven W.

Flores, Lori S.

LaRose, Mary E.

Landreth, Leigha D.

Morris, Peter E.

Sturgill, Jamie L.

Cassity, Evan P.

Dhar, Sanjay

Montgomery-Yates, Ashley A.

Pasha, Sara N.

Mayer, Kirby P.

Bissel, Brittany

Bledsoe, Joseph

Brown, Samuel

Lanspa, Michael

Leither, Lindsey

Armbruster, Brent P.

Montgomery, Quinn

Applegate, Darrin

Kumar, Naresh

Fergus, Melissa

Serezlic, Erna

Imel, Karah

Palmer, Ghazal

Webb, Brandon

Aston, Valerie T.

Johnson, Jakea

Gray, Christopher

Hays, Margaret

Roth, Megan

Sánchez, Adriana

Popielski, Laura

Rivasplata, Heather

Turner, Melissa

Vjecha, Michael

Petersen, Tianna

Kamel, Dena

Hansen, Laura

Lucas, Claudia Sanchez

DellaValle, Natalie

Gonzales, Sonia

Scott, James

Wyles, David

Douglas, Ivor

Haukoos, Jason

Kamis, Kevin

Robinson, Caitlin

Baker, Jason V.

Frosch, Anne

Goldsmith, Rachael

Jibrell, Hodan

Lo, Melanie

Klaphake, Jonathan

Mackedanz, Shari

Ngo, Linh

Garcia-Myers, Kelly

Markowitz, Norman

Pastor, Erika

Ramesh, Mayur

Brar, Indira

Rivers, Emanuel

Kumar, Princy

Menna, Maximiliano

Biswas, Kousick

Harrington, Cristin

Delp, Alex

Pandit, Lavannya

Hines-Munson, Casey

Van, John

Dillon, Laura

Want, Yiqun

Lichtenberger, Paola

Baracco, Gio

Ramos, Carol

Bjork, Lauren

Sueiro, Melyssa

Tien, Phyllis

Freasier, Heather

Buck, Theresa

Nekach, Hafida

Nagy-Agren, Stephanie

Vasudeva, Shikha

Ochalek, Tracy

Roller, Brentin

Nguyen, Chinh

Mikail, Amani

Raben, Dorthe

Jensen, Tomas O.

Aagaard, Bitten

Nielsen, Charlotte B.

Krapp, Katharina

Nykjær, Bente Rosdahl

Kanne, Katja Lisa

Grevsen, Anne Louise

Joensen, Zillah Maria

Bruun, Tina

Bojesen, Ane

Woldbye, Frederik

Normand, Nick E.

Esmann, Frederik V.L.

Clausen, Clara Lundetoft

Hovmand, Nichlas

Pedersen, Karen Brorup

Thorlacius-Ussing, Louise

Tinggaard, Michaela

Høgsberg, Dorthe S.

Rastoder, Ema

Kamstrup, Thobias

Bergsøe, Christina Marisa

Østergaard, Lars

Stærke, Nina Breinholt

Johansen, Isik S.

Knudtzen, Fredrikke C.

Larsen, Lykke

Hertz, Mathias A.

Fabricius, Thilde

Helleberg, Marie

Gerstoft, Jan

Jensen, Tomas Østergaard

Lindegaard, Birgitte

Pedersen, Thomas Ingemann

Røge, Birgit Thorup

Løfberg, Sandra Valborg

Hansen, Thomas Michael

Nielsen, Ariella Denize

von Huth, Sebastian Leicht

Nielsen, Henrik

Thisted, Rikke Krog

Podlekareva, Daria

Johnsen, Stine

Andreassen, Helle Frost

Pedersen, Lars

Lindnér, Cecilia Ebba Clara Ellinor

Wiese, Lothar

Knudsen, Lene Surland

Nytofte, Nikolaj Julian Skrøder

Havmøller, Signe Ravn

Paredes, Roger

Exposito, Maria

Fernández-Cruz, Eduardo

Muñoz, José

Arribas, Jose R.

Estrada, Vicente

Horcajada, Juan P.

Burgos, Joaquin

Morales-Rull, Jose Luis

Braun, Dominique L.

West, Emily

M'Rabeth-Bensalah, Khadija

Eichinger, Mareile L.

Grüttner-Durmaz, Manuela

Grube, Christina

Zink, Veronika

Horban, Andrzej

Bednarska, Agnieszka

Jurek, Natalia

Fätkenheuer, Gerd

Malinm, Jakob J.

Matthews, Gail

Kelleher, Anthony

Cabrera, Gesalit

Carey, Catherine

Hough, Sally

Virachit, Sophie

Zhong, Amy

Young, Barnaby E.

Chia, Po Ying

Lee, Tau Hong

Lin, Ray J.

Lye, David

Ong, Sean

Puah, Ser Hon

Yeo, Tsin Wen

Diong, Shiau Hui

Ongko, Juwinda

Hudson, Fleur

Parmar, Mahesh KB

Goodman, Anna

Badrock, Jonathan

Gregory, Adam

Harris, Nicola

Touloumi, Giota

Pantaz, Nikos

Gioukari, Vicky

Lutaakome, Joseph

Kityo, Cissy M.

Mugerwa, Henry

Kiweewa, Francis

Osinusi, Anu

Tipple, Craig

Willis, Angela

Peppercorn, Amanda

Watson, Helen

Alexander, Elizabeth

Mogalian, Erik

Lin, Leo

Ding, Xiao

Yan, Li

Girardet, Jean-Luc

Ma, Ji

Hong, Zhi

Adams, Amy

Albert, Sara

Balde, Abby

Baracz, Michelle

Baseler, Beth

Becker, Nancy

Bielica, Mona

Billouin-Frazier, Shere

Cash, Jennifer

Choudhary, Jay

Dolney, Suzanne

Dixon, Mary

Eyler, Carolyn

Frye, Leanna

Galcik, Michael

Gertz, Jensen

Giebeig, Lisa

Gulati, Neelam

Hankinson, Liz

Hissey, Debbie

Hogarty, Debi

Hohn, Matt

Holley, H Preston

Hoopengardner, Lisa

Huber, Lynda

Jankelevich, Shirley

Krauss, Gary

Lake, Eileen

Linton, Jessica

MacDonald, Leah

Manandhar, Meryan

Spinelli-Nadzam, Mary

Oluremi, Charles

Proffitt, Calvin

Rudzinski, Erin

Sandrus, Jen

Schaffhauser, Marylu

Schechner, Adam

Suders, Connie

Gerry, Norman P.

Smith, Kenneth

Solomon, Courtney

Kubernac, Amanda

Rashid, Marium

Patel, Bhakti

Kubernac, Robert

Murphy, Joseph

Hoover, Marie L.

Brown, Craig

DuChateau, Nadine

Flosi, Adam

Johnson, Les

Treagus, Amy

Wenner, Christine

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2022

Umfang:

14

Übergeordnetes Werk:

Enthalten in: Identification of Advanced Fibrosis in Hepatitis C Patients following Sustained Virologic Response: A New Predictive Model - Berhane, S. ELSEVIER, 2016, New York, NY

Übergeordnetes Werk:

volume:22 ; year:2022 ; number:5 ; pages:622-635 ; extent:14

Links:

Volltext

DOI / URN:

10.1016/S1473-3099(21)00751-9

Katalog-ID:

ELV057455694

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