Understanding the antibacterial mechanisms of copper ion treatment on Mycobacterium avium subsp. paratuberculosis
Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tejeda, Carlos [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds - 2013, an international journal concerned with microbiological diseases of all animals that are useful to man, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:268 ; year:2022 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.vetmic.2022.109412 |
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ELV057476691 |
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| 520 | |a Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. | ||
| 520 | |a Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. | ||
| 650 | 7 | |a Mechanisms |2 Elsevier | |
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| 650 | 7 | |a Copper ions |2 Elsevier | |
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| 700 | 1 | |a Steuer, Pamela |4 oth | |
| 700 | 1 | |a Iranzo, Esperanza C. |4 oth | |
| 700 | 1 | |a González, Nicolas |4 oth | |
| 700 | 1 | |a Ramirez-Reveco, Alfredo |4 oth | |
| 700 | 1 | |a Salgado, Miguel |4 oth | |
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10.1016/j.vetmic.2022.109412 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001746.pica (DE-627)ELV057476691 (ELSEVIER)S0378-1135(22)00082-7 DE-627 ger DE-627 rakwb eng Tejeda, Carlos verfasserin aut Understanding the antibacterial mechanisms of copper ion treatment on Mycobacterium avium subsp. paratuberculosis 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Mechanisms Elsevier Tolerance Elsevier Copper ions Elsevier MAP Elsevier Villegas, Marcela oth Steuer, Pamela oth Iranzo, Esperanza C. oth González, Nicolas oth Ramirez-Reveco, Alfredo oth Salgado, Miguel oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:268 year:2022 pages:0 https://doi.org/10.1016/j.vetmic.2022.109412 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 268 2022 0 |
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10.1016/j.vetmic.2022.109412 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001746.pica (DE-627)ELV057476691 (ELSEVIER)S0378-1135(22)00082-7 DE-627 ger DE-627 rakwb eng Tejeda, Carlos verfasserin aut Understanding the antibacterial mechanisms of copper ion treatment on Mycobacterium avium subsp. paratuberculosis 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Mechanisms Elsevier Tolerance Elsevier Copper ions Elsevier MAP Elsevier Villegas, Marcela oth Steuer, Pamela oth Iranzo, Esperanza C. oth González, Nicolas oth Ramirez-Reveco, Alfredo oth Salgado, Miguel oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:268 year:2022 pages:0 https://doi.org/10.1016/j.vetmic.2022.109412 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 268 2022 0 |
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10.1016/j.vetmic.2022.109412 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001746.pica (DE-627)ELV057476691 (ELSEVIER)S0378-1135(22)00082-7 DE-627 ger DE-627 rakwb eng Tejeda, Carlos verfasserin aut Understanding the antibacterial mechanisms of copper ion treatment on Mycobacterium avium subsp. paratuberculosis 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Mechanisms Elsevier Tolerance Elsevier Copper ions Elsevier MAP Elsevier Villegas, Marcela oth Steuer, Pamela oth Iranzo, Esperanza C. oth González, Nicolas oth Ramirez-Reveco, Alfredo oth Salgado, Miguel oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:268 year:2022 pages:0 https://doi.org/10.1016/j.vetmic.2022.109412 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 268 2022 0 |
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10.1016/j.vetmic.2022.109412 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001746.pica (DE-627)ELV057476691 (ELSEVIER)S0378-1135(22)00082-7 DE-627 ger DE-627 rakwb eng Tejeda, Carlos verfasserin aut Understanding the antibacterial mechanisms of copper ion treatment on Mycobacterium avium subsp. paratuberculosis 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Mechanisms Elsevier Tolerance Elsevier Copper ions Elsevier MAP Elsevier Villegas, Marcela oth Steuer, Pamela oth Iranzo, Esperanza C. oth González, Nicolas oth Ramirez-Reveco, Alfredo oth Salgado, Miguel oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:268 year:2022 pages:0 https://doi.org/10.1016/j.vetmic.2022.109412 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 268 2022 0 |
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10.1016/j.vetmic.2022.109412 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001746.pica (DE-627)ELV057476691 (ELSEVIER)S0378-1135(22)00082-7 DE-627 ger DE-627 rakwb eng Tejeda, Carlos verfasserin aut Understanding the antibacterial mechanisms of copper ion treatment on Mycobacterium avium subsp. paratuberculosis 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. Mechanisms Elsevier Tolerance Elsevier Copper ions Elsevier MAP Elsevier Villegas, Marcela oth Steuer, Pamela oth Iranzo, Esperanza C. oth González, Nicolas oth Ramirez-Reveco, Alfredo oth Salgado, Miguel oth Enthalten in Elsevier Science Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds 2013 an international journal concerned with microbiological diseases of all animals that are useful to man Amsterdam [u.a.] (DE-627)ELV011521430 volume:268 year:2022 pages:0 https://doi.org/10.1016/j.vetmic.2022.109412 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 268 2022 0 |
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Understanding the antibacterial mechanisms of copper ion treatment on Mycobacterium avium subsp. paratuberculosis |
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Tejeda, Carlos |
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understanding the antibacterial mechanisms of copper ion treatment on mycobacterium avium subsp. paratuberculosis |
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Understanding the antibacterial mechanisms of copper ion treatment on Mycobacterium avium subsp. paratuberculosis |
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Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. |
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Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. |
| abstract_unstemmed |
Copper and its alloys are natural and very well-proven antimicrobial materials. The mechanisms of action through which copper is highly effective have been described at the molecular and cellular level. However, both the design of the studies carried out and the nature of the microorganisms studied have meant that this research has been of limited scope. In the present study, we examined the action mechanisms of a copper ion treatment on the integrity of Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant animal pathogen. The copper ion treatment applied to MAP cells, resulted in nucleic acid degradation and disintegration, increased ROS production and protein alteration. However, the observed susceptibility of MAP to copper-based treatment was dose-dependent. Finally, it had no effect on the integrity of the MAP cell wall. This new evidence about the observed tolerance in the MAP cell wall against the copper ions, may help us to understand how we can improve the proposed copper-based treatment, and finally achieve a totally effective alternative to control MAP in calf´s milk. |
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Villegas, Marcela Steuer, Pamela Iranzo, Esperanza C. González, Nicolas Ramirez-Reveco, Alfredo Salgado, Miguel |
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