Design, synthesis of novel triptolide-glucose conjugates targeting glucose Transporter-1 and their selective antitumor effect

Six positional isomers of triptolide–glucose conjugates (TG1α, TG1β, TG2, TG3, TG4 and TG6) were designed and synthesized. These conjugates exhibited better water solubility, and had selective cytotoxicity between tumor cells with high expression of glucose transport-1 (Glut-1) and non-tumor cells w...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Liu, Yan [verfasserIn]

Huang, Jiaqing

Wu, Min

Liu, Bi

Lin, Qiaofa

Wu, Jingjing

Ouyang, Yuhua

Guo, Xin

Huang, Ruyi

Zhang, Yongmin

Xu, Jianhua

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2022transfer abstract

Schlagwörter:

Glucose transporter

Triptolide-glucose conjugate

Triptolide

Antitumor

Übergeordnetes Werk:

Enthalten in: Electrochemical synthesis, photodegradation and antibacterial properties of PEG capped zinc oxide nanoparticles - Jose, Ajay ELSEVIER, 2018, Amsterdam [u.a.]

Übergeordnetes Werk:

volume:238 ; year:2022 ; day:5 ; month:08 ; pages:0

Links:

Volltext

DOI / URN:

10.1016/j.ejmech.2022.114463

Katalog-ID:

ELV058188398

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