Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects

Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Liu, Peng [verfasserIn] Li, Heng [verfasserIn] Li, Ruiyi [verfasserIn] Geng, Yan [verfasserIn] Gong, Jinsong [verfasserIn] Xu, Hongyu [verfasserIn] Xu, Zhenghong [verfasserIn] Shi, Jinsong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Chitooligosaccharides Nanoencapsulation Liver fibrosis Bioavailability Microfold cell Apoptosis Liver sinusoidal endothelial cell capillarization

Übergeordnetes Werk:	Enthalten in: Food research international - New York, NY [u.a.] : Elsevier, 1992, 157
Übergeordnetes Werk:	volume:157

DOI / URN:	10.1016/j.foodres.2022.111471

Katalog-ID:	ELV058239405

Internformat


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245	1	0	\|a Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects
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520			\|a Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect.
650		4	\|a Chitooligosaccharides
650		4	\|a Nanoencapsulation
650		4	\|a Liver fibrosis
650		4	\|a Bioavailability
650		4	\|a Microfold cell
650		4	\|a Apoptosis
650		4	\|a Liver sinusoidal endothelial cell capillarization
700	1		\|a Li, Heng \|e verfasserin \|4 aut
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700	1		\|a Gong, Jinsong \|e verfasserin \|4 aut
700	1		\|a Xu, Hongyu \|e verfasserin \|4 aut
700	1		\|a Xu, Zhenghong \|e verfasserin \|4 aut
700	1		\|a Shi, Jinsong \|e verfasserin \|4 aut
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936	b	k	\|a 58.34 \|j Lebensmitteltechnologie \|q VZ
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Indexfelder

author_variant	p l pl h l hl r l rl y g yg j g jg h x hx z x zx j s js
matchkey_str	article:18737145:2022----::aonasltoociolgschrdsnacstoaboviaiiyn
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publishDate	2022
allfields	10.1016/j.foodres.2022.111471 doi (DE-627)ELV058239405 (ELSEVIER)S0963-9969(22)00529-4 DE-627 ger DE-627 rda eng 630 640 540 660 VZ 58.34 bkl Liu, Peng verfasserin aut Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect. Chitooligosaccharides Nanoencapsulation Liver fibrosis Bioavailability Microfold cell Apoptosis Liver sinusoidal endothelial cell capillarization Li, Heng verfasserin aut Li, Ruiyi verfasserin aut Geng, Yan verfasserin aut Gong, Jinsong verfasserin aut Xu, Hongyu verfasserin aut Xu, Zhenghong verfasserin aut Shi, Jinsong verfasserin aut Enthalten in Food research international New York, NY [u.a.] : Elsevier, 1992 157 Online-Ressource (DE-627)300898541 (DE-600)1483651-8 (DE-576)25526660X 1873-7145 nnns volume:157 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.34 Lebensmitteltechnologie VZ AR 157
spelling	10.1016/j.foodres.2022.111471 doi (DE-627)ELV058239405 (ELSEVIER)S0963-9969(22)00529-4 DE-627 ger DE-627 rda eng 630 640 540 660 VZ 58.34 bkl Liu, Peng verfasserin aut Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect. Chitooligosaccharides Nanoencapsulation Liver fibrosis Bioavailability Microfold cell Apoptosis Liver sinusoidal endothelial cell capillarization Li, Heng verfasserin aut Li, Ruiyi verfasserin aut Geng, Yan verfasserin aut Gong, Jinsong verfasserin aut Xu, Hongyu verfasserin aut Xu, Zhenghong verfasserin aut Shi, Jinsong verfasserin aut Enthalten in Food research international New York, NY [u.a.] : Elsevier, 1992 157 Online-Ressource (DE-627)300898541 (DE-600)1483651-8 (DE-576)25526660X 1873-7145 nnns volume:157 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.34 Lebensmitteltechnologie VZ AR 157
allfields_unstemmed	10.1016/j.foodres.2022.111471 doi (DE-627)ELV058239405 (ELSEVIER)S0963-9969(22)00529-4 DE-627 ger DE-627 rda eng 630 640 540 660 VZ 58.34 bkl Liu, Peng verfasserin aut Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect. Chitooligosaccharides Nanoencapsulation Liver fibrosis Bioavailability Microfold cell Apoptosis Liver sinusoidal endothelial cell capillarization Li, Heng verfasserin aut Li, Ruiyi verfasserin aut Geng, Yan verfasserin aut Gong, Jinsong verfasserin aut Xu, Hongyu verfasserin aut Xu, Zhenghong verfasserin aut Shi, Jinsong verfasserin aut Enthalten in Food research international New York, NY [u.a.] : Elsevier, 1992 157 Online-Ressource (DE-627)300898541 (DE-600)1483651-8 (DE-576)25526660X 1873-7145 nnns volume:157 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.34 Lebensmitteltechnologie VZ AR 157
allfieldsGer	10.1016/j.foodres.2022.111471 doi (DE-627)ELV058239405 (ELSEVIER)S0963-9969(22)00529-4 DE-627 ger DE-627 rda eng 630 640 540 660 VZ 58.34 bkl Liu, Peng verfasserin aut Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect. Chitooligosaccharides Nanoencapsulation Liver fibrosis Bioavailability Microfold cell Apoptosis Liver sinusoidal endothelial cell capillarization Li, Heng verfasserin aut Li, Ruiyi verfasserin aut Geng, Yan verfasserin aut Gong, Jinsong verfasserin aut Xu, Hongyu verfasserin aut Xu, Zhenghong verfasserin aut Shi, Jinsong verfasserin aut Enthalten in Food research international New York, NY [u.a.] : Elsevier, 1992 157 Online-Ressource (DE-627)300898541 (DE-600)1483651-8 (DE-576)25526660X 1873-7145 nnns volume:157 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.34 Lebensmitteltechnologie VZ AR 157
allfieldsSound	10.1016/j.foodres.2022.111471 doi (DE-627)ELV058239405 (ELSEVIER)S0963-9969(22)00529-4 DE-627 ger DE-627 rda eng 630 640 540 660 VZ 58.34 bkl Liu, Peng verfasserin aut Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects 2022 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect. Chitooligosaccharides Nanoencapsulation Liver fibrosis Bioavailability Microfold cell Apoptosis Liver sinusoidal endothelial cell capillarization Li, Heng verfasserin aut Li, Ruiyi verfasserin aut Geng, Yan verfasserin aut Gong, Jinsong verfasserin aut Xu, Hongyu verfasserin aut Xu, Zhenghong verfasserin aut Shi, Jinsong verfasserin aut Enthalten in Food research international New York, NY [u.a.] : Elsevier, 1992 157 Online-Ressource (DE-627)300898541 (DE-600)1483651-8 (DE-576)25526660X 1873-7145 nnns volume:157 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 58.34 Lebensmitteltechnologie VZ AR 157
language	English
source	Enthalten in Food research international 157 volume:157
sourceStr	Enthalten in Food research international 157 volume:157
format_phy_str_mv	Article
bklname	Lebensmitteltechnologie
institution	findex.gbv.de
topic_facet	Chitooligosaccharides Nanoencapsulation Liver fibrosis Bioavailability Microfold cell Apoptosis Liver sinusoidal endothelial cell capillarization
dewey-raw	630
isfreeaccess_bool	false
container_title	Food research international
authorswithroles_txt_mv	Liu, Peng @@aut@@ Li, Heng @@aut@@ Li, Ruiyi @@aut@@ Geng, Yan @@aut@@ Gong, Jinsong @@aut@@ Xu, Hongyu @@aut@@ Xu, Zhenghong @@aut@@ Shi, Jinsong @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	300898541
dewey-sort	3630
id	ELV058239405
language_de	englisch
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author	Liu, Peng
spellingShingle	Liu, Peng ddc 630 bkl 58.34 misc Chitooligosaccharides misc Nanoencapsulation misc Liver fibrosis misc Bioavailability misc Microfold cell misc Apoptosis misc Liver sinusoidal endothelial cell capillarization Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects
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topic_title	630 640 540 660 VZ 58.34 bkl Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects Chitooligosaccharides Nanoencapsulation Liver fibrosis Bioavailability Microfold cell Apoptosis Liver sinusoidal endothelial cell capillarization
topic	ddc 630 bkl 58.34 misc Chitooligosaccharides misc Nanoencapsulation misc Liver fibrosis misc Bioavailability misc Microfold cell misc Apoptosis misc Liver sinusoidal endothelial cell capillarization
topic_unstemmed	ddc 630 bkl 58.34 misc Chitooligosaccharides misc Nanoencapsulation misc Liver fibrosis misc Bioavailability misc Microfold cell misc Apoptosis misc Liver sinusoidal endothelial cell capillarization
topic_browse	ddc 630 bkl 58.34 misc Chitooligosaccharides misc Nanoencapsulation misc Liver fibrosis misc Bioavailability misc Microfold cell misc Apoptosis misc Liver sinusoidal endothelial cell capillarization
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title	Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects
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title_full	Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects
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doi_str_mv	10.1016/j.foodres.2022.111471
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title_sort	nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects
title_auth	Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects
abstract	Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect.
abstractGer	Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect.
abstract_unstemmed	Chitooligosaccharides (COS) significantly attenuates liver dysfunction. However, the conundrum of the oral bioavailability of COS limits their pharmacological effects. Therefore, a strategy of nanoencapsulation was employed to enhance oral bioavailability and tissue-targeted distribution of COS. In this study, nanospheres loaded with COS (CANs) were prepared, their bioavailability, biodistribution, transport mechanism and anti-liver fibrosis effects were explored. Nanoencapsulation improved the oral bioavailability of various COS monomers through microfold cell-mediated absorption route in an indiscriminate manner. CANs were more favorably enriched and protractedly accumulated in the liver. In a liver fibrosis model, CANs ameliorated the pathological state and extracellular matrix deposition. The alleviation of liver fibrosis for COS could be attributed to the inhibition of liver cell apoptosis and liver sinusoidal endothelial cell (LSEC) capillarization. Consequently, this study highlights the improved oral bioavailability of COS and proposes a novel mechanism of COS, for better understanding its hepatoprotective effect.
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title_short	Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects
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author2	Li, Heng Li, Ruiyi Geng, Yan Gong, Jinsong Xu, Hongyu Xu, Zhenghong Shi, Jinsong
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doi_str	10.1016/j.foodres.2022.111471
up_date	2024-07-06T18:27:12.226Z
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Nanoencapsulation of chitooligosaccharides enhances its oral bioavailability and anti-liver fibrotic effects

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