Fabrication of red-emissive ZIF-8QDs nanoprobe with improved fluorescence based on assembly strategy for enhanced biosensing
In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Junyang [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Association between binge eating disorder and psychiatric comorbidity profiles in patients with obesity seeking bariatric surgery - Borgès Da Silva, Virginie ELSEVIER, 2018, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:368 ; year:2022 ; day:1 ; month:10 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.snb.2022.132188 |
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ELV058310878 |
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| 245 | 1 | 0 | |a Fabrication of red-emissive ZIF-8QDs nanoprobe with improved fluorescence based on assembly strategy for enhanced biosensing |
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| 520 | |a In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. | ||
| 520 | |a In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. | ||
| 650 | 7 | |a Quantum dots |2 Elsevier | |
| 650 | 7 | |a ZIF-8@QDs nanoprobe |2 Elsevier | |
| 650 | 7 | |a Fluorescence |2 Elsevier | |
| 650 | 7 | |a Glutathione S-transferase |2 Elsevier | |
| 650 | 7 | |a Metal–organic frameworks |2 Elsevier | |
| 700 | 1 | |a Wang, Guannan |4 oth | |
| 700 | 1 | |a Su, Xingguang |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Borgès Da Silva, Virginie ELSEVIER |t Association between binge eating disorder and psychiatric comorbidity profiles in patients with obesity seeking bariatric surgery |d 2018 |g Amsterdam [u.a.] |w (DE-627)ELV001079875 |
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10.1016/j.snb.2022.132188 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001855.pica (DE-627)ELV058310878 (ELSEVIER)S0925-4005(22)00830-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.91 bkl Chen, Junyang verfasserin aut Fabrication of red-emissive ZIF-8QDs nanoprobe with improved fluorescence based on assembly strategy for enhanced biosensing 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. Quantum dots Elsevier ZIF-8@QDs nanoprobe Elsevier Fluorescence Elsevier Glutathione S-transferase Elsevier Metal–organic frameworks Elsevier Wang, Guannan oth Su, Xingguang oth Enthalten in Elsevier Science Borgès Da Silva, Virginie ELSEVIER Association between binge eating disorder and psychiatric comorbidity profiles in patients with obesity seeking bariatric surgery 2018 Amsterdam [u.a.] (DE-627)ELV001079875 volume:368 year:2022 day:1 month:10 pages:0 https://doi.org/10.1016/j.snb.2022.132188 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.91 Psychiatrie Psychopathologie VZ AR 368 2022 1 1001 0 |
| spelling |
10.1016/j.snb.2022.132188 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001855.pica (DE-627)ELV058310878 (ELSEVIER)S0925-4005(22)00830-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.91 bkl Chen, Junyang verfasserin aut Fabrication of red-emissive ZIF-8QDs nanoprobe with improved fluorescence based on assembly strategy for enhanced biosensing 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. Quantum dots Elsevier ZIF-8@QDs nanoprobe Elsevier Fluorescence Elsevier Glutathione S-transferase Elsevier Metal–organic frameworks Elsevier Wang, Guannan oth Su, Xingguang oth Enthalten in Elsevier Science Borgès Da Silva, Virginie ELSEVIER Association between binge eating disorder and psychiatric comorbidity profiles in patients with obesity seeking bariatric surgery 2018 Amsterdam [u.a.] (DE-627)ELV001079875 volume:368 year:2022 day:1 month:10 pages:0 https://doi.org/10.1016/j.snb.2022.132188 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.91 Psychiatrie Psychopathologie VZ AR 368 2022 1 1001 0 |
| allfields_unstemmed |
10.1016/j.snb.2022.132188 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001855.pica (DE-627)ELV058310878 (ELSEVIER)S0925-4005(22)00830-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.91 bkl Chen, Junyang verfasserin aut Fabrication of red-emissive ZIF-8QDs nanoprobe with improved fluorescence based on assembly strategy for enhanced biosensing 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. Quantum dots Elsevier ZIF-8@QDs nanoprobe Elsevier Fluorescence Elsevier Glutathione S-transferase Elsevier Metal–organic frameworks Elsevier Wang, Guannan oth Su, Xingguang oth Enthalten in Elsevier Science Borgès Da Silva, Virginie ELSEVIER Association between binge eating disorder and psychiatric comorbidity profiles in patients with obesity seeking bariatric surgery 2018 Amsterdam [u.a.] (DE-627)ELV001079875 volume:368 year:2022 day:1 month:10 pages:0 https://doi.org/10.1016/j.snb.2022.132188 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.91 Psychiatrie Psychopathologie VZ AR 368 2022 1 1001 0 |
| allfieldsGer |
10.1016/j.snb.2022.132188 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001855.pica (DE-627)ELV058310878 (ELSEVIER)S0925-4005(22)00830-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.91 bkl Chen, Junyang verfasserin aut Fabrication of red-emissive ZIF-8QDs nanoprobe with improved fluorescence based on assembly strategy for enhanced biosensing 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. Quantum dots Elsevier ZIF-8@QDs nanoprobe Elsevier Fluorescence Elsevier Glutathione S-transferase Elsevier Metal–organic frameworks Elsevier Wang, Guannan oth Su, Xingguang oth Enthalten in Elsevier Science Borgès Da Silva, Virginie ELSEVIER Association between binge eating disorder and psychiatric comorbidity profiles in patients with obesity seeking bariatric surgery 2018 Amsterdam [u.a.] (DE-627)ELV001079875 volume:368 year:2022 day:1 month:10 pages:0 https://doi.org/10.1016/j.snb.2022.132188 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.91 Psychiatrie Psychopathologie VZ AR 368 2022 1 1001 0 |
| allfieldsSound |
10.1016/j.snb.2022.132188 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001855.pica (DE-627)ELV058310878 (ELSEVIER)S0925-4005(22)00830-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.91 bkl Chen, Junyang verfasserin aut Fabrication of red-emissive ZIF-8QDs nanoprobe with improved fluorescence based on assembly strategy for enhanced biosensing 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. Quantum dots Elsevier ZIF-8@QDs nanoprobe Elsevier Fluorescence Elsevier Glutathione S-transferase Elsevier Metal–organic frameworks Elsevier Wang, Guannan oth Su, Xingguang oth Enthalten in Elsevier Science Borgès Da Silva, Virginie ELSEVIER Association between binge eating disorder and psychiatric comorbidity profiles in patients with obesity seeking bariatric surgery 2018 Amsterdam [u.a.] (DE-627)ELV001079875 volume:368 year:2022 day:1 month:10 pages:0 https://doi.org/10.1016/j.snb.2022.132188 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.91 Psychiatrie Psychopathologie VZ AR 368 2022 1 1001 0 |
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Association between binge eating disorder and psychiatric comorbidity profiles in patients with obesity seeking bariatric surgery |
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Fabrication of red-emissive ZIF-8QDs nanoprobe with improved fluorescence based on assembly strategy for enhanced biosensing |
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In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. |
| abstractGer |
In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. |
| abstract_unstemmed |
In this study, brightly red-emissive nanoprobe (ZIF-8QDs) was constructed based on the assembly between Hg-ZnSe QDs and zeolitic imidazolate framework-8 (ZIF-8) for ultrasensitive determination of glutathione S-transferase (GST). The ZIF-8@QDs nanoprobe not only enhanced the fluorescence of QDs, but also had the advantages of MOFs, which largely improved the analytical sensitivity. Cu2+ could be selectively enriched on the surface of ZIF-8@QDs, and resulting in its fluorescence quenching. However, in the presence of glutathione (GSH), ZIF-8@QDs fluorescence was recovered due to the strong affinity between Cu2+ and GSH. Moreover, with the catalysis of GST, GSH would react with 1-chloro-2,4-dinitrobenzene (CDNB) to form an adduct that could not coordinate with Cu2+, leading to ZIF-8@QDs fluorescence quenched again. Hence, a simple and sensitive "off-on-off" fluorescent sensing platform was fabricated for the determination of GST with a wide linear range of 0.05–1.2 mU/L. Moreover, the LOD of the ZIF-8@QDs nanoprobe for GST was 0.014 mU/L, which was improved about 15 times compared with QDs nanoprobe. This assay provided a promising method to design and synthesize high-performance MOF-based nanoprobe for in vitro diagnosis and possessed great potential in the field of bioinformatics and clinical medicine. |
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