Vaccine-associated attenuation of subjective severity among outpatients with influenza
Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with m...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chung, Jessie R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement - Li, Yaoyao ELSEVIER, 2022, Amsterdam |
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| Übergeordnetes Werk: |
volume:40 ; year:2022 ; number:32 ; day:30 ; month:07 ; pages:4322-4327 ; extent:6 |
| Links: |
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| DOI / URN: |
10.1016/j.vaccine.2022.06.019 |
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| 520 | |a Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. | ||
| 520 | |a Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. | ||
| 650 | 7 | |a Influenza |2 Elsevier | |
| 650 | 7 | |a Vaccines |2 Elsevier | |
| 700 | 1 | |a Kim, Sara S. |4 oth | |
| 700 | 1 | |a Flannery, Brendan |4 oth | |
| 700 | 1 | |a Smith, Michael E. |4 oth | |
| 700 | 1 | |a Dunnigan, Kayan |4 oth | |
| 700 | 1 | |a Raiyani, Chandni |4 oth | |
| 700 | 1 | |a Murthy, Kempapura |4 oth | |
| 700 | 1 | |a Gaglani, Manjusha |4 oth | |
| 700 | 1 | |a Jackson, Michael L. |4 oth | |
| 700 | 1 | |a Jackson, Lisa A. |4 oth | |
| 700 | 1 | |a Bear, Todd |4 oth | |
| 700 | 1 | |a Moehling Geffel, Krissy |4 oth | |
| 700 | 1 | |a Nowalk, Mary Patricia |4 oth | |
| 700 | 1 | |a Zimmerman, Richard K. |4 oth | |
| 700 | 1 | |a Martin, Emily T. |4 oth | |
| 700 | 1 | |a Lamerato, Lois |4 oth | |
| 700 | 1 | |a McLean, Huong Q. |4 oth | |
| 700 | 1 | |a King, Jennifer P. |4 oth | |
| 700 | 1 | |a Belongia, Edward A. |4 oth | |
| 700 | 1 | |a Thompson, Mark G. |4 oth | |
| 700 | 1 | |a Patel, Manish |4 oth | |
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10.1016/j.vaccine.2022.06.019 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001836.pica (DE-627)ELV05837079X (ELSEVIER)S0264-410X(22)00767-8 DE-627 ger DE-627 rakwb eng 630 640 VZ 48.00 bkl Chung, Jessie R. verfasserin aut Vaccine-associated attenuation of subjective severity among outpatients with influenza 2022transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza Elsevier Vaccines Elsevier Kim, Sara S. oth Flannery, Brendan oth Smith, Michael E. oth Dunnigan, Kayan oth Raiyani, Chandni oth Murthy, Kempapura oth Gaglani, Manjusha oth Jackson, Michael L. oth Jackson, Lisa A. oth Bear, Todd oth Moehling Geffel, Krissy oth Nowalk, Mary Patricia oth Zimmerman, Richard K. oth Martin, Emily T. oth Lamerato, Lois oth McLean, Huong Q. oth King, Jennifer P. oth Belongia, Edward A. oth Thompson, Mark G. oth Patel, Manish oth Enthalten in Elsevier Li, Yaoyao ELSEVIER Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement 2022 Amsterdam (DE-627)ELV007884451 volume:40 year:2022 number:32 day:30 month:07 pages:4322-4327 extent:6 https://doi.org/10.1016/j.vaccine.2022.06.019 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 40 2022 32 30 0730 4322-4327 6 |
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10.1016/j.vaccine.2022.06.019 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001836.pica (DE-627)ELV05837079X (ELSEVIER)S0264-410X(22)00767-8 DE-627 ger DE-627 rakwb eng 630 640 VZ 48.00 bkl Chung, Jessie R. verfasserin aut Vaccine-associated attenuation of subjective severity among outpatients with influenza 2022transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza Elsevier Vaccines Elsevier Kim, Sara S. oth Flannery, Brendan oth Smith, Michael E. oth Dunnigan, Kayan oth Raiyani, Chandni oth Murthy, Kempapura oth Gaglani, Manjusha oth Jackson, Michael L. oth Jackson, Lisa A. oth Bear, Todd oth Moehling Geffel, Krissy oth Nowalk, Mary Patricia oth Zimmerman, Richard K. oth Martin, Emily T. oth Lamerato, Lois oth McLean, Huong Q. oth King, Jennifer P. oth Belongia, Edward A. oth Thompson, Mark G. oth Patel, Manish oth Enthalten in Elsevier Li, Yaoyao ELSEVIER Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement 2022 Amsterdam (DE-627)ELV007884451 volume:40 year:2022 number:32 day:30 month:07 pages:4322-4327 extent:6 https://doi.org/10.1016/j.vaccine.2022.06.019 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 40 2022 32 30 0730 4322-4327 6 |
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10.1016/j.vaccine.2022.06.019 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001836.pica (DE-627)ELV05837079X (ELSEVIER)S0264-410X(22)00767-8 DE-627 ger DE-627 rakwb eng 630 640 VZ 48.00 bkl Chung, Jessie R. verfasserin aut Vaccine-associated attenuation of subjective severity among outpatients with influenza 2022transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza Elsevier Vaccines Elsevier Kim, Sara S. oth Flannery, Brendan oth Smith, Michael E. oth Dunnigan, Kayan oth Raiyani, Chandni oth Murthy, Kempapura oth Gaglani, Manjusha oth Jackson, Michael L. oth Jackson, Lisa A. oth Bear, Todd oth Moehling Geffel, Krissy oth Nowalk, Mary Patricia oth Zimmerman, Richard K. oth Martin, Emily T. oth Lamerato, Lois oth McLean, Huong Q. oth King, Jennifer P. oth Belongia, Edward A. oth Thompson, Mark G. oth Patel, Manish oth Enthalten in Elsevier Li, Yaoyao ELSEVIER Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement 2022 Amsterdam (DE-627)ELV007884451 volume:40 year:2022 number:32 day:30 month:07 pages:4322-4327 extent:6 https://doi.org/10.1016/j.vaccine.2022.06.019 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 40 2022 32 30 0730 4322-4327 6 |
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10.1016/j.vaccine.2022.06.019 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001836.pica (DE-627)ELV05837079X (ELSEVIER)S0264-410X(22)00767-8 DE-627 ger DE-627 rakwb eng 630 640 VZ 48.00 bkl Chung, Jessie R. verfasserin aut Vaccine-associated attenuation of subjective severity among outpatients with influenza 2022transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza Elsevier Vaccines Elsevier Kim, Sara S. oth Flannery, Brendan oth Smith, Michael E. oth Dunnigan, Kayan oth Raiyani, Chandni oth Murthy, Kempapura oth Gaglani, Manjusha oth Jackson, Michael L. oth Jackson, Lisa A. oth Bear, Todd oth Moehling Geffel, Krissy oth Nowalk, Mary Patricia oth Zimmerman, Richard K. oth Martin, Emily T. oth Lamerato, Lois oth McLean, Huong Q. oth King, Jennifer P. oth Belongia, Edward A. oth Thompson, Mark G. oth Patel, Manish oth Enthalten in Elsevier Li, Yaoyao ELSEVIER Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement 2022 Amsterdam (DE-627)ELV007884451 volume:40 year:2022 number:32 day:30 month:07 pages:4322-4327 extent:6 https://doi.org/10.1016/j.vaccine.2022.06.019 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 40 2022 32 30 0730 4322-4327 6 |
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10.1016/j.vaccine.2022.06.019 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001836.pica (DE-627)ELV05837079X (ELSEVIER)S0264-410X(22)00767-8 DE-627 ger DE-627 rakwb eng 630 640 VZ 48.00 bkl Chung, Jessie R. verfasserin aut Vaccine-associated attenuation of subjective severity among outpatients with influenza 2022transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. Influenza Elsevier Vaccines Elsevier Kim, Sara S. oth Flannery, Brendan oth Smith, Michael E. oth Dunnigan, Kayan oth Raiyani, Chandni oth Murthy, Kempapura oth Gaglani, Manjusha oth Jackson, Michael L. oth Jackson, Lisa A. oth Bear, Todd oth Moehling Geffel, Krissy oth Nowalk, Mary Patricia oth Zimmerman, Richard K. oth Martin, Emily T. oth Lamerato, Lois oth McLean, Huong Q. oth King, Jennifer P. oth Belongia, Edward A. oth Thompson, Mark G. oth Patel, Manish oth Enthalten in Elsevier Li, Yaoyao ELSEVIER Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement 2022 Amsterdam (DE-627)ELV007884451 volume:40 year:2022 number:32 day:30 month:07 pages:4322-4327 extent:6 https://doi.org/10.1016/j.vaccine.2022.06.019 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 40 2022 32 30 0730 4322-4327 6 |
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Enthalten in Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement Amsterdam volume:40 year:2022 number:32 day:30 month:07 pages:4322-4327 extent:6 |
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Enthalten in Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement Amsterdam volume:40 year:2022 number:32 day:30 month:07 pages:4322-4327 extent:6 |
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Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement |
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Chung, Jessie R. @@aut@@ Kim, Sara S. @@oth@@ Flannery, Brendan @@oth@@ Smith, Michael E. @@oth@@ Dunnigan, Kayan @@oth@@ Raiyani, Chandni @@oth@@ Murthy, Kempapura @@oth@@ Gaglani, Manjusha @@oth@@ Jackson, Michael L. @@oth@@ Jackson, Lisa A. @@oth@@ Bear, Todd @@oth@@ Moehling Geffel, Krissy @@oth@@ Nowalk, Mary Patricia @@oth@@ Zimmerman, Richard K. @@oth@@ Martin, Emily T. @@oth@@ Lamerato, Lois @@oth@@ McLean, Huong Q. @@oth@@ King, Jennifer P. @@oth@@ Belongia, Edward A. @@oth@@ Thompson, Mark G. @@oth@@ Patel, Manish @@oth@@ |
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Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement |
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Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. |
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Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. |
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Influenza vaccines can mitigate illness severity, including reduced risk of ICU admission and death, in people with breakthrough infection. Less is known about vaccine attenuation of mild/moderate influenza illness. We compared subjective severity scores in vaccinated and unvaccinated persons with medically attended illness and laboratory-confirmed influenza. Participants were prospectively recruited when presenting for care at five US sites over nine seasons. Participants aged ≥ 16 years completed the EQ-5D-5L visual analog scale (VAS) at enrollment. After controlling for potential confounders in a multivariable model, including age and general health status, VAS scores were significantly higher among 2,830 vaccinated participants compared with 3,459 unvaccinated participants, indicating vaccinated participants felt better at the time of presentation for care. No differences in VAS scores were observed by the type of vaccine received among persons aged ≥ 65 years. Our findings suggest vaccine-associated attenuation of milder influenza illness is possible. |
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