Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity
Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experim...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ma, Yonghui [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: β-carotene isolated from the marine red alga, - Kavalappa, Yogendra Prasad ELSEVIER, 2018, the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:203 ; year:2022 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.phytochem.2022.113413 |
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| 520 | |a Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. | ||
| 520 | |a Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. | ||
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10.1016/j.phytochem.2022.113413 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001926.pica (DE-627)ELV059095822 (ELSEVIER)S0031-9422(22)00329-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Ma, Yonghui verfasserin aut Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Hepatoprotective activity Elsevier Hypericaceae Elsevier PPAPs Elsevier Hyperbeanin A-G Elsevier Hypericum beanii Elsevier Suo, Xinyue oth Li, Xiaoxiu oth Zhu, Tingting oth Li, Jin oth Ji, Tengfei oth Liu, Bo oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:203 year:2022 pages:0 https://doi.org/10.1016/j.phytochem.2022.113413 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 203 2022 0 |
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10.1016/j.phytochem.2022.113413 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001926.pica (DE-627)ELV059095822 (ELSEVIER)S0031-9422(22)00329-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Ma, Yonghui verfasserin aut Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Hepatoprotective activity Elsevier Hypericaceae Elsevier PPAPs Elsevier Hyperbeanin A-G Elsevier Hypericum beanii Elsevier Suo, Xinyue oth Li, Xiaoxiu oth Zhu, Tingting oth Li, Jin oth Ji, Tengfei oth Liu, Bo oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:203 year:2022 pages:0 https://doi.org/10.1016/j.phytochem.2022.113413 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 203 2022 0 |
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10.1016/j.phytochem.2022.113413 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001926.pica (DE-627)ELV059095822 (ELSEVIER)S0031-9422(22)00329-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Ma, Yonghui verfasserin aut Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Hepatoprotective activity Elsevier Hypericaceae Elsevier PPAPs Elsevier Hyperbeanin A-G Elsevier Hypericum beanii Elsevier Suo, Xinyue oth Li, Xiaoxiu oth Zhu, Tingting oth Li, Jin oth Ji, Tengfei oth Liu, Bo oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:203 year:2022 pages:0 https://doi.org/10.1016/j.phytochem.2022.113413 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 203 2022 0 |
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10.1016/j.phytochem.2022.113413 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001926.pica (DE-627)ELV059095822 (ELSEVIER)S0031-9422(22)00329-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Ma, Yonghui verfasserin aut Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Hepatoprotective activity Elsevier Hypericaceae Elsevier PPAPs Elsevier Hyperbeanin A-G Elsevier Hypericum beanii Elsevier Suo, Xinyue oth Li, Xiaoxiu oth Zhu, Tingting oth Li, Jin oth Ji, Tengfei oth Liu, Bo oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:203 year:2022 pages:0 https://doi.org/10.1016/j.phytochem.2022.113413 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 203 2022 0 |
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10.1016/j.phytochem.2022.113413 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001926.pica (DE-627)ELV059095822 (ELSEVIER)S0031-9422(22)00329-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Ma, Yonghui verfasserin aut Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. Hepatoprotective activity Elsevier Hypericaceae Elsevier PPAPs Elsevier Hyperbeanin A-G Elsevier Hypericum beanii Elsevier Suo, Xinyue oth Li, Xiaoxiu oth Zhu, Tingting oth Li, Jin oth Ji, Tengfei oth Liu, Bo oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:203 year:2022 pages:0 https://doi.org/10.1016/j.phytochem.2022.113413 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 203 2022 0 |
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Enthalten in β-carotene isolated from the marine red alga, New York, NY [u.a.] volume:203 year:2022 pages:0 |
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β-carotene isolated from the marine red alga, |
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Ma, Yonghui @@aut@@ Suo, Xinyue @@oth@@ Li, Xiaoxiu @@oth@@ Zhu, Tingting @@oth@@ Li, Jin @@oth@@ Ji, Tengfei @@oth@@ Liu, Bo @@oth@@ |
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Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity |
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Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. |
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Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. |
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Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring. Four of the isolated compounds showed obvious hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 μM. The present results suggested that these compounds would be potential hepatoprotective agents. In addition, the plausible biogenetic pathways of hyperbeanins A-G were proposed, which gave an insight for future biomimetic synthesis of them. |
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