MOF-based DNA hydrolases optimized by atom engineering for the removal of antibiotic-resistant genes from aquatic environment
In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fang, Ge [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: Comparability studies of hemin from two different origins porcine and bovine in the production of - Beri, Suresh ELSEVIER, 2020, an international journal devoted to catalytic science and its applications, Amsterdam |
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| Übergeordnetes Werk: |
volume:320 ; year:2023 ; pages:0 |
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| DOI / URN: |
10.1016/j.apcatb.2022.121931 |
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| 520 | |a In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. | ||
| 520 | |a In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. | ||
| 650 | 7 | |a Atomic engineering |2 Elsevier | |
| 650 | 7 | |a Antibiotic-resistant genes |2 Elsevier | |
| 650 | 7 | |a MOF-based nanozyme |2 Elsevier | |
| 650 | 7 | |a Activity optimization |2 Elsevier | |
| 650 | 7 | |a Horizontal gene transfer |2 Elsevier | |
| 700 | 1 | |a Kang, Ruonan |4 oth | |
| 700 | 1 | |a Chong, Yu |4 oth | |
| 700 | 1 | |a Wang, Liming |4 oth | |
| 700 | 1 | |a Wu, Chuanqiang |4 oth | |
| 700 | 1 | |a Ge, Cuicui |4 oth | |
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10.1016/j.apcatb.2022.121931 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001927.pica (DE-627)ELV059134852 (ELSEVIER)S0926-3373(22)00872-4 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid PHARM DE-84 fid 44.00 bkl Fang, Ge verfasserin aut MOF-based DNA hydrolases optimized by atom engineering for the removal of antibiotic-resistant genes from aquatic environment 2023transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. Atomic engineering Elsevier Antibiotic-resistant genes Elsevier MOF-based nanozyme Elsevier Activity optimization Elsevier Horizontal gene transfer Elsevier Kang, Ruonan oth Chong, Yu oth Wang, Liming oth Wu, Chuanqiang oth Ge, Cuicui oth Enthalten in Elsevier Beri, Suresh ELSEVIER Comparability studies of hemin from two different origins porcine and bovine in the production of 2020 an international journal devoted to catalytic science and its applications Amsterdam (DE-627)ELV004775082 volume:320 year:2023 pages:0 https://doi.org/10.1016/j.apcatb.2022.121931 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.00 Medizin: Allgemeines VZ AR 320 2023 0 |
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10.1016/j.apcatb.2022.121931 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001927.pica (DE-627)ELV059134852 (ELSEVIER)S0926-3373(22)00872-4 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid PHARM DE-84 fid 44.00 bkl Fang, Ge verfasserin aut MOF-based DNA hydrolases optimized by atom engineering for the removal of antibiotic-resistant genes from aquatic environment 2023transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. Atomic engineering Elsevier Antibiotic-resistant genes Elsevier MOF-based nanozyme Elsevier Activity optimization Elsevier Horizontal gene transfer Elsevier Kang, Ruonan oth Chong, Yu oth Wang, Liming oth Wu, Chuanqiang oth Ge, Cuicui oth Enthalten in Elsevier Beri, Suresh ELSEVIER Comparability studies of hemin from two different origins porcine and bovine in the production of 2020 an international journal devoted to catalytic science and its applications Amsterdam (DE-627)ELV004775082 volume:320 year:2023 pages:0 https://doi.org/10.1016/j.apcatb.2022.121931 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.00 Medizin: Allgemeines VZ AR 320 2023 0 |
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10.1016/j.apcatb.2022.121931 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001927.pica (DE-627)ELV059134852 (ELSEVIER)S0926-3373(22)00872-4 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid PHARM DE-84 fid 44.00 bkl Fang, Ge verfasserin aut MOF-based DNA hydrolases optimized by atom engineering for the removal of antibiotic-resistant genes from aquatic environment 2023transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. Atomic engineering Elsevier Antibiotic-resistant genes Elsevier MOF-based nanozyme Elsevier Activity optimization Elsevier Horizontal gene transfer Elsevier Kang, Ruonan oth Chong, Yu oth Wang, Liming oth Wu, Chuanqiang oth Ge, Cuicui oth Enthalten in Elsevier Beri, Suresh ELSEVIER Comparability studies of hemin from two different origins porcine and bovine in the production of 2020 an international journal devoted to catalytic science and its applications Amsterdam (DE-627)ELV004775082 volume:320 year:2023 pages:0 https://doi.org/10.1016/j.apcatb.2022.121931 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.00 Medizin: Allgemeines VZ AR 320 2023 0 |
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10.1016/j.apcatb.2022.121931 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001927.pica (DE-627)ELV059134852 (ELSEVIER)S0926-3373(22)00872-4 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid PHARM DE-84 fid 44.00 bkl Fang, Ge verfasserin aut MOF-based DNA hydrolases optimized by atom engineering for the removal of antibiotic-resistant genes from aquatic environment 2023transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. Atomic engineering Elsevier Antibiotic-resistant genes Elsevier MOF-based nanozyme Elsevier Activity optimization Elsevier Horizontal gene transfer Elsevier Kang, Ruonan oth Chong, Yu oth Wang, Liming oth Wu, Chuanqiang oth Ge, Cuicui oth Enthalten in Elsevier Beri, Suresh ELSEVIER Comparability studies of hemin from two different origins porcine and bovine in the production of 2020 an international journal devoted to catalytic science and its applications Amsterdam (DE-627)ELV004775082 volume:320 year:2023 pages:0 https://doi.org/10.1016/j.apcatb.2022.121931 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.00 Medizin: Allgemeines VZ AR 320 2023 0 |
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10.1016/j.apcatb.2022.121931 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001927.pica (DE-627)ELV059134852 (ELSEVIER)S0926-3373(22)00872-4 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid PHARM DE-84 fid 44.00 bkl Fang, Ge verfasserin aut MOF-based DNA hydrolases optimized by atom engineering for the removal of antibiotic-resistant genes from aquatic environment 2023transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. Atomic engineering Elsevier Antibiotic-resistant genes Elsevier MOF-based nanozyme Elsevier Activity optimization Elsevier Horizontal gene transfer Elsevier Kang, Ruonan oth Chong, Yu oth Wang, Liming oth Wu, Chuanqiang oth Ge, Cuicui oth Enthalten in Elsevier Beri, Suresh ELSEVIER Comparability studies of hemin from two different origins porcine and bovine in the production of 2020 an international journal devoted to catalytic science and its applications Amsterdam (DE-627)ELV004775082 volume:320 year:2023 pages:0 https://doi.org/10.1016/j.apcatb.2022.121931 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.00 Medizin: Allgemeines VZ AR 320 2023 0 |
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UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. 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MOF-based DNA hydrolases optimized by atom engineering for the removal of antibiotic-resistant genes from aquatic environment |
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In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. |
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In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. |
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In this study, the spatial location effect of the incorporated metal atoms on the hydrolysis activity of metal organic framework-based nanomaterials (MOFs) was investigated. UiO-type MOFs incorporated with single-atom Cu at different spatial positions were prepared and their hydrolysis activity towards phosphoester bonds was found to be highly depended on the location of the atomically dispersed Cu atoms. Especially, the attachment of Cu atoms to ligand (UiO-67-CuN) resulted in the most significant increase of their hydrolysis activity, which can be attributed to the elevated oxygen vacancies and increased Lewis acidity of MOFs. As a result, UiO-67-CuN efficiently catalyzed the cleavage of DNA acting as DNA hydrolases, thereby effectively inhibiting the horizontal gene transfer of ARGs and eliminating bacterial resistance to antibiotic. This study opens up new prospects for the rational design of high-performance MOF-based DNA hydrolases and developing new treatment strategies for the removal of ARGs. |
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