Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB
RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yuen, Man-Fung [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Umfang: |
12 |
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| Übergeordnetes Werk: |
Enthalten in: Identification of the antigenic region of - Abdelbaky, Hanan H. ELSEVIER, 2018, official journal of the European Association for the Study of the Liver, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:77 ; year:2022 ; number:5 ; pages:1287-1298 ; extent:12 |
| Links: |
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| DOI / URN: |
10.1016/j.jhep.2022.07.010 |
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ELV059210923 |
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10.1016/j.jhep.2022.07.010 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001931.pica (DE-627)ELV059210923 (ELSEVIER)S0168-8278(22)02941-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.44 bkl Yuen, Man-Fung verfasserin aut Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB 2022 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small-interfering RNA JNJ-73763989 (JNJ-3989) plus a nucleos(t)ide analogue (NA), with/without the capsid assembly modulator JNJ-56136379 (JNJ-6379) in patients with chronic hepatitis B. chronic hepatitis B Elsevier RNA interference Elsevier hepatitis B surface antigen Elsevier Hepatitis B virus Elsevier JNJ-3989 Elsevier antiviral therapy Elsevier Locarnini, Stephen oth Lim, Tien Huey oth Strasser, Simone I. oth Sievert, William oth Cheng, Wendy oth Thompson, Alex J. oth Given, Bruce D. oth Schluep, Thomas oth Hamilton, James oth Biermer, Michael oth Kalmeijer, Ronald oth Beumont, Maria oth Lenz, Oliver oth De Ridder, Filip oth Cloherty, Gavin oth Ka-Ho Wong, Danny oth Schwabe, Christian oth Jackson, Kathy oth Lai, Ching Lung oth Gish, Robert G. oth Gane, Edward oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:77 year:2022 number:5 pages:1287-1298 extent:12 https://doi.org/10.1016/j.jhep.2022.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 77 2022 5 1287-1298 12 |
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10.1016/j.jhep.2022.07.010 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001931.pica (DE-627)ELV059210923 (ELSEVIER)S0168-8278(22)02941-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.44 bkl Yuen, Man-Fung verfasserin aut Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB 2022 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small-interfering RNA JNJ-73763989 (JNJ-3989) plus a nucleos(t)ide analogue (NA), with/without the capsid assembly modulator JNJ-56136379 (JNJ-6379) in patients with chronic hepatitis B. chronic hepatitis B Elsevier RNA interference Elsevier hepatitis B surface antigen Elsevier Hepatitis B virus Elsevier JNJ-3989 Elsevier antiviral therapy Elsevier Locarnini, Stephen oth Lim, Tien Huey oth Strasser, Simone I. oth Sievert, William oth Cheng, Wendy oth Thompson, Alex J. oth Given, Bruce D. oth Schluep, Thomas oth Hamilton, James oth Biermer, Michael oth Kalmeijer, Ronald oth Beumont, Maria oth Lenz, Oliver oth De Ridder, Filip oth Cloherty, Gavin oth Ka-Ho Wong, Danny oth Schwabe, Christian oth Jackson, Kathy oth Lai, Ching Lung oth Gish, Robert G. oth Gane, Edward oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:77 year:2022 number:5 pages:1287-1298 extent:12 https://doi.org/10.1016/j.jhep.2022.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 77 2022 5 1287-1298 12 |
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10.1016/j.jhep.2022.07.010 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001931.pica (DE-627)ELV059210923 (ELSEVIER)S0168-8278(22)02941-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.44 bkl Yuen, Man-Fung verfasserin aut Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB 2022 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small-interfering RNA JNJ-73763989 (JNJ-3989) plus a nucleos(t)ide analogue (NA), with/without the capsid assembly modulator JNJ-56136379 (JNJ-6379) in patients with chronic hepatitis B. chronic hepatitis B Elsevier RNA interference Elsevier hepatitis B surface antigen Elsevier Hepatitis B virus Elsevier JNJ-3989 Elsevier antiviral therapy Elsevier Locarnini, Stephen oth Lim, Tien Huey oth Strasser, Simone I. oth Sievert, William oth Cheng, Wendy oth Thompson, Alex J. oth Given, Bruce D. oth Schluep, Thomas oth Hamilton, James oth Biermer, Michael oth Kalmeijer, Ronald oth Beumont, Maria oth Lenz, Oliver oth De Ridder, Filip oth Cloherty, Gavin oth Ka-Ho Wong, Danny oth Schwabe, Christian oth Jackson, Kathy oth Lai, Ching Lung oth Gish, Robert G. oth Gane, Edward oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:77 year:2022 number:5 pages:1287-1298 extent:12 https://doi.org/10.1016/j.jhep.2022.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 77 2022 5 1287-1298 12 |
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10.1016/j.jhep.2022.07.010 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001931.pica (DE-627)ELV059210923 (ELSEVIER)S0168-8278(22)02941-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.44 bkl Yuen, Man-Fung verfasserin aut Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB 2022 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small-interfering RNA JNJ-73763989 (JNJ-3989) plus a nucleos(t)ide analogue (NA), with/without the capsid assembly modulator JNJ-56136379 (JNJ-6379) in patients with chronic hepatitis B. chronic hepatitis B Elsevier RNA interference Elsevier hepatitis B surface antigen Elsevier Hepatitis B virus Elsevier JNJ-3989 Elsevier antiviral therapy Elsevier Locarnini, Stephen oth Lim, Tien Huey oth Strasser, Simone I. oth Sievert, William oth Cheng, Wendy oth Thompson, Alex J. oth Given, Bruce D. oth Schluep, Thomas oth Hamilton, James oth Biermer, Michael oth Kalmeijer, Ronald oth Beumont, Maria oth Lenz, Oliver oth De Ridder, Filip oth Cloherty, Gavin oth Ka-Ho Wong, Danny oth Schwabe, Christian oth Jackson, Kathy oth Lai, Ching Lung oth Gish, Robert G. oth Gane, Edward oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:77 year:2022 number:5 pages:1287-1298 extent:12 https://doi.org/10.1016/j.jhep.2022.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 77 2022 5 1287-1298 12 |
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10.1016/j.jhep.2022.07.010 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001931.pica (DE-627)ELV059210923 (ELSEVIER)S0168-8278(22)02941-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.44 bkl Yuen, Man-Fung verfasserin aut Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB 2022 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small-interfering RNA JNJ-73763989 (JNJ-3989) plus a nucleos(t)ide analogue (NA), with/without the capsid assembly modulator JNJ-56136379 (JNJ-6379) in patients with chronic hepatitis B. chronic hepatitis B Elsevier RNA interference Elsevier hepatitis B surface antigen Elsevier Hepatitis B virus Elsevier JNJ-3989 Elsevier antiviral therapy Elsevier Locarnini, Stephen oth Lim, Tien Huey oth Strasser, Simone I. oth Sievert, William oth Cheng, Wendy oth Thompson, Alex J. oth Given, Bruce D. oth Schluep, Thomas oth Hamilton, James oth Biermer, Michael oth Kalmeijer, Ronald oth Beumont, Maria oth Lenz, Oliver oth De Ridder, Filip oth Cloherty, Gavin oth Ka-Ho Wong, Danny oth Schwabe, Christian oth Jackson, Kathy oth Lai, Ching Lung oth Gish, Robert G. oth Gane, Edward oth Enthalten in Elsevier Science Abdelbaky, Hanan H. ELSEVIER Identification of the antigenic region of 2018 official journal of the European Association for the Study of the Liver Amsterdam [u.a.] (DE-627)ELV000433829 volume:77 year:2022 number:5 pages:1287-1298 extent:12 https://doi.org/10.1016/j.jhep.2022.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 77 2022 5 1287-1298 12 |
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Yuen, Man-Fung @@aut@@ Locarnini, Stephen @@oth@@ Lim, Tien Huey @@oth@@ Strasser, Simone I. @@oth@@ Sievert, William @@oth@@ Cheng, Wendy @@oth@@ Thompson, Alex J. @@oth@@ Given, Bruce D. @@oth@@ Schluep, Thomas @@oth@@ Hamilton, James @@oth@@ Biermer, Michael @@oth@@ Kalmeijer, Ronald @@oth@@ Beumont, Maria @@oth@@ Lenz, Oliver @@oth@@ De Ridder, Filip @@oth@@ Cloherty, Gavin @@oth@@ Ka-Ho Wong, Danny @@oth@@ Schwabe, Christian @@oth@@ Jackson, Kathy @@oth@@ Lai, Ching Lung @@oth@@ Gish, Robert G. @@oth@@ Gane, Edward @@oth@@ |
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Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB |
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RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small-interfering RNA JNJ-73763989 (JNJ-3989) plus a nucleos(t)ide analogue (NA), with/without the capsid assembly modulator JNJ-56136379 (JNJ-6379) in patients with chronic hepatitis B. |
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RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small-interfering RNA JNJ-73763989 (JNJ-3989) plus a nucleos(t)ide analogue (NA), with/without the capsid assembly modulator JNJ-56136379 (JNJ-6379) in patients with chronic hepatitis B. |
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RNA interference therapy has been shown to reduce hepatitis B surface antigen (HBsAg) levels in preclinical models, which could confer functional cure in patients with chronic hepatitis B. This phase IIa trial (ClinicalTrials.gov Identifier: NCT03365947) assessed the safety and efficacy of the small-interfering RNA JNJ-73763989 (JNJ-3989) plus a nucleos(t)ide analogue (NA), with/without the capsid assembly modulator JNJ-56136379 (JNJ-6379) in patients with chronic hepatitis B. |
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Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB |
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