Novel Therapeutic Strategies to Reduce Reperfusion Injury After Acute Myocardial Infarction
For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion in...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Schäfer, Andreas [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls - Bally, L. ELSEVIER, 2015, Chicago, Ill |
|---|---|
| Übergeordnetes Werk: |
volume:47 ; year:2022 ; number:12 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.cpcardiol.2022.101398 |
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| 520 | |a For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. | ||
| 520 | |a For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. | ||
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10.1016/j.cpcardiol.2022.101398 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001952.pica (DE-627)ELV059395575 (ELSEVIER)S0146-2806(22)00295-X DE-627 ger DE-627 rakwb eng 610 VZ 540 VZ 35.40 bkl Schäfer, Andreas verfasserin aut Novel Therapeutic Strategies to Reduce Reperfusion Injury After Acute Myocardial Infarction 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. König, Tobias oth Bauersachs, Johann oth Akin, Muharrem oth Enthalten in Yearbook Medical Publ Bally, L. ELSEVIER Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls 2015 Chicago, Ill (DE-627)ELV023365331 volume:47 year:2022 number:12 pages:0 https://doi.org/10.1016/j.cpcardiol.2022.101398 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_651 35.40 Anorganische Chemie: Allgemeines VZ AR 47 2022 12 0 |
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10.1016/j.cpcardiol.2022.101398 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001952.pica (DE-627)ELV059395575 (ELSEVIER)S0146-2806(22)00295-X DE-627 ger DE-627 rakwb eng 610 VZ 540 VZ 35.40 bkl Schäfer, Andreas verfasserin aut Novel Therapeutic Strategies to Reduce Reperfusion Injury After Acute Myocardial Infarction 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. König, Tobias oth Bauersachs, Johann oth Akin, Muharrem oth Enthalten in Yearbook Medical Publ Bally, L. ELSEVIER Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls 2015 Chicago, Ill (DE-627)ELV023365331 volume:47 year:2022 number:12 pages:0 https://doi.org/10.1016/j.cpcardiol.2022.101398 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_651 35.40 Anorganische Chemie: Allgemeines VZ AR 47 2022 12 0 |
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10.1016/j.cpcardiol.2022.101398 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001952.pica (DE-627)ELV059395575 (ELSEVIER)S0146-2806(22)00295-X DE-627 ger DE-627 rakwb eng 610 VZ 540 VZ 35.40 bkl Schäfer, Andreas verfasserin aut Novel Therapeutic Strategies to Reduce Reperfusion Injury After Acute Myocardial Infarction 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. König, Tobias oth Bauersachs, Johann oth Akin, Muharrem oth Enthalten in Yearbook Medical Publ Bally, L. ELSEVIER Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls 2015 Chicago, Ill (DE-627)ELV023365331 volume:47 year:2022 number:12 pages:0 https://doi.org/10.1016/j.cpcardiol.2022.101398 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_651 35.40 Anorganische Chemie: Allgemeines VZ AR 47 2022 12 0 |
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10.1016/j.cpcardiol.2022.101398 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001952.pica (DE-627)ELV059395575 (ELSEVIER)S0146-2806(22)00295-X DE-627 ger DE-627 rakwb eng 610 VZ 540 VZ 35.40 bkl Schäfer, Andreas verfasserin aut Novel Therapeutic Strategies to Reduce Reperfusion Injury After Acute Myocardial Infarction 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. König, Tobias oth Bauersachs, Johann oth Akin, Muharrem oth Enthalten in Yearbook Medical Publ Bally, L. ELSEVIER Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls 2015 Chicago, Ill (DE-627)ELV023365331 volume:47 year:2022 number:12 pages:0 https://doi.org/10.1016/j.cpcardiol.2022.101398 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_651 35.40 Anorganische Chemie: Allgemeines VZ AR 47 2022 12 0 |
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10.1016/j.cpcardiol.2022.101398 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001952.pica (DE-627)ELV059395575 (ELSEVIER)S0146-2806(22)00295-X DE-627 ger DE-627 rakwb eng 610 VZ 540 VZ 35.40 bkl Schäfer, Andreas verfasserin aut Novel Therapeutic Strategies to Reduce Reperfusion Injury After Acute Myocardial Infarction 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. König, Tobias oth Bauersachs, Johann oth Akin, Muharrem oth Enthalten in Yearbook Medical Publ Bally, L. ELSEVIER Hepatic and intramyocellular glycogen stores in adults with type 1 diabetes and healthy controls 2015 Chicago, Ill (DE-627)ELV023365331 volume:47 year:2022 number:12 pages:0 https://doi.org/10.1016/j.cpcardiol.2022.101398 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_651 35.40 Anorganische Chemie: Allgemeines VZ AR 47 2022 12 0 |
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Novel Therapeutic Strategies to Reduce Reperfusion Injury After Acute Myocardial Infarction |
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For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. |
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For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. |
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For almost 30 years, urgent revascularization termed primary percutaneous coronary intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It lowers mortality and improved cardiovascular outcome compared to conservative therapy including thrombolysis. Reperfusion injury, which occurs after successful re-opening of the formerly occluded coronary artery, had been exploited as a potential therapeutic target. When revascularization became faster and primary percutaneous coronary intervention was successfully performed within 60-90 minutes of symptom onset, the interest in a potential additive effect of targeting reperfusion injury vanished. More recently, several meta-analyses indicated that limiting reperfusion injury prevents microvascular obstruction and reduces final infarct size, thereby lowering the probability of heart failure events and improving quality of life in AMI survivors. Here, we describe the current strategies to limit reperfusion injury and to improve post-AMI outcomes such as systemic or intracoronary hypothermia, left-ventricular unloading, intracoronary infusion of super-saturated oxygen, intermittent coronary sinus occlusion, and C-reactive protein apheresis. |
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