Binary SiO2–CoO spherical bioactive glass nanoparticles for tissue engineering applications
Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mim...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Viana, Marcelo da Silva Mantini [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: Soil and water bioengineering: Practice and research needs for reconciling natural hazard control and ecological restoration - Rey, F. ELSEVIER, 2018, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:48 ; year:2022 ; number:23 ; day:1 ; month:12 ; pages:34885-34894 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1016/j.ceramint.2022.08.078 |
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ELV059418427 |
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| 245 | 1 | 0 | |a Binary SiO2–CoO spherical bioactive glass nanoparticles for tissue engineering applications |
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| 520 | |a Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. | ||
| 520 | |a Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. | ||
| 650 | 7 | |a Nanoparticles |2 Elsevier | |
| 650 | 7 | |a Bioactive glass |2 Elsevier | |
| 650 | 7 | |a Sol-gel |2 Elsevier | |
| 650 | 7 | |a Cobalt |2 Elsevier | |
| 700 | 1 | |a Valverde, Thalita Marcolan |4 oth | |
| 700 | 1 | |a Barrioni, Breno Rocha |4 oth | |
| 700 | 1 | |a de Goes, Alfredo Miranda |4 oth | |
| 700 | 1 | |a de Sá, Marcos Augusto |4 oth | |
| 700 | 1 | |a Pereira, Marivalda de Magalhães |4 oth | |
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10.1016/j.ceramint.2022.08.078 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001955.pica (DE-627)ELV059418427 (ELSEVIER)S0272-8842(22)02865-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Viana, Marcelo da Silva Mantini verfasserin aut Binary SiO2–CoO spherical bioactive glass nanoparticles for tissue engineering applications 2022transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Nanoparticles Elsevier Bioactive glass Elsevier Sol-gel Elsevier Cobalt Elsevier Valverde, Thalita Marcolan oth Barrioni, Breno Rocha oth de Goes, Alfredo Miranda oth de Sá, Marcos Augusto oth Pereira, Marivalda de Magalhães oth Enthalten in Elsevier Science Rey, F. ELSEVIER Soil and water bioengineering: Practice and research needs for reconciling natural hazard control and ecological restoration 2018 Amsterdam [u.a.] (DE-627)ELV000899798 volume:48 year:2022 number:23 day:1 month:12 pages:34885-34894 extent:10 https://doi.org/10.1016/j.ceramint.2022.08.078 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 48 2022 23 1 1201 34885-34894 10 |
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10.1016/j.ceramint.2022.08.078 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001955.pica (DE-627)ELV059418427 (ELSEVIER)S0272-8842(22)02865-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Viana, Marcelo da Silva Mantini verfasserin aut Binary SiO2–CoO spherical bioactive glass nanoparticles for tissue engineering applications 2022transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Nanoparticles Elsevier Bioactive glass Elsevier Sol-gel Elsevier Cobalt Elsevier Valverde, Thalita Marcolan oth Barrioni, Breno Rocha oth de Goes, Alfredo Miranda oth de Sá, Marcos Augusto oth Pereira, Marivalda de Magalhães oth Enthalten in Elsevier Science Rey, F. ELSEVIER Soil and water bioengineering: Practice and research needs for reconciling natural hazard control and ecological restoration 2018 Amsterdam [u.a.] (DE-627)ELV000899798 volume:48 year:2022 number:23 day:1 month:12 pages:34885-34894 extent:10 https://doi.org/10.1016/j.ceramint.2022.08.078 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 48 2022 23 1 1201 34885-34894 10 |
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10.1016/j.ceramint.2022.08.078 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001955.pica (DE-627)ELV059418427 (ELSEVIER)S0272-8842(22)02865-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Viana, Marcelo da Silva Mantini verfasserin aut Binary SiO2–CoO spherical bioactive glass nanoparticles for tissue engineering applications 2022transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Nanoparticles Elsevier Bioactive glass Elsevier Sol-gel Elsevier Cobalt Elsevier Valverde, Thalita Marcolan oth Barrioni, Breno Rocha oth de Goes, Alfredo Miranda oth de Sá, Marcos Augusto oth Pereira, Marivalda de Magalhães oth Enthalten in Elsevier Science Rey, F. ELSEVIER Soil and water bioengineering: Practice and research needs for reconciling natural hazard control and ecological restoration 2018 Amsterdam [u.a.] (DE-627)ELV000899798 volume:48 year:2022 number:23 day:1 month:12 pages:34885-34894 extent:10 https://doi.org/10.1016/j.ceramint.2022.08.078 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 48 2022 23 1 1201 34885-34894 10 |
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10.1016/j.ceramint.2022.08.078 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001955.pica (DE-627)ELV059418427 (ELSEVIER)S0272-8842(22)02865-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Viana, Marcelo da Silva Mantini verfasserin aut Binary SiO2–CoO spherical bioactive glass nanoparticles for tissue engineering applications 2022transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Nanoparticles Elsevier Bioactive glass Elsevier Sol-gel Elsevier Cobalt Elsevier Valverde, Thalita Marcolan oth Barrioni, Breno Rocha oth de Goes, Alfredo Miranda oth de Sá, Marcos Augusto oth Pereira, Marivalda de Magalhães oth Enthalten in Elsevier Science Rey, F. ELSEVIER Soil and water bioengineering: Practice and research needs for reconciling natural hazard control and ecological restoration 2018 Amsterdam [u.a.] (DE-627)ELV000899798 volume:48 year:2022 number:23 day:1 month:12 pages:34885-34894 extent:10 https://doi.org/10.1016/j.ceramint.2022.08.078 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 48 2022 23 1 1201 34885-34894 10 |
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10.1016/j.ceramint.2022.08.078 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001955.pica (DE-627)ELV059418427 (ELSEVIER)S0272-8842(22)02865-6 DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Viana, Marcelo da Silva Mantini verfasserin aut Binary SiO2–CoO spherical bioactive glass nanoparticles for tissue engineering applications 2022transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. Nanoparticles Elsevier Bioactive glass Elsevier Sol-gel Elsevier Cobalt Elsevier Valverde, Thalita Marcolan oth Barrioni, Breno Rocha oth de Goes, Alfredo Miranda oth de Sá, Marcos Augusto oth Pereira, Marivalda de Magalhães oth Enthalten in Elsevier Science Rey, F. ELSEVIER Soil and water bioengineering: Practice and research needs for reconciling natural hazard control and ecological restoration 2018 Amsterdam [u.a.] (DE-627)ELV000899798 volume:48 year:2022 number:23 day:1 month:12 pages:34885-34894 extent:10 https://doi.org/10.1016/j.ceramint.2022.08.078 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 48 2022 23 1 1201 34885-34894 10 |
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Enthalten in Soil and water bioengineering: Practice and research needs for reconciling natural hazard control and ecological restoration Amsterdam [u.a.] volume:48 year:2022 number:23 day:1 month:12 pages:34885-34894 extent:10 |
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Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. |
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Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. |
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Pro-angiogenic capabilities are desired for biomaterials intended for tissue repair and tissue engineering applications, and bioactive glass (BG) nanoparticles are good vehicles for the delivery of ions with therapeutic properties, such as cobalt, which displays a well-known angiogenic effect by mimicking hypoxic conditions by HIF-1α stabilization. In this work, novel monodispersed spherical dense BG nanoparticles were obtained by the sol-gel process with the incorporation of cobalt into the glass structure as a potential platform for the delivery of pro-angiogenic ions, and particles with sizes ranging from 93 to 112 nm were obtained. Structural evaluation showed that cobalt (II,III) oxide were formed and deposited on the particles’ surface, while X-ray photoelectron spectroscopy (XPS) analysis pointed that Co2+ ions were also incorporated in the glass as a network modifier. Glasses also displayed a rapid and sustained Co release when immersed in phosphate buffered saline, and MTT assay showed good cell viability for BG concentrations of 100 μg mL−1 and 500 μg mL−1, confirming its potential to be applied for tissue engineering. Therefore, this study showed that Co containing nanoparticles, with great potential for tissue repair with the release of pro-angiogenic ions, can be obtained by a simple sol-gel based method. |
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