Non-coding RNA-based regulation of inflammation
Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) compris...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ashrafizadeh, Milad [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists - Fabritius, Charles-Henry ELSEVIER, 2016, London |
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| Übergeordnetes Werk: |
volume:59 ; year:2022 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.smim.2022.101606 |
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ELV059857234 |
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| 520 | |a Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. | ||
| 520 | |a Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. | ||
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10.1016/j.smim.2022.101606 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001995.pica (DE-627)ELV059857234 (ELSEVIER)S1044-5323(22)00023-9 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Ashrafizadeh, Milad verfasserin aut Non-coding RNA-based regulation of inflammation 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. CHF Elsevier circRNAs Elsevier BBB Elsevier JNK Elsevier PTEN Elsevier HBE Elsevier HMGB1 Elsevier OPN Elsevier ncRNAs Elsevier I/R Elsevier SLE Elsevier UC Elsevier LFH Elsevier NF-κB Elsevier UTR Elsevier MSCs Elsevier OLP Elsevier PI3K Elsevier IDO Elsevier mTOR Elsevier PAMPs Elsevier HFLSs Elsevier EA Elsevier IL Elsevier MS Elsevier CAD Elsevier IP Elsevier AIS Elsevier SIRT1 Elsevier LSS Elsevier ER Elsevier RA Elsevier CVD Elsevier MMP Elsevier AR Elsevier AS Elsevier ROS Elsevier BPD Elsevier TLR9 Elsevier FMDV Elsevier PD-1 Elsevier NK Elsevier HDAC4 Elsevier NAFLD Elsevier mRNA Elsevier DAMPs Elsevier INS Elsevier OA Elsevier TAMs Elsevier CSE Elsevier CAFs Elsevier HNECs Elsevier VECs Elsevier TGF-β Elsevier CGA Elsevier AKI Elsevier SCI’ Elsevier STAT3 Elsevier IFN-I Elsevier CCI Elsevier SOD Elsevier Akt Elsevier EV71 Elsevier CO Elsevier TME Elsevier LPs Elsevier Ang II Elsevier MDSCs Elsevier TNF-α Elsevier HTNV Elsevier SCI Elsevier Col X Elsevier EZH2 Elsevier COPD Elsevier DC Elsevier Zarrabi, Ali oth Mostafavi, Ebrahim oth Aref, Amir Reza oth Sethi, Gautam oth Wang, Lingzhi oth Tergaonkar, Vinay oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:59 year:2022 pages:0 https://doi.org/10.1016/j.smim.2022.101606 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 59 2022 0 |
| spelling |
10.1016/j.smim.2022.101606 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001995.pica (DE-627)ELV059857234 (ELSEVIER)S1044-5323(22)00023-9 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Ashrafizadeh, Milad verfasserin aut Non-coding RNA-based regulation of inflammation 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. CHF Elsevier circRNAs Elsevier BBB Elsevier JNK Elsevier PTEN Elsevier HBE Elsevier HMGB1 Elsevier OPN Elsevier ncRNAs Elsevier I/R Elsevier SLE Elsevier UC Elsevier LFH Elsevier NF-κB Elsevier UTR Elsevier MSCs Elsevier OLP Elsevier PI3K Elsevier IDO Elsevier mTOR Elsevier PAMPs Elsevier HFLSs Elsevier EA Elsevier IL Elsevier MS Elsevier CAD Elsevier IP Elsevier AIS Elsevier SIRT1 Elsevier LSS Elsevier ER Elsevier RA Elsevier CVD Elsevier MMP Elsevier AR Elsevier AS Elsevier ROS Elsevier BPD Elsevier TLR9 Elsevier FMDV Elsevier PD-1 Elsevier NK Elsevier HDAC4 Elsevier NAFLD Elsevier mRNA Elsevier DAMPs Elsevier INS Elsevier OA Elsevier TAMs Elsevier CSE Elsevier CAFs Elsevier HNECs Elsevier VECs Elsevier TGF-β Elsevier CGA Elsevier AKI Elsevier SCI’ Elsevier STAT3 Elsevier IFN-I Elsevier CCI Elsevier SOD Elsevier Akt Elsevier EV71 Elsevier CO Elsevier TME Elsevier LPs Elsevier Ang II Elsevier MDSCs Elsevier TNF-α Elsevier HTNV Elsevier SCI Elsevier Col X Elsevier EZH2 Elsevier COPD Elsevier DC Elsevier Zarrabi, Ali oth Mostafavi, Ebrahim oth Aref, Amir Reza oth Sethi, Gautam oth Wang, Lingzhi oth Tergaonkar, Vinay oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:59 year:2022 pages:0 https://doi.org/10.1016/j.smim.2022.101606 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 59 2022 0 |
| allfields_unstemmed |
10.1016/j.smim.2022.101606 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001995.pica (DE-627)ELV059857234 (ELSEVIER)S1044-5323(22)00023-9 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Ashrafizadeh, Milad verfasserin aut Non-coding RNA-based regulation of inflammation 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. CHF Elsevier circRNAs Elsevier BBB Elsevier JNK Elsevier PTEN Elsevier HBE Elsevier HMGB1 Elsevier OPN Elsevier ncRNAs Elsevier I/R Elsevier SLE Elsevier UC Elsevier LFH Elsevier NF-κB Elsevier UTR Elsevier MSCs Elsevier OLP Elsevier PI3K Elsevier IDO Elsevier mTOR Elsevier PAMPs Elsevier HFLSs Elsevier EA Elsevier IL Elsevier MS Elsevier CAD Elsevier IP Elsevier AIS Elsevier SIRT1 Elsevier LSS Elsevier ER Elsevier RA Elsevier CVD Elsevier MMP Elsevier AR Elsevier AS Elsevier ROS Elsevier BPD Elsevier TLR9 Elsevier FMDV Elsevier PD-1 Elsevier NK Elsevier HDAC4 Elsevier NAFLD Elsevier mRNA Elsevier DAMPs Elsevier INS Elsevier OA Elsevier TAMs Elsevier CSE Elsevier CAFs Elsevier HNECs Elsevier VECs Elsevier TGF-β Elsevier CGA Elsevier AKI Elsevier SCI’ Elsevier STAT3 Elsevier IFN-I Elsevier CCI Elsevier SOD Elsevier Akt Elsevier EV71 Elsevier CO Elsevier TME Elsevier LPs Elsevier Ang II Elsevier MDSCs Elsevier TNF-α Elsevier HTNV Elsevier SCI Elsevier Col X Elsevier EZH2 Elsevier COPD Elsevier DC Elsevier Zarrabi, Ali oth Mostafavi, Ebrahim oth Aref, Amir Reza oth Sethi, Gautam oth Wang, Lingzhi oth Tergaonkar, Vinay oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:59 year:2022 pages:0 https://doi.org/10.1016/j.smim.2022.101606 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 59 2022 0 |
| allfieldsGer |
10.1016/j.smim.2022.101606 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001995.pica (DE-627)ELV059857234 (ELSEVIER)S1044-5323(22)00023-9 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Ashrafizadeh, Milad verfasserin aut Non-coding RNA-based regulation of inflammation 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. CHF Elsevier circRNAs Elsevier BBB Elsevier JNK Elsevier PTEN Elsevier HBE Elsevier HMGB1 Elsevier OPN Elsevier ncRNAs Elsevier I/R Elsevier SLE Elsevier UC Elsevier LFH Elsevier NF-κB Elsevier UTR Elsevier MSCs Elsevier OLP Elsevier PI3K Elsevier IDO Elsevier mTOR Elsevier PAMPs Elsevier HFLSs Elsevier EA Elsevier IL Elsevier MS Elsevier CAD Elsevier IP Elsevier AIS Elsevier SIRT1 Elsevier LSS Elsevier ER Elsevier RA Elsevier CVD Elsevier MMP Elsevier AR Elsevier AS Elsevier ROS Elsevier BPD Elsevier TLR9 Elsevier FMDV Elsevier PD-1 Elsevier NK Elsevier HDAC4 Elsevier NAFLD Elsevier mRNA Elsevier DAMPs Elsevier INS Elsevier OA Elsevier TAMs Elsevier CSE Elsevier CAFs Elsevier HNECs Elsevier VECs Elsevier TGF-β Elsevier CGA Elsevier AKI Elsevier SCI’ Elsevier STAT3 Elsevier IFN-I Elsevier CCI Elsevier SOD Elsevier Akt Elsevier EV71 Elsevier CO Elsevier TME Elsevier LPs Elsevier Ang II Elsevier MDSCs Elsevier TNF-α Elsevier HTNV Elsevier SCI Elsevier Col X Elsevier EZH2 Elsevier COPD Elsevier DC Elsevier Zarrabi, Ali oth Mostafavi, Ebrahim oth Aref, Amir Reza oth Sethi, Gautam oth Wang, Lingzhi oth Tergaonkar, Vinay oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:59 year:2022 pages:0 https://doi.org/10.1016/j.smim.2022.101606 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 59 2022 0 |
| allfieldsSound |
10.1016/j.smim.2022.101606 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001995.pica (DE-627)ELV059857234 (ELSEVIER)S1044-5323(22)00023-9 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Ashrafizadeh, Milad verfasserin aut Non-coding RNA-based regulation of inflammation 2022transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. CHF Elsevier circRNAs Elsevier BBB Elsevier JNK Elsevier PTEN Elsevier HBE Elsevier HMGB1 Elsevier OPN Elsevier ncRNAs Elsevier I/R Elsevier SLE Elsevier UC Elsevier LFH Elsevier NF-κB Elsevier UTR Elsevier MSCs Elsevier OLP Elsevier PI3K Elsevier IDO Elsevier mTOR Elsevier PAMPs Elsevier HFLSs Elsevier EA Elsevier IL Elsevier MS Elsevier CAD Elsevier IP Elsevier AIS Elsevier SIRT1 Elsevier LSS Elsevier ER Elsevier RA Elsevier CVD Elsevier MMP Elsevier AR Elsevier AS Elsevier ROS Elsevier BPD Elsevier TLR9 Elsevier FMDV Elsevier PD-1 Elsevier NK Elsevier HDAC4 Elsevier NAFLD Elsevier mRNA Elsevier DAMPs Elsevier INS Elsevier OA Elsevier TAMs Elsevier CSE Elsevier CAFs Elsevier HNECs Elsevier VECs Elsevier TGF-β Elsevier CGA Elsevier AKI Elsevier SCI’ Elsevier STAT3 Elsevier IFN-I Elsevier CCI Elsevier SOD Elsevier Akt Elsevier EV71 Elsevier CO Elsevier TME Elsevier LPs Elsevier Ang II Elsevier MDSCs Elsevier TNF-α Elsevier HTNV Elsevier SCI Elsevier Col X Elsevier EZH2 Elsevier COPD Elsevier DC Elsevier Zarrabi, Ali oth Mostafavi, Ebrahim oth Aref, Amir Reza oth Sethi, Gautam oth Wang, Lingzhi oth Tergaonkar, Vinay oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:59 year:2022 pages:0 https://doi.org/10.1016/j.smim.2022.101606 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 59 2022 0 |
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Enthalten in 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists London volume:59 year:2022 pages:0 |
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Enthalten in 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists London volume:59 year:2022 pages:0 |
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1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists |
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Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. |
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Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. |
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Inflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of transcribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflammation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3'-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown capacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAs can serve as diagnostic, prognostic and therapeutic targets in inflammation-related diseases in pre-clinical and clinical backgrounds. |
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