Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering

Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineeri...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ma, Wuchao [verfasserIn] Yang, Meilian [verfasserIn] Wu, Di [verfasserIn] Li, Yao [verfasserIn] Wang, Li-Shu [verfasserIn] El-Seedi, Hesham R. [verfasserIn] Wu, Chao [verfasserIn] Du, Ming [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Gelatin Dopamine Hydrogel Cod peptides Bone tissue engineering

Übergeordnetes Werk:	Enthalten in: Colloids and surfaces / A - Amsterdam [u.a.] : Elsevier Science, 1993, 673
Übergeordnetes Werk:	volume:673

DOI / URN:	10.1016/j.colsurfa.2023.131695

Katalog-ID:	ELV060078804

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245	1	0	\|a Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering
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520			\|a Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering.
650		4	\|a Gelatin
650		4	\|a Dopamine
650		4	\|a Hydrogel
650		4	\|a Cod peptides
650		4	\|a Bone tissue engineering
700	1		\|a Yang, Meilian \|e verfasserin \|4 aut
700	1		\|a Wu, Di \|e verfasserin \|4 aut
700	1		\|a Li, Yao \|e verfasserin \|4 aut
700	1		\|a Wang, Li-Shu \|e verfasserin \|0 (orcid)0000-0002-6500-6943 \|4 aut
700	1		\|a El-Seedi, Hesham R. \|e verfasserin \|4 aut
700	1		\|a Wu, Chao \|e verfasserin \|4 aut
700	1		\|a Du, Ming \|e verfasserin \|0 (orcid)0000-0001-5872-8529 \|4 aut
773	0	8	\|i Enthalten in \|t Colloids and surfaces / A \|d Amsterdam [u.a.] : Elsevier Science, 1993 \|g 673 \|h Online-Ressource \|w (DE-627)306659956 \|w (DE-600)1500517-3 \|w (DE-576)098614843 \|x 1873-4359 \|7 nnns
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912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
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912			\|a GBV_ILN_224
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912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
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912			\|a GBV_ILN_2009
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912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2411
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
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912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
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912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
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912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 35.18 \|j Kolloidchemie \|j Grenzflächenchemie \|q VZ
936	b	k	\|a 33.68 \|j Oberflächen \|j Dünne Schichten \|j Grenzflächen \|x Physik \|q VZ
936	b	k	\|a 52.78 \|j Oberflächentechnik \|j Wärmebehandlung \|q VZ
936	b	k	\|a 58.20 \|j Chemische Technologien: Allgemeines \|q VZ
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Indexfelder

author_variant	w m wm m y my d w dw y l yl l s w lsw h r e s hre hres c w cw m d md
matchkey_str	article:18734359:2023----::ihkneaibsddeieyrgllaigoppiewtotoeiatv
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bklnumber	35.18 33.68 52.78 58.20
publishDate	2023
allfields	10.1016/j.colsurfa.2023.131695 doi (DE-627)ELV060078804 (ELSEVIER)S0927-7757(23)00779-3 DE-627 ger DE-627 rda eng 540 VZ 35.18 bkl 33.68 bkl 52.78 bkl 58.20 bkl Ma, Wuchao verfasserin aut Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering. Gelatin Dopamine Hydrogel Cod peptides Bone tissue engineering Yang, Meilian verfasserin aut Wu, Di verfasserin aut Li, Yao verfasserin aut Wang, Li-Shu verfasserin (orcid)0000-0002-6500-6943 aut El-Seedi, Hesham R. verfasserin aut Wu, Chao verfasserin aut Du, Ming verfasserin (orcid)0000-0001-5872-8529 aut Enthalten in Colloids and surfaces / A Amsterdam [u.a.] : Elsevier Science, 1993 673 Online-Ressource (DE-627)306659956 (DE-600)1500517-3 (DE-576)098614843 1873-4359 nnns volume:673 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 52.78 Oberflächentechnik Wärmebehandlung VZ 58.20 Chemische Technologien: Allgemeines VZ AR 673
spelling	10.1016/j.colsurfa.2023.131695 doi (DE-627)ELV060078804 (ELSEVIER)S0927-7757(23)00779-3 DE-627 ger DE-627 rda eng 540 VZ 35.18 bkl 33.68 bkl 52.78 bkl 58.20 bkl Ma, Wuchao verfasserin aut Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering. Gelatin Dopamine Hydrogel Cod peptides Bone tissue engineering Yang, Meilian verfasserin aut Wu, Di verfasserin aut Li, Yao verfasserin aut Wang, Li-Shu verfasserin (orcid)0000-0002-6500-6943 aut El-Seedi, Hesham R. verfasserin aut Wu, Chao verfasserin aut Du, Ming verfasserin (orcid)0000-0001-5872-8529 aut Enthalten in Colloids and surfaces / A Amsterdam [u.a.] : Elsevier Science, 1993 673 Online-Ressource (DE-627)306659956 (DE-600)1500517-3 (DE-576)098614843 1873-4359 nnns volume:673 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 52.78 Oberflächentechnik Wärmebehandlung VZ 58.20 Chemische Technologien: Allgemeines VZ AR 673
allfields_unstemmed	10.1016/j.colsurfa.2023.131695 doi (DE-627)ELV060078804 (ELSEVIER)S0927-7757(23)00779-3 DE-627 ger DE-627 rda eng 540 VZ 35.18 bkl 33.68 bkl 52.78 bkl 58.20 bkl Ma, Wuchao verfasserin aut Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering. Gelatin Dopamine Hydrogel Cod peptides Bone tissue engineering Yang, Meilian verfasserin aut Wu, Di verfasserin aut Li, Yao verfasserin aut Wang, Li-Shu verfasserin (orcid)0000-0002-6500-6943 aut El-Seedi, Hesham R. verfasserin aut Wu, Chao verfasserin aut Du, Ming verfasserin (orcid)0000-0001-5872-8529 aut Enthalten in Colloids and surfaces / A Amsterdam [u.a.] : Elsevier Science, 1993 673 Online-Ressource (DE-627)306659956 (DE-600)1500517-3 (DE-576)098614843 1873-4359 nnns volume:673 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 52.78 Oberflächentechnik Wärmebehandlung VZ 58.20 Chemische Technologien: Allgemeines VZ AR 673
allfieldsGer	10.1016/j.colsurfa.2023.131695 doi (DE-627)ELV060078804 (ELSEVIER)S0927-7757(23)00779-3 DE-627 ger DE-627 rda eng 540 VZ 35.18 bkl 33.68 bkl 52.78 bkl 58.20 bkl Ma, Wuchao verfasserin aut Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering. Gelatin Dopamine Hydrogel Cod peptides Bone tissue engineering Yang, Meilian verfasserin aut Wu, Di verfasserin aut Li, Yao verfasserin aut Wang, Li-Shu verfasserin (orcid)0000-0002-6500-6943 aut El-Seedi, Hesham R. verfasserin aut Wu, Chao verfasserin aut Du, Ming verfasserin (orcid)0000-0001-5872-8529 aut Enthalten in Colloids and surfaces / A Amsterdam [u.a.] : Elsevier Science, 1993 673 Online-Ressource (DE-627)306659956 (DE-600)1500517-3 (DE-576)098614843 1873-4359 nnns volume:673 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 52.78 Oberflächentechnik Wärmebehandlung VZ 58.20 Chemische Technologien: Allgemeines VZ AR 673
allfieldsSound	10.1016/j.colsurfa.2023.131695 doi (DE-627)ELV060078804 (ELSEVIER)S0927-7757(23)00779-3 DE-627 ger DE-627 rda eng 540 VZ 35.18 bkl 33.68 bkl 52.78 bkl 58.20 bkl Ma, Wuchao verfasserin aut Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering. Gelatin Dopamine Hydrogel Cod peptides Bone tissue engineering Yang, Meilian verfasserin aut Wu, Di verfasserin aut Li, Yao verfasserin aut Wang, Li-Shu verfasserin (orcid)0000-0002-6500-6943 aut El-Seedi, Hesham R. verfasserin aut Wu, Chao verfasserin aut Du, Ming verfasserin (orcid)0000-0001-5872-8529 aut Enthalten in Colloids and surfaces / A Amsterdam [u.a.] : Elsevier Science, 1993 673 Online-Ressource (DE-627)306659956 (DE-600)1500517-3 (DE-576)098614843 1873-4359 nnns volume:673 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.18 Kolloidchemie Grenzflächenchemie VZ 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 52.78 Oberflächentechnik Wärmebehandlung VZ 58.20 Chemische Technologien: Allgemeines VZ AR 673
language	English
source	Enthalten in Colloids and surfaces / A 673 volume:673
sourceStr	Enthalten in Colloids and surfaces / A 673 volume:673
format_phy_str_mv	Article
bklname	Kolloidchemie Grenzflächenchemie Oberflächen Dünne Schichten Grenzflächen Oberflächentechnik Wärmebehandlung Chemische Technologien: Allgemeines
institution	findex.gbv.de
topic_facet	Gelatin Dopamine Hydrogel Cod peptides Bone tissue engineering
dewey-raw	540
isfreeaccess_bool	false
container_title	Colloids and surfaces / A
authorswithroles_txt_mv	Ma, Wuchao @@aut@@ Yang, Meilian @@aut@@ Wu, Di @@aut@@ Li, Yao @@aut@@ Wang, Li-Shu @@aut@@ El-Seedi, Hesham R. @@aut@@ Wu, Chao @@aut@@ Du, Ming @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	306659956
dewey-sort	3540
id	ELV060078804
language_de	englisch
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spellingShingle	Ma, Wuchao ddc 540 bkl 35.18 bkl 33.68 bkl 52.78 bkl 58.20 misc Gelatin misc Dopamine misc Hydrogel misc Cod peptides misc Bone tissue engineering Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering
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topic_title	540 VZ 35.18 bkl 33.68 bkl 52.78 bkl 58.20 bkl Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering Gelatin Dopamine Hydrogel Cod peptides Bone tissue engineering
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title	Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering
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title_full	Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering
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title_sort	fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering
title_auth	Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering
abstract	Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering.
abstractGer	Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering.
abstract_unstemmed	Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 ± 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 ± 38.95 kPa and 4.93 ± 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering.
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title_short	Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering
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author2	Yang, Meilian Wu, Di Li, Yao Wang, Li-Shu El-Seedi, Hesham R. Wu, Chao Du, Ming
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up_date	2024-07-06T23:32:21.190Z
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Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 ± 0.02 U.mg/protein to 0.19 ± 0.02 U.mg/protein as compared to Gel-DA hydrogel. 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Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering

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