Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis

Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational stu...
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Autor*in:	Chakrabarti, Rituparna [verfasserIn] Duddu, Sushmitha [verfasserIn] Tiwari, Ashutosh [verfasserIn] Naidu, K. Tejaswi [verfasserIn] Sharma, Pooja [verfasserIn] Chakravorty, Nishant [verfasserIn] Shukla, Praphulla Chandra [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Atherosclerosis NKT cells iNKT vNKT Meta-analysis

Übergeordnetes Werk:	Enthalten in: Life sciences - New York, NY [u.a.] : Elsevier Science, 1963, 321
Übergeordnetes Werk:	volume:321

DOI / URN:	10.1016/j.lfs.2023.121620

Katalog-ID:	ELV060142316

Internformat


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100	1		\|a Chakrabarti, Rituparna \|e verfasserin \|4 aut
245	1	0	\|a Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis
264		1	\|c 2023
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans.
650		4	\|a Atherosclerosis
650		4	\|a NKT cells
650		4	\|a iNKT
650		4	\|a vNKT
650		4	\|a Meta-analysis
700	1		\|a Duddu, Sushmitha \|e verfasserin \|4 aut
700	1		\|a Tiwari, Ashutosh \|e verfasserin \|4 aut
700	1		\|a Naidu, K. Tejaswi \|e verfasserin \|4 aut
700	1		\|a Sharma, Pooja \|e verfasserin \|4 aut
700	1		\|a Chakravorty, Nishant \|e verfasserin \|4 aut
700	1		\|a Shukla, Praphulla Chandra \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Life sciences \|d New York, NY [u.a.] : Elsevier Science, 1963 \|g 321 \|h Online-Ressource \|w (DE-627)320515605 \|w (DE-600)2013911-1 \|w (DE-576)09095503X \|x 1879-0631 \|7 nnns
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912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
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912			\|a GBV_ILN_4313
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912			\|a GBV_ILN_4325
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936	b	k	\|a 42.00 \|j Biologie: Allgemeines \|q VZ
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matchkey_str	article:18790631:2023----::auakleteladhivratustrmtahrs
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publishDate	2023
allfields	10.1016/j.lfs.2023.121620 doi (DE-627)ELV060142316 (ELSEVIER)S0024-3205(23)00254-0 DE-627 ger DE-627 rda eng 570 VZ BIODIV DE-30 fid 42.00 bkl 44.40 bkl Chakrabarti, Rituparna verfasserin aut Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans. Atherosclerosis NKT cells iNKT vNKT Meta-analysis Duddu, Sushmitha verfasserin aut Tiwari, Ashutosh verfasserin aut Naidu, K. Tejaswi verfasserin aut Sharma, Pooja verfasserin aut Chakravorty, Nishant verfasserin aut Shukla, Praphulla Chandra verfasserin aut Enthalten in Life sciences New York, NY [u.a.] : Elsevier Science, 1963 321 Online-Ressource (DE-627)320515605 (DE-600)2013911-1 (DE-576)09095503X 1879-0631 nnns volume:321 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 Biologie: Allgemeines VZ 44.40 Pharmazie Pharmazeutika VZ AR 321
spelling	10.1016/j.lfs.2023.121620 doi (DE-627)ELV060142316 (ELSEVIER)S0024-3205(23)00254-0 DE-627 ger DE-627 rda eng 570 VZ BIODIV DE-30 fid 42.00 bkl 44.40 bkl Chakrabarti, Rituparna verfasserin aut Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans. Atherosclerosis NKT cells iNKT vNKT Meta-analysis Duddu, Sushmitha verfasserin aut Tiwari, Ashutosh verfasserin aut Naidu, K. Tejaswi verfasserin aut Sharma, Pooja verfasserin aut Chakravorty, Nishant verfasserin aut Shukla, Praphulla Chandra verfasserin aut Enthalten in Life sciences New York, NY [u.a.] : Elsevier Science, 1963 321 Online-Ressource (DE-627)320515605 (DE-600)2013911-1 (DE-576)09095503X 1879-0631 nnns volume:321 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 Biologie: Allgemeines VZ 44.40 Pharmazie Pharmazeutika VZ AR 321
allfields_unstemmed	10.1016/j.lfs.2023.121620 doi (DE-627)ELV060142316 (ELSEVIER)S0024-3205(23)00254-0 DE-627 ger DE-627 rda eng 570 VZ BIODIV DE-30 fid 42.00 bkl 44.40 bkl Chakrabarti, Rituparna verfasserin aut Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans. Atherosclerosis NKT cells iNKT vNKT Meta-analysis Duddu, Sushmitha verfasserin aut Tiwari, Ashutosh verfasserin aut Naidu, K. Tejaswi verfasserin aut Sharma, Pooja verfasserin aut Chakravorty, Nishant verfasserin aut Shukla, Praphulla Chandra verfasserin aut Enthalten in Life sciences New York, NY [u.a.] : Elsevier Science, 1963 321 Online-Ressource (DE-627)320515605 (DE-600)2013911-1 (DE-576)09095503X 1879-0631 nnns volume:321 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 Biologie: Allgemeines VZ 44.40 Pharmazie Pharmazeutika VZ AR 321
allfieldsGer	10.1016/j.lfs.2023.121620 doi (DE-627)ELV060142316 (ELSEVIER)S0024-3205(23)00254-0 DE-627 ger DE-627 rda eng 570 VZ BIODIV DE-30 fid 42.00 bkl 44.40 bkl Chakrabarti, Rituparna verfasserin aut Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans. Atherosclerosis NKT cells iNKT vNKT Meta-analysis Duddu, Sushmitha verfasserin aut Tiwari, Ashutosh verfasserin aut Naidu, K. Tejaswi verfasserin aut Sharma, Pooja verfasserin aut Chakravorty, Nishant verfasserin aut Shukla, Praphulla Chandra verfasserin aut Enthalten in Life sciences New York, NY [u.a.] : Elsevier Science, 1963 321 Online-Ressource (DE-627)320515605 (DE-600)2013911-1 (DE-576)09095503X 1879-0631 nnns volume:321 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 Biologie: Allgemeines VZ 44.40 Pharmazie Pharmazeutika VZ AR 321
allfieldsSound	10.1016/j.lfs.2023.121620 doi (DE-627)ELV060142316 (ELSEVIER)S0024-3205(23)00254-0 DE-627 ger DE-627 rda eng 570 VZ BIODIV DE-30 fid 42.00 bkl 44.40 bkl Chakrabarti, Rituparna verfasserin aut Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans. Atherosclerosis NKT cells iNKT vNKT Meta-analysis Duddu, Sushmitha verfasserin aut Tiwari, Ashutosh verfasserin aut Naidu, K. Tejaswi verfasserin aut Sharma, Pooja verfasserin aut Chakravorty, Nishant verfasserin aut Shukla, Praphulla Chandra verfasserin aut Enthalten in Life sciences New York, NY [u.a.] : Elsevier Science, 1963 321 Online-Ressource (DE-627)320515605 (DE-600)2013911-1 (DE-576)09095503X 1879-0631 nnns volume:321 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.00 Biologie: Allgemeines VZ 44.40 Pharmazie Pharmazeutika VZ AR 321
language	English
source	Enthalten in Life sciences 321 volume:321
sourceStr	Enthalten in Life sciences 321 volume:321
format_phy_str_mv	Article
bklname	Biologie: Allgemeines Pharmazie Pharmazeutika
institution	findex.gbv.de
topic_facet	Atherosclerosis NKT cells iNKT vNKT Meta-analysis
dewey-raw	570
isfreeaccess_bool	false
container_title	Life sciences
authorswithroles_txt_mv	Chakrabarti, Rituparna @@aut@@ Duddu, Sushmitha @@aut@@ Tiwari, Ashutosh @@aut@@ Naidu, K. Tejaswi @@aut@@ Sharma, Pooja @@aut@@ Chakravorty, Nishant @@aut@@ Shukla, Praphulla Chandra @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	320515605
dewey-sort	3570
id	ELV060142316
language_de	englisch
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author	Chakrabarti, Rituparna
spellingShingle	Chakrabarti, Rituparna ddc 570 fid BIODIV bkl 42.00 bkl 44.40 misc Atherosclerosis misc NKT cells misc iNKT misc vNKT misc Meta-analysis Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis
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topic_title	570 VZ BIODIV DE-30 fid 42.00 bkl 44.40 bkl Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis Atherosclerosis NKT cells iNKT vNKT Meta-analysis
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title	Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis
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title_full	Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis
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author_browse	Chakrabarti, Rituparna Duddu, Sushmitha Tiwari, Ashutosh Naidu, K. Tejaswi Sharma, Pooja Chakravorty, Nishant Shukla, Praphulla Chandra
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title_sort	natural killer t cells and the invariant subset promote atherosclerosis: a meta-analysis
title_auth	Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis
abstract	Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans.
abstractGer	Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans.
abstract_unstemmed	Aims: Natural Killer T (NKT) cells are reported to be both pro- and anti-atherosclerotic. With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. In general, NKT cell population increases with the progression of the plaque in mice and the numbers of iNKT cells reduce once the disease is established both in mice and humans.
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title_short	Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis
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author2	Duddu, Sushmitha Tiwari, Ashutosh Naidu, K. Tejaswi Sharma, Pooja Chakravorty, Nishant Shukla, Praphulla Chandra
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doi_str	10.1016/j.lfs.2023.121620
up_date	2024-07-06T23:35:39.182Z
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With this meta-analysis, we evaluated the NKT population and their subsets in regulating the atherosclerotic disease in mice.Main methods: Eighteen pre-clinical (mice, n = 1276) and 6 clinical observational studies (humans, n = 116) met the eligibility criteria for inclusion. Random effects model was used and standard mean difference (SMD) was calculated for the cell counts and aortic lesion area.Key findings: Lesion area decreased in the absence of whole NKT cell population (−1.33[95%CI, −2.14, −0.52]), and in the absence of only iNKT subset (−0.66[95%CI, −1.69, 0.37]). However, lesion area increased after over-expression/activation of iNKTs (1.40[95%CI, 0.28, 2.52]). Atherogenic diet (AD) or high fat diet (HFD) increased the number of NKT cells (2.51[95%CI, 1.42, 3.61]), whereas the iNKT cell numbers and iNKT cell-specific gene expression decreased in mice (−2.04[95%CI, −3.34, −0.75]) and atherosclerotic patients (−1.81[95 % CI, −2.89, −0.74]).Significance: Here we show that, NKT and iNKT cells promote atherosclerosis. 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Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis

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