Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators

Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Inde...
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Autor*in:	Bufano, Marianna [verfasserIn] Puxeddu, Michela [verfasserIn] Nalli, Marianna [verfasserIn] La Regina, Giuseppe [verfasserIn] Toto, Angelo [verfasserIn] Liberati, Francesca Romana [verfasserIn] Paone, Alessio [verfasserIn] Cutruzzolà, Francesca [verfasserIn] Masci, Domiziana [verfasserIn] Bigogno, Chiara [verfasserIn] Dondio, Giulio [verfasserIn] Silvestri, Romano [verfasserIn] Gianni, Stefano [verfasserIn] Coluccia, Antonio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Grb2-Gab2 system SH3 domain Anticancer Small Molecules Structure activity Relationship

Übergeordnetes Werk:	Enthalten in: Bioorganic chemistry - San Diego, Calif. : Elsevier, 1971, 138
Übergeordnetes Werk:	volume:138

DOI / URN:	10.1016/j.bioorg.2023.106607

Katalog-ID:	ELV060180307

Internformat


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100	1		\|a Bufano, Marianna \|e verfasserin \|4 aut
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520			\|a Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug.
650		4	\|a Grb2-Gab2 system
650		4	\|a SH3 domain
650		4	\|a Anticancer
650		4	\|a Small Molecules
650		4	\|a Structure activity Relationship
700	1		\|a Puxeddu, Michela \|e verfasserin \|4 aut
700	1		\|a Nalli, Marianna \|e verfasserin \|4 aut
700	1		\|a La Regina, Giuseppe \|e verfasserin \|4 aut
700	1		\|a Toto, Angelo \|e verfasserin \|4 aut
700	1		\|a Liberati, Francesca Romana \|e verfasserin \|4 aut
700	1		\|a Paone, Alessio \|e verfasserin \|4 aut
700	1		\|a Cutruzzolà, Francesca \|e verfasserin \|4 aut
700	1		\|a Masci, Domiziana \|e verfasserin \|4 aut
700	1		\|a Bigogno, Chiara \|e verfasserin \|4 aut
700	1		\|a Dondio, Giulio \|e verfasserin \|4 aut
700	1		\|a Silvestri, Romano \|e verfasserin \|4 aut
700	1		\|a Gianni, Stefano \|e verfasserin \|4 aut
700	1		\|a Coluccia, Antonio \|e verfasserin \|0 (orcid)0000-0002-7940-8206 \|4 aut
773	0	8	\|i Enthalten in \|t Bioorganic chemistry \|d San Diego, Calif. : Elsevier, 1971 \|g 138 \|h Online-Ressource \|w (DE-627)254631681 \|w (DE-600)1462232-4 \|w (DE-576)104193603 \|x 1090-2120 \|7 nnns
773	1	8	\|g volume:138
912			\|a GBV_USEFLAG_U
912			\|a GBV_ELV
912			\|a SYSFLAG_U
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 35.50 \|j Organische Chemie: Allgemeines \|q VZ
936	b	k	\|a 35.70 \|j Biochemie: Allgemeines \|q VZ
951			\|a AR
952			\|d 138

Indexfelder

author_variant	m b mb m p mp m n mn r g l rg rgl a t at f r l fr frl a p ap f c fc d m dm c b cb g d gd r s rs s g sg a c ac
matchkey_str	article:10902120:2023----::agtnter2s3oaneinyteiadilgclvlainfh
hierarchy_sort_str	2023
bklnumber	35.50 35.70
publishDate	2023
allfields	10.1016/j.bioorg.2023.106607 doi (DE-627)ELV060180307 (ELSEVIER)S0045-2068(23)00268-7 DE-627 ger DE-627 rda eng 540 VZ 35.50 bkl 35.70 bkl Bufano, Marianna verfasserin aut Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug. Grb2-Gab2 system SH3 domain Anticancer Small Molecules Structure activity Relationship Puxeddu, Michela verfasserin aut Nalli, Marianna verfasserin aut La Regina, Giuseppe verfasserin aut Toto, Angelo verfasserin aut Liberati, Francesca Romana verfasserin aut Paone, Alessio verfasserin aut Cutruzzolà, Francesca verfasserin aut Masci, Domiziana verfasserin aut Bigogno, Chiara verfasserin aut Dondio, Giulio verfasserin aut Silvestri, Romano verfasserin aut Gianni, Stefano verfasserin aut Coluccia, Antonio verfasserin (orcid)0000-0002-7940-8206 aut Enthalten in Bioorganic chemistry San Diego, Calif. : Elsevier, 1971 138 Online-Ressource (DE-627)254631681 (DE-600)1462232-4 (DE-576)104193603 1090-2120 nnns volume:138 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.50 Organische Chemie: Allgemeines VZ 35.70 Biochemie: Allgemeines VZ AR 138
spelling	10.1016/j.bioorg.2023.106607 doi (DE-627)ELV060180307 (ELSEVIER)S0045-2068(23)00268-7 DE-627 ger DE-627 rda eng 540 VZ 35.50 bkl 35.70 bkl Bufano, Marianna verfasserin aut Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug. Grb2-Gab2 system SH3 domain Anticancer Small Molecules Structure activity Relationship Puxeddu, Michela verfasserin aut Nalli, Marianna verfasserin aut La Regina, Giuseppe verfasserin aut Toto, Angelo verfasserin aut Liberati, Francesca Romana verfasserin aut Paone, Alessio verfasserin aut Cutruzzolà, Francesca verfasserin aut Masci, Domiziana verfasserin aut Bigogno, Chiara verfasserin aut Dondio, Giulio verfasserin aut Silvestri, Romano verfasserin aut Gianni, Stefano verfasserin aut Coluccia, Antonio verfasserin (orcid)0000-0002-7940-8206 aut Enthalten in Bioorganic chemistry San Diego, Calif. : Elsevier, 1971 138 Online-Ressource (DE-627)254631681 (DE-600)1462232-4 (DE-576)104193603 1090-2120 nnns volume:138 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.50 Organische Chemie: Allgemeines VZ 35.70 Biochemie: Allgemeines VZ AR 138
allfields_unstemmed	10.1016/j.bioorg.2023.106607 doi (DE-627)ELV060180307 (ELSEVIER)S0045-2068(23)00268-7 DE-627 ger DE-627 rda eng 540 VZ 35.50 bkl 35.70 bkl Bufano, Marianna verfasserin aut Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug. Grb2-Gab2 system SH3 domain Anticancer Small Molecules Structure activity Relationship Puxeddu, Michela verfasserin aut Nalli, Marianna verfasserin aut La Regina, Giuseppe verfasserin aut Toto, Angelo verfasserin aut Liberati, Francesca Romana verfasserin aut Paone, Alessio verfasserin aut Cutruzzolà, Francesca verfasserin aut Masci, Domiziana verfasserin aut Bigogno, Chiara verfasserin aut Dondio, Giulio verfasserin aut Silvestri, Romano verfasserin aut Gianni, Stefano verfasserin aut Coluccia, Antonio verfasserin (orcid)0000-0002-7940-8206 aut Enthalten in Bioorganic chemistry San Diego, Calif. : Elsevier, 1971 138 Online-Ressource (DE-627)254631681 (DE-600)1462232-4 (DE-576)104193603 1090-2120 nnns volume:138 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.50 Organische Chemie: Allgemeines VZ 35.70 Biochemie: Allgemeines VZ AR 138
allfieldsGer	10.1016/j.bioorg.2023.106607 doi (DE-627)ELV060180307 (ELSEVIER)S0045-2068(23)00268-7 DE-627 ger DE-627 rda eng 540 VZ 35.50 bkl 35.70 bkl Bufano, Marianna verfasserin aut Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug. Grb2-Gab2 system SH3 domain Anticancer Small Molecules Structure activity Relationship Puxeddu, Michela verfasserin aut Nalli, Marianna verfasserin aut La Regina, Giuseppe verfasserin aut Toto, Angelo verfasserin aut Liberati, Francesca Romana verfasserin aut Paone, Alessio verfasserin aut Cutruzzolà, Francesca verfasserin aut Masci, Domiziana verfasserin aut Bigogno, Chiara verfasserin aut Dondio, Giulio verfasserin aut Silvestri, Romano verfasserin aut Gianni, Stefano verfasserin aut Coluccia, Antonio verfasserin (orcid)0000-0002-7940-8206 aut Enthalten in Bioorganic chemistry San Diego, Calif. : Elsevier, 1971 138 Online-Ressource (DE-627)254631681 (DE-600)1462232-4 (DE-576)104193603 1090-2120 nnns volume:138 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.50 Organische Chemie: Allgemeines VZ 35.70 Biochemie: Allgemeines VZ AR 138
allfieldsSound	10.1016/j.bioorg.2023.106607 doi (DE-627)ELV060180307 (ELSEVIER)S0045-2068(23)00268-7 DE-627 ger DE-627 rda eng 540 VZ 35.50 bkl 35.70 bkl Bufano, Marianna verfasserin aut Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug. Grb2-Gab2 system SH3 domain Anticancer Small Molecules Structure activity Relationship Puxeddu, Michela verfasserin aut Nalli, Marianna verfasserin aut La Regina, Giuseppe verfasserin aut Toto, Angelo verfasserin aut Liberati, Francesca Romana verfasserin aut Paone, Alessio verfasserin aut Cutruzzolà, Francesca verfasserin aut Masci, Domiziana verfasserin aut Bigogno, Chiara verfasserin aut Dondio, Giulio verfasserin aut Silvestri, Romano verfasserin aut Gianni, Stefano verfasserin aut Coluccia, Antonio verfasserin (orcid)0000-0002-7940-8206 aut Enthalten in Bioorganic chemistry San Diego, Calif. : Elsevier, 1971 138 Online-Ressource (DE-627)254631681 (DE-600)1462232-4 (DE-576)104193603 1090-2120 nnns volume:138 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.50 Organische Chemie: Allgemeines VZ 35.70 Biochemie: Allgemeines VZ AR 138
language	English
source	Enthalten in Bioorganic chemistry 138 volume:138
sourceStr	Enthalten in Bioorganic chemistry 138 volume:138
format_phy_str_mv	Article
bklname	Organische Chemie: Allgemeines Biochemie: Allgemeines
institution	findex.gbv.de
topic_facet	Grb2-Gab2 system SH3 domain Anticancer Small Molecules Structure activity Relationship
dewey-raw	540
isfreeaccess_bool	false
container_title	Bioorganic chemistry
authorswithroles_txt_mv	Bufano, Marianna @@aut@@ Puxeddu, Michela @@aut@@ Nalli, Marianna @@aut@@ La Regina, Giuseppe @@aut@@ Toto, Angelo @@aut@@ Liberati, Francesca Romana @@aut@@ Paone, Alessio @@aut@@ Cutruzzolà, Francesca @@aut@@ Masci, Domiziana @@aut@@ Bigogno, Chiara @@aut@@ Dondio, Giulio @@aut@@ Silvestri, Romano @@aut@@ Gianni, Stefano @@aut@@ Coluccia, Antonio @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	254631681
dewey-sort	3540
id	ELV060180307
language_de	englisch
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author	Bufano, Marianna
spellingShingle	Bufano, Marianna ddc 540 bkl 35.50 bkl 35.70 misc Grb2-Gab2 system misc SH3 domain misc Anticancer misc Small Molecules misc Structure activity Relationship Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators
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topic_title	540 VZ 35.50 bkl 35.70 bkl Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators Grb2-Gab2 system SH3 domain Anticancer Small Molecules Structure activity Relationship
topic	ddc 540 bkl 35.50 bkl 35.70 misc Grb2-Gab2 system misc SH3 domain misc Anticancer misc Small Molecules misc Structure activity Relationship
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title	Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators
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title_full	Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators
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author_browse	Bufano, Marianna Puxeddu, Michela Nalli, Marianna La Regina, Giuseppe Toto, Angelo Liberati, Francesca Romana Paone, Alessio Cutruzzolà, Francesca Masci, Domiziana Bigogno, Chiara Dondio, Giulio Silvestri, Romano Gianni, Stefano Coluccia, Antonio
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title_sort	targeting the grb2 csh3 domain: design, synthesis and biological evaluation of the first series of modulators
title_auth	Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators
abstract	Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug.
abstractGer	Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug.
abstract_unstemmed	Growth factor receptor bound protein 2 (Grb2) is an adaptor protein featured by a nSH3-SH2-cSH3 domains. Grb2 finely regulates important cellular pathways such as growth, proliferation and metabolism and a minor lapse of this tight control may totally change the entire pathway to the oncogenic. Indeed, Grb2 is found overexpressed in many tumours type. Consequently, Grb2 is an attractive therapeutic target for the development of new anticancer drug.
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title_short	Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators
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author2	Puxeddu, Michela Nalli, Marianna La Regina, Giuseppe Toto, Angelo Liberati, Francesca Romana Paone, Alessio Cutruzzolà, Francesca Masci, Domiziana Bigogno, Chiara Dondio, Giulio Silvestri, Romano Gianni, Stefano Coluccia, Antonio
author2Str	Puxeddu, Michela Nalli, Marianna La Regina, Giuseppe Toto, Angelo Liberati, Francesca Romana Paone, Alessio Cutruzzolà, Francesca Masci, Domiziana Bigogno, Chiara Dondio, Giulio Silvestri, Romano Gianni, Stefano Coluccia, Antonio
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up_date	2024-07-06T23:37:37.702Z
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Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators

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