A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines

A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulati...
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Autor*in:	Masuri, Sebastiano [verfasserIn] Moráň, Lukáš [verfasserIn] Vesselá, Tereza [verfasserIn] Cadoni, Enzo [verfasserIn] Cabiddu, Maria Grazia [verfasserIn] Pečinka, Lukáš [verfasserIn] Gabrielová, Viktorie [verfasserIn] Meloni, Francesca [verfasserIn] Havel, Josef [verfasserIn] Vaňhara, Petr [verfasserIn] Pivetta, Tiziana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Copper complex Solution equilibria Mass spectrometry Lipoxygenase Molecular docking ER stress

Übergeordnetes Werk:	Enthalten in: Journal of inorganic biochemistry - New York, NY [u.a.] : Elsevier, 1979, 246
Übergeordnetes Werk:	volume:246

DOI / URN:	10.1016/j.jinorgbio.2023.112301

Katalog-ID:	ELV06025355X

Internformat


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245	1	0	\|a A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines
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520			\|a A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints.
650		4	\|a Copper complex
650		4	\|a Solution equilibria
650		4	\|a Mass spectrometry
650		4	\|a Lipoxygenase
650		4	\|a Molecular docking
650		4	\|a ER stress
700	1		\|a Moráň, Lukáš \|e verfasserin \|4 aut
700	1		\|a Vesselá, Tereza \|e verfasserin \|4 aut
700	1		\|a Cadoni, Enzo \|e verfasserin \|4 aut
700	1		\|a Cabiddu, Maria Grazia \|e verfasserin \|4 aut
700	1		\|a Pečinka, Lukáš \|e verfasserin \|4 aut
700	1		\|a Gabrielová, Viktorie \|e verfasserin \|4 aut
700	1		\|a Meloni, Francesca \|e verfasserin \|4 aut
700	1		\|a Havel, Josef \|e verfasserin \|4 aut
700	1		\|a Vaňhara, Petr \|e verfasserin \|4 aut
700	1		\|a Pivetta, Tiziana \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Journal of inorganic biochemistry \|d New York, NY [u.a.] : Elsevier, 1979 \|g 246 \|h Online-Ressource \|w (DE-627)302468013 \|w (DE-600)1491314-8 \|w (DE-576)081952775 \|x 1873-3344 \|7 nnns
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912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
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912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
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912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
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912			\|a GBV_ILN_230
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912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
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912			\|a GBV_ILN_2010
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912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
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912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
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912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 35.49 \|j Anorganische Chemie: Sonstiges \|q VZ
936	b	k	\|a 35.70 \|j Biochemie: Allgemeines \|q VZ
951			\|a AR
952			\|d 246

Indexfelder

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allfields	10.1016/j.jinorgbio.2023.112301 doi (DE-627)ELV06025355X (ELSEVIER)S0162-0134(23)00183-6 DE-627 ger DE-627 rda eng 540 VZ 35.49 bkl 35.70 bkl Masuri, Sebastiano verfasserin aut A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints. Copper complex Solution equilibria Mass spectrometry Lipoxygenase Molecular docking ER stress Moráň, Lukáš verfasserin aut Vesselá, Tereza verfasserin aut Cadoni, Enzo verfasserin aut Cabiddu, Maria Grazia verfasserin aut Pečinka, Lukáš verfasserin aut Gabrielová, Viktorie verfasserin aut Meloni, Francesca verfasserin aut Havel, Josef verfasserin aut Vaňhara, Petr verfasserin aut Pivetta, Tiziana verfasserin aut Enthalten in Journal of inorganic biochemistry New York, NY [u.a.] : Elsevier, 1979 246 Online-Ressource (DE-627)302468013 (DE-600)1491314-8 (DE-576)081952775 1873-3344 nnns volume:246 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.49 Anorganische Chemie: Sonstiges VZ 35.70 Biochemie: Allgemeines VZ AR 246
spelling	10.1016/j.jinorgbio.2023.112301 doi (DE-627)ELV06025355X (ELSEVIER)S0162-0134(23)00183-6 DE-627 ger DE-627 rda eng 540 VZ 35.49 bkl 35.70 bkl Masuri, Sebastiano verfasserin aut A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints. Copper complex Solution equilibria Mass spectrometry Lipoxygenase Molecular docking ER stress Moráň, Lukáš verfasserin aut Vesselá, Tereza verfasserin aut Cadoni, Enzo verfasserin aut Cabiddu, Maria Grazia verfasserin aut Pečinka, Lukáš verfasserin aut Gabrielová, Viktorie verfasserin aut Meloni, Francesca verfasserin aut Havel, Josef verfasserin aut Vaňhara, Petr verfasserin aut Pivetta, Tiziana verfasserin aut Enthalten in Journal of inorganic biochemistry New York, NY [u.a.] : Elsevier, 1979 246 Online-Ressource (DE-627)302468013 (DE-600)1491314-8 (DE-576)081952775 1873-3344 nnns volume:246 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.49 Anorganische Chemie: Sonstiges VZ 35.70 Biochemie: Allgemeines VZ AR 246
allfields_unstemmed	10.1016/j.jinorgbio.2023.112301 doi (DE-627)ELV06025355X (ELSEVIER)S0162-0134(23)00183-6 DE-627 ger DE-627 rda eng 540 VZ 35.49 bkl 35.70 bkl Masuri, Sebastiano verfasserin aut A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints. Copper complex Solution equilibria Mass spectrometry Lipoxygenase Molecular docking ER stress Moráň, Lukáš verfasserin aut Vesselá, Tereza verfasserin aut Cadoni, Enzo verfasserin aut Cabiddu, Maria Grazia verfasserin aut Pečinka, Lukáš verfasserin aut Gabrielová, Viktorie verfasserin aut Meloni, Francesca verfasserin aut Havel, Josef verfasserin aut Vaňhara, Petr verfasserin aut Pivetta, Tiziana verfasserin aut Enthalten in Journal of inorganic biochemistry New York, NY [u.a.] : Elsevier, 1979 246 Online-Ressource (DE-627)302468013 (DE-600)1491314-8 (DE-576)081952775 1873-3344 nnns volume:246 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.49 Anorganische Chemie: Sonstiges VZ 35.70 Biochemie: Allgemeines VZ AR 246
allfieldsGer	10.1016/j.jinorgbio.2023.112301 doi (DE-627)ELV06025355X (ELSEVIER)S0162-0134(23)00183-6 DE-627 ger DE-627 rda eng 540 VZ 35.49 bkl 35.70 bkl Masuri, Sebastiano verfasserin aut A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints. Copper complex Solution equilibria Mass spectrometry Lipoxygenase Molecular docking ER stress Moráň, Lukáš verfasserin aut Vesselá, Tereza verfasserin aut Cadoni, Enzo verfasserin aut Cabiddu, Maria Grazia verfasserin aut Pečinka, Lukáš verfasserin aut Gabrielová, Viktorie verfasserin aut Meloni, Francesca verfasserin aut Havel, Josef verfasserin aut Vaňhara, Petr verfasserin aut Pivetta, Tiziana verfasserin aut Enthalten in Journal of inorganic biochemistry New York, NY [u.a.] : Elsevier, 1979 246 Online-Ressource (DE-627)302468013 (DE-600)1491314-8 (DE-576)081952775 1873-3344 nnns volume:246 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.49 Anorganische Chemie: Sonstiges VZ 35.70 Biochemie: Allgemeines VZ AR 246
allfieldsSound	10.1016/j.jinorgbio.2023.112301 doi (DE-627)ELV06025355X (ELSEVIER)S0162-0134(23)00183-6 DE-627 ger DE-627 rda eng 540 VZ 35.49 bkl 35.70 bkl Masuri, Sebastiano verfasserin aut A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints. Copper complex Solution equilibria Mass spectrometry Lipoxygenase Molecular docking ER stress Moráň, Lukáš verfasserin aut Vesselá, Tereza verfasserin aut Cadoni, Enzo verfasserin aut Cabiddu, Maria Grazia verfasserin aut Pečinka, Lukáš verfasserin aut Gabrielová, Viktorie verfasserin aut Meloni, Francesca verfasserin aut Havel, Josef verfasserin aut Vaňhara, Petr verfasserin aut Pivetta, Tiziana verfasserin aut Enthalten in Journal of inorganic biochemistry New York, NY [u.a.] : Elsevier, 1979 246 Online-Ressource (DE-627)302468013 (DE-600)1491314-8 (DE-576)081952775 1873-3344 nnns volume:246 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.49 Anorganische Chemie: Sonstiges VZ 35.70 Biochemie: Allgemeines VZ AR 246
language	English
source	Enthalten in Journal of inorganic biochemistry 246 volume:246
sourceStr	Enthalten in Journal of inorganic biochemistry 246 volume:246
format_phy_str_mv	Article
bklname	Anorganische Chemie: Sonstiges Biochemie: Allgemeines
institution	findex.gbv.de
topic_facet	Copper complex Solution equilibria Mass spectrometry Lipoxygenase Molecular docking ER stress
dewey-raw	540
isfreeaccess_bool	false
container_title	Journal of inorganic biochemistry
authorswithroles_txt_mv	Masuri, Sebastiano @@aut@@ Moráň, Lukáš @@aut@@ Vesselá, Tereza @@aut@@ Cadoni, Enzo @@aut@@ Cabiddu, Maria Grazia @@aut@@ Pečinka, Lukáš @@aut@@ Gabrielová, Viktorie @@aut@@ Meloni, Francesca @@aut@@ Havel, Josef @@aut@@ Vaňhara, Petr @@aut@@ Pivetta, Tiziana @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	302468013
dewey-sort	3540
id	ELV06025355X
language_de	englisch
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author	Masuri, Sebastiano
spellingShingle	Masuri, Sebastiano ddc 540 bkl 35.49 bkl 35.70 misc Copper complex misc Solution equilibria misc Mass spectrometry misc Lipoxygenase misc Molecular docking misc ER stress A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines
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topic_title	540 VZ 35.49 bkl 35.70 bkl A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines Copper complex Solution equilibria Mass spectrometry Lipoxygenase Molecular docking ER stress
topic	ddc 540 bkl 35.49 bkl 35.70 misc Copper complex misc Solution equilibria misc Mass spectrometry misc Lipoxygenase misc Molecular docking misc ER stress
topic_unstemmed	ddc 540 bkl 35.49 bkl 35.70 misc Copper complex misc Solution equilibria misc Mass spectrometry misc Lipoxygenase misc Molecular docking misc ER stress
topic_browse	ddc 540 bkl 35.49 bkl 35.70 misc Copper complex misc Solution equilibria misc Mass spectrometry misc Lipoxygenase misc Molecular docking misc ER stress
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title	A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines
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title_full	A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines
author_sort	Masuri, Sebastiano
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author_browse	Masuri, Sebastiano Moráň, Lukáš Vesselá, Tereza Cadoni, Enzo Cabiddu, Maria Grazia Pečinka, Lukáš Gabrielová, Viktorie Meloni, Francesca Havel, Josef Vaňhara, Petr Pivetta, Tiziana
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author-letter	Masuri, Sebastiano
doi_str_mv	10.1016/j.jinorgbio.2023.112301
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title_sort	a novel heteroleptic cu(ii)-phenanthroline-udca complex as lipoxygenase inhibitor and er-stress inducer in cancer cell lines
title_auth	A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines
abstract	A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints.
abstractGer	A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints.
abstract_unstemmed	A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints.
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title_short	A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines
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author2	Moráň, Lukáš Vesselá, Tereza Cadoni, Enzo Cabiddu, Maria Grazia Pečinka, Lukáš Gabrielová, Viktorie Meloni, Francesca Havel, Josef Vaňhara, Petr Pivetta, Tiziana
author2Str	Moráň, Lukáš Vesselá, Tereza Cadoni, Enzo Cabiddu, Maria Grazia Pečinka, Lukáš Gabrielová, Viktorie Meloni, Francesca Havel, Josef Vaňhara, Petr Pivetta, Tiziana
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doi_str	10.1016/j.jinorgbio.2023.112301
up_date	2024-07-06T23:41:42.459Z
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A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines

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