Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients
Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pignatti, Patrizia [verfasserIn] Ramirez, Giuseppe Alvise [verfasserIn] Russo, Marco [verfasserIn] Marraccini, Paolo [verfasserIn] Nannipieri, Serena [verfasserIn] Asperti, Chiara [verfasserIn] Torre, Fabrizio Della [verfasserIn] Tiri, Antonio [verfasserIn] Gatti, Beatrice Maria [verfasserIn] Gurrado, Antonella [verfasserIn] Meriggi, Antonio [verfasserIn] Benanti, Giovanni [verfasserIn] Cilona, Maria Bernadette [verfasserIn] Pigatto, Paolo [verfasserIn] Burastero, Samuele E. [verfasserIn] Dagna, Lorenzo [verfasserIn] Yacoub, Mona-Rita [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Vaccine - Amsterdam : Elsevier, 1983, 41, Seite 4693-4699 |
|---|---|
| Übergeordnetes Werk: |
volume:41 ; pages:4693-4699 |
| DOI / URN: |
10.1016/j.vaccine.2023.06.039 |
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| Katalog-ID: |
ELV060372613 |
|---|
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| 245 | 1 | 0 | |a Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients |
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| 520 | |a Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. | ||
| 650 | 4 | |a Basophil activation test | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Vaccine | |
| 650 | 4 | |a Allergy | |
| 650 | 4 | |a Hypersensitivity | |
| 650 | 4 | |a Adverse reaction | |
| 650 | 4 | |a Polyethylene glycol | |
| 700 | 1 | |a Ramirez, Giuseppe Alvise |e verfasserin |4 aut | |
| 700 | 1 | |a Russo, Marco |e verfasserin |0 (orcid)0000-0003-3884-5562 |4 aut | |
| 700 | 1 | |a Marraccini, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Nannipieri, Serena |e verfasserin |0 (orcid)0000-0003-3560-9759 |4 aut | |
| 700 | 1 | |a Asperti, Chiara |e verfasserin |0 (orcid)0000-0002-2963-9882 |4 aut | |
| 700 | 1 | |a Torre, Fabrizio Della |e verfasserin |4 aut | |
| 700 | 1 | |a Tiri, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Gatti, Beatrice Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Gurrado, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Meriggi, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Benanti, Giovanni |e verfasserin |0 (orcid)0000-0002-4310-6951 |4 aut | |
| 700 | 1 | |a Cilona, Maria Bernadette |e verfasserin |4 aut | |
| 700 | 1 | |a Pigatto, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Burastero, Samuele E. |e verfasserin |4 aut | |
| 700 | 1 | |a Dagna, Lorenzo |e verfasserin |0 (orcid)0000-0002-7428-315X |4 aut | |
| 700 | 1 | |a Yacoub, Mona-Rita |e verfasserin |0 (orcid)0000-0003-2417-0410 |4 aut | |
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10.1016/j.vaccine.2023.06.039 doi (DE-627)ELV060372613 (ELSEVIER)S0264-410X(23)00714-4 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Pignatti, Patrizia verfasserin (orcid)0000-0001-5283-3897 aut Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. Basophil activation test SARS-CoV-2 COVID-19 Vaccine Allergy Hypersensitivity Adverse reaction Polyethylene glycol Ramirez, Giuseppe Alvise verfasserin aut Russo, Marco verfasserin (orcid)0000-0003-3884-5562 aut Marraccini, Paolo verfasserin aut Nannipieri, Serena verfasserin (orcid)0000-0003-3560-9759 aut Asperti, Chiara verfasserin (orcid)0000-0002-2963-9882 aut Torre, Fabrizio Della verfasserin aut Tiri, Antonio verfasserin aut Gatti, Beatrice Maria verfasserin aut Gurrado, Antonella verfasserin aut Meriggi, Antonio verfasserin aut Benanti, Giovanni verfasserin (orcid)0000-0002-4310-6951 aut Cilona, Maria Bernadette verfasserin aut Pigatto, Paolo verfasserin aut Burastero, Samuele E. verfasserin aut Dagna, Lorenzo verfasserin (orcid)0000-0002-7428-315X aut Yacoub, Mona-Rita verfasserin (orcid)0000-0003-2417-0410 aut Enthalten in Vaccine Amsterdam : Elsevier, 1983 41, Seite 4693-4699 Online-Ressource (DE-627)266886078 (DE-600)1468474-3 (DE-576)075961857 1873-2518 nnns volume:41 pages:4693-4699 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 41 4693-4699 |
| spelling |
10.1016/j.vaccine.2023.06.039 doi (DE-627)ELV060372613 (ELSEVIER)S0264-410X(23)00714-4 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Pignatti, Patrizia verfasserin (orcid)0000-0001-5283-3897 aut Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. Basophil activation test SARS-CoV-2 COVID-19 Vaccine Allergy Hypersensitivity Adverse reaction Polyethylene glycol Ramirez, Giuseppe Alvise verfasserin aut Russo, Marco verfasserin (orcid)0000-0003-3884-5562 aut Marraccini, Paolo verfasserin aut Nannipieri, Serena verfasserin (orcid)0000-0003-3560-9759 aut Asperti, Chiara verfasserin (orcid)0000-0002-2963-9882 aut Torre, Fabrizio Della verfasserin aut Tiri, Antonio verfasserin aut Gatti, Beatrice Maria verfasserin aut Gurrado, Antonella verfasserin aut Meriggi, Antonio verfasserin aut Benanti, Giovanni verfasserin (orcid)0000-0002-4310-6951 aut Cilona, Maria Bernadette verfasserin aut Pigatto, Paolo verfasserin aut Burastero, Samuele E. verfasserin aut Dagna, Lorenzo verfasserin (orcid)0000-0002-7428-315X aut Yacoub, Mona-Rita verfasserin (orcid)0000-0003-2417-0410 aut Enthalten in Vaccine Amsterdam : Elsevier, 1983 41, Seite 4693-4699 Online-Ressource (DE-627)266886078 (DE-600)1468474-3 (DE-576)075961857 1873-2518 nnns volume:41 pages:4693-4699 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 41 4693-4699 |
| allfields_unstemmed |
10.1016/j.vaccine.2023.06.039 doi (DE-627)ELV060372613 (ELSEVIER)S0264-410X(23)00714-4 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Pignatti, Patrizia verfasserin (orcid)0000-0001-5283-3897 aut Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. Basophil activation test SARS-CoV-2 COVID-19 Vaccine Allergy Hypersensitivity Adverse reaction Polyethylene glycol Ramirez, Giuseppe Alvise verfasserin aut Russo, Marco verfasserin (orcid)0000-0003-3884-5562 aut Marraccini, Paolo verfasserin aut Nannipieri, Serena verfasserin (orcid)0000-0003-3560-9759 aut Asperti, Chiara verfasserin (orcid)0000-0002-2963-9882 aut Torre, Fabrizio Della verfasserin aut Tiri, Antonio verfasserin aut Gatti, Beatrice Maria verfasserin aut Gurrado, Antonella verfasserin aut Meriggi, Antonio verfasserin aut Benanti, Giovanni verfasserin (orcid)0000-0002-4310-6951 aut Cilona, Maria Bernadette verfasserin aut Pigatto, Paolo verfasserin aut Burastero, Samuele E. verfasserin aut Dagna, Lorenzo verfasserin (orcid)0000-0002-7428-315X aut Yacoub, Mona-Rita verfasserin (orcid)0000-0003-2417-0410 aut Enthalten in Vaccine Amsterdam : Elsevier, 1983 41, Seite 4693-4699 Online-Ressource (DE-627)266886078 (DE-600)1468474-3 (DE-576)075961857 1873-2518 nnns volume:41 pages:4693-4699 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 41 4693-4699 |
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10.1016/j.vaccine.2023.06.039 doi (DE-627)ELV060372613 (ELSEVIER)S0264-410X(23)00714-4 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Pignatti, Patrizia verfasserin (orcid)0000-0001-5283-3897 aut Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. Basophil activation test SARS-CoV-2 COVID-19 Vaccine Allergy Hypersensitivity Adverse reaction Polyethylene glycol Ramirez, Giuseppe Alvise verfasserin aut Russo, Marco verfasserin (orcid)0000-0003-3884-5562 aut Marraccini, Paolo verfasserin aut Nannipieri, Serena verfasserin (orcid)0000-0003-3560-9759 aut Asperti, Chiara verfasserin (orcid)0000-0002-2963-9882 aut Torre, Fabrizio Della verfasserin aut Tiri, Antonio verfasserin aut Gatti, Beatrice Maria verfasserin aut Gurrado, Antonella verfasserin aut Meriggi, Antonio verfasserin aut Benanti, Giovanni verfasserin (orcid)0000-0002-4310-6951 aut Cilona, Maria Bernadette verfasserin aut Pigatto, Paolo verfasserin aut Burastero, Samuele E. verfasserin aut Dagna, Lorenzo verfasserin (orcid)0000-0002-7428-315X aut Yacoub, Mona-Rita verfasserin (orcid)0000-0003-2417-0410 aut Enthalten in Vaccine Amsterdam : Elsevier, 1983 41, Seite 4693-4699 Online-Ressource (DE-627)266886078 (DE-600)1468474-3 (DE-576)075961857 1873-2518 nnns volume:41 pages:4693-4699 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 41 4693-4699 |
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10.1016/j.vaccine.2023.06.039 doi (DE-627)ELV060372613 (ELSEVIER)S0264-410X(23)00714-4 DE-627 ger DE-627 rda eng 610 VZ 44.45 bkl Pignatti, Patrizia verfasserin (orcid)0000-0001-5283-3897 aut Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. Basophil activation test SARS-CoV-2 COVID-19 Vaccine Allergy Hypersensitivity Adverse reaction Polyethylene glycol Ramirez, Giuseppe Alvise verfasserin aut Russo, Marco verfasserin (orcid)0000-0003-3884-5562 aut Marraccini, Paolo verfasserin aut Nannipieri, Serena verfasserin (orcid)0000-0003-3560-9759 aut Asperti, Chiara verfasserin (orcid)0000-0002-2963-9882 aut Torre, Fabrizio Della verfasserin aut Tiri, Antonio verfasserin aut Gatti, Beatrice Maria verfasserin aut Gurrado, Antonella verfasserin aut Meriggi, Antonio verfasserin aut Benanti, Giovanni verfasserin (orcid)0000-0002-4310-6951 aut Cilona, Maria Bernadette verfasserin aut Pigatto, Paolo verfasserin aut Burastero, Samuele E. verfasserin aut Dagna, Lorenzo verfasserin (orcid)0000-0002-7428-315X aut Yacoub, Mona-Rita verfasserin (orcid)0000-0003-2417-0410 aut Enthalten in Vaccine Amsterdam : Elsevier, 1983 41, Seite 4693-4699 Online-Ressource (DE-627)266886078 (DE-600)1468474-3 (DE-576)075961857 1873-2518 nnns volume:41 pages:4693-4699 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.45 Immunologie VZ AR 41 4693-4699 |
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Enthalten in Vaccine 41, Seite 4693-4699 volume:41 pages:4693-4699 |
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Enthalten in Vaccine 41, Seite 4693-4699 volume:41 pages:4693-4699 |
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Basophil activation test SARS-CoV-2 COVID-19 Vaccine Allergy Hypersensitivity Adverse reaction Polyethylene glycol |
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Pignatti, Patrizia @@aut@@ Ramirez, Giuseppe Alvise @@aut@@ Russo, Marco @@aut@@ Marraccini, Paolo @@aut@@ Nannipieri, Serena @@aut@@ Asperti, Chiara @@aut@@ Torre, Fabrizio Della @@aut@@ Tiri, Antonio @@aut@@ Gatti, Beatrice Maria @@aut@@ Gurrado, Antonella @@aut@@ Meriggi, Antonio @@aut@@ Benanti, Giovanni @@aut@@ Cilona, Maria Bernadette @@aut@@ Pigatto, Paolo @@aut@@ Burastero, Samuele E. @@aut@@ Dagna, Lorenzo @@aut@@ Yacoub, Mona-Rita @@aut@@ |
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Pignatti, Patrizia ddc 610 bkl 44.45 misc Basophil activation test misc SARS-CoV-2 misc COVID-19 misc Vaccine misc Allergy misc Hypersensitivity misc Adverse reaction misc Polyethylene glycol Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients |
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610 VZ 44.45 bkl Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients Basophil activation test SARS-CoV-2 COVID-19 Vaccine Allergy Hypersensitivity Adverse reaction Polyethylene glycol |
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Pignatti, Patrizia Ramirez, Giuseppe Alvise Russo, Marco Marraccini, Paolo Nannipieri, Serena Asperti, Chiara Torre, Fabrizio Della Tiri, Antonio Gatti, Beatrice Maria Gurrado, Antonella Meriggi, Antonio Benanti, Giovanni Cilona, Maria Bernadette Pigatto, Paolo Burastero, Samuele E. Dagna, Lorenzo Yacoub, Mona-Rita |
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hypersensitivity reactions to anti-sars-cov-2 vaccines: basophil reactivity to excipients |
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Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients |
| abstract |
Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. |
| abstractGer |
Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. |
| abstract_unstemmed |
Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. Natural immunity might be a key player in basophil activation. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV060372613</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230926161637.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230712s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.vaccine.2023.06.039</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV060372613</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0264-410X(23)00714-4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.45</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Pignatti, Patrizia</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-5283-3897</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Basophil activation test (BAT) can tackle multiple mechanisms underlying acute and delayed hypersensitivity to drugs and vaccines and might complement conventional allergy diagnostics but its role in anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-related hypersensitivity is ill-defined. Therefore, 89 patients with possible hypersensitivity (56 % with delayed mucocutaneous manifestations) to anti-SARS-CoV-2 vaccines were tested with BAT for Macrogol 3350, DMG-PEG 2000, PEG 20000, polysorbate-80 and trometamol and compared to 156 subjects undergoing pre-vaccine BAT. A positive BAT was associated with delayed reaction onset (p = 0.010) and resolution (p = 0.011). BAT was more frequently positive to DMG-PEG 2000 than to other excipients in both groups (p < 0.001). DMG-PEG 2000 reactivity was less frequent in vaccine-naïve (6 %) than vaccinated subjects (35 %, p < 0.001) and associated with mRNA-1273 vaccination. DMG-PEG 2000 BAT might therefore have a diagnostic role in subjects with delayed hypersensitivity reactions. 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