Distance to criticality undergoes critical transition before epileptic seizure attacks

Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address t...
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Gespeichert in:

Autor*in:	Liu, Shun [verfasserIn] Li, Fali [verfasserIn] Wan, Feng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Epileptic seizures Electroencephalogram (EEG) Brain network Criticality

Übergeordnetes Werk:	Enthalten in: Brain research bulletin - Amsterdam [u.a.] : Elsevier Science, 1976, 200
Übergeordnetes Werk:	volume:200

DOI / URN:	10.1016/j.brainresbull.2023.110684

Katalog-ID:	ELV060586680

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520			\|a Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures.
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650		4	\|a Electroencephalogram (EEG)
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allfields	10.1016/j.brainresbull.2023.110684 doi (DE-627)ELV060586680 (ELSEVIER)S0361-9230(23)00109-0 DE-627 ger DE-627 rda eng 610 150 VZ 44.90 bkl Liu, Shun verfasserin aut Distance to criticality undergoes critical transition before epileptic seizure attacks 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures. Epileptic seizures Electroencephalogram (EEG) Brain network Criticality Li, Fali verfasserin aut Wan, Feng verfasserin (orcid)0000-0002-9359-0737 aut Enthalten in Brain research bulletin Amsterdam [u.a.] : Elsevier Science, 1976 200 Online-Ressource (DE-627)320433676 (DE-600)2004068-4 (DE-576)090954653 1873-2747 nnns volume:200 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie VZ AR 200
spelling	10.1016/j.brainresbull.2023.110684 doi (DE-627)ELV060586680 (ELSEVIER)S0361-9230(23)00109-0 DE-627 ger DE-627 rda eng 610 150 VZ 44.90 bkl Liu, Shun verfasserin aut Distance to criticality undergoes critical transition before epileptic seizure attacks 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures. Epileptic seizures Electroencephalogram (EEG) Brain network Criticality Li, Fali verfasserin aut Wan, Feng verfasserin (orcid)0000-0002-9359-0737 aut Enthalten in Brain research bulletin Amsterdam [u.a.] : Elsevier Science, 1976 200 Online-Ressource (DE-627)320433676 (DE-600)2004068-4 (DE-576)090954653 1873-2747 nnns volume:200 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie VZ AR 200
allfields_unstemmed	10.1016/j.brainresbull.2023.110684 doi (DE-627)ELV060586680 (ELSEVIER)S0361-9230(23)00109-0 DE-627 ger DE-627 rda eng 610 150 VZ 44.90 bkl Liu, Shun verfasserin aut Distance to criticality undergoes critical transition before epileptic seizure attacks 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures. Epileptic seizures Electroencephalogram (EEG) Brain network Criticality Li, Fali verfasserin aut Wan, Feng verfasserin (orcid)0000-0002-9359-0737 aut Enthalten in Brain research bulletin Amsterdam [u.a.] : Elsevier Science, 1976 200 Online-Ressource (DE-627)320433676 (DE-600)2004068-4 (DE-576)090954653 1873-2747 nnns volume:200 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie VZ AR 200
allfieldsGer	10.1016/j.brainresbull.2023.110684 doi (DE-627)ELV060586680 (ELSEVIER)S0361-9230(23)00109-0 DE-627 ger DE-627 rda eng 610 150 VZ 44.90 bkl Liu, Shun verfasserin aut Distance to criticality undergoes critical transition before epileptic seizure attacks 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures. Epileptic seizures Electroencephalogram (EEG) Brain network Criticality Li, Fali verfasserin aut Wan, Feng verfasserin (orcid)0000-0002-9359-0737 aut Enthalten in Brain research bulletin Amsterdam [u.a.] : Elsevier Science, 1976 200 Online-Ressource (DE-627)320433676 (DE-600)2004068-4 (DE-576)090954653 1873-2747 nnns volume:200 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie VZ AR 200
allfieldsSound	10.1016/j.brainresbull.2023.110684 doi (DE-627)ELV060586680 (ELSEVIER)S0361-9230(23)00109-0 DE-627 ger DE-627 rda eng 610 150 VZ 44.90 bkl Liu, Shun verfasserin aut Distance to criticality undergoes critical transition before epileptic seizure attacks 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures. Epileptic seizures Electroencephalogram (EEG) Brain network Criticality Li, Fali verfasserin aut Wan, Feng verfasserin (orcid)0000-0002-9359-0737 aut Enthalten in Brain research bulletin Amsterdam [u.a.] : Elsevier Science, 1976 200 Online-Ressource (DE-627)320433676 (DE-600)2004068-4 (DE-576)090954653 1873-2747 nnns volume:200 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 Neurologie VZ AR 200
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author	Liu, Shun
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topic_title	610 150 VZ 44.90 bkl Distance to criticality undergoes critical transition before epileptic seizure attacks Epileptic seizures Electroencephalogram (EEG) Brain network Criticality
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title	Distance to criticality undergoes critical transition before epileptic seizure attacks
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title_full	Distance to criticality undergoes critical transition before epileptic seizure attacks
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title_sort	distance to criticality undergoes critical transition before epileptic seizure attacks
title_auth	Distance to criticality undergoes critical transition before epileptic seizure attacks
abstract	Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures.
abstractGer	Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures.
abstract_unstemmed	Epilepsy is a common neurological disorder characterized by recurring seizures, but its underlying mechanisms remain poorly understood. Despite extensive research, there are still gaps in our knowledge about the relationship between brain dynamics and seizures. In this study, our aim is to address these gaps by proposing a novel approach to assess the role of brain network dynamics in the onset of seizures. Specifically, we investigate the relationship between brain dynamics and seizures by tracking the distance to criticality. Our hypothesis is that this distance plays a crucial role in brain state changes and that seizures may be related to critical transitions of this distance. To test this hypothesis, we develop a method to measure the evolution of the brain network’s distance to the critical dynamic systems (i.e., the distance to the tipping point, DTP) using dynamic network biomarker theory and random matrix theory. The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. This study advances our understanding of the relationship between brain dynamics and seizures and highlights the potential for using criticality-based measures to predict and prevent seizures.
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title_short	Distance to criticality undergoes critical transition before epileptic seizure attacks
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up_date	2024-07-06T16:36:01.308Z
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The results show that the DTP of the brain decreases significantly immediately after onset of an epileptic seizure, suggesting that the brain loses its well-defined quasi-critical state during seizures. We refer to this phenomenon as the “criticality of the criticality” (COC). Furthermore, we observe that DTP exhibits a shape transition before and after the onset of the seizures. This phenomenon suggests the possibility of early warning signal (EWS) identification in the dynamic sequence of DTP, which could be utilized for seizure prediction. Our results show that the Hurst exponent, skewness, kurtosis, autocorrelation, and variance of the DTP sequence are potential EWS features. 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Distance to criticality undergoes critical transition before epileptic seizure attacks

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