Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review

Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Belletti, Alessandro [verfasserIn] Pallanch, Ottavia [verfasserIn] Bonizzoni, Matteo Aldo [verfasserIn] Guidi, Leonardo [verfasserIn] De Cobelli, Francesco [verfasserIn] Landoni, Giovanni [verfasserIn] Zangrillo, Alberto [verfasserIn] De Bonis, Michele [verfasserIn] Palumbo, Diego [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Macklin effect Barotrauma Pneumothorax Pneumomediastinum Mechanical ventilation Acute respiratory distress syndrome

Übergeordnetes Werk:	Enthalten in: Respiratory medicine - Burlington, Mass. : Harcourt, 1999, 210
Übergeordnetes Werk:	volume:210

DOI / URN:	10.1016/j.rmed.2023.107178

Katalog-ID:	ELV060632313

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100	1		\|a Belletti, Alessandro \|e verfasserin \|0 (orcid)0000-0003-3131-0565 \|4 aut
245	1	0	\|a Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review
264		1	\|c 2023
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520			\|a Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified.
650		4	\|a Macklin effect
650		4	\|a Barotrauma
650		4	\|a Pneumothorax
650		4	\|a Pneumomediastinum
650		4	\|a Mechanical ventilation
650		4	\|a Acute respiratory distress syndrome
700	1		\|a Pallanch, Ottavia \|e verfasserin \|4 aut
700	1		\|a Bonizzoni, Matteo Aldo \|e verfasserin \|0 (orcid)0000-0003-2007-7665 \|4 aut
700	1		\|a Guidi, Leonardo \|e verfasserin \|4 aut
700	1		\|a De Cobelli, Francesco \|e verfasserin \|4 aut
700	1		\|a Landoni, Giovanni \|e verfasserin \|4 aut
700	1		\|a Zangrillo, Alberto \|e verfasserin \|0 (orcid)0000-0002-7687-7648 \|4 aut
700	1		\|a De Bonis, Michele \|e verfasserin \|4 aut
700	1		\|a Palumbo, Diego \|e verfasserin \|0 (orcid)0000-0002-7906-540X \|4 aut
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allfields	10.1016/j.rmed.2023.107178 doi (DE-627)ELV060632313 (ELSEVIER)S0954-6111(23)00066-5 DE-627 ger DE-627 rda eng 610 VZ 44.84 bkl Belletti, Alessandro verfasserin (orcid)0000-0003-3131-0565 aut Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified. Macklin effect Barotrauma Pneumothorax Pneumomediastinum Mechanical ventilation Acute respiratory distress syndrome Pallanch, Ottavia verfasserin aut Bonizzoni, Matteo Aldo verfasserin (orcid)0000-0003-2007-7665 aut Guidi, Leonardo verfasserin aut De Cobelli, Francesco verfasserin aut Landoni, Giovanni verfasserin aut Zangrillo, Alberto verfasserin (orcid)0000-0002-7687-7648 aut De Bonis, Michele verfasserin aut Palumbo, Diego verfasserin (orcid)0000-0002-7906-540X aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 210 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:210 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2055 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.84 Pulmologie VZ AR 210
spelling	10.1016/j.rmed.2023.107178 doi (DE-627)ELV060632313 (ELSEVIER)S0954-6111(23)00066-5 DE-627 ger DE-627 rda eng 610 VZ 44.84 bkl Belletti, Alessandro verfasserin (orcid)0000-0003-3131-0565 aut Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified. Macklin effect Barotrauma Pneumothorax Pneumomediastinum Mechanical ventilation Acute respiratory distress syndrome Pallanch, Ottavia verfasserin aut Bonizzoni, Matteo Aldo verfasserin (orcid)0000-0003-2007-7665 aut Guidi, Leonardo verfasserin aut De Cobelli, Francesco verfasserin aut Landoni, Giovanni verfasserin aut Zangrillo, Alberto verfasserin (orcid)0000-0002-7687-7648 aut De Bonis, Michele verfasserin aut Palumbo, Diego verfasserin (orcid)0000-0002-7906-540X aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 210 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:210 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2055 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.84 Pulmologie VZ AR 210
allfields_unstemmed	10.1016/j.rmed.2023.107178 doi (DE-627)ELV060632313 (ELSEVIER)S0954-6111(23)00066-5 DE-627 ger DE-627 rda eng 610 VZ 44.84 bkl Belletti, Alessandro verfasserin (orcid)0000-0003-3131-0565 aut Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified. Macklin effect Barotrauma Pneumothorax Pneumomediastinum Mechanical ventilation Acute respiratory distress syndrome Pallanch, Ottavia verfasserin aut Bonizzoni, Matteo Aldo verfasserin (orcid)0000-0003-2007-7665 aut Guidi, Leonardo verfasserin aut De Cobelli, Francesco verfasserin aut Landoni, Giovanni verfasserin aut Zangrillo, Alberto verfasserin (orcid)0000-0002-7687-7648 aut De Bonis, Michele verfasserin aut Palumbo, Diego verfasserin (orcid)0000-0002-7906-540X aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 210 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:210 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2055 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.84 Pulmologie VZ AR 210
allfieldsGer	10.1016/j.rmed.2023.107178 doi (DE-627)ELV060632313 (ELSEVIER)S0954-6111(23)00066-5 DE-627 ger DE-627 rda eng 610 VZ 44.84 bkl Belletti, Alessandro verfasserin (orcid)0000-0003-3131-0565 aut Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified. Macklin effect Barotrauma Pneumothorax Pneumomediastinum Mechanical ventilation Acute respiratory distress syndrome Pallanch, Ottavia verfasserin aut Bonizzoni, Matteo Aldo verfasserin (orcid)0000-0003-2007-7665 aut Guidi, Leonardo verfasserin aut De Cobelli, Francesco verfasserin aut Landoni, Giovanni verfasserin aut Zangrillo, Alberto verfasserin (orcid)0000-0002-7687-7648 aut De Bonis, Michele verfasserin aut Palumbo, Diego verfasserin (orcid)0000-0002-7906-540X aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 210 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:210 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2055 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.84 Pulmologie VZ AR 210
allfieldsSound	10.1016/j.rmed.2023.107178 doi (DE-627)ELV060632313 (ELSEVIER)S0954-6111(23)00066-5 DE-627 ger DE-627 rda eng 610 VZ 44.84 bkl Belletti, Alessandro verfasserin (orcid)0000-0003-3131-0565 aut Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified. Macklin effect Barotrauma Pneumothorax Pneumomediastinum Mechanical ventilation Acute respiratory distress syndrome Pallanch, Ottavia verfasserin aut Bonizzoni, Matteo Aldo verfasserin (orcid)0000-0003-2007-7665 aut Guidi, Leonardo verfasserin aut De Cobelli, Francesco verfasserin aut Landoni, Giovanni verfasserin aut Zangrillo, Alberto verfasserin (orcid)0000-0002-7687-7648 aut De Bonis, Michele verfasserin aut Palumbo, Diego verfasserin (orcid)0000-0002-7906-540X aut Enthalten in Respiratory medicine Burlington, Mass. : Harcourt, 1999 210 Online-Ressource (DE-627)320420973 (DE-600)2002557-9 (DE-576)103746870 1532-3064 nnns volume:210 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2021 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2055 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.84 Pulmologie VZ AR 210
language	English
source	Enthalten in Respiratory medicine 210 volume:210
sourceStr	Enthalten in Respiratory medicine 210 volume:210
format_phy_str_mv	Article
bklname	Pulmologie
institution	findex.gbv.de
topic_facet	Macklin effect Barotrauma Pneumothorax Pneumomediastinum Mechanical ventilation Acute respiratory distress syndrome
dewey-raw	610
isfreeaccess_bool	false
container_title	Respiratory medicine
authorswithroles_txt_mv	Belletti, Alessandro @@aut@@ Pallanch, Ottavia @@aut@@ Bonizzoni, Matteo Aldo @@aut@@ Guidi, Leonardo @@aut@@ De Cobelli, Francesco @@aut@@ Landoni, Giovanni @@aut@@ Zangrillo, Alberto @@aut@@ De Bonis, Michele @@aut@@ Palumbo, Diego @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	320420973
dewey-sort	3610
id	ELV060632313
language_de	englisch
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We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. 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author	Belletti, Alessandro
spellingShingle	Belletti, Alessandro ddc 610 bkl 44.84 misc Macklin effect misc Barotrauma misc Pneumothorax misc Pneumomediastinum misc Mechanical ventilation misc Acute respiratory distress syndrome Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review
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topic_title	610 VZ 44.84 bkl Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review Macklin effect Barotrauma Pneumothorax Pneumomediastinum Mechanical ventilation Acute respiratory distress syndrome
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title	Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review
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title_full	Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review
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author_browse	Belletti, Alessandro Pallanch, Ottavia Bonizzoni, Matteo Aldo Guidi, Leonardo De Cobelli, Francesco Landoni, Giovanni Zangrillo, Alberto De Bonis, Michele Palumbo, Diego
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title_sort	clinical use of macklin-like radiological sign (macklin effect): a systematic review
title_auth	Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review
abstract	Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified.
abstractGer	Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified.
abstract_unstemmed	Introduction: Recent studies suggested that Macklin sign is a predictor of barotrauma in patients with acute respiratory distress syndrome (ARDS). We performed a systematic review to further characterize the clinical role of Macklin.Methods: PubMed, Scopus, Cochrane Central Register and Embase were searched for studies reporting data on Macklin. Studies without data on chest CT, pediatric studies, non-human and cadaver studies, case reports and series including <5 patients were excluded. The primary objective was to assess the number of patients with Macklin sign and barotrauma. Secondary objectives were: occurrence of Macklin in different populations, clinical use of Macklin, prognostic impact of Macklin.Results: Seven studies enrolling 979 patients were included. Macklin was present in 4–22% of COVID-19 patients. It was associated with barotrauma in 124/138 (89.8%) of cases. Macklin sign preceded barotrauma in 65/69 cases (94.2%) 3–8 days in advance. Four studies used Macklin as pathophysiological explanation for barotrauma, two studies as a predictor of barotrauma and one as a decision-making tool. Two studies suggested that Macklin is a strong predictor of barotrauma in ARDS patients and one study used Macklin sign to candidate high-risk ARDS patients to awake extracorporeal membrane oxygenation (ECMO). A possible correlation between Macklin and worse prognosis was suggested in two studies on COVID-19 and blunt chest trauma.Conclusions: Increasing evidence suggests that Macklin sign anticipate barotrauma in patients with ARDS and there are initial reports on use of Macklin as a decision-making tool. Further studies investigating the role of Macklin sign in ARDS are justified.
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title_short	Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review
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author2	Pallanch, Ottavia Bonizzoni, Matteo Aldo Guidi, Leonardo De Cobelli, Francesco Landoni, Giovanni Zangrillo, Alberto De Bonis, Michele Palumbo, Diego
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up_date	2024-07-06T16:38:49.058Z
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Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review

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