Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults

Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid arte...
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Autor*in:	Zhou, Tianyu [verfasserIn] Im, Pek Kei [verfasserIn] Hariri, Parisa [verfasserIn] Du, Huaidong [verfasserIn] Guo, Yu [verfasserIn] Lin, Kuang [verfasserIn] Yang, Ling [verfasserIn] Yu, Canqing [verfasserIn] Chen, Yiping [verfasserIn] Sohoni, Rajani [verfasserIn] Avery, Daniel [verfasserIn] Guan, Meiyu [verfasserIn] Yang, Meng [verfasserIn] Lv, Jun [verfasserIn] Clarke, Robert [verfasserIn] Li, Liming [verfasserIn] Walters, Robin G. [verfasserIn] Chen, Zhengming [verfasserIn] Millwood, Iona Y. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Alcohol Aldehyde dehydrogenase Alcohol dehydrogenase Mendelian randomization Carotid intima media thickness Carotid plaque Atherosclerosis

Übergeordnetes Werk:	Enthalten in: Atherosclerosis - Amsterdam [u.a.] : Elsevier Science, 1970, 377, Seite 34-42
Übergeordnetes Werk:	volume:377 ; pages:34-42

DOI / URN:	10.1016/j.atherosclerosis.2023.06.012

Katalog-ID:	ELV060705175

Internformat


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035			\|a (DE-627)ELV060705175
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100	1		\|a Zhou, Tianyu \|e verfasserin \|4 aut
245	1	0	\|a Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults
264		1	\|c 2023
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis.
650		4	\|a Alcohol
650		4	\|a Aldehyde dehydrogenase
650		4	\|a Alcohol dehydrogenase
650		4	\|a Mendelian randomization
650		4	\|a Carotid intima media thickness
650		4	\|a Carotid plaque
650		4	\|a Atherosclerosis
700	1		\|a Im, Pek Kei \|e verfasserin \|0 (orcid)0000-0002-2624-9766 \|4 aut
700	1		\|a Hariri, Parisa \|e verfasserin \|4 aut
700	1		\|a Du, Huaidong \|e verfasserin \|4 aut
700	1		\|a Guo, Yu \|e verfasserin \|4 aut
700	1		\|a Lin, Kuang \|e verfasserin \|4 aut
700	1		\|a Yang, Ling \|e verfasserin \|4 aut
700	1		\|a Yu, Canqing \|e verfasserin \|4 aut
700	1		\|a Chen, Yiping \|e verfasserin \|4 aut
700	1		\|a Sohoni, Rajani \|e verfasserin \|4 aut
700	1		\|a Avery, Daniel \|e verfasserin \|4 aut
700	1		\|a Guan, Meiyu \|e verfasserin \|4 aut
700	1		\|a Yang, Meng \|e verfasserin \|4 aut
700	1		\|a Lv, Jun \|e verfasserin \|4 aut
700	1		\|a Clarke, Robert \|e verfasserin \|4 aut
700	1		\|a Li, Liming \|e verfasserin \|4 aut
700	1		\|a Walters, Robin G. \|e verfasserin \|4 aut
700	1		\|a Chen, Zhengming \|e verfasserin \|4 aut
700	1		\|a Millwood, Iona Y. \|e verfasserin \|0 (orcid)0000-0002-0807-0682 \|4 aut
773	0	8	\|i Enthalten in \|t Atherosclerosis \|d Amsterdam [u.a.] : Elsevier Science, 1970 \|g 377, Seite 34-42 \|h Online-Ressource \|w (DE-627)306654091 \|w (DE-600)1499887-7 \|w (DE-576)081984545 \|x 1879-1484 \|7 nnns
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912			\|a GBV_ILN_62
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912			\|a GBV_ILN_69
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912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
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912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
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912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
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912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.85 \|j Kardiologie \|j Angiologie \|q VZ
951			\|a AR
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Indexfelder

author_variant	t z tz p k i pk pki p h ph h d hd y g yg k l kl l y ly c y cy y c yc r s rs d a da m g mg m y my j l jl r c rc l l ll r g w rg rgw z c zc i y m iy iym
matchkey_str	article:18791484:2023----::soitosflooitkwtsblnclaoiahrslrs
hierarchy_sort_str	2023
bklnumber	44.85
publishDate	2023
allfields	10.1016/j.atherosclerosis.2023.06.012 doi (DE-627)ELV060705175 (ELSEVIER)S0021-9150(23)03400-7 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Zhou, Tianyu verfasserin aut Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis. Alcohol Aldehyde dehydrogenase Alcohol dehydrogenase Mendelian randomization Carotid intima media thickness Carotid plaque Atherosclerosis Im, Pek Kei verfasserin (orcid)0000-0002-2624-9766 aut Hariri, Parisa verfasserin aut Du, Huaidong verfasserin aut Guo, Yu verfasserin aut Lin, Kuang verfasserin aut Yang, Ling verfasserin aut Yu, Canqing verfasserin aut Chen, Yiping verfasserin aut Sohoni, Rajani verfasserin aut Avery, Daniel verfasserin aut Guan, Meiyu verfasserin aut Yang, Meng verfasserin aut Lv, Jun verfasserin aut Clarke, Robert verfasserin aut Li, Liming verfasserin aut Walters, Robin G. verfasserin aut Chen, Zhengming verfasserin aut Millwood, Iona Y. verfasserin (orcid)0000-0002-0807-0682 aut Enthalten in Atherosclerosis Amsterdam [u.a.] : Elsevier Science, 1970 377, Seite 34-42 Online-Ressource (DE-627)306654091 (DE-600)1499887-7 (DE-576)081984545 1879-1484 nnns volume:377 pages:34-42 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 377 34-42
spelling	10.1016/j.atherosclerosis.2023.06.012 doi (DE-627)ELV060705175 (ELSEVIER)S0021-9150(23)03400-7 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Zhou, Tianyu verfasserin aut Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis. Alcohol Aldehyde dehydrogenase Alcohol dehydrogenase Mendelian randomization Carotid intima media thickness Carotid plaque Atherosclerosis Im, Pek Kei verfasserin (orcid)0000-0002-2624-9766 aut Hariri, Parisa verfasserin aut Du, Huaidong verfasserin aut Guo, Yu verfasserin aut Lin, Kuang verfasserin aut Yang, Ling verfasserin aut Yu, Canqing verfasserin aut Chen, Yiping verfasserin aut Sohoni, Rajani verfasserin aut Avery, Daniel verfasserin aut Guan, Meiyu verfasserin aut Yang, Meng verfasserin aut Lv, Jun verfasserin aut Clarke, Robert verfasserin aut Li, Liming verfasserin aut Walters, Robin G. verfasserin aut Chen, Zhengming verfasserin aut Millwood, Iona Y. verfasserin (orcid)0000-0002-0807-0682 aut Enthalten in Atherosclerosis Amsterdam [u.a.] : Elsevier Science, 1970 377, Seite 34-42 Online-Ressource (DE-627)306654091 (DE-600)1499887-7 (DE-576)081984545 1879-1484 nnns volume:377 pages:34-42 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 377 34-42
allfields_unstemmed	10.1016/j.atherosclerosis.2023.06.012 doi (DE-627)ELV060705175 (ELSEVIER)S0021-9150(23)03400-7 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Zhou, Tianyu verfasserin aut Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis. Alcohol Aldehyde dehydrogenase Alcohol dehydrogenase Mendelian randomization Carotid intima media thickness Carotid plaque Atherosclerosis Im, Pek Kei verfasserin (orcid)0000-0002-2624-9766 aut Hariri, Parisa verfasserin aut Du, Huaidong verfasserin aut Guo, Yu verfasserin aut Lin, Kuang verfasserin aut Yang, Ling verfasserin aut Yu, Canqing verfasserin aut Chen, Yiping verfasserin aut Sohoni, Rajani verfasserin aut Avery, Daniel verfasserin aut Guan, Meiyu verfasserin aut Yang, Meng verfasserin aut Lv, Jun verfasserin aut Clarke, Robert verfasserin aut Li, Liming verfasserin aut Walters, Robin G. verfasserin aut Chen, Zhengming verfasserin aut Millwood, Iona Y. verfasserin (orcid)0000-0002-0807-0682 aut Enthalten in Atherosclerosis Amsterdam [u.a.] : Elsevier Science, 1970 377, Seite 34-42 Online-Ressource (DE-627)306654091 (DE-600)1499887-7 (DE-576)081984545 1879-1484 nnns volume:377 pages:34-42 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 377 34-42
allfieldsGer	10.1016/j.atherosclerosis.2023.06.012 doi (DE-627)ELV060705175 (ELSEVIER)S0021-9150(23)03400-7 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Zhou, Tianyu verfasserin aut Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis. Alcohol Aldehyde dehydrogenase Alcohol dehydrogenase Mendelian randomization Carotid intima media thickness Carotid plaque Atherosclerosis Im, Pek Kei verfasserin (orcid)0000-0002-2624-9766 aut Hariri, Parisa verfasserin aut Du, Huaidong verfasserin aut Guo, Yu verfasserin aut Lin, Kuang verfasserin aut Yang, Ling verfasserin aut Yu, Canqing verfasserin aut Chen, Yiping verfasserin aut Sohoni, Rajani verfasserin aut Avery, Daniel verfasserin aut Guan, Meiyu verfasserin aut Yang, Meng verfasserin aut Lv, Jun verfasserin aut Clarke, Robert verfasserin aut Li, Liming verfasserin aut Walters, Robin G. verfasserin aut Chen, Zhengming verfasserin aut Millwood, Iona Y. verfasserin (orcid)0000-0002-0807-0682 aut Enthalten in Atherosclerosis Amsterdam [u.a.] : Elsevier Science, 1970 377, Seite 34-42 Online-Ressource (DE-627)306654091 (DE-600)1499887-7 (DE-576)081984545 1879-1484 nnns volume:377 pages:34-42 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 377 34-42
allfieldsSound	10.1016/j.atherosclerosis.2023.06.012 doi (DE-627)ELV060705175 (ELSEVIER)S0021-9150(23)03400-7 DE-627 ger DE-627 rda eng 610 VZ 44.85 bkl Zhou, Tianyu verfasserin aut Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis. Alcohol Aldehyde dehydrogenase Alcohol dehydrogenase Mendelian randomization Carotid intima media thickness Carotid plaque Atherosclerosis Im, Pek Kei verfasserin (orcid)0000-0002-2624-9766 aut Hariri, Parisa verfasserin aut Du, Huaidong verfasserin aut Guo, Yu verfasserin aut Lin, Kuang verfasserin aut Yang, Ling verfasserin aut Yu, Canqing verfasserin aut Chen, Yiping verfasserin aut Sohoni, Rajani verfasserin aut Avery, Daniel verfasserin aut Guan, Meiyu verfasserin aut Yang, Meng verfasserin aut Lv, Jun verfasserin aut Clarke, Robert verfasserin aut Li, Liming verfasserin aut Walters, Robin G. verfasserin aut Chen, Zhengming verfasserin aut Millwood, Iona Y. verfasserin (orcid)0000-0002-0807-0682 aut Enthalten in Atherosclerosis Amsterdam [u.a.] : Elsevier Science, 1970 377, Seite 34-42 Online-Ressource (DE-627)306654091 (DE-600)1499887-7 (DE-576)081984545 1879-1484 nnns volume:377 pages:34-42 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 377 34-42
language	English
source	Enthalten in Atherosclerosis 377, Seite 34-42 volume:377 pages:34-42
sourceStr	Enthalten in Atherosclerosis 377, Seite 34-42 volume:377 pages:34-42
format_phy_str_mv	Article
bklname	Kardiologie Angiologie
institution	findex.gbv.de
topic_facet	Alcohol Aldehyde dehydrogenase Alcohol dehydrogenase Mendelian randomization Carotid intima media thickness Carotid plaque Atherosclerosis
dewey-raw	610
isfreeaccess_bool	false
container_title	Atherosclerosis
authorswithroles_txt_mv	Zhou, Tianyu @@aut@@ Im, Pek Kei @@aut@@ Hariri, Parisa @@aut@@ Du, Huaidong @@aut@@ Guo, Yu @@aut@@ Lin, Kuang @@aut@@ Yang, Ling @@aut@@ Yu, Canqing @@aut@@ Chen, Yiping @@aut@@ Sohoni, Rajani @@aut@@ Avery, Daniel @@aut@@ Guan, Meiyu @@aut@@ Yang, Meng @@aut@@ Lv, Jun @@aut@@ Clarke, Robert @@aut@@ Li, Liming @@aut@@ Walters, Robin G. @@aut@@ Chen, Zhengming @@aut@@ Millwood, Iona Y. @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	306654091
dewey-sort	3610
id	ELV060705175
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV060705175</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230927074529.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230721s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.atherosclerosis.2023.06.012</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV060705175</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0021-9150(23)03400-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.85</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Zhou, Tianyu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alcohol</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Aldehyde dehydrogenase</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alcohol dehydrogenase</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mendelian randomization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carotid intima media thickness</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carotid 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author	Zhou, Tianyu
spellingShingle	Zhou, Tianyu ddc 610 bkl 44.85 misc Alcohol misc Aldehyde dehydrogenase misc Alcohol dehydrogenase misc Mendelian randomization misc Carotid intima media thickness misc Carotid plaque misc Atherosclerosis Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults
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topic_title	610 VZ 44.85 bkl Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults Alcohol Aldehyde dehydrogenase Alcohol dehydrogenase Mendelian randomization Carotid intima media thickness Carotid plaque Atherosclerosis
topic	ddc 610 bkl 44.85 misc Alcohol misc Aldehyde dehydrogenase misc Alcohol dehydrogenase misc Mendelian randomization misc Carotid intima media thickness misc Carotid plaque misc Atherosclerosis
topic_unstemmed	ddc 610 bkl 44.85 misc Alcohol misc Aldehyde dehydrogenase misc Alcohol dehydrogenase misc Mendelian randomization misc Carotid intima media thickness misc Carotid plaque misc Atherosclerosis
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title	Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults
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title_full	Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults
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author_browse	Zhou, Tianyu Im, Pek Kei Hariri, Parisa Du, Huaidong Guo, Yu Lin, Kuang Yang, Ling Yu, Canqing Chen, Yiping Sohoni, Rajani Avery, Daniel Guan, Meiyu Yang, Meng Lv, Jun Clarke, Robert Li, Liming Walters, Robin G. Chen, Zhengming Millwood, Iona Y.
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title_sort	associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 chinese adults
title_auth	Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults
abstract	Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis.
abstractGer	Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis.
abstract_unstemmed	Background and aims: We investigated the causal relevance of alcohol intake with measures of carotid artery thickness and atherosclerosis in Chinese adults.Methods: The study included 22,384 adults from the China Kadoorie Biobank, with self-reported alcohol use at baseline and resurvey, carotid artery ultrasound measurements, and genotyping data for ALDH2-rs671 and ADH1B-rs1229984. Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis.
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title_short	Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults
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author2	Im, Pek Kei Hariri, Parisa Du, Huaidong Guo, Yu Lin, Kuang Yang, Ling Yu, Canqing Chen, Yiping Sohoni, Rajani Avery, Daniel Guan, Meiyu Yang, Meng Lv, Jun Clarke, Robert Li, Liming Walters, Robin G. Chen, Zhengming Millwood, Iona Y.
author2Str	Im, Pek Kei Hariri, Parisa Du, Huaidong Guo, Yu Lin, Kuang Yang, Ling Yu, Canqing Chen, Yiping Sohoni, Rajani Avery, Daniel Guan, Meiyu Yang, Meng Lv, Jun Clarke, Robert Li, Liming Walters, Robin G. Chen, Zhengming Millwood, Iona Y.
ppnlink	306654091
mediatype_str_mv	c
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doi_str	10.1016/j.atherosclerosis.2023.06.012
up_date	2024-07-06T16:43:26.578Z
_version_	1803848732201975808
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Associations of carotid intima media thickness (cIMT), any carotid plaque, and total plaque burden (derived from plaque number and size) with self-reported (conventional analyses) and genotype-predicted mean alcohol intake (Mendelian randomization) were assessed using linear and logistic regression models.Results: Overall 34.2% men and 2.1% women drank alcohol regularly at baseline. Mean cIMT was 0.70 mm in men and 0.64 mm in women, with 39.1% and 26.5% having carotid plaque, respectively. Among men, cIMT was not associated with self-reported or genotype-predicted mean alcohol intake. The risk of plaque increased significantly with self-reported intake among current drinkers (odds ratio 1.42 [95% CI 1.14–1.76] per 280 g/week), with directionally consistent findings with genotype-predicted mean intake (1.21 [0.99–1.49]). Higher alcohol intake was significantly associated with higher carotid plaque burden in both conventional (0.19 [0.10–0.28] mm higher per 280 g/week) and genetic analyses (0.09 [0.02–0.17]). Genetic findings in women suggested the association of genotype-predicted alcohol with carotid plaque burden in men was likely to due to alcohol itself, rather than pleiotropic genotypic effects.Conclusions: Higher alcohol intake was associated with a higher carotid plaque burden, but not with cIMT, providing support for a potential causal association of alcohol intake with carotid atherosclerosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alcohol</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Aldehyde dehydrogenase</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alcohol dehydrogenase</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mendelian randomization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carotid intima media thickness</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carotid 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Associations of alcohol intake with subclinical carotid atherosclerosis in 22,000 Chinese adults

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