Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy
A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sun, Chang [verfasserIn] van Soest, Johan [verfasserIn] Dumontier, Michel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of biomedical informatics - San Diego, Calif. : Academic Press, 2001, 143 |
|---|---|
| Übergeordnetes Werk: |
volume:143 |
| DOI / URN: |
10.1016/j.jbi.2023.104404 |
|---|
| Katalog-ID: |
ELV060735767 |
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| 520 | |a A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. | ||
| 650 | 4 | |a Synthetic data | |
| 650 | 4 | |a Synthetic health data | |
| 650 | 4 | |a Generative adversarial network | |
| 650 | 4 | |a Data privacy | |
| 650 | 4 | |a Health data sharing | |
| 700 | 1 | |a van Soest, Johan |e verfasserin |0 (orcid)0000-0003-2548-0330 |4 aut | |
| 700 | 1 | |a Dumontier, Michel |e verfasserin |0 (orcid)0000-0003-4727-9435 |4 aut | |
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10.1016/j.jbi.2023.104404 doi (DE-627)ELV060735767 (ELSEVIER)S1532-0464(23)00125-9 DE-627 ger DE-627 rda eng 330 004 570 VZ 44.32 bkl Sun, Chang verfasserin (orcid)0000-0001-8325-8848 aut Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. Synthetic data Synthetic health data Generative adversarial network Data privacy Health data sharing van Soest, Johan verfasserin (orcid)0000-0003-2548-0330 aut Dumontier, Michel verfasserin (orcid)0000-0003-4727-9435 aut Enthalten in Journal of biomedical informatics San Diego, Calif. : Academic Press, 2001 143 Online-Ressource (DE-627)334290791 (DE-600)2057141-0 (DE-576)104194502 1532-0480 nnns volume:143 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.32 Medizinische Mathematik medizinische Statistik VZ AR 143 |
| spelling |
10.1016/j.jbi.2023.104404 doi (DE-627)ELV060735767 (ELSEVIER)S1532-0464(23)00125-9 DE-627 ger DE-627 rda eng 330 004 570 VZ 44.32 bkl Sun, Chang verfasserin (orcid)0000-0001-8325-8848 aut Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. Synthetic data Synthetic health data Generative adversarial network Data privacy Health data sharing van Soest, Johan verfasserin (orcid)0000-0003-2548-0330 aut Dumontier, Michel verfasserin (orcid)0000-0003-4727-9435 aut Enthalten in Journal of biomedical informatics San Diego, Calif. : Academic Press, 2001 143 Online-Ressource (DE-627)334290791 (DE-600)2057141-0 (DE-576)104194502 1532-0480 nnns volume:143 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.32 Medizinische Mathematik medizinische Statistik VZ AR 143 |
| allfields_unstemmed |
10.1016/j.jbi.2023.104404 doi (DE-627)ELV060735767 (ELSEVIER)S1532-0464(23)00125-9 DE-627 ger DE-627 rda eng 330 004 570 VZ 44.32 bkl Sun, Chang verfasserin (orcid)0000-0001-8325-8848 aut Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. Synthetic data Synthetic health data Generative adversarial network Data privacy Health data sharing van Soest, Johan verfasserin (orcid)0000-0003-2548-0330 aut Dumontier, Michel verfasserin (orcid)0000-0003-4727-9435 aut Enthalten in Journal of biomedical informatics San Diego, Calif. : Academic Press, 2001 143 Online-Ressource (DE-627)334290791 (DE-600)2057141-0 (DE-576)104194502 1532-0480 nnns volume:143 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.32 Medizinische Mathematik medizinische Statistik VZ AR 143 |
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10.1016/j.jbi.2023.104404 doi (DE-627)ELV060735767 (ELSEVIER)S1532-0464(23)00125-9 DE-627 ger DE-627 rda eng 330 004 570 VZ 44.32 bkl Sun, Chang verfasserin (orcid)0000-0001-8325-8848 aut Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. Synthetic data Synthetic health data Generative adversarial network Data privacy Health data sharing van Soest, Johan verfasserin (orcid)0000-0003-2548-0330 aut Dumontier, Michel verfasserin (orcid)0000-0003-4727-9435 aut Enthalten in Journal of biomedical informatics San Diego, Calif. : Academic Press, 2001 143 Online-Ressource (DE-627)334290791 (DE-600)2057141-0 (DE-576)104194502 1532-0480 nnns volume:143 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.32 Medizinische Mathematik medizinische Statistik VZ AR 143 |
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10.1016/j.jbi.2023.104404 doi (DE-627)ELV060735767 (ELSEVIER)S1532-0464(23)00125-9 DE-627 ger DE-627 rda eng 330 004 570 VZ 44.32 bkl Sun, Chang verfasserin (orcid)0000-0001-8325-8848 aut Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. Synthetic data Synthetic health data Generative adversarial network Data privacy Health data sharing van Soest, Johan verfasserin (orcid)0000-0003-2548-0330 aut Dumontier, Michel verfasserin (orcid)0000-0003-4727-9435 aut Enthalten in Journal of biomedical informatics San Diego, Calif. : Academic Press, 2001 143 Online-Ressource (DE-627)334290791 (DE-600)2057141-0 (DE-576)104194502 1532-0480 nnns volume:143 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.32 Medizinische Mathematik medizinische Statistik VZ AR 143 |
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Sun, Chang |
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Sun, Chang ddc 330 bkl 44.32 misc Synthetic data misc Synthetic health data misc Generative adversarial network misc Data privacy misc Health data sharing Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy |
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330 004 570 VZ 44.32 bkl Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy Synthetic data Synthetic health data Generative adversarial network Data privacy Health data sharing |
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generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy |
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Generating synthetic personal health data using conditional generative adversarial networks combining with differential privacy |
| abstract |
A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. |
| abstractGer |
A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. |
| abstract_unstemmed |
A large amount of personal health data that is highly valuable to the scientific community is still not accessible or requires a lengthy request process due to privacy concerns and legal restrictions. As a solution, synthetic data has been studied and proposed to be a promising alternative to this issue. However, generating realistic and privacy-preserving synthetic personal health data retains challenges such as simulating the characteristics of the patients’ data that are in the minority classes, capturing the relations among variables in imbalanced data and transferring them to the synthetic data, and preserving individual patients’ privacy. In this paper, we propose a differentially private conditional Generative Adversarial Network model (DP-CGANS) consisting of data transformation, sampling, conditioning, and network training to generate realistic and privacy-preserving personal data. Our model distinguishes categorical and continuous variables and transforms them into latent space separately for better training performance. We tackle the unique challenges of generating synthetic patient data due to the special data characteristics of personal health data. For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. Finally, we present the balance between data utility and privacy in synthetic data generation considering the different data structures and characteristics of real-world personal health data such as imbalanced classes, abnormal distributions, and data sparsity. |
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For example, patients with a certain disease are typically the minority in the dataset and the relations among variables are crucial to be observed. Our model is structured with a conditional vector as an additional input to present the minority class in the imbalanced data and maximally capture the dependency between variables. Moreover, we inject statistical noise into the gradients in the networking training process of DP-CGANS to provide a differential privacy guarantee. We extensively evaluate our model with state-of-the-art generative models on personal socio-economic datasets and real-world personal health datasets in terms of statistical similarity, machine learning performance, and privacy measurement. We demonstrate that our model outperforms other comparable models, especially in capturing the dependence between variables. 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