Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study
Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhang, Jiayou [verfasserIn] Nian, Xuanxuan [verfasserIn] Liu, Bo [verfasserIn] Zhang, Zhegang [verfasserIn] Zhao, Wei [verfasserIn] Han, Xixin [verfasserIn] Ma, Yumei [verfasserIn] Jin, Dongwu [verfasserIn] Ma, Hua [verfasserIn] Zhang, Qingmei [verfasserIn] Qiu, Ran [verfasserIn] Li, Fang [verfasserIn] Gong, Zheng [verfasserIn] Li, Xuedan [verfasserIn] Yang, Ying [verfasserIn] Tian, Yichao [verfasserIn] Zhou, Li [verfasserIn] Duan, Kai [verfasserIn] Li, Xinguo [verfasserIn] Ma, Zhongren [verfasserIn] Yang, Xiaoming [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Antiviral research - Amsterdam [u.a.] : Elsevier Science, 1981, 216 |
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| Übergeordnetes Werk: |
volume:216 |
| DOI / URN: |
10.1016/j.antiviral.2023.105639 |
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| Katalog-ID: |
ELV061036358 |
|---|
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| 520 | |a Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. | ||
| 650 | 4 | |a Influenza | |
| 650 | 4 | |a Madin–Darby canine kidney (MDCK) cells | |
| 650 | 4 | |a Tolerance | |
| 650 | 4 | |a Safety | |
| 650 | 4 | |a Immunogenicity | |
| 650 | 4 | |a Protection | |
| 700 | 1 | |a Nian, Xuanxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhegang |e verfasserin |0 (orcid)0000-0002-6085-9859 |4 aut | |
| 700 | 1 | |a Zhao, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Xixin |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Yumei |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Dongwu |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qingmei |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Ran |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Gong, Zheng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xuedan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Yichao |e verfasserin |0 (orcid)0009-0005-1570-0848 |4 aut | |
| 700 | 1 | |a Zhou, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Duan, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xinguo |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Zhongren |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xiaoming |e verfasserin |0 (orcid)0000-0002-2598-4355 |4 aut | |
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| 912 | |a GBV_ILN_4338 | ||
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10.1016/j.antiviral.2023.105639 doi (DE-627)ELV061036358 (ELSEVIER)S0166-3542(23)00117-1 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 15,3 ssgn 44.43 bkl Zhang, Jiayou verfasserin aut Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. Influenza Madin–Darby canine kidney (MDCK) cells Tolerance Safety Immunogenicity Protection Nian, Xuanxuan verfasserin aut Liu, Bo verfasserin aut Zhang, Zhegang verfasserin (orcid)0000-0002-6085-9859 aut Zhao, Wei verfasserin aut Han, Xixin verfasserin aut Ma, Yumei verfasserin aut Jin, Dongwu verfasserin aut Ma, Hua verfasserin aut Zhang, Qingmei verfasserin aut Qiu, Ran verfasserin aut Li, Fang verfasserin aut Gong, Zheng verfasserin aut Li, Xuedan verfasserin aut Yang, Ying verfasserin aut Tian, Yichao verfasserin (orcid)0009-0005-1570-0848 aut Zhou, Li verfasserin aut Duan, Kai verfasserin aut Li, Xinguo verfasserin aut Ma, Zhongren verfasserin aut Yang, Xiaoming verfasserin (orcid)0000-0002-2598-4355 aut Enthalten in Antiviral research Amsterdam [u.a.] : Elsevier Science, 1981 216 Online-Ressource (DE-627)306311534 (DE-600)1495861-2 (DE-576)256113157 1872-9096 nnns volume:216 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ AR 216 |
| spelling |
10.1016/j.antiviral.2023.105639 doi (DE-627)ELV061036358 (ELSEVIER)S0166-3542(23)00117-1 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 15,3 ssgn 44.43 bkl Zhang, Jiayou verfasserin aut Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. Influenza Madin–Darby canine kidney (MDCK) cells Tolerance Safety Immunogenicity Protection Nian, Xuanxuan verfasserin aut Liu, Bo verfasserin aut Zhang, Zhegang verfasserin (orcid)0000-0002-6085-9859 aut Zhao, Wei verfasserin aut Han, Xixin verfasserin aut Ma, Yumei verfasserin aut Jin, Dongwu verfasserin aut Ma, Hua verfasserin aut Zhang, Qingmei verfasserin aut Qiu, Ran verfasserin aut Li, Fang verfasserin aut Gong, Zheng verfasserin aut Li, Xuedan verfasserin aut Yang, Ying verfasserin aut Tian, Yichao verfasserin (orcid)0009-0005-1570-0848 aut Zhou, Li verfasserin aut Duan, Kai verfasserin aut Li, Xinguo verfasserin aut Ma, Zhongren verfasserin aut Yang, Xiaoming verfasserin (orcid)0000-0002-2598-4355 aut Enthalten in Antiviral research Amsterdam [u.a.] : Elsevier Science, 1981 216 Online-Ressource (DE-627)306311534 (DE-600)1495861-2 (DE-576)256113157 1872-9096 nnns volume:216 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ AR 216 |
| allfields_unstemmed |
10.1016/j.antiviral.2023.105639 doi (DE-627)ELV061036358 (ELSEVIER)S0166-3542(23)00117-1 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 15,3 ssgn 44.43 bkl Zhang, Jiayou verfasserin aut Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. Influenza Madin–Darby canine kidney (MDCK) cells Tolerance Safety Immunogenicity Protection Nian, Xuanxuan verfasserin aut Liu, Bo verfasserin aut Zhang, Zhegang verfasserin (orcid)0000-0002-6085-9859 aut Zhao, Wei verfasserin aut Han, Xixin verfasserin aut Ma, Yumei verfasserin aut Jin, Dongwu verfasserin aut Ma, Hua verfasserin aut Zhang, Qingmei verfasserin aut Qiu, Ran verfasserin aut Li, Fang verfasserin aut Gong, Zheng verfasserin aut Li, Xuedan verfasserin aut Yang, Ying verfasserin aut Tian, Yichao verfasserin (orcid)0009-0005-1570-0848 aut Zhou, Li verfasserin aut Duan, Kai verfasserin aut Li, Xinguo verfasserin aut Ma, Zhongren verfasserin aut Yang, Xiaoming verfasserin (orcid)0000-0002-2598-4355 aut Enthalten in Antiviral research Amsterdam [u.a.] : Elsevier Science, 1981 216 Online-Ressource (DE-627)306311534 (DE-600)1495861-2 (DE-576)256113157 1872-9096 nnns volume:216 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ AR 216 |
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10.1016/j.antiviral.2023.105639 doi (DE-627)ELV061036358 (ELSEVIER)S0166-3542(23)00117-1 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 15,3 ssgn 44.43 bkl Zhang, Jiayou verfasserin aut Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. Influenza Madin–Darby canine kidney (MDCK) cells Tolerance Safety Immunogenicity Protection Nian, Xuanxuan verfasserin aut Liu, Bo verfasserin aut Zhang, Zhegang verfasserin (orcid)0000-0002-6085-9859 aut Zhao, Wei verfasserin aut Han, Xixin verfasserin aut Ma, Yumei verfasserin aut Jin, Dongwu verfasserin aut Ma, Hua verfasserin aut Zhang, Qingmei verfasserin aut Qiu, Ran verfasserin aut Li, Fang verfasserin aut Gong, Zheng verfasserin aut Li, Xuedan verfasserin aut Yang, Ying verfasserin aut Tian, Yichao verfasserin (orcid)0009-0005-1570-0848 aut Zhou, Li verfasserin aut Duan, Kai verfasserin aut Li, Xinguo verfasserin aut Ma, Zhongren verfasserin aut Yang, Xiaoming verfasserin (orcid)0000-0002-2598-4355 aut Enthalten in Antiviral research Amsterdam [u.a.] : Elsevier Science, 1981 216 Online-Ressource (DE-627)306311534 (DE-600)1495861-2 (DE-576)256113157 1872-9096 nnns volume:216 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ AR 216 |
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10.1016/j.antiviral.2023.105639 doi (DE-627)ELV061036358 (ELSEVIER)S0166-3542(23)00117-1 DE-627 ger DE-627 rda eng 610 VZ PHARM DE-84 fid 15,3 ssgn 44.43 bkl Zhang, Jiayou verfasserin aut Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. Influenza Madin–Darby canine kidney (MDCK) cells Tolerance Safety Immunogenicity Protection Nian, Xuanxuan verfasserin aut Liu, Bo verfasserin aut Zhang, Zhegang verfasserin (orcid)0000-0002-6085-9859 aut Zhao, Wei verfasserin aut Han, Xixin verfasserin aut Ma, Yumei verfasserin aut Jin, Dongwu verfasserin aut Ma, Hua verfasserin aut Zhang, Qingmei verfasserin aut Qiu, Ran verfasserin aut Li, Fang verfasserin aut Gong, Zheng verfasserin aut Li, Xuedan verfasserin aut Yang, Ying verfasserin aut Tian, Yichao verfasserin (orcid)0009-0005-1570-0848 aut Zhou, Li verfasserin aut Duan, Kai verfasserin aut Li, Xinguo verfasserin aut Ma, Zhongren verfasserin aut Yang, Xiaoming verfasserin (orcid)0000-0002-2598-4355 aut Enthalten in Antiviral research Amsterdam [u.a.] : Elsevier Science, 1981 216 Online-Ressource (DE-627)306311534 (DE-600)1495861-2 (DE-576)256113157 1872-9096 nnns volume:216 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.43 Medizinische Mikrobiologie VZ AR 216 |
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Zhang, Jiayou @@aut@@ Nian, Xuanxuan @@aut@@ Liu, Bo @@aut@@ Zhang, Zhegang @@aut@@ Zhao, Wei @@aut@@ Han, Xixin @@aut@@ Ma, Yumei @@aut@@ Jin, Dongwu @@aut@@ Ma, Hua @@aut@@ Zhang, Qingmei @@aut@@ Qiu, Ran @@aut@@ Li, Fang @@aut@@ Gong, Zheng @@aut@@ Li, Xuedan @@aut@@ Yang, Ying @@aut@@ Tian, Yichao @@aut@@ Zhou, Li @@aut@@ Duan, Kai @@aut@@ Li, Xinguo @@aut@@ Ma, Zhongren @@aut@@ Yang, Xiaoming @@aut@@ |
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2023-01-01T00:00:00Z |
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610 VZ PHARM DE-84 fid 15,3 ssgn 44.43 bkl Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study Influenza Madin–Darby canine kidney (MDCK) cells Tolerance Safety Immunogenicity Protection |
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Zhang, Jiayou Nian, Xuanxuan Liu, Bo Zhang, Zhegang Zhao, Wei Han, Xixin Ma, Yumei Jin, Dongwu Ma, Hua Zhang, Qingmei Qiu, Ran Li, Fang Gong, Zheng Li, Xuedan Yang, Ying Tian, Yichao Zhou, Li Duan, Kai Li, Xinguo Ma, Zhongren Yang, Xiaoming |
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development of mdck-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: a preclinical study |
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Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study |
| abstract |
Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. |
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Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. |
| abstract_unstemmed |
Vaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. Thus, data supported that MDCK-QIV could be further evaluated in human clinical trial, which is currently underway. |
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The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague–Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo–fetal development, and perinatal toxicity in the SD rats and immunogenicity in Wistar rats and BALB/c mice. Regarding the safety profile, MDCK-QIV demonstrated tolerance in local stimulation with repeated dose administration and presented no significant effect on the development, growth, behavior, fertility, and reproductive performance of the adult male rats, maternal rats, and their offspring. MDCK-QIV elicited strong hemagglutination inhibition neutralizing antibody response and protection against the influenza virus in the mouse model. 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