Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation

The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bon...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ma, Le [verfasserIn] Su, Chun-Ru [verfasserIn] Li, Shi-Ying [verfasserIn] He, Shan [verfasserIn] Nag, Anindya [verfasserIn] Yuan, Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Zein-Chitosan Bilayer structure Complex coacervation Curcumin Quercetin

Übergeordnetes Werk:	Enthalten in: Food hydrocolloids - Amsterdam : Elsevier, 1986, 144
Übergeordnetes Werk:	volume:144

DOI / URN:	10.1016/j.foodhyd.2023.108907

Katalog-ID:	ELV061231053

Internformat


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520			\|a The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics.
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publishDate	2023
allfields	10.1016/j.foodhyd.2023.108907 doi (DE-627)ELV061231053 (ELSEVIER)S0268-005X(23)00453-8 DE-627 ger DE-627 rda eng 630 640 VZ 58.34 bkl Ma, Le verfasserin aut Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics. Zein-Chitosan Bilayer structure Complex coacervation Curcumin Quercetin Su, Chun-Ru verfasserin aut Li, Shi-Ying verfasserin aut He, Shan verfasserin aut Nag, Anindya verfasserin aut Yuan, Yang verfasserin aut Enthalten in Food hydrocolloids Amsterdam : Elsevier, 1986 144 Online-Ressource (DE-627)324455631 (DE-600)2026957-2 (DE-576)259271993 1873-7137 nnns volume:144 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.34 Lebensmitteltechnologie VZ AR 144
spelling	10.1016/j.foodhyd.2023.108907 doi (DE-627)ELV061231053 (ELSEVIER)S0268-005X(23)00453-8 DE-627 ger DE-627 rda eng 630 640 VZ 58.34 bkl Ma, Le verfasserin aut Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics. Zein-Chitosan Bilayer structure Complex coacervation Curcumin Quercetin Su, Chun-Ru verfasserin aut Li, Shi-Ying verfasserin aut He, Shan verfasserin aut Nag, Anindya verfasserin aut Yuan, Yang verfasserin aut Enthalten in Food hydrocolloids Amsterdam : Elsevier, 1986 144 Online-Ressource (DE-627)324455631 (DE-600)2026957-2 (DE-576)259271993 1873-7137 nnns volume:144 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.34 Lebensmitteltechnologie VZ AR 144
allfields_unstemmed	10.1016/j.foodhyd.2023.108907 doi (DE-627)ELV061231053 (ELSEVIER)S0268-005X(23)00453-8 DE-627 ger DE-627 rda eng 630 640 VZ 58.34 bkl Ma, Le verfasserin aut Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics. Zein-Chitosan Bilayer structure Complex coacervation Curcumin Quercetin Su, Chun-Ru verfasserin aut Li, Shi-Ying verfasserin aut He, Shan verfasserin aut Nag, Anindya verfasserin aut Yuan, Yang verfasserin aut Enthalten in Food hydrocolloids Amsterdam : Elsevier, 1986 144 Online-Ressource (DE-627)324455631 (DE-600)2026957-2 (DE-576)259271993 1873-7137 nnns volume:144 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.34 Lebensmitteltechnologie VZ AR 144
allfieldsGer	10.1016/j.foodhyd.2023.108907 doi (DE-627)ELV061231053 (ELSEVIER)S0268-005X(23)00453-8 DE-627 ger DE-627 rda eng 630 640 VZ 58.34 bkl Ma, Le verfasserin aut Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics. Zein-Chitosan Bilayer structure Complex coacervation Curcumin Quercetin Su, Chun-Ru verfasserin aut Li, Shi-Ying verfasserin aut He, Shan verfasserin aut Nag, Anindya verfasserin aut Yuan, Yang verfasserin aut Enthalten in Food hydrocolloids Amsterdam : Elsevier, 1986 144 Online-Ressource (DE-627)324455631 (DE-600)2026957-2 (DE-576)259271993 1873-7137 nnns volume:144 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.34 Lebensmitteltechnologie VZ AR 144
allfieldsSound	10.1016/j.foodhyd.2023.108907 doi (DE-627)ELV061231053 (ELSEVIER)S0268-005X(23)00453-8 DE-627 ger DE-627 rda eng 630 640 VZ 58.34 bkl Ma, Le verfasserin aut Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics. Zein-Chitosan Bilayer structure Complex coacervation Curcumin Quercetin Su, Chun-Ru verfasserin aut Li, Shi-Ying verfasserin aut He, Shan verfasserin aut Nag, Anindya verfasserin aut Yuan, Yang verfasserin aut Enthalten in Food hydrocolloids Amsterdam : Elsevier, 1986 144 Online-Ressource (DE-627)324455631 (DE-600)2026957-2 (DE-576)259271993 1873-7137 nnns volume:144 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 58.34 Lebensmitteltechnologie VZ AR 144
language	English
source	Enthalten in Food hydrocolloids 144 volume:144
sourceStr	Enthalten in Food hydrocolloids 144 volume:144
format_phy_str_mv	Article
bklname	Lebensmitteltechnologie
institution	findex.gbv.de
topic_facet	Zein-Chitosan Bilayer structure Complex coacervation Curcumin Quercetin
dewey-raw	630
isfreeaccess_bool	false
container_title	Food hydrocolloids
authorswithroles_txt_mv	Ma, Le @@aut@@ Su, Chun-Ru @@aut@@ Li, Shi-Ying @@aut@@ He, Shan @@aut@@ Nag, Anindya @@aut@@ Yuan, Yang @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	324455631
dewey-sort	3630
id	ELV061231053
language_de	englisch
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author	Ma, Le
spellingShingle	Ma, Le ddc 630 bkl 58.34 misc Zein-Chitosan misc Bilayer structure misc Complex coacervation misc Curcumin misc Quercetin Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation
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topic_title	630 640 VZ 58.34 bkl Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation Zein-Chitosan Bilayer structure Complex coacervation Curcumin Quercetin
topic	ddc 630 bkl 58.34 misc Zein-Chitosan misc Bilayer structure misc Complex coacervation misc Curcumin misc Quercetin
topic_unstemmed	ddc 630 bkl 58.34 misc Zein-Chitosan misc Bilayer structure misc Complex coacervation misc Curcumin misc Quercetin
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title	Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation
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title_full	Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation
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author_browse	Ma, Le Su, Chun-Ru Li, Shi-Ying He, Shan Nag, Anindya Yuan, Yang
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doi_str_mv	10.1016/j.foodhyd.2023.108907
dewey-full	630 640
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title_sort	co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation
title_auth	Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation
abstract	The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics.
abstractGer	The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics.
abstract_unstemmed	The formation of Zein-chitosan complex coacervates (ZCSC) with a co-encapsulated bilayer structure were successfully fabricated from Zein (Z) and chitosan (CS) for co-encapsulating the curcumin (Cur) and quercetin (Que). A combination of electrostatic attraction, hydrophobic effects and hydrogen bonding was demonstrated to be responsible for the formation of bilayer structure with chitosan covering on the surfaces of the Zein nanoparticles co-loading with curcumin and quercetin. The impacts of pH, type of polyphenols, protein-polyphenol ratio and curcumin-quercetin ratio on formation mechanism of bilayer structure was studied using the size, PDI, ζ-potential, size distribution and phase diagram measurement. The chemical structure and microstructure were further explored by Fourier transformed infrared spectroscopy (FTIR), UV–visible spectroscopy and Scanning electron microscope (SEM). Interestingly, the phase diagram and SEM images revealed that larger coacervates were favorably formed far away from the polyphenol-polyphenol ratio of 1:1 and near neutral pH. The bilayer-structured complexes showed high encapsulation efficiency (EE) for curcumin and quercetin, as well as a slow-release effect for both compounds. Additionally, these complexes were physically stable throughout a 3-week storage period. In conclusion, the nano-scale complexes and micron-level coacervates with a co-encapsulated bilayer structure based on hydrophobic Zein core and hydrophilic chitosan shell are an effective co-delivery system for two bioactive agents with different molecular characteristics.
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title_short	Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation
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author2	Su, Chun-Ru Li, Shi-Ying He, Shan Nag, Anindya Yuan, Yang
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doi_str	10.1016/j.foodhyd.2023.108907
up_date	2024-07-06T17:22:03.295Z
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Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation

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