Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery

Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable h...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Li, Jie [verfasserIn] Yang, Yubin [verfasserIn] Liu, Peng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Unimolecular micelles Hyperbranched polymer prodrug Tumor-specific chemotherapy GSH-triggered disintegration

Übergeordnetes Werk:	Enthalten in: European polymer journal - New York, NY [u.a.] : Elsevier, 1965, 196
Übergeordnetes Werk:	volume:196

DOI / URN:	10.1016/j.eurpolymj.2023.112279

Katalog-ID:	ELV061266906

Internformat


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100	1		\|a Li, Jie \|e verfasserin \|4 aut
245	1	0	\|a Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery
264		1	\|c 2023
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
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520			\|a Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT.
650		4	\|a Unimolecular micelles
650		4	\|a Hyperbranched polymer prodrug
650		4	\|a Tumor-specific chemotherapy
650		4	\|a GSH-triggered disintegration
700	1		\|a Yang, Yubin \|e verfasserin \|4 aut
700	1		\|a Liu, Peng \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t European polymer journal \|d New York, NY [u.a.] : Elsevier, 1965 \|g 196 \|h Online-Ressource \|w (DE-627)300897375 \|w (DE-600)1483529-0 \|w (DE-576)259270830 \|7 nnns
773	1	8	\|g volume:196
912			\|a GBV_USEFLAG_U
912			\|a GBV_ELV
912			\|a SYSFLAG_U
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2411
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 35.80 \|j Makromolekulare Chemie \|q VZ
951			\|a AR
952			\|d 196

Indexfelder

author_variant	j l jl y y yy p l pl
matchkey_str	lijieyangyubinliupeng:2023----:aieyteioghrgeeseeocevbeyebaceplmrrduauioeuamclef
hierarchy_sort_str	2023
bklnumber	35.80
publishDate	2023
allfields	10.1016/j.eurpolymj.2023.112279 doi (DE-627)ELV061266906 (ELSEVIER)S0014-3057(23)00462-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Li, Jie verfasserin aut Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT. Unimolecular micelles Hyperbranched polymer prodrug Tumor-specific chemotherapy GSH-triggered disintegration Yang, Yubin verfasserin aut Liu, Peng verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 196 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:196 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.80 Makromolekulare Chemie VZ AR 196
spelling	10.1016/j.eurpolymj.2023.112279 doi (DE-627)ELV061266906 (ELSEVIER)S0014-3057(23)00462-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Li, Jie verfasserin aut Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT. Unimolecular micelles Hyperbranched polymer prodrug Tumor-specific chemotherapy GSH-triggered disintegration Yang, Yubin verfasserin aut Liu, Peng verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 196 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:196 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.80 Makromolekulare Chemie VZ AR 196
allfields_unstemmed	10.1016/j.eurpolymj.2023.112279 doi (DE-627)ELV061266906 (ELSEVIER)S0014-3057(23)00462-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Li, Jie verfasserin aut Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT. Unimolecular micelles Hyperbranched polymer prodrug Tumor-specific chemotherapy GSH-triggered disintegration Yang, Yubin verfasserin aut Liu, Peng verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 196 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:196 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.80 Makromolekulare Chemie VZ AR 196
allfieldsGer	10.1016/j.eurpolymj.2023.112279 doi (DE-627)ELV061266906 (ELSEVIER)S0014-3057(23)00462-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Li, Jie verfasserin aut Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT. Unimolecular micelles Hyperbranched polymer prodrug Tumor-specific chemotherapy GSH-triggered disintegration Yang, Yubin verfasserin aut Liu, Peng verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 196 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:196 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.80 Makromolekulare Chemie VZ AR 196
allfieldsSound	10.1016/j.eurpolymj.2023.112279 doi (DE-627)ELV061266906 (ELSEVIER)S0014-3057(23)00462-7 DE-627 ger DE-627 rda eng 670 VZ 35.80 bkl Li, Jie verfasserin aut Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT. Unimolecular micelles Hyperbranched polymer prodrug Tumor-specific chemotherapy GSH-triggered disintegration Yang, Yubin verfasserin aut Liu, Peng verfasserin aut Enthalten in European polymer journal New York, NY [u.a.] : Elsevier, 1965 196 Online-Ressource (DE-627)300897375 (DE-600)1483529-0 (DE-576)259270830 nnns volume:196 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.80 Makromolekulare Chemie VZ AR 196
language	English
source	Enthalten in European polymer journal 196 volume:196
sourceStr	Enthalten in European polymer journal 196 volume:196
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topic_facet	Unimolecular micelles Hyperbranched polymer prodrug Tumor-specific chemotherapy GSH-triggered disintegration
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container_title	European polymer journal
authorswithroles_txt_mv	Li, Jie @@aut@@ Yang, Yubin @@aut@@ Liu, Peng @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
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author	Li, Jie
spellingShingle	Li, Jie ddc 670 bkl 35.80 misc Unimolecular micelles misc Hyperbranched polymer prodrug misc Tumor-specific chemotherapy misc GSH-triggered disintegration Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery
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topic_title	670 VZ 35.80 bkl Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery Unimolecular micelles Hyperbranched polymer prodrug Tumor-specific chemotherapy GSH-triggered disintegration
topic	ddc 670 bkl 35.80 misc Unimolecular micelles misc Hyperbranched polymer prodrug misc Tumor-specific chemotherapy misc GSH-triggered disintegration
topic_unstemmed	ddc 670 bkl 35.80 misc Unimolecular micelles misc Hyperbranched polymer prodrug misc Tumor-specific chemotherapy misc GSH-triggered disintegration
topic_browse	ddc 670 bkl 35.80 misc Unimolecular micelles misc Hyperbranched polymer prodrug misc Tumor-specific chemotherapy misc GSH-triggered disintegration
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title	Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery
ctrlnum	(DE-627)ELV061266906 (ELSEVIER)S0014-3057(23)00462-7
title_full	Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery
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title_sort	facile synthesis of gsh-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery
title_auth	Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery
abstract	Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT.
abstractGer	Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT.
abstract_unstemmed	Prodrug unimolecular micelles based on dendrimers or hyperbranched polymers have attracted intense interest in tumor chemotherapy. The preparation of the former one is usually cumbersome, while the stable skeleton in the latter one restricts the drug release. Here, GSH-triggered skeleton-cleavable hyperbranched polymer prodrug was designed via a “Bottom-up” construction strategy, by the self-condensing vinyl polymerization (SCVP) of GSH-sensitive prodrug monomer MA-SS-CPT and PEGMA with a GSH-sensitive inimer MA-SS-Br. It could self-assemble into stable unimolecular micelles, possessing GSH-triggered drug release and disintegration of the hyperbranched skeleton. So, they showed an excellent tumor-specific CPT release in the in vitro drug release and consequently tumor-specific cytotoxicity with an enhanced tumor cell growth inhibition than the free CPT.
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title_short	Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery
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doi_str	10.1016/j.eurpolymj.2023.112279
up_date	2024-07-06T17:24:57.847Z
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Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery

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