Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia

Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients wit...
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Gespeichert in:

Autor*in:	Bae, Hyoeun [verfasserIn] Cho, Yong Won [verfasserIn] Kim, Keun Tae [verfasserIn] Li, Xu [verfasserIn] Earley, Christopher J. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Restless legs syndrome Iron deficiency Anemia Brain iron

Übergeordnetes Werk:	Enthalten in: Sleep medicine - Amsterdam [u.a.] : Elsevier, 2000, 109, Seite 128-131
Übergeordnetes Werk:	volume:109 ; pages:128-131

DOI / URN:	10.1016/j.sleep.2023.06.023

Katalog-ID:	ELV061401986

Internformat


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024	7		\|a 10.1016/j.sleep.2023.06.023 \|2 doi
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100	1		\|a Bae, Hyoeun \|e verfasserin \|4 aut
245	1	0	\|a Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia
264		1	\|c 2023
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
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520			\|a Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients.
650		4	\|a Restless legs syndrome
650		4	\|a Iron deficiency
650		4	\|a Anemia
650		4	\|a Brain iron
700	1		\|a Cho, Yong Won \|e verfasserin \|0 (orcid)0000-0002-6127-1045 \|4 aut
700	1		\|a Kim, Keun Tae \|e verfasserin \|4 aut
700	1		\|a Li, Xu \|e verfasserin \|4 aut
700	1		\|a Earley, Christopher J. \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Sleep medicine \|d Amsterdam [u.a.] : Elsevier, 2000 \|g 109, Seite 128-131 \|h Online-Ressource \|w (DE-627)326646949 \|w (DE-600)2041737-8 \|w (DE-576)105536768 \|x 1878-5506 \|7 nnns
773	1	8	\|g volume:109 \|g pages:128-131
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912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.90 \|j Neurologie \|q VZ
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952			\|d 109 \|h 128-131

Indexfelder

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publishDate	2023
allfields	10.1016/j.sleep.2023.06.023 doi (DE-627)ELV061401986 (ELSEVIER)S1389-9457(23)00228-9 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl Bae, Hyoeun verfasserin aut Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients. Restless legs syndrome Iron deficiency Anemia Brain iron Cho, Yong Won verfasserin (orcid)0000-0002-6127-1045 aut Kim, Keun Tae verfasserin aut Li, Xu verfasserin aut Earley, Christopher J. verfasserin aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 109, Seite 128-131 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:109 pages:128-131 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 109 128-131
spelling	10.1016/j.sleep.2023.06.023 doi (DE-627)ELV061401986 (ELSEVIER)S1389-9457(23)00228-9 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl Bae, Hyoeun verfasserin aut Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients. Restless legs syndrome Iron deficiency Anemia Brain iron Cho, Yong Won verfasserin (orcid)0000-0002-6127-1045 aut Kim, Keun Tae verfasserin aut Li, Xu verfasserin aut Earley, Christopher J. verfasserin aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 109, Seite 128-131 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:109 pages:128-131 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 109 128-131
allfields_unstemmed	10.1016/j.sleep.2023.06.023 doi (DE-627)ELV061401986 (ELSEVIER)S1389-9457(23)00228-9 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl Bae, Hyoeun verfasserin aut Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients. Restless legs syndrome Iron deficiency Anemia Brain iron Cho, Yong Won verfasserin (orcid)0000-0002-6127-1045 aut Kim, Keun Tae verfasserin aut Li, Xu verfasserin aut Earley, Christopher J. verfasserin aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 109, Seite 128-131 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:109 pages:128-131 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 109 128-131
allfieldsGer	10.1016/j.sleep.2023.06.023 doi (DE-627)ELV061401986 (ELSEVIER)S1389-9457(23)00228-9 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl Bae, Hyoeun verfasserin aut Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients. Restless legs syndrome Iron deficiency Anemia Brain iron Cho, Yong Won verfasserin (orcid)0000-0002-6127-1045 aut Kim, Keun Tae verfasserin aut Li, Xu verfasserin aut Earley, Christopher J. verfasserin aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 109, Seite 128-131 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:109 pages:128-131 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 109 128-131
allfieldsSound	10.1016/j.sleep.2023.06.023 doi (DE-627)ELV061401986 (ELSEVIER)S1389-9457(23)00228-9 DE-627 ger DE-627 rda eng 610 VZ 44.90 bkl Bae, Hyoeun verfasserin aut Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients. Restless legs syndrome Iron deficiency Anemia Brain iron Cho, Yong Won verfasserin (orcid)0000-0002-6127-1045 aut Kim, Keun Tae verfasserin aut Li, Xu verfasserin aut Earley, Christopher J. verfasserin aut Enthalten in Sleep medicine Amsterdam [u.a.] : Elsevier, 2000 109, Seite 128-131 Online-Ressource (DE-627)326646949 (DE-600)2041737-8 (DE-576)105536768 1878-5506 nnns volume:109 pages:128-131 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 Neurologie VZ AR 109 128-131
language	English
source	Enthalten in Sleep medicine 109, Seite 128-131 volume:109 pages:128-131
sourceStr	Enthalten in Sleep medicine 109, Seite 128-131 volume:109 pages:128-131
format_phy_str_mv	Article
bklname	Neurologie
institution	findex.gbv.de
topic_facet	Restless legs syndrome Iron deficiency Anemia Brain iron
dewey-raw	610
isfreeaccess_bool	false
container_title	Sleep medicine
authorswithroles_txt_mv	Bae, Hyoeun @@aut@@ Cho, Yong Won @@aut@@ Kim, Keun Tae @@aut@@ Li, Xu @@aut@@ Earley, Christopher J. @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	326646949
dewey-sort	3610
id	ELV061401986
language_de	englisch
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The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Restless legs syndrome</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Iron deficiency</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anemia</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Brain iron</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cho, Yong Won</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-6127-1045</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield 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author	Bae, Hyoeun
spellingShingle	Bae, Hyoeun ddc 610 bkl 44.90 misc Restless legs syndrome misc Iron deficiency misc Anemia misc Brain iron Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia
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topic_title	610 VZ 44.90 bkl Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia Restless legs syndrome Iron deficiency Anemia Brain iron
topic	ddc 610 bkl 44.90 misc Restless legs syndrome misc Iron deficiency misc Anemia misc Brain iron
topic_unstemmed	ddc 610 bkl 44.90 misc Restless legs syndrome misc Iron deficiency misc Anemia misc Brain iron
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title	Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia
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title_full	Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia
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title_sort	ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia
title_auth	Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia
abstract	Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients.
abstractGer	Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients.
abstract_unstemmed	Objective: Brain iron status is fundamental in RLS pathogenesis. The aim of this study was to determine the clinical efficacy and brain iron concentration improvement in RLS patients with IDA, using 1500 mg FCM.Methods: This is a randomized, double-blinded, placebo-controlled study. RLS patients with IDA were grouped into either 1500 mg FCM or placebo. The primary outcomes were the change from baseline on the International Restless Legs Syndrome Study Group scale (IRLS) and brain iron measured by QSM and R2∗.Results: A total of 18 RLS patients with IDA were enrolled, 10 in the FCM group and 8 in the placebo. At the week 6 endpoint, the FCM group showed significant improvement in both IRLS (−13.60 ± 9.47 vs. −3.63 ± 5.40, p = 0.011) and VAS (−40.50 ± 28.81 vs. −0.63 ± 28.28, p = 0.004) from baseline. Change from baseline with R2∗ techniques showed a treatment effect for the thalamus and QSM technique for both the substantia nigra and pulvinar. A correlation was proved between the IRLS difference and the difference of QSM in thalamus (p = 0.028).Conclusion: This study demonstrates that 1500 mg FCM effectively treats RLS symptoms in IDA patients over six weeks, with MRI measurements of improved brain iron content serving as a potential biomarker for RLS patients.
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title_short	Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia
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author2	Cho, Yong Won Kim, Keun Tae Li, Xu Earley, Christopher J.
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up_date	2024-07-06T17:36:39.967Z
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Ferric carboxymaltose effects on restless legs syndrome and on brain iron in patients with iron deficiency anemia

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