New 5-methyl-4-hydroxycoumarin polyketide derivatives from

Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted t...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yang, Yong-xun [verfasserIn] Wang, Qun [verfasserIn] Huang, Hai-Yan [verfasserIn] Wang, Zhi-Jie [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	5-Methyl-4-hydroxycoumarin polyketide derivatives Monoterpene polyketide coumarins Phenylpropanoid polyketide coumarin Anti-inflammatory activity

Übergeordnetes Werk:	Enthalten in: Fitoterapia - Amsterdam [u.a.] : Elsevier Science, 1999, 169
Übergeordnetes Werk:	volume:169

DOI / URN:	10.1016/j.fitote.2023.105568

Katalog-ID:	ELV061813702

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520			\|a Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity.
650		4	\|a 5-Methyl-4-hydroxycoumarin polyketide derivatives
650		4	\|a Monoterpene polyketide coumarins
650		4	\|a Phenylpropanoid polyketide coumarin
650		4	\|a Anti-inflammatory activity
700	1		\|a Wang, Qun \|e verfasserin \|4 aut
700	1		\|a Huang, Hai-Yan \|e verfasserin \|4 aut
700	1		\|a Wang, Zhi-Jie \|e verfasserin \|4 aut
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912			\|a GBV_ILN_2014
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912			\|a GBV_ILN_2020
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912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
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912			\|a GBV_ILN_4333
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allfields	10.1016/j.fitote.2023.105568 doi (DE-627)ELV061813702 (ELSEVIER)S0367-326X(23)00143-0 DE-627 ger DE-627 rda eng 570 VZ Yang, Yong-xun verfasserin aut New 5-methyl-4-hydroxycoumarin polyketide derivatives from 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity. 5-Methyl-4-hydroxycoumarin polyketide derivatives Monoterpene polyketide coumarins Phenylpropanoid polyketide coumarin Anti-inflammatory activity Wang, Qun verfasserin aut Huang, Hai-Yan verfasserin aut Wang, Zhi-Jie verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 169 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:169 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 169
spelling	10.1016/j.fitote.2023.105568 doi (DE-627)ELV061813702 (ELSEVIER)S0367-326X(23)00143-0 DE-627 ger DE-627 rda eng 570 VZ Yang, Yong-xun verfasserin aut New 5-methyl-4-hydroxycoumarin polyketide derivatives from 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity. 5-Methyl-4-hydroxycoumarin polyketide derivatives Monoterpene polyketide coumarins Phenylpropanoid polyketide coumarin Anti-inflammatory activity Wang, Qun verfasserin aut Huang, Hai-Yan verfasserin aut Wang, Zhi-Jie verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 169 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:169 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 169
allfields_unstemmed	10.1016/j.fitote.2023.105568 doi (DE-627)ELV061813702 (ELSEVIER)S0367-326X(23)00143-0 DE-627 ger DE-627 rda eng 570 VZ Yang, Yong-xun verfasserin aut New 5-methyl-4-hydroxycoumarin polyketide derivatives from 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity. 5-Methyl-4-hydroxycoumarin polyketide derivatives Monoterpene polyketide coumarins Phenylpropanoid polyketide coumarin Anti-inflammatory activity Wang, Qun verfasserin aut Huang, Hai-Yan verfasserin aut Wang, Zhi-Jie verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 169 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:169 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 169
allfieldsGer	10.1016/j.fitote.2023.105568 doi (DE-627)ELV061813702 (ELSEVIER)S0367-326X(23)00143-0 DE-627 ger DE-627 rda eng 570 VZ Yang, Yong-xun verfasserin aut New 5-methyl-4-hydroxycoumarin polyketide derivatives from 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity. 5-Methyl-4-hydroxycoumarin polyketide derivatives Monoterpene polyketide coumarins Phenylpropanoid polyketide coumarin Anti-inflammatory activity Wang, Qun verfasserin aut Huang, Hai-Yan verfasserin aut Wang, Zhi-Jie verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 169 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:169 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 169
allfieldsSound	10.1016/j.fitote.2023.105568 doi (DE-627)ELV061813702 (ELSEVIER)S0367-326X(23)00143-0 DE-627 ger DE-627 rda eng 570 VZ Yang, Yong-xun verfasserin aut New 5-methyl-4-hydroxycoumarin polyketide derivatives from 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity. 5-Methyl-4-hydroxycoumarin polyketide derivatives Monoterpene polyketide coumarins Phenylpropanoid polyketide coumarin Anti-inflammatory activity Wang, Qun verfasserin aut Huang, Hai-Yan verfasserin aut Wang, Zhi-Jie verfasserin aut Enthalten in Fitoterapia Amsterdam [u.a.] : Elsevier Science, 1999 169 Online-Ressource (DE-627)324489099 (DE-600)2027649-7 (DE-576)094146756 1873-6971 nnns volume:169 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 169
language	English
source	Enthalten in Fitoterapia 169 volume:169
sourceStr	Enthalten in Fitoterapia 169 volume:169
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	5-Methyl-4-hydroxycoumarin polyketide derivatives Monoterpene polyketide coumarins Phenylpropanoid polyketide coumarin Anti-inflammatory activity
dewey-raw	570
isfreeaccess_bool	false
container_title	Fitoterapia
authorswithroles_txt_mv	Yang, Yong-xun @@aut@@ Wang, Qun @@aut@@ Huang, Hai-Yan @@aut@@ Wang, Zhi-Jie @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	324489099
dewey-sort	3570
id	ELV061813702
language_de	englisch
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author	Yang, Yong-xun
spellingShingle	Yang, Yong-xun ddc 570 misc 5-Methyl-4-hydroxycoumarin polyketide derivatives misc Monoterpene polyketide coumarins misc Phenylpropanoid polyketide coumarin misc Anti-inflammatory activity New 5-methyl-4-hydroxycoumarin polyketide derivatives from
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topic_title	570 VZ New 5-methyl-4-hydroxycoumarin polyketide derivatives from 5-Methyl-4-hydroxycoumarin polyketide derivatives Monoterpene polyketide coumarins Phenylpropanoid polyketide coumarin Anti-inflammatory activity
topic	ddc 570 misc 5-Methyl-4-hydroxycoumarin polyketide derivatives misc Monoterpene polyketide coumarins misc Phenylpropanoid polyketide coumarin misc Anti-inflammatory activity
topic_unstemmed	ddc 570 misc 5-Methyl-4-hydroxycoumarin polyketide derivatives misc Monoterpene polyketide coumarins misc Phenylpropanoid polyketide coumarin misc Anti-inflammatory activity
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title	New 5-methyl-4-hydroxycoumarin polyketide derivatives from
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title_full	New 5-methyl-4-hydroxycoumarin polyketide derivatives from
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title_sort	new 5-methyl-4-hydroxycoumarin polyketide derivatives from
title_auth	New 5-methyl-4-hydroxycoumarin polyketide derivatives from
abstract	Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity.
abstractGer	Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity.
abstract_unstemmed	Five new 5-methyl-4-hydroxycoumarin polyketide derivatives (MPDs), delavayicoumarins A-E (1–5), were isolated from the whole plants of Gerbera delavayi. Among them, compounds 1–3 are the common monoterpene polyketide coumarins (MPCs), while 4 is a modified MPC with both the lactone ring contracted to a five-membered furan ring and a carboxyl at C-3, and 5 is a pair of unusual phenylpropanoid polyketide coumarin enantiomers (5a and 5b), featuring a phenylpropanoid unit at C-3. The planar structures were elucidated by spectroscopic methods and biosynthetic arguments, and the absolute configurations of 1–3, 5a and 5b were confirmed by calculated electronic circular dichroism (ECD) experiment. Furthermore, compounds 1–3, (+)-5 and (−)-5 were tested for the nitric oxide (NO) inhibitory activity by using lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. The results showed that compounds 1–3, (+)-5 and (−)-5 remarkably inhibited NO production at the concentration of 10.0 μM, exhibiting that they have significant anti-inflammatory activity.
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title_short	New 5-methyl-4-hydroxycoumarin polyketide derivatives from
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doi_str	10.1016/j.fitote.2023.105568
up_date	2024-07-06T18:04:55.259Z
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