A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation

In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zhou, Kangming [verfasserIn] Liu, Zeng [verfasserIn] Fan, Renyu [verfasserIn] Zhao, Mengtao [verfasserIn] Luo, Linxiu [verfasserIn] Wang, Yuting [verfasserIn] Jiang, Yanling [verfasserIn] Lu, Zheng [verfasserIn] Tang, Jincao [verfasserIn] Luo, Anqi [verfasserIn] Guan, Tianbing [verfasserIn] Sun, Huimin [verfasserIn] Zhou, Taigang [verfasserIn] Dai, Chuanyun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Sticky powder High shear wet granulation Binder liquid Molecular dynamics simulation

Übergeordnetes Werk:	Enthalten in: International journal of pharmaceutics - New York, NY [u.a.] : Elsevier, 1978, 638
Übergeordnetes Werk:	volume:638

DOI / URN:	10.1016/j.ijpharm.2023.122923

Katalog-ID:	ELV062809415

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100	1		\|a Zhou, Kangming \|e verfasserin \|4 aut
245	1	0	\|a A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation
264		1	\|c 2023
336			\|a nicht spezifiziert \|b zzz \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules.
650		4	\|a Sticky powder
650		4	\|a High shear wet granulation
650		4	\|a Binder liquid
650		4	\|a Molecular dynamics simulation
700	1		\|a Liu, Zeng \|e verfasserin \|4 aut
700	1		\|a Fan, Renyu \|e verfasserin \|4 aut
700	1		\|a Zhao, Mengtao \|e verfasserin \|4 aut
700	1		\|a Luo, Linxiu \|e verfasserin \|4 aut
700	1		\|a Wang, Yuting \|e verfasserin \|4 aut
700	1		\|a Jiang, Yanling \|e verfasserin \|4 aut
700	1		\|a Lu, Zheng \|e verfasserin \|4 aut
700	1		\|a Tang, Jincao \|e verfasserin \|4 aut
700	1		\|a Luo, Anqi \|e verfasserin \|4 aut
700	1		\|a Guan, Tianbing \|e verfasserin \|4 aut
700	1		\|a Sun, Huimin \|e verfasserin \|4 aut
700	1		\|a Zhou, Taigang \|e verfasserin \|4 aut
700	1		\|a Dai, Chuanyun \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t International journal of pharmaceutics \|d New York, NY [u.a.] : Elsevier, 1978 \|g 638 \|h Online-Ressource \|w (DE-627)301512817 \|w (DE-600)1484643-3 \|w (DE-576)081952708 \|x 1873-3476 \|7 nnns
773	1	8	\|g volume:638
912			\|a GBV_USEFLAG_U
912			\|a GBV_ELV
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912			\|a SSG-OPC-PHA
912			\|a SSG-OPC-DE-84
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.40 \|j Pharmazie \|j Pharmazeutika \|q VZ
951			\|a AR
952			\|d 638

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allfields	10.1016/j.ijpharm.2023.122923 doi (DE-627)ELV062809415 (ELSEVIER)S0378-5173(23)00343-5 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Zhou, Kangming verfasserin aut A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules. Sticky powder High shear wet granulation Binder liquid Molecular dynamics simulation Liu, Zeng verfasserin aut Fan, Renyu verfasserin aut Zhao, Mengtao verfasserin aut Luo, Linxiu verfasserin aut Wang, Yuting verfasserin aut Jiang, Yanling verfasserin aut Lu, Zheng verfasserin aut Tang, Jincao verfasserin aut Luo, Anqi verfasserin aut Guan, Tianbing verfasserin aut Sun, Huimin verfasserin aut Zhou, Taigang verfasserin aut Dai, Chuanyun verfasserin aut Enthalten in International journal of pharmaceutics New York, NY [u.a.] : Elsevier, 1978 638 Online-Ressource (DE-627)301512817 (DE-600)1484643-3 (DE-576)081952708 1873-3476 nnns volume:638 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-DE-84 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 638
spelling	10.1016/j.ijpharm.2023.122923 doi (DE-627)ELV062809415 (ELSEVIER)S0378-5173(23)00343-5 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Zhou, Kangming verfasserin aut A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules. Sticky powder High shear wet granulation Binder liquid Molecular dynamics simulation Liu, Zeng verfasserin aut Fan, Renyu verfasserin aut Zhao, Mengtao verfasserin aut Luo, Linxiu verfasserin aut Wang, Yuting verfasserin aut Jiang, Yanling verfasserin aut Lu, Zheng verfasserin aut Tang, Jincao verfasserin aut Luo, Anqi verfasserin aut Guan, Tianbing verfasserin aut Sun, Huimin verfasserin aut Zhou, Taigang verfasserin aut Dai, Chuanyun verfasserin aut Enthalten in International journal of pharmaceutics New York, NY [u.a.] : Elsevier, 1978 638 Online-Ressource (DE-627)301512817 (DE-600)1484643-3 (DE-576)081952708 1873-3476 nnns volume:638 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-DE-84 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 638
allfields_unstemmed	10.1016/j.ijpharm.2023.122923 doi (DE-627)ELV062809415 (ELSEVIER)S0378-5173(23)00343-5 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Zhou, Kangming verfasserin aut A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules. Sticky powder High shear wet granulation Binder liquid Molecular dynamics simulation Liu, Zeng verfasserin aut Fan, Renyu verfasserin aut Zhao, Mengtao verfasserin aut Luo, Linxiu verfasserin aut Wang, Yuting verfasserin aut Jiang, Yanling verfasserin aut Lu, Zheng verfasserin aut Tang, Jincao verfasserin aut Luo, Anqi verfasserin aut Guan, Tianbing verfasserin aut Sun, Huimin verfasserin aut Zhou, Taigang verfasserin aut Dai, Chuanyun verfasserin aut Enthalten in International journal of pharmaceutics New York, NY [u.a.] : Elsevier, 1978 638 Online-Ressource (DE-627)301512817 (DE-600)1484643-3 (DE-576)081952708 1873-3476 nnns volume:638 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-DE-84 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 638
allfieldsGer	10.1016/j.ijpharm.2023.122923 doi (DE-627)ELV062809415 (ELSEVIER)S0378-5173(23)00343-5 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Zhou, Kangming verfasserin aut A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules. Sticky powder High shear wet granulation Binder liquid Molecular dynamics simulation Liu, Zeng verfasserin aut Fan, Renyu verfasserin aut Zhao, Mengtao verfasserin aut Luo, Linxiu verfasserin aut Wang, Yuting verfasserin aut Jiang, Yanling verfasserin aut Lu, Zheng verfasserin aut Tang, Jincao verfasserin aut Luo, Anqi verfasserin aut Guan, Tianbing verfasserin aut Sun, Huimin verfasserin aut Zhou, Taigang verfasserin aut Dai, Chuanyun verfasserin aut Enthalten in International journal of pharmaceutics New York, NY [u.a.] : Elsevier, 1978 638 Online-Ressource (DE-627)301512817 (DE-600)1484643-3 (DE-576)081952708 1873-3476 nnns volume:638 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-DE-84 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 638
allfieldsSound	10.1016/j.ijpharm.2023.122923 doi (DE-627)ELV062809415 (ELSEVIER)S0378-5173(23)00343-5 DE-627 ger DE-627 rda eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Zhou, Kangming verfasserin aut A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules. Sticky powder High shear wet granulation Binder liquid Molecular dynamics simulation Liu, Zeng verfasserin aut Fan, Renyu verfasserin aut Zhao, Mengtao verfasserin aut Luo, Linxiu verfasserin aut Wang, Yuting verfasserin aut Jiang, Yanling verfasserin aut Lu, Zheng verfasserin aut Tang, Jincao verfasserin aut Luo, Anqi verfasserin aut Guan, Tianbing verfasserin aut Sun, Huimin verfasserin aut Zhou, Taigang verfasserin aut Dai, Chuanyun verfasserin aut Enthalten in International journal of pharmaceutics New York, NY [u.a.] : Elsevier, 1978 638 Online-Ressource (DE-627)301512817 (DE-600)1484643-3 (DE-576)081952708 1873-3476 nnns volume:638 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-DE-84 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 638
language	English
source	Enthalten in International journal of pharmaceutics 638 volume:638
sourceStr	Enthalten in International journal of pharmaceutics 638 volume:638
format_phy_str_mv	Article
bklname	Pharmazie Pharmazeutika
institution	findex.gbv.de
topic_facet	Sticky powder High shear wet granulation Binder liquid Molecular dynamics simulation
dewey-raw	610
isfreeaccess_bool	false
container_title	International journal of pharmaceutics
authorswithroles_txt_mv	Zhou, Kangming @@aut@@ Liu, Zeng @@aut@@ Fan, Renyu @@aut@@ Zhao, Mengtao @@aut@@ Luo, Linxiu @@aut@@ Wang, Yuting @@aut@@ Jiang, Yanling @@aut@@ Lu, Zheng @@aut@@ Tang, Jincao @@aut@@ Luo, Anqi @@aut@@ Guan, Tianbing @@aut@@ Sun, Huimin @@aut@@ Zhou, Taigang @@aut@@ Dai, Chuanyun @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	301512817
dewey-sort	3610
id	ELV062809415
language_de	englisch
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author	Zhou, Kangming
spellingShingle	Zhou, Kangming ddc 610 ssgn 15,3 fid PHARM bkl 44.40 misc Sticky powder misc High shear wet granulation misc Binder liquid misc Molecular dynamics simulation A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation
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topic_title	610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation Sticky powder High shear wet granulation Binder liquid Molecular dynamics simulation
topic	ddc 610 ssgn 15,3 fid PHARM bkl 44.40 misc Sticky powder misc High shear wet granulation misc Binder liquid misc Molecular dynamics simulation
topic_unstemmed	ddc 610 ssgn 15,3 fid PHARM bkl 44.40 misc Sticky powder misc High shear wet granulation misc Binder liquid misc Molecular dynamics simulation
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title	A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation
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title_full	A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation
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author_browse	Zhou, Kangming Liu, Zeng Fan, Renyu Zhao, Mengtao Luo, Linxiu Wang, Yuting Jiang, Yanling Lu, Zheng Tang, Jincao Luo, Anqi Guan, Tianbing Sun, Huimin Zhou, Taigang Dai, Chuanyun
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doi_str_mv	10.1016/j.ijpharm.2023.122923
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title_sort	a new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation
title_auth	A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation
abstract	In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules.
abstractGer	In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules.
abstract_unstemmed	In high shear wet granulation (HSWG), the interaction mechanism between binder and powder with different sugar content is still unclear. Herein, the law and mechanism of the interaction between binder and powder were studied on the molecular level by combining experiment analysis through the Kriging model and molecular dynamics (MD) simulation. For the sticky powder with high sugar content, the ethanol in the binder played a pivotal role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitates the penetration of ethanol molecules. The concentration of ethanol determines whether the mixture is blended uniformly in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for the in-depth understanding of the HSWG process where the powder is sticky, as well as providing guidelines for the practical application of preparation for Traditional Chinese Medicine (TCM) granules.
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title_short	A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation
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author2	Liu, Zeng Fan, Renyu Zhao, Mengtao Luo, Linxiu Wang, Yuting Jiang, Yanling Lu, Zheng Tang, Jincao Luo, Anqi Guan, Tianbing Sun, Huimin Zhou, Taigang Dai, Chuanyun
author2Str	Liu, Zeng Fan, Renyu Zhao, Mengtao Luo, Linxiu Wang, Yuting Jiang, Yanling Lu, Zheng Tang, Jincao Luo, Anqi Guan, Tianbing Sun, Huimin Zhou, Taigang Dai, Chuanyun
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doi_str	10.1016/j.ijpharm.2023.122923
up_date	2024-07-06T19:11:05.509Z
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A new methodology of understanding the mechanism of high shear wet granulation based on experiment and molecular dynamics simulation

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