A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management
The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Curren...
Ausführliche Beschreibung
Autor*in: |
Sharma, Neetu [verfasserIn] Rohilla, Rajesh [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Computers & industrial engineering - Amsterdam [u.a.] : Elsevier Science, 1976, 183 |
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Übergeordnetes Werk: |
volume:183 |
DOI / URN: |
10.1016/j.cie.2023.109501 |
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Katalog-ID: |
ELV06287246X |
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520 | |a The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Current drug discovery chains use centralised systems, which are susceptible to lockdown by cyberattacks. Blockchain, with its many characteristics such as accountability, immutability, integrity, privacy, and security, has the potential to be extremely useful in drug discovery chain management. The purpose of this work is to create a drug discovery framework utilizing the strengths of blockchain technology in combination with machine learning (ML). Such a system would provide a secure, efficient, and faster drug development life cycle. This study presents a novel Hyperledger fabric-based drug discovery application that empowers the permissioned organisations to upload, update, view, and verify contributions. ML is used to preprocess data and visualise features. In the proposed work, a unique identifier is assigned to each contribution asset using the secure hash algorithm (SHA-256). The proposed design also enables the regulatory authority to issue certificates proving the ownership of contributions to the contributing organisations. The blockchain ledger has been used to store the meta-data and InChIKey of drug contributions, and actual contributions are in off-chain storage. In this work, we have successfully built an end-to-end decentralised drug discovery application with a front-end interface and demonstrated chaincode algorithms. The end-to-end application is not available in any previous work. The Caliper tool has been used to investigate throughput, latency, and resource statistics. The performance and comparative analysis show that the proposed design is scalable and promising for drug discovery chain management. | ||
650 | 4 | |a Drug discovery | |
650 | 4 | |a Blockchain | |
650 | 4 | |a Drug development | |
650 | 4 | |a Machine learning | |
650 | 4 | |a Hyperledger fabric | |
650 | 4 | |a Chain management | |
700 | 1 | |a Rohilla, Rajesh |e verfasserin |4 aut | |
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allfields |
10.1016/j.cie.2023.109501 doi (DE-627)ELV06287246X (ELSEVIER)S0360-8352(23)00525-9 DE-627 ger DE-627 rda eng 004 VZ 85.35 bkl 54.80 bkl Sharma, Neetu verfasserin (orcid)0000-0002-3434-742X aut A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Current drug discovery chains use centralised systems, which are susceptible to lockdown by cyberattacks. Blockchain, with its many characteristics such as accountability, immutability, integrity, privacy, and security, has the potential to be extremely useful in drug discovery chain management. The purpose of this work is to create a drug discovery framework utilizing the strengths of blockchain technology in combination with machine learning (ML). Such a system would provide a secure, efficient, and faster drug development life cycle. This study presents a novel Hyperledger fabric-based drug discovery application that empowers the permissioned organisations to upload, update, view, and verify contributions. ML is used to preprocess data and visualise features. In the proposed work, a unique identifier is assigned to each contribution asset using the secure hash algorithm (SHA-256). The proposed design also enables the regulatory authority to issue certificates proving the ownership of contributions to the contributing organisations. The blockchain ledger has been used to store the meta-data and InChIKey of drug contributions, and actual contributions are in off-chain storage. In this work, we have successfully built an end-to-end decentralised drug discovery application with a front-end interface and demonstrated chaincode algorithms. The end-to-end application is not available in any previous work. The Caliper tool has been used to investigate throughput, latency, and resource statistics. The performance and comparative analysis show that the proposed design is scalable and promising for drug discovery chain management. Drug discovery Blockchain Drug development Machine learning Hyperledger fabric Chain management Rohilla, Rajesh verfasserin aut Enthalten in Computers & industrial engineering Amsterdam [u.a.] : Elsevier Science, 1976 183 Online-Ressource (DE-627)320606899 (DE-600)2020859-5 (DE-576)259271780 0360-8352 nnns volume:183 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 85.35 Fertigung VZ 54.80 Angewandte Informatik VZ AR 183 |
spelling |
10.1016/j.cie.2023.109501 doi (DE-627)ELV06287246X (ELSEVIER)S0360-8352(23)00525-9 DE-627 ger DE-627 rda eng 004 VZ 85.35 bkl 54.80 bkl Sharma, Neetu verfasserin (orcid)0000-0002-3434-742X aut A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Current drug discovery chains use centralised systems, which are susceptible to lockdown by cyberattacks. Blockchain, with its many characteristics such as accountability, immutability, integrity, privacy, and security, has the potential to be extremely useful in drug discovery chain management. The purpose of this work is to create a drug discovery framework utilizing the strengths of blockchain technology in combination with machine learning (ML). Such a system would provide a secure, efficient, and faster drug development life cycle. This study presents a novel Hyperledger fabric-based drug discovery application that empowers the permissioned organisations to upload, update, view, and verify contributions. ML is used to preprocess data and visualise features. In the proposed work, a unique identifier is assigned to each contribution asset using the secure hash algorithm (SHA-256). The proposed design also enables the regulatory authority to issue certificates proving the ownership of contributions to the contributing organisations. The blockchain ledger has been used to store the meta-data and InChIKey of drug contributions, and actual contributions are in off-chain storage. In this work, we have successfully built an end-to-end decentralised drug discovery application with a front-end interface and demonstrated chaincode algorithms. The end-to-end application is not available in any previous work. The Caliper tool has been used to investigate throughput, latency, and resource statistics. The performance and comparative analysis show that the proposed design is scalable and promising for drug discovery chain management. Drug discovery Blockchain Drug development Machine learning Hyperledger fabric Chain management Rohilla, Rajesh verfasserin aut Enthalten in Computers & industrial engineering Amsterdam [u.a.] : Elsevier Science, 1976 183 Online-Ressource (DE-627)320606899 (DE-600)2020859-5 (DE-576)259271780 0360-8352 nnns volume:183 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 85.35 Fertigung VZ 54.80 Angewandte Informatik VZ AR 183 |
allfields_unstemmed |
10.1016/j.cie.2023.109501 doi (DE-627)ELV06287246X (ELSEVIER)S0360-8352(23)00525-9 DE-627 ger DE-627 rda eng 004 VZ 85.35 bkl 54.80 bkl Sharma, Neetu verfasserin (orcid)0000-0002-3434-742X aut A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Current drug discovery chains use centralised systems, which are susceptible to lockdown by cyberattacks. Blockchain, with its many characteristics such as accountability, immutability, integrity, privacy, and security, has the potential to be extremely useful in drug discovery chain management. The purpose of this work is to create a drug discovery framework utilizing the strengths of blockchain technology in combination with machine learning (ML). Such a system would provide a secure, efficient, and faster drug development life cycle. This study presents a novel Hyperledger fabric-based drug discovery application that empowers the permissioned organisations to upload, update, view, and verify contributions. ML is used to preprocess data and visualise features. In the proposed work, a unique identifier is assigned to each contribution asset using the secure hash algorithm (SHA-256). The proposed design also enables the regulatory authority to issue certificates proving the ownership of contributions to the contributing organisations. The blockchain ledger has been used to store the meta-data and InChIKey of drug contributions, and actual contributions are in off-chain storage. In this work, we have successfully built an end-to-end decentralised drug discovery application with a front-end interface and demonstrated chaincode algorithms. The end-to-end application is not available in any previous work. The Caliper tool has been used to investigate throughput, latency, and resource statistics. The performance and comparative analysis show that the proposed design is scalable and promising for drug discovery chain management. Drug discovery Blockchain Drug development Machine learning Hyperledger fabric Chain management Rohilla, Rajesh verfasserin aut Enthalten in Computers & industrial engineering Amsterdam [u.a.] : Elsevier Science, 1976 183 Online-Ressource (DE-627)320606899 (DE-600)2020859-5 (DE-576)259271780 0360-8352 nnns volume:183 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 85.35 Fertigung VZ 54.80 Angewandte Informatik VZ AR 183 |
allfieldsGer |
10.1016/j.cie.2023.109501 doi (DE-627)ELV06287246X (ELSEVIER)S0360-8352(23)00525-9 DE-627 ger DE-627 rda eng 004 VZ 85.35 bkl 54.80 bkl Sharma, Neetu verfasserin (orcid)0000-0002-3434-742X aut A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Current drug discovery chains use centralised systems, which are susceptible to lockdown by cyberattacks. Blockchain, with its many characteristics such as accountability, immutability, integrity, privacy, and security, has the potential to be extremely useful in drug discovery chain management. The purpose of this work is to create a drug discovery framework utilizing the strengths of blockchain technology in combination with machine learning (ML). Such a system would provide a secure, efficient, and faster drug development life cycle. This study presents a novel Hyperledger fabric-based drug discovery application that empowers the permissioned organisations to upload, update, view, and verify contributions. ML is used to preprocess data and visualise features. In the proposed work, a unique identifier is assigned to each contribution asset using the secure hash algorithm (SHA-256). The proposed design also enables the regulatory authority to issue certificates proving the ownership of contributions to the contributing organisations. The blockchain ledger has been used to store the meta-data and InChIKey of drug contributions, and actual contributions are in off-chain storage. In this work, we have successfully built an end-to-end decentralised drug discovery application with a front-end interface and demonstrated chaincode algorithms. The end-to-end application is not available in any previous work. The Caliper tool has been used to investigate throughput, latency, and resource statistics. The performance and comparative analysis show that the proposed design is scalable and promising for drug discovery chain management. Drug discovery Blockchain Drug development Machine learning Hyperledger fabric Chain management Rohilla, Rajesh verfasserin aut Enthalten in Computers & industrial engineering Amsterdam [u.a.] : Elsevier Science, 1976 183 Online-Ressource (DE-627)320606899 (DE-600)2020859-5 (DE-576)259271780 0360-8352 nnns volume:183 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 85.35 Fertigung VZ 54.80 Angewandte Informatik VZ AR 183 |
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004 VZ 85.35 bkl 54.80 bkl A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management Drug discovery Blockchain Drug development Machine learning Hyperledger fabric Chain management |
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ddc 004 bkl 85.35 bkl 54.80 misc Drug discovery misc Blockchain misc Drug development misc Machine learning misc Hyperledger fabric misc Chain management |
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ddc 004 bkl 85.35 bkl 54.80 misc Drug discovery misc Blockchain misc Drug development misc Machine learning misc Hyperledger fabric misc Chain management |
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A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management |
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A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management |
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Sharma, Neetu |
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a novel hyperledger blockchain-enabled decentralized application for drug discovery chain management |
title_auth |
A novel Hyperledger blockchain-enabled decentralized application for drug discovery chain management |
abstract |
The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Current drug discovery chains use centralised systems, which are susceptible to lockdown by cyberattacks. Blockchain, with its many characteristics such as accountability, immutability, integrity, privacy, and security, has the potential to be extremely useful in drug discovery chain management. The purpose of this work is to create a drug discovery framework utilizing the strengths of blockchain technology in combination with machine learning (ML). Such a system would provide a secure, efficient, and faster drug development life cycle. This study presents a novel Hyperledger fabric-based drug discovery application that empowers the permissioned organisations to upload, update, view, and verify contributions. ML is used to preprocess data and visualise features. In the proposed work, a unique identifier is assigned to each contribution asset using the secure hash algorithm (SHA-256). The proposed design also enables the regulatory authority to issue certificates proving the ownership of contributions to the contributing organisations. The blockchain ledger has been used to store the meta-data and InChIKey of drug contributions, and actual contributions are in off-chain storage. In this work, we have successfully built an end-to-end decentralised drug discovery application with a front-end interface and demonstrated chaincode algorithms. The end-to-end application is not available in any previous work. The Caliper tool has been used to investigate throughput, latency, and resource statistics. The performance and comparative analysis show that the proposed design is scalable and promising for drug discovery chain management. |
abstractGer |
The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Current drug discovery chains use centralised systems, which are susceptible to lockdown by cyberattacks. Blockchain, with its many characteristics such as accountability, immutability, integrity, privacy, and security, has the potential to be extremely useful in drug discovery chain management. The purpose of this work is to create a drug discovery framework utilizing the strengths of blockchain technology in combination with machine learning (ML). Such a system would provide a secure, efficient, and faster drug development life cycle. This study presents a novel Hyperledger fabric-based drug discovery application that empowers the permissioned organisations to upload, update, view, and verify contributions. ML is used to preprocess data and visualise features. In the proposed work, a unique identifier is assigned to each contribution asset using the secure hash algorithm (SHA-256). The proposed design also enables the regulatory authority to issue certificates proving the ownership of contributions to the contributing organisations. The blockchain ledger has been used to store the meta-data and InChIKey of drug contributions, and actual contributions are in off-chain storage. In this work, we have successfully built an end-to-end decentralised drug discovery application with a front-end interface and demonstrated chaincode algorithms. The end-to-end application is not available in any previous work. The Caliper tool has been used to investigate throughput, latency, and resource statistics. The performance and comparative analysis show that the proposed design is scalable and promising for drug discovery chain management. |
abstract_unstemmed |
The aim of the drug discovery process is to create a brand-new drug that is both safe and useful for treating disease in patients. The trustworthy collaboration of the organisations involved in the drug discovery process and the integrity of their contributions are essential for this process. Current drug discovery chains use centralised systems, which are susceptible to lockdown by cyberattacks. Blockchain, with its many characteristics such as accountability, immutability, integrity, privacy, and security, has the potential to be extremely useful in drug discovery chain management. The purpose of this work is to create a drug discovery framework utilizing the strengths of blockchain technology in combination with machine learning (ML). Such a system would provide a secure, efficient, and faster drug development life cycle. This study presents a novel Hyperledger fabric-based drug discovery application that empowers the permissioned organisations to upload, update, view, and verify contributions. ML is used to preprocess data and visualise features. In the proposed work, a unique identifier is assigned to each contribution asset using the secure hash algorithm (SHA-256). The proposed design also enables the regulatory authority to issue certificates proving the ownership of contributions to the contributing organisations. The blockchain ledger has been used to store the meta-data and InChIKey of drug contributions, and actual contributions are in off-chain storage. In this work, we have successfully built an end-to-end decentralised drug discovery application with a front-end interface and demonstrated chaincode algorithms. The end-to-end application is not available in any previous work. The Caliper tool has been used to investigate throughput, latency, and resource statistics. The performance and comparative analysis show that the proposed design is scalable and promising for drug discovery chain management. |
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