A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats
Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depressio...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tian, Jun-sheng [verfasserIn] Zhao, Yun-hao [verfasserIn] Ling-hu, Ting [verfasserIn] Wu, Wen-ze [verfasserIn] Wang, Xian-xian [verfasserIn] Ji, Cui [verfasserIn] Zhao, Wei-di [verfasserIn] Han, Yu-mei [verfasserIn] Qin, Xue-mei [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
Stable isotope-resolved metabolomics High-rate and low-efficiency glucose metabolism Chronic unpredictable mild stress |
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| Übergeordnetes Werk: |
Enthalten in: Journal of affective disorders - Amsterdam [u.a.] : Elsevier Science, 1979, 331, Seite 121-129 |
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| Übergeordnetes Werk: |
volume:331 ; pages:121-129 |
| DOI / URN: |
10.1016/j.jad.2023.03.061 |
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| Katalog-ID: |
ELV063308703 |
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| 245 | 1 | 0 | |a A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats |
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| 520 | |a Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. | ||
| 650 | 4 | |a Depression | |
| 650 | 4 | |a Stable isotope-resolved metabolomics | |
| 650 | 4 | |a High-rate and low-efficiency glucose metabolism | |
| 650 | 4 | |a Chronic unpredictable mild stress | |
| 650 | 4 | |a Liquid chromatography-mass spectrometry | |
| 650 | 4 | |a Cecal contents | |
| 700 | 1 | |a Zhao, Yun-hao |e verfasserin |4 aut | |
| 700 | 1 | |a Ling-hu, Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Wen-ze |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xian-xian |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Cui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Wei-di |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Yu-mei |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Xue-mei |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of affective disorders |d Amsterdam [u.a.] : Elsevier Science, 1979 |g 331, Seite 121-129 |h Online-Ressource |w (DE-627)306659670 |w (DE-600)1500487-9 |w (DE-576)081986327 |x 1573-2517 |7 nnns |
| 773 | 1 | 8 | |g volume:331 |g pages:121-129 |
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10.1016/j.jad.2023.03.061 doi (DE-627)ELV063308703 (ELSEVIER)S0165-0327(23)00408-1 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Tian, Jun-sheng verfasserin aut A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. Depression Stable isotope-resolved metabolomics High-rate and low-efficiency glucose metabolism Chronic unpredictable mild stress Liquid chromatography-mass spectrometry Cecal contents Zhao, Yun-hao verfasserin aut Ling-hu, Ting verfasserin aut Wu, Wen-ze verfasserin aut Wang, Xian-xian verfasserin aut Ji, Cui verfasserin aut Zhao, Wei-di verfasserin aut Han, Yu-mei verfasserin aut Qin, Xue-mei verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 331, Seite 121-129 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:331 pages:121-129 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 331 121-129 |
| spelling |
10.1016/j.jad.2023.03.061 doi (DE-627)ELV063308703 (ELSEVIER)S0165-0327(23)00408-1 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Tian, Jun-sheng verfasserin aut A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. Depression Stable isotope-resolved metabolomics High-rate and low-efficiency glucose metabolism Chronic unpredictable mild stress Liquid chromatography-mass spectrometry Cecal contents Zhao, Yun-hao verfasserin aut Ling-hu, Ting verfasserin aut Wu, Wen-ze verfasserin aut Wang, Xian-xian verfasserin aut Ji, Cui verfasserin aut Zhao, Wei-di verfasserin aut Han, Yu-mei verfasserin aut Qin, Xue-mei verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 331, Seite 121-129 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:331 pages:121-129 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 331 121-129 |
| allfields_unstemmed |
10.1016/j.jad.2023.03.061 doi (DE-627)ELV063308703 (ELSEVIER)S0165-0327(23)00408-1 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Tian, Jun-sheng verfasserin aut A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. Depression Stable isotope-resolved metabolomics High-rate and low-efficiency glucose metabolism Chronic unpredictable mild stress Liquid chromatography-mass spectrometry Cecal contents Zhao, Yun-hao verfasserin aut Ling-hu, Ting verfasserin aut Wu, Wen-ze verfasserin aut Wang, Xian-xian verfasserin aut Ji, Cui verfasserin aut Zhao, Wei-di verfasserin aut Han, Yu-mei verfasserin aut Qin, Xue-mei verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 331, Seite 121-129 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:331 pages:121-129 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 331 121-129 |
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10.1016/j.jad.2023.03.061 doi (DE-627)ELV063308703 (ELSEVIER)S0165-0327(23)00408-1 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Tian, Jun-sheng verfasserin aut A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. Depression Stable isotope-resolved metabolomics High-rate and low-efficiency glucose metabolism Chronic unpredictable mild stress Liquid chromatography-mass spectrometry Cecal contents Zhao, Yun-hao verfasserin aut Ling-hu, Ting verfasserin aut Wu, Wen-ze verfasserin aut Wang, Xian-xian verfasserin aut Ji, Cui verfasserin aut Zhao, Wei-di verfasserin aut Han, Yu-mei verfasserin aut Qin, Xue-mei verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 331, Seite 121-129 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:331 pages:121-129 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 331 121-129 |
| allfieldsSound |
10.1016/j.jad.2023.03.061 doi (DE-627)ELV063308703 (ELSEVIER)S0165-0327(23)00408-1 DE-627 ger DE-627 rda eng 610 VZ 44.91 bkl Tian, Jun-sheng verfasserin aut A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. Depression Stable isotope-resolved metabolomics High-rate and low-efficiency glucose metabolism Chronic unpredictable mild stress Liquid chromatography-mass spectrometry Cecal contents Zhao, Yun-hao verfasserin aut Ling-hu, Ting verfasserin aut Wu, Wen-ze verfasserin aut Wang, Xian-xian verfasserin aut Ji, Cui verfasserin aut Zhao, Wei-di verfasserin aut Han, Yu-mei verfasserin aut Qin, Xue-mei verfasserin aut Enthalten in Journal of affective disorders Amsterdam [u.a.] : Elsevier Science, 1979 331, Seite 121-129 Online-Ressource (DE-627)306659670 (DE-600)1500487-9 (DE-576)081986327 1573-2517 nnns volume:331 pages:121-129 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.91 Psychiatrie Psychopathologie VZ AR 331 121-129 |
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Enthalten in Journal of affective disorders 331, Seite 121-129 volume:331 pages:121-129 |
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Depression Stable isotope-resolved metabolomics High-rate and low-efficiency glucose metabolism Chronic unpredictable mild stress Liquid chromatography-mass spectrometry Cecal contents |
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Tian, Jun-sheng @@aut@@ Zhao, Yun-hao @@aut@@ Ling-hu, Ting @@aut@@ Wu, Wen-ze @@aut@@ Wang, Xian-xian @@aut@@ Ji, Cui @@aut@@ Zhao, Wei-di @@aut@@ Han, Yu-mei @@aut@@ Qin, Xue-mei @@aut@@ |
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2023-01-01T00:00:00Z |
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Tian, Jun-sheng |
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Tian, Jun-sheng ddc 610 bkl 44.91 misc Depression misc Stable isotope-resolved metabolomics misc High-rate and low-efficiency glucose metabolism misc Chronic unpredictable mild stress misc Liquid chromatography-mass spectrometry misc Cecal contents A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats |
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610 VZ 44.91 bkl A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats Depression Stable isotope-resolved metabolomics High-rate and low-efficiency glucose metabolism Chronic unpredictable mild stress Liquid chromatography-mass spectrometry Cecal contents |
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ddc 610 bkl 44.91 misc Depression misc Stable isotope-resolved metabolomics misc High-rate and low-efficiency glucose metabolism misc Chronic unpredictable mild stress misc Liquid chromatography-mass spectrometry misc Cecal contents |
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Tian, Jun-sheng Zhao, Yun-hao Ling-hu, Ting Wu, Wen-ze Wang, Xian-xian Ji, Cui Zhao, Wei-di Han, Yu-mei Qin, Xue-mei |
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a novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in cums-induced rats |
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A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats |
| abstract |
Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. |
| abstractGer |
Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. |
| abstract_unstemmed |
Background: Existing research has suggested that depression results in disorders of glucose metabolism in the organism which causing insufficient energy supply. However, the overall changes in glucose metabolism that arise from depression have not been clarified.Methods: In this study, the depression-like behavior in chronically unpredictable mild stressed rats was investigated, and the fate of glucose was tracked through isotope tracing and mass spectrometry, with a focus on metabolite changes in cecal contents.Results: As indicated by the results, the isotopic results of cecal contents can indicate the metabolic end of the organism. Moreover, the TCA cycle activity was notably reduced, and the gluconeogenesis pathway was abnormally up-regulated in the CUMS-induced rats. The organism expedited other glucose metabolism pathways to make up for the insufficiency of energy. As a result, the activity of the inefficient glycolysis pathway was increased.Limitations: Existing research has only investigated the metabolism of 13C-glucose, and lipids and proteins have been rarely explored.Conclusions: The chronic unpredictable mild stress can inhibit the entry of pyruvate into mitochondria in SD rats, such that the activity of TCA is reduced, and insufficient energy supply is caused. The organism is capable of expediting other glucose metabolism rate pathways to make up for the insufficiency of energy, whereas it still cannot compensate for the loss of energy. As a result, CUMS-induced rats exhibited high-rate and low-efficiency glucose metabolism. |
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A novel insight for high-rate and low-efficiency glucose metabolism in depression through stable isotope-resolved metabolomics in CUMS-induced rats |
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