Target epidermal damage of

Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Tan, Xiaoping [verfasserIn] Yan, Ying [verfasserIn] Zhang, Gengrong [verfasserIn] Li, Pengfei [verfasserIn] Ling, Fei [verfasserIn] Liu, Tianqiang [verfasserIn] Wang, Gaoxue [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Target epidermal Glacial acetic acid Anthelmintic efficacy

Übergeordnetes Werk:	Enthalten in: Aquaculture - Amsterdam [u.a.] : Elsevier Science, 1972, 577
Übergeordnetes Werk:	volume:577

DOI / URN:	10.1016/j.aquaculture.2023.739993

Katalog-ID:	ELV063511789

Internformat


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024	7		\|a 10.1016/j.aquaculture.2023.739993 \|2 doi
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100	1		\|a Tan, Xiaoping \|e verfasserin \|4 aut
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520			\|a Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite.
650		4	\|a Target epidermal
650		4	\|a Glacial acetic acid
650		4	\|a Anthelmintic efficacy
700	1		\|a Yan, Ying \|e verfasserin \|4 aut
700	1		\|a Zhang, Gengrong \|e verfasserin \|4 aut
700	1		\|a Li, Pengfei \|e verfasserin \|4 aut
700	1		\|a Ling, Fei \|e verfasserin \|4 aut
700	1		\|a Liu, Tianqiang \|e verfasserin \|4 aut
700	1		\|a Wang, Gaoxue \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Aquaculture \|d Amsterdam [u.a.] : Elsevier Science, 1972 \|g 577 \|h Online-Ressource \|w (DE-627)306314002 \|w (DE-600)1495998-7 \|w (DE-576)094503966 \|7 nnns
773	1	8	\|g volume:577
912			\|a GBV_USEFLAG_U
912			\|a GBV_ELV
912			\|a SYSFLAG_U
912			\|a FID-BIODIV
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 48.68 \|j Aquakultur \|q VZ
951			\|a AR
952			\|d 577

Indexfelder

author_variant	x t xt y y yy g z gz p l pl f l fl t l tl g w gw
matchkey_str	tanxiaopingyanyingzhanggengronglipengfei:2023----:agtpdra
hierarchy_sort_str	2023
bklnumber	48.68
publishDate	2023
allfields	10.1016/j.aquaculture.2023.739993 doi (DE-627)ELV063511789 (ELSEVIER)S0044-8486(23)00767-6 DE-627 ger DE-627 rda eng 570 550 VZ BIODIV DE-30 fid 48.68 bkl Tan, Xiaoping verfasserin aut Target epidermal damage of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite. Target epidermal Glacial acetic acid Anthelmintic efficacy Yan, Ying verfasserin aut Zhang, Gengrong verfasserin aut Li, Pengfei verfasserin aut Ling, Fei verfasserin aut Liu, Tianqiang verfasserin aut Wang, Gaoxue verfasserin aut Enthalten in Aquaculture Amsterdam [u.a.] : Elsevier Science, 1972 577 Online-Ressource (DE-627)306314002 (DE-600)1495998-7 (DE-576)094503966 nnns volume:577 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.68 Aquakultur VZ AR 577
spelling	10.1016/j.aquaculture.2023.739993 doi (DE-627)ELV063511789 (ELSEVIER)S0044-8486(23)00767-6 DE-627 ger DE-627 rda eng 570 550 VZ BIODIV DE-30 fid 48.68 bkl Tan, Xiaoping verfasserin aut Target epidermal damage of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite. Target epidermal Glacial acetic acid Anthelmintic efficacy Yan, Ying verfasserin aut Zhang, Gengrong verfasserin aut Li, Pengfei verfasserin aut Ling, Fei verfasserin aut Liu, Tianqiang verfasserin aut Wang, Gaoxue verfasserin aut Enthalten in Aquaculture Amsterdam [u.a.] : Elsevier Science, 1972 577 Online-Ressource (DE-627)306314002 (DE-600)1495998-7 (DE-576)094503966 nnns volume:577 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.68 Aquakultur VZ AR 577
allfields_unstemmed	10.1016/j.aquaculture.2023.739993 doi (DE-627)ELV063511789 (ELSEVIER)S0044-8486(23)00767-6 DE-627 ger DE-627 rda eng 570 550 VZ BIODIV DE-30 fid 48.68 bkl Tan, Xiaoping verfasserin aut Target epidermal damage of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite. Target epidermal Glacial acetic acid Anthelmintic efficacy Yan, Ying verfasserin aut Zhang, Gengrong verfasserin aut Li, Pengfei verfasserin aut Ling, Fei verfasserin aut Liu, Tianqiang verfasserin aut Wang, Gaoxue verfasserin aut Enthalten in Aquaculture Amsterdam [u.a.] : Elsevier Science, 1972 577 Online-Ressource (DE-627)306314002 (DE-600)1495998-7 (DE-576)094503966 nnns volume:577 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.68 Aquakultur VZ AR 577
allfieldsGer	10.1016/j.aquaculture.2023.739993 doi (DE-627)ELV063511789 (ELSEVIER)S0044-8486(23)00767-6 DE-627 ger DE-627 rda eng 570 550 VZ BIODIV DE-30 fid 48.68 bkl Tan, Xiaoping verfasserin aut Target epidermal damage of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite. Target epidermal Glacial acetic acid Anthelmintic efficacy Yan, Ying verfasserin aut Zhang, Gengrong verfasserin aut Li, Pengfei verfasserin aut Ling, Fei verfasserin aut Liu, Tianqiang verfasserin aut Wang, Gaoxue verfasserin aut Enthalten in Aquaculture Amsterdam [u.a.] : Elsevier Science, 1972 577 Online-Ressource (DE-627)306314002 (DE-600)1495998-7 (DE-576)094503966 nnns volume:577 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.68 Aquakultur VZ AR 577
allfieldsSound	10.1016/j.aquaculture.2023.739993 doi (DE-627)ELV063511789 (ELSEVIER)S0044-8486(23)00767-6 DE-627 ger DE-627 rda eng 570 550 VZ BIODIV DE-30 fid 48.68 bkl Tan, Xiaoping verfasserin aut Target epidermal damage of 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite. Target epidermal Glacial acetic acid Anthelmintic efficacy Yan, Ying verfasserin aut Zhang, Gengrong verfasserin aut Li, Pengfei verfasserin aut Ling, Fei verfasserin aut Liu, Tianqiang verfasserin aut Wang, Gaoxue verfasserin aut Enthalten in Aquaculture Amsterdam [u.a.] : Elsevier Science, 1972 577 Online-Ressource (DE-627)306314002 (DE-600)1495998-7 (DE-576)094503966 nnns volume:577 GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 48.68 Aquakultur VZ AR 577
language	English
source	Enthalten in Aquaculture 577 volume:577
sourceStr	Enthalten in Aquaculture 577 volume:577
format_phy_str_mv	Article
bklname	Aquakultur
institution	findex.gbv.de
topic_facet	Target epidermal Glacial acetic acid Anthelmintic efficacy
dewey-raw	570
isfreeaccess_bool	false
container_title	Aquaculture
authorswithroles_txt_mv	Tan, Xiaoping @@aut@@ Yan, Ying @@aut@@ Zhang, Gengrong @@aut@@ Li, Pengfei @@aut@@ Ling, Fei @@aut@@ Liu, Tianqiang @@aut@@ Wang, Gaoxue @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	306314002
dewey-sort	3570
id	ELV063511789
language_de	englisch
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author	Tan, Xiaoping
spellingShingle	Tan, Xiaoping ddc 570 fid BIODIV bkl 48.68 misc Target epidermal misc Glacial acetic acid misc Anthelmintic efficacy Target epidermal damage of
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title	Target epidermal damage of
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title_sort	target epidermal damage of
title_auth	Target epidermal damage of
abstract	Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite.
abstractGer	Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite.
abstract_unstemmed	Gyrodactylosis causes fish to be infected by other harmful pathogens, resulting in high mortality rates and serious economic losses to the aquaculture industry. Currently, unapproved chemicals are the main reliance for gyrodactylosis treatment, which is not always satisfactory. Targeted selection of compounds that destroy the epidermal structure of the parasite becomes an ideal strategy for parasites control. Therefore, glacial acetic acid (GAA) was found to have the ability to corrode the body surface of the parasite and thus achieve an antiparasitic effect. Next, we evaluated the anthelmintic activity of GAA, the maximum anthelmintic activity of 0.005% GAA for 48 h was 89%, and 0.01% GAA completely killed all Gyrodactylus kobayashii in 40 min. Further research involved evaluating water quality parameters and mRNA expression patterns of xenobiotics sensitive genes, ultimately selecting the treatment method of 0.01% for 40 min followed by transferring the goldfish to normal water for further study. In vitro experiments and scanning electron microscopy results revealed that GAA inhibits parasite activity and ultimately leads to parasite death by disrupting the structure of the parasite's body surface. Overall, these findings suggest that GAA could be a promising alternative compound for controlling Gyrodactylus infections and targeted disruption of the worm's body surface structure is an effective strategy for eliminating the parasite.
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title_short	Target epidermal damage of
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up_date	2024-07-06T19:44:12.444Z
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