Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant

A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zhang, Fang [verfasserIn] Li, Qixian [verfasserIn] Zhu, Jingru [verfasserIn] Liu, Xinyue [verfasserIn] Ding, Juan [verfasserIn] Sun, Jie [verfasserIn] Liu, Yang [verfasserIn] Jiang, Tingting [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy

Übergeordnetes Werk:	Enthalten in: Colloids and surfaces / B - Amsterdam [u.a.] : Elsevier Science, 1993, 224
Übergeordnetes Werk:	volume:224

DOI / URN:	10.1016/j.colsurfb.2023.113207

Katalog-ID:	ELV06364567X

Internformat


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245	1	0	\|a Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant
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520			\|a A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms.
650		4	\|a Carbon nanodots
650		4	\|a Vancomycin
650		4	\|a Surface-charge-switch
650		4	\|a Vancomycin-resistant
650		4	\|a Photothermal therapy
700	1		\|a Li, Qixian \|e verfasserin \|4 aut
700	1		\|a Zhu, Jingru \|e verfasserin \|4 aut
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700	1		\|a Ding, Juan \|e verfasserin \|4 aut
700	1		\|a Sun, Jie \|e verfasserin \|4 aut
700	1		\|a Liu, Yang \|e verfasserin \|4 aut
700	1		\|a Jiang, Tingting \|e verfasserin \|4 aut
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912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_187
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912			\|a GBV_ILN_230
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912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
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912			\|a GBV_ILN_2004
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912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
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912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 42.15 \|j Zellbiologie \|q VZ
951			\|a AR
952			\|d 224

Indexfelder

author_variant	f z fz q l ql j z jz x l xl j d jd j s js y l yl t j tj
matchkey_str	article:18734367:2023----::ufccagsictigrdefsebyfacmcnoiidabnaoosoehnepoohra
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publishDate	2023
allfields	10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224
spelling	10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224
allfields_unstemmed	10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224
allfieldsGer	10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224
allfieldsSound	10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224
language	English
source	Enthalten in Colloids and surfaces / B 224 volume:224
sourceStr	Enthalten in Colloids and surfaces / B 224 volume:224
format_phy_str_mv	Article
bklname	Zellbiologie
institution	findex.gbv.de
topic_facet	Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy
dewey-raw	540
isfreeaccess_bool	false
container_title	Colloids and surfaces / B
authorswithroles_txt_mv	Zhang, Fang @@aut@@ Li, Qixian @@aut@@ Zhu, Jingru @@aut@@ Liu, Xinyue @@aut@@ Ding, Juan @@aut@@ Sun, Jie @@aut@@ Liu, Yang @@aut@@ Jiang, Tingting @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	306660016
dewey-sort	3540
id	ELV06364567X
language_de	englisch
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author	Zhang, Fang
spellingShingle	Zhang, Fang ddc 540 bkl 42.15 misc Carbon nanodots misc Vancomycin misc Surface-charge-switch misc Vancomycin-resistant misc Photothermal therapy Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant
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topic_title	540 VZ 42.15 bkl Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy
topic	ddc 540 bkl 42.15 misc Carbon nanodots misc Vancomycin misc Surface-charge-switch misc Vancomycin-resistant misc Photothermal therapy
topic_unstemmed	ddc 540 bkl 42.15 misc Carbon nanodots misc Vancomycin misc Surface-charge-switch misc Vancomycin-resistant misc Photothermal therapy
topic_browse	ddc 540 bkl 42.15 misc Carbon nanodots misc Vancomycin misc Surface-charge-switch misc Vancomycin-resistant misc Photothermal therapy
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title	Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant
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title_full	Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant
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journal	Colloids and surfaces / B
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author_browse	Zhang, Fang Li, Qixian Zhu, Jingru Liu, Xinyue Ding, Juan Sun, Jie Liu, Yang Jiang, Tingting
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doi_str_mv	10.1016/j.colsurfb.2023.113207
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title_sort	surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant
title_auth	Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant
abstract	A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms.
abstractGer	A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms.
abstract_unstemmed	A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms.
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title_short	Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant
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author2	Li, Qixian Zhu, Jingru Liu, Xinyue Ding, Juan Sun, Jie Liu, Yang Jiang, Tingting
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doi_str	10.1016/j.colsurfb.2023.113207
up_date	2024-07-06T19:51:03.235Z
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Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant

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