Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant
A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which...
Ausführliche Beschreibung
Autor*in: |
Zhang, Fang [verfasserIn] Li, Qixian [verfasserIn] Zhu, Jingru [verfasserIn] Liu, Xinyue [verfasserIn] Ding, Juan [verfasserIn] Sun, Jie [verfasserIn] Liu, Yang [verfasserIn] Jiang, Tingting [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Colloids and surfaces / B - Amsterdam [u.a.] : Elsevier Science, 1993, 224 |
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Übergeordnetes Werk: |
volume:224 |
DOI / URN: |
10.1016/j.colsurfb.2023.113207 |
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Katalog-ID: |
ELV06364567X |
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520 | |a A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. | ||
650 | 4 | |a Carbon nanodots | |
650 | 4 | |a Vancomycin | |
650 | 4 | |a Surface-charge-switch | |
650 | 4 | |a Vancomycin-resistant | |
650 | 4 | |a Photothermal therapy | |
700 | 1 | |a Li, Qixian |e verfasserin |4 aut | |
700 | 1 | |a Zhu, Jingru |e verfasserin |4 aut | |
700 | 1 | |a Liu, Xinyue |e verfasserin |4 aut | |
700 | 1 | |a Ding, Juan |e verfasserin |4 aut | |
700 | 1 | |a Sun, Jie |e verfasserin |4 aut | |
700 | 1 | |a Liu, Yang |e verfasserin |4 aut | |
700 | 1 | |a Jiang, Tingting |e verfasserin |4 aut | |
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allfields |
10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224 |
spelling |
10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224 |
allfields_unstemmed |
10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224 |
allfieldsGer |
10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224 |
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10.1016/j.colsurfb.2023.113207 doi (DE-627)ELV06364567X (ELSEVIER)S0927-7765(23)00085-1 DE-627 ger DE-627 rda eng 540 VZ 42.15 bkl Zhang, Fang verfasserin aut Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy Li, Qixian verfasserin aut Zhu, Jingru verfasserin aut Liu, Xinyue verfasserin aut Ding, Juan verfasserin aut Sun, Jie verfasserin aut Liu, Yang verfasserin aut Jiang, Tingting verfasserin aut Enthalten in Colloids and surfaces / B Amsterdam [u.a.] : Elsevier Science, 1993 224 Online-Ressource (DE-627)306660016 (DE-600)1500523-9 (DE-576)098614851 1873-4367 nnns volume:224 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.15 Zellbiologie VZ AR 224 |
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Zhang, Fang @@aut@@ Li, Qixian @@aut@@ Zhu, Jingru @@aut@@ Liu, Xinyue @@aut@@ Ding, Juan @@aut@@ Sun, Jie @@aut@@ Liu, Yang @@aut@@ Jiang, Tingting @@aut@@ |
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Zhang, Fang ddc 540 bkl 42.15 misc Carbon nanodots misc Vancomycin misc Surface-charge-switch misc Vancomycin-resistant misc Photothermal therapy Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant |
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540 VZ 42.15 bkl Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant Carbon nanodots Vancomycin Surface-charge-switch Vancomycin-resistant Photothermal therapy |
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ddc 540 bkl 42.15 misc Carbon nanodots misc Vancomycin misc Surface-charge-switch misc Vancomycin-resistant misc Photothermal therapy |
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ddc 540 bkl 42.15 misc Carbon nanodots misc Vancomycin misc Surface-charge-switch misc Vancomycin-resistant misc Photothermal therapy |
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ddc 540 bkl 42.15 misc Carbon nanodots misc Vancomycin misc Surface-charge-switch misc Vancomycin-resistant misc Photothermal therapy |
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Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant |
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Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant |
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Colloids and surfaces / B |
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Zhang, Fang Li, Qixian Zhu, Jingru Liu, Xinyue Ding, Juan Sun, Jie Liu, Yang Jiang, Tingting |
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surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant |
title_auth |
Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant |
abstract |
A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. |
abstractGer |
A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. |
abstract_unstemmed |
A new type of vancomycin (Van)-modified carbon nanodots (CNDsVan) with pH-responsive surface charge switchable activity was successfully developed by covalently cross-linking Van on the surface of carbon nanodots (CNDs). Polymeric Van was formed on the surface of CNDs by covalent modification, which enhanced the targeted binding of CNDs@Van to vancomycin-resistant enterococci (VRE) biofilms and effectively reduced the carboxyl groups on the surface of CNDs to achieve pH-responsive surface charge switching. Most importantly, CNDs@Van was free at pH 7.4, but assembled at pH 5.5 owing to surface charge switching from negative to zero, resulting in remarkably enhanced near-infrared (NIR) absorption and photothermal properties. CNDs@Van exhibited good biocompatibility, low cytotoxicity, and weak hemolytic effects under physiological conditions (pH 7.4). Regarding targeted binding to VRE bacteria, CNDs@Van self-assembled in a weakly acidic environment (pH 5.5) generated by VRE biofilms, giving enhanced photokilling effects in in vitro and in vivo assays. Therefore, potentially, CNDs@Van can be used as a novel antimicrobial agent against VRE bacterial infections and their biofilms. |
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title_short |
Surface-charge-switch triggered self assembly of vancomycin modified carbon nanodots for enhanced photothermal eradication of vancomycin-resistant |
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Li, Qixian Zhu, Jingru Liu, Xinyue Ding, Juan Sun, Jie Liu, Yang Jiang, Tingting |
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up_date |
2024-07-06T19:51:03.235Z |
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