Thin and hypokinetic myocardial segments in cats with cardiomyopathy
Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV w...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Novo Matos, J. [verfasserIn] Sargent, J. [verfasserIn] Silva, J. [verfasserIn] Payne, J.R. [verfasserIn] Seo, J. [verfasserIn] Spalla, I. [verfasserIn] Borgeat, K. [verfasserIn] Loureiro, J. [verfasserIn] Pereira, N. [verfasserIn] Simcock, I.C. [verfasserIn] Hutchinson, J.C. [verfasserIn] Arthurs, O.J. [verfasserIn] Luis Fuentes, V. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of veterinary cardiology - Amsterdam [u.a.] : Elsevier, 1999, 46, Seite 5-17 |
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| Übergeordnetes Werk: |
volume:46 ; pages:5-17 |
| DOI / URN: |
10.1016/j.jvc.2023.02.002 |
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ELV064267466 |
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| 100 | 1 | |a Novo Matos, J. |e verfasserin |0 (orcid)0000-0001-8128-8111 |4 aut | |
| 245 | 1 | 0 | |a Thin and hypokinetic myocardial segments in cats with cardiomyopathy |
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| 520 | |a Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. | ||
| 650 | 4 | |a Infarct | |
| 650 | 4 | |a Hypertrophic cardiomyopathy | |
| 650 | 4 | |a Fibrosis | |
| 650 | 4 | |a Cardiomyopathy of non-specific phenotype | |
| 650 | 4 | |a Micro-CT | |
| 700 | 1 | |a Sargent, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Payne, J.R. |e verfasserin |0 (orcid)0000-0001-6057-520X |4 aut | |
| 700 | 1 | |a Seo, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Spalla, I. |e verfasserin |0 (orcid)0000-0003-0039-1438 |4 aut | |
| 700 | 1 | |a Borgeat, K. |e verfasserin |4 aut | |
| 700 | 1 | |a Loureiro, J. |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, N. |e verfasserin |0 (orcid)0000-0001-5966-2613 |4 aut | |
| 700 | 1 | |a Simcock, I.C. |e verfasserin |0 (orcid)0000-0002-5619-0785 |4 aut | |
| 700 | 1 | |a Hutchinson, J.C. |e verfasserin |0 (orcid)0000-0002-1708-2634 |4 aut | |
| 700 | 1 | |a Arthurs, O.J. |e verfasserin |4 aut | |
| 700 | 1 | |a Luis Fuentes, V. |e verfasserin |0 (orcid)0000-0001-8076-3806 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of veterinary cardiology |d Amsterdam [u.a.] : Elsevier, 1999 |g 46, Seite 5-17 |h Online-Ressource |w (DE-627)495743127 |w (DE-600)2198278-8 |w (DE-576)271586230 |x 1875-0834 |7 nnns |
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10.1016/j.jvc.2023.02.002 doi (DE-627)ELV064267466 (ELSEVIER)S1760-2734(23)00009-7 DE-627 ger DE-627 rda eng 630 VZ Novo Matos, J. verfasserin (orcid)0000-0001-8128-8111 aut Thin and hypokinetic myocardial segments in cats with cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. Infarct Hypertrophic cardiomyopathy Fibrosis Cardiomyopathy of non-specific phenotype Micro-CT Sargent, J. verfasserin aut Silva, J. verfasserin aut Payne, J.R. verfasserin (orcid)0000-0001-6057-520X aut Seo, J. verfasserin aut Spalla, I. verfasserin (orcid)0000-0003-0039-1438 aut Borgeat, K. verfasserin aut Loureiro, J. verfasserin aut Pereira, N. verfasserin (orcid)0000-0001-5966-2613 aut Simcock, I.C. verfasserin (orcid)0000-0002-5619-0785 aut Hutchinson, J.C. verfasserin (orcid)0000-0002-1708-2634 aut Arthurs, O.J. verfasserin aut Luis Fuentes, V. verfasserin (orcid)0000-0001-8076-3806 aut Enthalten in Journal of veterinary cardiology Amsterdam [u.a.] : Elsevier, 1999 46, Seite 5-17 Online-Ressource (DE-627)495743127 (DE-600)2198278-8 (DE-576)271586230 1875-0834 nnns volume:46 pages:5-17 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 5-17 |
| spelling |
10.1016/j.jvc.2023.02.002 doi (DE-627)ELV064267466 (ELSEVIER)S1760-2734(23)00009-7 DE-627 ger DE-627 rda eng 630 VZ Novo Matos, J. verfasserin (orcid)0000-0001-8128-8111 aut Thin and hypokinetic myocardial segments in cats with cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. Infarct Hypertrophic cardiomyopathy Fibrosis Cardiomyopathy of non-specific phenotype Micro-CT Sargent, J. verfasserin aut Silva, J. verfasserin aut Payne, J.R. verfasserin (orcid)0000-0001-6057-520X aut Seo, J. verfasserin aut Spalla, I. verfasserin (orcid)0000-0003-0039-1438 aut Borgeat, K. verfasserin aut Loureiro, J. verfasserin aut Pereira, N. verfasserin (orcid)0000-0001-5966-2613 aut Simcock, I.C. verfasserin (orcid)0000-0002-5619-0785 aut Hutchinson, J.C. verfasserin (orcid)0000-0002-1708-2634 aut Arthurs, O.J. verfasserin aut Luis Fuentes, V. verfasserin (orcid)0000-0001-8076-3806 aut Enthalten in Journal of veterinary cardiology Amsterdam [u.a.] : Elsevier, 1999 46, Seite 5-17 Online-Ressource (DE-627)495743127 (DE-600)2198278-8 (DE-576)271586230 1875-0834 nnns volume:46 pages:5-17 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 5-17 |
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10.1016/j.jvc.2023.02.002 doi (DE-627)ELV064267466 (ELSEVIER)S1760-2734(23)00009-7 DE-627 ger DE-627 rda eng 630 VZ Novo Matos, J. verfasserin (orcid)0000-0001-8128-8111 aut Thin and hypokinetic myocardial segments in cats with cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. Infarct Hypertrophic cardiomyopathy Fibrosis Cardiomyopathy of non-specific phenotype Micro-CT Sargent, J. verfasserin aut Silva, J. verfasserin aut Payne, J.R. verfasserin (orcid)0000-0001-6057-520X aut Seo, J. verfasserin aut Spalla, I. verfasserin (orcid)0000-0003-0039-1438 aut Borgeat, K. verfasserin aut Loureiro, J. verfasserin aut Pereira, N. verfasserin (orcid)0000-0001-5966-2613 aut Simcock, I.C. verfasserin (orcid)0000-0002-5619-0785 aut Hutchinson, J.C. verfasserin (orcid)0000-0002-1708-2634 aut Arthurs, O.J. verfasserin aut Luis Fuentes, V. verfasserin (orcid)0000-0001-8076-3806 aut Enthalten in Journal of veterinary cardiology Amsterdam [u.a.] : Elsevier, 1999 46, Seite 5-17 Online-Ressource (DE-627)495743127 (DE-600)2198278-8 (DE-576)271586230 1875-0834 nnns volume:46 pages:5-17 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 5-17 |
| allfieldsGer |
10.1016/j.jvc.2023.02.002 doi (DE-627)ELV064267466 (ELSEVIER)S1760-2734(23)00009-7 DE-627 ger DE-627 rda eng 630 VZ Novo Matos, J. verfasserin (orcid)0000-0001-8128-8111 aut Thin and hypokinetic myocardial segments in cats with cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. Infarct Hypertrophic cardiomyopathy Fibrosis Cardiomyopathy of non-specific phenotype Micro-CT Sargent, J. verfasserin aut Silva, J. verfasserin aut Payne, J.R. verfasserin (orcid)0000-0001-6057-520X aut Seo, J. verfasserin aut Spalla, I. verfasserin (orcid)0000-0003-0039-1438 aut Borgeat, K. verfasserin aut Loureiro, J. verfasserin aut Pereira, N. verfasserin (orcid)0000-0001-5966-2613 aut Simcock, I.C. verfasserin (orcid)0000-0002-5619-0785 aut Hutchinson, J.C. verfasserin (orcid)0000-0002-1708-2634 aut Arthurs, O.J. verfasserin aut Luis Fuentes, V. verfasserin (orcid)0000-0001-8076-3806 aut Enthalten in Journal of veterinary cardiology Amsterdam [u.a.] : Elsevier, 1999 46, Seite 5-17 Online-Ressource (DE-627)495743127 (DE-600)2198278-8 (DE-576)271586230 1875-0834 nnns volume:46 pages:5-17 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 5-17 |
| allfieldsSound |
10.1016/j.jvc.2023.02.002 doi (DE-627)ELV064267466 (ELSEVIER)S1760-2734(23)00009-7 DE-627 ger DE-627 rda eng 630 VZ Novo Matos, J. verfasserin (orcid)0000-0001-8128-8111 aut Thin and hypokinetic myocardial segments in cats with cardiomyopathy 2023 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. Infarct Hypertrophic cardiomyopathy Fibrosis Cardiomyopathy of non-specific phenotype Micro-CT Sargent, J. verfasserin aut Silva, J. verfasserin aut Payne, J.R. verfasserin (orcid)0000-0001-6057-520X aut Seo, J. verfasserin aut Spalla, I. verfasserin (orcid)0000-0003-0039-1438 aut Borgeat, K. verfasserin aut Loureiro, J. verfasserin aut Pereira, N. verfasserin (orcid)0000-0001-5966-2613 aut Simcock, I.C. verfasserin (orcid)0000-0002-5619-0785 aut Hutchinson, J.C. verfasserin (orcid)0000-0002-1708-2634 aut Arthurs, O.J. verfasserin aut Luis Fuentes, V. verfasserin (orcid)0000-0001-8076-3806 aut Enthalten in Journal of veterinary cardiology Amsterdam [u.a.] : Elsevier, 1999 46, Seite 5-17 Online-Ressource (DE-627)495743127 (DE-600)2198278-8 (DE-576)271586230 1875-0834 nnns volume:46 pages:5-17 GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 46 5-17 |
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Novo Matos, J. @@aut@@ Sargent, J. @@aut@@ Silva, J. @@aut@@ Payne, J.R. @@aut@@ Seo, J. @@aut@@ Spalla, I. @@aut@@ Borgeat, K. @@aut@@ Loureiro, J. @@aut@@ Pereira, N. @@aut@@ Simcock, I.C. @@aut@@ Hutchinson, J.C. @@aut@@ Arthurs, O.J. @@aut@@ Luis Fuentes, V. @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV064267466</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230926164343.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230915s2023 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jvc.2023.02.002</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV064267466</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1760-2734(23)00009-7</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Novo Matos, J.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0001-8128-8111</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Thin and hypokinetic myocardial segments in cats with cardiomyopathy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Infarct</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hypertrophic cardiomyopathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fibrosis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cardiomyopathy of non-specific phenotype</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Micro-CT</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sargent, J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Silva, J.</subfield><subfield code="e">verfasserin</subfield><subfield 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Novo Matos, J. |
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Novo Matos, J. ddc 630 misc Infarct misc Hypertrophic cardiomyopathy misc Fibrosis misc Cardiomyopathy of non-specific phenotype misc Micro-CT Thin and hypokinetic myocardial segments in cats with cardiomyopathy |
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630 VZ Thin and hypokinetic myocardial segments in cats with cardiomyopathy Infarct Hypertrophic cardiomyopathy Fibrosis Cardiomyopathy of non-specific phenotype Micro-CT |
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ddc 630 misc Infarct misc Hypertrophic cardiomyopathy misc Fibrosis misc Cardiomyopathy of non-specific phenotype misc Micro-CT |
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ddc 630 misc Infarct misc Hypertrophic cardiomyopathy misc Fibrosis misc Cardiomyopathy of non-specific phenotype misc Micro-CT |
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Thin and hypokinetic myocardial segments in cats with cardiomyopathy |
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Thin and hypokinetic myocardial segments in cats with cardiomyopathy |
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Novo Matos, J. |
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Journal of veterinary cardiology |
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Journal of veterinary cardiology |
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Novo Matos, J. Sargent, J. Silva, J. Payne, J.R. Seo, J. Spalla, I. Borgeat, K. Loureiro, J. Pereira, N. Simcock, I.C. Hutchinson, J.C. Arthurs, O.J. Luis Fuentes, V. |
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Novo Matos, J. |
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10.1016/j.jvc.2023.02.002 |
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thin and hypokinetic myocardial segments in cats with cardiomyopathy |
| title_auth |
Thin and hypokinetic myocardial segments in cats with cardiomyopathy |
| abstract |
Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. |
| abstractGer |
Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. |
| abstract_unstemmed |
Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. |
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| title_short |
Thin and hypokinetic myocardial segments in cats with cardiomyopathy |
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Sargent, J. Silva, J. Payne, J.R. Seo, J. Spalla, I. Borgeat, K. Loureiro, J. Pereira, N. Simcock, I.C. Hutchinson, J.C. Arthurs, O.J. Luis Fuentes, V. |
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Sargent, J. Silva, J. Payne, J.R. Seo, J. Spalla, I. Borgeat, K. Loureiro, J. Pereira, N. Simcock, I.C. Hutchinson, J.C. Arthurs, O.J. Luis Fuentes, V. |
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| doi_str |
10.1016/j.jvc.2023.02.002 |
| up_date |
2024-07-06T20:19:28.655Z |
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1803862323920633856 |
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We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).Animals: Eighty client-owned cats.Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). 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